ns 1619 has been researched along with Benign Neoplasms, Brain in 6 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
| Excerpt | Relevance | Reference |
|---|---|---|
| " For example, Temozolomide (TMZ) exhibits some antitumor activity against brain tumors, so does Trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2 neu overexpressing gliomas." | 3.75 | Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model. ( Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, TS, 2009) |
| "The expression of potassium channels in brain tumors is variable, which may be associated with different tumor permeability to therapeutic agents among patients." | 2.73 | Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. ( Bayan, JA; Black, KL; Espinoza, AJ; Hu, J; Irvin, D; Ko, MK; Konda, BM; Ong, JM; Sacapano, MR; Shu, Y; Wang, X; Yin, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, RP | 1 |
| Xue, YX | 3 |
| Huang, J | 1 |
| Wang, JH | 3 |
| Zhao, SY | 1 |
| Guan, TT | 1 |
| Zhang, Z | 1 |
| Gu, YT | 3 |
| Black, KL | 2 |
| Yin, D | 1 |
| Konda, BM | 1 |
| Wang, X | 1 |
| Hu, J | 1 |
| Ko, MK | 1 |
| Bayan, JA | 1 |
| Sacapano, MR | 1 |
| Espinoza, AJ | 1 |
| Ong, JM | 1 |
| Irvin, D | 1 |
| Shu, Y | 1 |
| Ningaraj, NS | 2 |
| Sankpal, UT | 1 |
| Khaitan, D | 1 |
| Meister, EA | 1 |
| Vats, TS | 1 |
| Wei, XY | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Wang, YF | 1 |
| ShangGuan, QR | 1 |
| Zhang, JX | 1 |
| Qin, LJ | 1 |
| Rao, M | 1 |
1 trial available for ns 1619 and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeabi | 2008 |
5 other studies available for ns 1619 and Benign Neoplasms, Brain
| Article | Year |
|---|---|
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell | 2016 |
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl | 2009 |
Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Cell Membrane Permeability; Disease M | 2011 |
Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Claudin-5; En | 2012 |
Calcium-dependent potassium channels as a target protein for modulation of the blood-brain tumor barrier.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain; Brain Neoplasms; Capillary Permeability; Carbop | 2003 |