Page last updated: 2024-11-01

ns 1619 and Anoxia, Brain

ns 1619 has been researched along with Anoxia, Brain in 3 studies

NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Research Excerpts

ExcerptRelevanceReference
"For aprikalim (n=7), values were as follows: 6+/-2% versus 8+/-2% at 10(-5) mol/L, 22+/-6% versus 15+/-3% at 5 x 10(-5) mol/L, and 41+/-5% versus 32+/-6% at 10(-4) mol/L."1.30Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Veltkamp, R, 1998)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Veltkamp, R1
Domoki, F1
Bari, F1
Busija, DW1
Ben-Haim, G1
Armstead, WM1
Rundén-Pran, E1
Haug, FM1
Storm, JF1
Ottersen, OP1

Other Studies

3 other studies available for ns 1619 and Anoxia, Brain

ArticleYear
Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets.
    Stroke, 1998, Volume: 29, Issue:4

    Topics: Analysis of Variance; Animals; Animals, Newborn; Benzimidazoles; Calcitonin Gene-Related Peptide; Fe

1998
Stimulus duration-dependent contribution of k(ca) channel activation and cAMP to hypoxic cerebrovasodilation.
    Brain research, 2000, Jan-24, Volume: 853, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzimidazoles; Blood Gas Analysis; Blood Pressure;

2000
BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures.
    Neuroscience, 2002, Volume: 112, Issue:2

    Topics: Animals; Benzimidazoles; Cell Death; Cell Hypoxia; Dose-Response Relationship, Drug; Fluorescent Dye

2002