ns-004 and Urinary-Incontinence

ns-004 has been researched along with Urinary-Incontinence* in 1 studies

Other Studies

1 other study(ies) available for ns-004 and Urinary-Incontinence

Article	Year
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence. Bioorganic & medicinal chemistry letters, 2002, Apr-08, Volume: 12, Issue:7 A series of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones was prepared and shown by electrophysiological analysis to activate a cloned maxi-K channel mSlo (or hSlo) expressed in Xenopus laevis oocytes. The effects of these structurally novel maxi-K channel openers on bladder contractile function were studied in vitro using isolated rat bladder strips pre-contracted with carbachol. Several 1,3-diaryl 1,2,4-(4H)-triazol-5-one derivatives were found to be potent smooth muscle relaxants but this activity did not completely correlate with maxi-K channel opening. Topics: Animals; Azo Compounds; Calcium; Carbachol; Cells, Cultured; Electrophysiology; Humans; Large-Conductance Calcium-Activated Potassium Channels; Male; Mice; Microinjections; Models, Molecular; Muscle Relaxation; Muscle, Smooth; Oocytes; Potassium Channels, Calcium-Activated; Rats; RNA, Messenger; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence; Xenopus laevis	2002

Article

Year

The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.

Bioorganic & medicinal chemistry letters, 2002, Apr-08, Volume: 12, Issue:7

A series of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones was prepared and shown by electrophysiological analysis to activate a cloned maxi-K channel mSlo (or hSlo) expressed in Xenopus laevis oocytes. The effects of these structurally novel maxi-K channel openers on bladder contractile function were studied in vitro using isolated rat bladder strips pre-contracted with carbachol. Several 1,3-diaryl 1,2,4-(4H)-triazol-5-one derivatives were found to be potent smooth muscle relaxants but this activity did not completely correlate with maxi-K channel opening.

Topics: Animals; Azo Compounds; Calcium; Carbachol; Cells, Cultured; Electrophysiology; Humans; Large-Conductance Calcium-Activated Potassium Channels; Male; Mice; Microinjections; Models, Molecular; Muscle Relaxation; Muscle, Smooth; Oocytes; Potassium Channels, Calcium-Activated; Rats; RNA, Messenger; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence; Xenopus laevis

2002