noxythiolin and Urethral-Obstruction

A randomised control trial was undertaken in 100 consecutive patients undergoing endoscopic surgery for outflow tract obstruction to assess the efficacy of noxythiolin in preventing post-operative bacteriuria; 1% noxythiolin or sterile water was instilled at the time of catheter removal. The incidence of bacteriuria in the treated group (7/50) was significantly lower than in the control group (19/50). This was statistically significant. This difference was more marked in patients who had been catheterised for retention of urine. There was no difference in the complication rate despite a reduction of infection in the treated group.

Topics: Administration, Intravesical; Aged; Aged, 80 and over; Bacteriuria; Clinical Trials as Topic; Humans; Middle Aged; Noxythiolin; Postoperative Complications; Thiourea; Urethral Obstruction; Urinary Bladder Neck Obstruction