ns-004 and Erectile-Dysfunction

ns-004 has been researched along with Erectile-Dysfunction* in 1 studies

Other Studies

1 other study(ies) available for ns-004 and Erectile-Dysfunction

Article	Year
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. From this study, a potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function. Topics: Animals; Blood Pressure; Electric Stimulation; Erectile Dysfunction; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Relaxation; Muscle, Smooth; Penile Erection; Penis; Potassium Channels, Calcium-Activated; Pressure; Quinolones; Rabbits; Rats; Rats, Inbred F344; Structure-Activity Relationship	2003

Article

Year

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.

Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. From this study, a potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function.

Topics: Animals; Blood Pressure; Electric Stimulation; Erectile Dysfunction; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Relaxation; Muscle, Smooth; Penile Erection; Penis; Potassium Channels, Calcium-Activated; Pressure; Quinolones; Rabbits; Rats; Rats, Inbred F344; Structure-Activity Relationship

2003