novobiocin and Osteomyelitis

Topics: Animals; Anti-Bacterial Agents; Antitoxins; Bacitracin; Carrier State; Erythromycin; Furunculosis; Humans; Immune Sera; Immunotherapy, Active; Methicillin; Novobiocin; Osteomyelitis; Penicillins; Probenecid; Staphylococcal Infections; Toxicology; Toxins, Biological; Vancomycin

Topics: Abscess; Adult; Amputation Stumps; Amputation, Surgical; Chloramphenicol; Humans; Male; Melioidosis; Military Medicine; Novobiocin; Osteomyelitis; Pseudomonas; Pseudomonas Infections; Sepsis; Sulfisoxazole; Surgical Wound Infection; Tetracycline; Wound Infection

Topics: Acute Disease; Anti-Infective Agents; Cephalosporins; Chronic Disease; Czechoslovakia; Drug Evaluation; Endocarditis, Bacterial; Erythromycin; Fusidic Acid; Gentamicins; Humans; Lincomycin; Novobiocin; Osteomyelitis; Penicillins; Recurrence; Rifamycins; Staphylococcal Infections; Sulfamethoxazole; Trimethoprim; Vancomycin

Topics: Adult; Anti-Bacterial Agents; Arthroplasty; Child, Preschool; Chronic Disease; Female; Femoral Fractures; Humans; Male; Methods; Novobiocin; Osteomyelitis; Surgical Wound Infection; Therapeutic Irrigation; Wound Infection

Topics: Adult; Female; Fusidic Acid; Humans; Male; Methicillin; Middle Aged; Novobiocin; Osteitis; Osteomyelitis; Staphylococcal Infections

Preliminary results suggest that the antibiotic lincomycin (a product of Streptomyces lincolnensis var. lincolnensis) possesses certain valuable properties which include good in vitro activity against many strains of hospital staphylococci resistant to many other antibiotics. During a study of this agent, a selected series of severe staphylococcal infections due to resistant organisms were treated with lincomycin, with encouraging responses. Favourable results were also noted in seven cases of osteomyelitis. Lincomycin may be administered by the oral or parenteral routes to adults and infants and satisfactory serum blood levels obtained. So far as the authors' limited experience enables them to conclude, and at the dose range tested, this antibiotic promises to be one of low toxicity.

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacteriology; Biomedical Research; Canada; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Erythromycin; Geriatrics; Gram-Positive Cocci; Humans; Infant; Lincomycin; Methicillin; Novobiocin; Osteomyelitis; Penicillins; Research; Staphylococcal Infections; Staphylococcus; Streptomycin; Tetracycline; Toxicology

Topics: Erythromycin; Femur; Hip; Humans; Joints; Knee; Novobiocin; Osteomyelitis; Staphylococcal Infections; Wrist; Wrist Joint

Topics: Adolescent; Child; Chloramphenicol; Erythromycin; Humans; Infant; Methicillin; Novobiocin; Osteomyelitis; Penicillins; Radiography; Staphylococcal Infections; Surgical Procedures, Operative

Topics: Abscess; Arthritis; Child; Chloramphenicol; Diagnosis, Differential; Drainage; Erythromycin; Humans; Infant; Joint Diseases; Novobiocin; Osteomyelitis; Oxytetracycline; Penicillins; Sepsis; Staphylococcal Infections; Streptococcal Infections; Suppuration; Surgical Procedures, Operative; Tetracycline

Topics: Anti-Bacterial Agents; Chlortetracycline; Dermatology; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Gastroenterology; In Vitro Techniques; Kitasamycin; Leukemia; Methicillin; Novobiocin; Osteomyelitis; Otolaryngology; Penicillins; Pharmacology; Research; Respiratory Tract Infections; Rifamycins; Staphylococcus; Streptococcus; Urinary Tract Infections

Topics: Humans; Novobiocin; Osteomyelitis; Staphylococcal Infections; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Detergents; Humans; Novobiocin; Osteomyelitis; Pharmaceutical Solutions; Therapeutic Irrigation; Wound Infection

Topics: Novobiocin; Orthopedic Procedures; Orthopedics; Osteomyelitis

Topics: Anti-Bacterial Agents; Bacteremia; Micrococcus; Novobiocin; Osteomyelitis; Sepsis