ns-004 and Disease-Models--Animal

ns-004 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for ns-004 and Disease-Models--Animal

Article	Year
The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection. Bioorganic & medicinal chemistry letters, 2002, Jul-08, Volume: 12, Issue:13 A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke. Topics: Animals; Brain; Clone Cells; Disease Models, Animal; Electrophysiology; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Quinolones; Rats; Stroke; Structure-Activity Relationship; Xenopus laevis	2002

Article

Year

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.

Bioorganic & medicinal chemistry letters, 2002, Jul-08, Volume: 12, Issue:13

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.

Topics: Animals; Brain; Clone Cells; Disease Models, Animal; Electrophysiology; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Quinolones; Rats; Stroke; Structure-Activity Relationship; Xenopus laevis

2002