noxythiolin and Bacterial-Infections

The susceptibility of 1,000 recent bacterial isolates to noxythiolin was determined by the disc susceptibility method. No Gram-positive strains were resistant to this method but 56 (5.6%) of Gram-negative strains gave zones of inhibition of 12 mm diameter or less. The minimum inhibitory concentration (MIC) of the latter were determined by the agar incorporation method. No strains had MIC values greater than 4096 mg/litre. Since concentrations of 50,000 mg/litre can be used for topical treatment, these organisms may be considered susceptible.

Topics: Bacteria; Bacterial Infections; Microbial Sensitivity Tests; Noxythiolin; Thiourea

A controlled mixed peritoneal infection was produced by inoculation of bacteria into the peritoneum and peritonitis was allowed to become established. A laparotomy was performed and peritoneal toilet with a variety of agents was carried out. Local povidone-iodine in the inflamed peritoneum proved to be not only of no benefit but, in fact, to be toxic. In the standard concentrations recommended it proved lethal. Noxythiolin 2.5 per cent also had no beneficial effect. There was a significant difference between the effect of povidone-iodine when instilled into an inflamed peritoneum and instillation into the intact peritoneal cavity. We would advise caution in the use of these antiseptics in any situation in which local defence mechanisms have been compromised as a result of established infection.

Topics: Animals; Bacterial Infections; Disease Models, Animal; Male; Noxythiolin; Peritonitis; Povidone; Povidone-Iodine; Rats; Rats, Inbred Strains; Thiourea

Topics: Abscess; Adolescent; Adult; Bacterial Infections; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Noxythiolin; Thiourea

We have made an in vitro preliminary study of the feasibility of incorporating suitable antibacterial agents with medical grade silicone rubber ("Silastic") with reference to the immediate and sustained effects in simulated conditions of use. The results are encouraging and further work is planned. The possible applications of such impregnated Silastic in clinical conditions involving implants of various kinds is discussed.

Topics: Anti-Bacterial Agents; Bacterial Infections; Clindamycin; Gentamicins; Humans; Metronidazole; Neomycin; Noxythiolin; Penicillin G; Prostheses and Implants; Silicone Elastomers