ns 1619 has been researched along with Disease Models, Animal in 12 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With Sprague-Dawley rats subjected to hemorrhagic shock and their isolated superior mesenteric artery, the protective effect of NS1619 (0." | 1.40 | Bkca opener, NS1619 pretreatment protects against shock-induced vascular hyporeactivity through PDZ-Rho GEF-RhoA-Rho kinase pathway in rats. ( Hu, Y; Li, T; Liu, L; Xiao, X; Yang, G, 2014) |
| "Partial bladder outlet obstruction (PBOO) was surgically induced in male New Zealand White rabbits." | 1.36 | Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. ( Alanzi, J; Chacko, S; Chang, S; Gomes, CM; Hypolite, JA; Malkowicz, B; Marx, J; Wein, AJ; Zderic, SA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ning, FL | 1 |
| Tao, J | 1 |
| Li, DD | 1 |
| Tian, LL | 1 |
| Wang, ML | 1 |
| Reilly, S | 1 |
| Liu, C | 1 |
| Cai, H | 1 |
| Xin, H | 1 |
| Zhang, XM | 1 |
| Hu, Y | 1 |
| Yang, G | 1 |
| Xiao, X | 1 |
| Liu, L | 1 |
| Li, T | 1 |
| Heinen, A | 1 |
| Ströthoff, M | 1 |
| Schmidt, A | 1 |
| Stracke, N | 1 |
| Behmenburg, F | 1 |
| Bauer, I | 1 |
| Hollmann, MW | 1 |
| Huhn, R | 1 |
| McCullough, DJ | 1 |
| Vang, A | 1 |
| Choudhary, G | 1 |
| Borbouse, L | 1 |
| Dick, GM | 1 |
| Asano, S | 1 |
| Bender, SB | 1 |
| Dincer, UD | 1 |
| Payne, GA | 1 |
| Neeb, ZP | 1 |
| Bratz, IN | 1 |
| Sturek, M | 1 |
| Tune, JD | 1 |
| Wang, Y | 1 |
| Zhang, HT | 1 |
| Su, XL | 1 |
| Deng, XL | 1 |
| Yuan, BX | 1 |
| Zhang, W | 1 |
| Wang, XF | 1 |
| Yang, YB | 1 |
| Chang, S | 1 |
| Gomes, CM | 1 |
| Hypolite, JA | 1 |
| Marx, J | 1 |
| Alanzi, J | 1 |
| Zderic, SA | 1 |
| Malkowicz, B | 1 |
| Wein, AJ | 1 |
| Chacko, S | 1 |
| Alviña, K | 1 |
| Khodakhah, K | 1 |
| Gu, YT | 1 |
| Xue, YX | 1 |
| Wei, XY | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Armstead, WM | 1 |
12 other studies available for ns 1619 and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling.
Topics: Alkaline Phosphatase; Animals; Aorta, Thoracic; Benzimidazoles; Cholecalciferol; Disease Models, Ani | 2022 |
Bkca opener, NS1619 pretreatment protects against shock-induced vascular hyporeactivity through PDZ-Rho GEF-RhoA-Rho kinase pathway in rats.
Topics: Amides; Animals; Benzimidazoles; Calcium; Dilatation, Pathologic; Disease Models, Animal; Hemodynami | 2014 |
Pharmacological options to protect the aged heart from ischemia and reperfusion injury by targeting the PKA-BK(Ca) signaling pathway.
Topics: Age Factors; Aging; Animals; Benzimidazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytopr | 2014 |
NS1619-induced vasodilation is enhanced and differentially mediated in chronically hypoxic lungs.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Calcium Channels, L-Type; Chronic Disease; Disease | 2014 |
Impaired function of coronary BK(Ca) channels in metabolic syndrome.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 2-Chloroadenosine; 3-Pyridinecar | 2009 |
Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance.
Topics: Animals; Benzimidazoles; Blood Glucose; Body Weight; Cerebral Arteries; Diabetes Mellitus, Experimen | 2010 |
Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein.
Topics: Aged; Aged, 80 and over; Animals; Benzimidazoles; Case-Control Studies; Cells, Cultured; Disease Mod | 2010 |
KCa channels as therapeutic targets in episodic ataxia type-2.
Topics: Analysis of Variance; Animals; Benzimidazoles; Cerebellar Ataxia; Cerebellum; Chlorzoxazone; Disease | 2010 |
Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Cell Membrane Permeability; Disease M | 2011 |
Vasopressin-induced protein kinase C-dependent superoxide generation contributes to atp-sensitive potassium channel but not calcium-sensitive potassium channel function impairment after brain injury.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Arteries; Benzimidazoles; Brain Injuries; Brain I | 2001 |