np-031112 and Staphylococcal-Infections

np-031112 has been researched along with Staphylococcal-Infections* in 1 studies

Other Studies

1 other study(ies) available for np-031112 and Staphylococcal-Infections

Article	Year
Tideglusib and Its Analogues As Inhibitors of Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15 Sortase A (SrtA) anchors surface proteins to the cell wall envelope, and it has attracted increasing interesting as a potential antivirulence target. Several small-molecule inhibitors for SrtA have been developed, but target validation remains largely underexplored. Herein, we report a new class of SrtA inhibitors that supports antivirulence therapy through small-molecule targeting of SrtA. Tideglusib ( Topics: Aminoacyltransferases; Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Staphylococcal Infections; Staphylococcus aureus; Thiadiazoles	2020

Article

Year

Tideglusib and Its Analogues As Inhibitors of

Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15

Sortase A (SrtA) anchors surface proteins to the cell wall envelope, and it has attracted increasing interesting as a potential antivirulence target. Several small-molecule inhibitors for SrtA have been developed, but target validation remains largely underexplored. Herein, we report a new class of SrtA inhibitors that supports antivirulence therapy through small-molecule targeting of SrtA. Tideglusib (

Topics: Aminoacyltransferases; Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Staphylococcal Infections; Staphylococcus aureus; Thiadiazoles

2020