ns 1619 has been researched along with Bladder, Overactive in 4 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Partial bladder outlet obstruction (PBOO) was surgically induced in male New Zealand White rabbits." | 1.36 | Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. ( Alanzi, J; Chacko, S; Chang, S; Gomes, CM; Hypolite, JA; Malkowicz, B; Marx, J; Wein, AJ; Zderic, SA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 1 |
| Ding, H | 1 |
| Zhang, P | 1 |
| Li, Z | 1 |
| Liu, Y | 1 |
| Wang, P | 1 |
| Chang, S | 1 |
| Gomes, CM | 1 |
| Hypolite, JA | 1 |
| Marx, J | 1 |
| Alanzi, J | 1 |
| Zderic, SA | 1 |
| Malkowicz, B | 1 |
| Wein, AJ | 1 |
| Chacko, S | 1 |
| Oger, S | 1 |
| Behr-Roussel, D | 1 |
| Gorny, D | 1 |
| Bernabé, J | 1 |
| Comperat, E | 1 |
| Chartier-Kastler, E | 1 |
| Denys, P | 1 |
| Giuliano, F | 1 |
| Hristov, KL | 1 |
| Parajuli, SP | 1 |
| Soder, RP | 1 |
| Cheng, Q | 1 |
| Rovner, ES | 1 |
| Petkov, GV | 1 |
4 other studies available for ns 1619 and Bladder, Overactive
| Article | Year |
|---|---|
Attenuated BK channel function promotes overactive bladder in a rat model of obesity.
Topics: Animals; Benzimidazoles; Diet, High-Fat; Electric Stimulation; Female; Gene Expression Regulation; L | 2019 |
Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein.
Topics: Aged; Aged, 80 and over; Animals; Benzimidazoles; Case-Control Studies; Cells, Cultured; Disease Mod | 2010 |
Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients.
Topics: Action Potentials; Adult; Aged; Apamin; Benzimidazoles; Case-Control Studies; Glyburide; Humans; In | 2011 |
Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+-activated K+ channels.
Topics: Aged; Aged, 80 and over; Benzimidazoles; Calcium; Female; Humans; Large-Conductance Calcium-Activate | 2012 |