noxythiolin and Breast-Neoplasms

The ability of commonly used operative lavage solutions to destroy breast cancer cells was investigated. The cytotoxicity of solutions of Savlon, noxythiolin, povidone iodine, hydrogen peroxide, bleomycin and water on two human breast cancer cell lines was measured in vitro. Viable cells were determined by ability to exclude trypan blue. Results have been analysed with standard non-parametric tests and demonstrate that all solutions tested significantly (P less than 0.01) reduced the number of viable cells recovered when compared with a control solution of phosphate buffered saline. Solutions of Savlon, 2.5% noxythiolin and povidone iodine were more effective than the other agents in reducing the number of recovered viable cells.

Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Bleomycin; Breast Neoplasms; Cell Line; Cell Survival; Cetrimonium Compounds; Chlorhexidine; Drug Combinations; Drug Screening Assays, Antitumor; Humans; Hydrogen Peroxide; Neoplasm Recurrence, Local; Noxythiolin; Povidone-Iodine; Therapeutic Irrigation; Tumor Cells, Cultured