noxythiolin and Acute-Disease

The efficacy of Noxythiolin in solution for peritoneal toilet during operation on 48 patients with acute generalized peritonitis was evaluated. The trial was prospective, with random selection of patients who were divided into two groups with identical backgrounds, initial affections, and therapies applied. No significant differences were noted in prognosis, bacteriological findings or subsequent course in the survivors in the two groups. The only favorable effect noted in the group treated with Noxythiolin was the frequency with which further operations had to be performed, but the difference was nos significant. Though the use of peritoneal antiseptics isjustified when positive bacteriological test are reported, the determining element in peritoneal toilet appears to be the volume of liquid employed, independently of its composition.

Topics: Acute Disease; Aged; Clinical Trials as Topic; Female; Humans; Intraoperative Care; Male; Middle Aged; Noxythiolin; Peritoneum; Peritonitis; Postoperative Period; Prognosis; Recurrence; Solutions; Therapeutic Irrigation; Thiourea

The authors present a series of 30 cases of acute supra- and inframesocolic peritonitis which, in addition to the treatment of their organic causes, benefitted from medical treatment by noxythioline, used as a peritoneal lavage, an irrigation with aspiration, or an instillation. A marked amelioration in the postoperative course was noted, particularly in those cases with infra-mesocolic peritonitis, with the absence of adhesions and suppurative collections on reintervention, and a rapid return to negativity of the positive bacteriological investigations performed systematically on the pe ritoneal fluid and on the drainage.

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Age Factors; Aged; Clinical Trials as Topic; Drug Tolerance; France; Humans; Middle Aged; Noxythiolin; Peritoneal Dialysis; Peritonitis; Therapeutic Irrigation; Thiourea