ns 1619 has been researched along with Brain Neoplasms in 6 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For example, Temozolomide (TMZ) exhibits some antitumor activity against brain tumors, so does Trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2 neu overexpressing gliomas." | 3.75 | Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model. ( Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, TS, 2009) |
| "The expression of potassium channels in brain tumors is variable, which may be associated with different tumor permeability to therapeutic agents among patients." | 2.73 | Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. ( Bayan, JA; Black, KL; Espinoza, AJ; Hu, J; Irvin, D; Ko, MK; Konda, BM; Ong, JM; Sacapano, MR; Shu, Y; Wang, X; Yin, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, RP | 1 |
| Xue, YX | 3 |
| Huang, J | 1 |
| Wang, JH | 3 |
| Zhao, SY | 1 |
| Guan, TT | 1 |
| Zhang, Z | 1 |
| Gu, YT | 3 |
| Black, KL | 2 |
| Yin, D | 1 |
| Konda, BM | 1 |
| Wang, X | 1 |
| Hu, J | 1 |
| Ko, MK | 1 |
| Bayan, JA | 1 |
| Sacapano, MR | 1 |
| Espinoza, AJ | 1 |
| Ong, JM | 1 |
| Irvin, D | 1 |
| Shu, Y | 1 |
| Ningaraj, NS | 2 |
| Sankpal, UT | 1 |
| Khaitan, D | 1 |
| Meister, EA | 1 |
| Vats, TS | 1 |
| Wei, XY | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Wang, YF | 1 |
| ShangGuan, QR | 1 |
| Zhang, JX | 1 |
| Qin, LJ | 1 |
| Rao, M | 1 |
1 trial available for ns 1619 and Brain Neoplasms
| Article | Year |
|---|---|
Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeabi | 2008 |
5 other studies available for ns 1619 and Brain Neoplasms
| Article | Year |
|---|---|
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell | 2016 |
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl | 2009 |
Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Cell Membrane Permeability; Disease M | 2011 |
Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Claudin-5; En | 2012 |
Calcium-dependent potassium channels as a target protein for modulation of the blood-brain tumor barrier.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain; Brain Neoplasms; Capillary Permeability; Carbop | 2003 |