ns 1619 has been researched along with Astrocytoma, Grade IV in 1 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The expression of potassium channels in brain tumors is variable, which may be associated with different tumor permeability to therapeutic agents among patients." | 2.73 | Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. ( Bayan, JA; Black, KL; Espinoza, AJ; Hu, J; Irvin, D; Ko, MK; Konda, BM; Ong, JM; Sacapano, MR; Shu, Y; Wang, X; Yin, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Black, KL | 1 |
| Yin, D | 1 |
| Konda, BM | 1 |
| Wang, X | 1 |
| Hu, J | 1 |
| Ko, MK | 1 |
| Bayan, JA | 1 |
| Sacapano, MR | 1 |
| Espinoza, AJ | 1 |
| Ong, JM | 1 |
| Irvin, D | 1 |
| Shu, Y | 1 |
1 trial available for ns 1619 and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeabi | 2008 |