ns 1619 has been researched along with Glial Cell Tumors in 6 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
| Excerpt | Relevance | Reference |
|---|---|---|
| " For example, Temozolomide (TMZ) exhibits some antitumor activity against brain tumors, so does Trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2 neu overexpressing gliomas." | 3.75 | Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model. ( Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, TS, 2009) |
| "The phloretin-induced increase in intracellular Ca(2+) was unaffected by the removal of extracellular Ca(2+) and co-application of paxilline." | 1.32 | BK channel openers inhibit migration of human glioma cells. ( Basrai, D; Bolz, J; Jung, S; Kraft, R; Krause, P; Liebmann, L; Patt, S, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, RP | 1 |
| Xue, YX | 3 |
| Huang, J | 1 |
| Wang, JH | 3 |
| Zhao, SY | 1 |
| Guan, TT | 1 |
| Zhang, Z | 1 |
| Gu, YT | 3 |
| Ningaraj, NS | 1 |
| Sankpal, UT | 1 |
| Khaitan, D | 1 |
| Meister, EA | 1 |
| Vats, TS | 1 |
| Wei, XY | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Wang, YF | 1 |
| ShangGuan, QR | 1 |
| Zhang, JX | 1 |
| Qin, LJ | 1 |
| Kraft, R | 1 |
| Krause, P | 1 |
| Jung, S | 1 |
| Basrai, D | 1 |
| Liebmann, L | 1 |
| Bolz, J | 1 |
| Patt, S | 1 |
| Debska, G | 1 |
| Kicinska, A | 1 |
| Dobrucki, J | 1 |
| Dworakowska, B | 1 |
| Nurowska, E | 1 |
| Skalska, J | 1 |
| Dolowy, K | 1 |
| Szewczyk, A | 1 |
6 other studies available for ns 1619 and Glial Cell Tumors
| Article | Year |
|---|---|
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell | 2016 |
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl | 2009 |
Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Cell Membrane Permeability; Disease M | 2011 |
Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Claudin-5; En | 2012 |
BK channel openers inhibit migration of human glioma cells.
Topics: Benzimidazoles; Cell Line, Tumor; Cell Migration Inhibition; Cell Movement; Glioma; Humans; Large-Co | 2003 |
Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
Topics: Benzimidazoles; Charybdotoxin; Chlorophenols; Glioma; Humans; Membrane Potentials; Mitochondria; Pat | 2003 |