novobiocin and Mast-Cell-Sarcoma

novobiocin has been researched along with Mast-Cell-Sarcoma* in 1 studies

Other Studies

1 other study(ies) available for novobiocin and Mast-Cell-Sarcoma

Article	Year
Evidence that mAMSA induces topoisomerase action. FEBS letters, 1983, Sep-05, Volume: 161, Issue:1 Evidence is presented that the topoisomerase inhibitors novobiocin and coumermycin inhibit the production of double-strand breaks in mouse mastocytoma cell nuclear DNA by the anticancer drug 4'[(9-acridinyl)amino]-methanesulphon-m-anisidide (mAMSA). Novobiocin did not inhibit resealing of DNA breaks induced by mAMSA. It is suggested that mAMSA intercalation into DNA induces the action of a type II topoisomerase. mAMSA and oAMSA were equally effective in breaking the DNA in isolated nuclei. Topics: Aminoacridines; Aminocoumarins; Amsacrine; Animals; Cell Line; Cell Nucleus; Coumarins; DNA Topoisomerases, Type I; DNA, Neoplasm; Intercalating Agents; Kinetics; Mast-Cell Sarcoma; Mice; Novobiocin; Sarcoma, Experimental	1983

Article

Year

Evidence that mAMSA induces topoisomerase action.

FEBS letters, 1983, Sep-05, Volume: 161, Issue:1

Evidence is presented that the topoisomerase inhibitors novobiocin and coumermycin inhibit the production of double-strand breaks in mouse mastocytoma cell nuclear DNA by the anticancer drug 4'[(9-acridinyl)amino]-methanesulphon-m-anisidide (mAMSA). Novobiocin did not inhibit resealing of DNA breaks induced by mAMSA. It is suggested that mAMSA intercalation into DNA induces the action of a type II topoisomerase. mAMSA and oAMSA were equally effective in breaking the DNA in isolated nuclei.

Topics: Aminoacridines; Aminocoumarins; Amsacrine; Animals; Cell Line; Cell Nucleus; Coumarins; DNA Topoisomerases, Type I; DNA, Neoplasm; Intercalating Agents; Kinetics; Mast-Cell Sarcoma; Mice; Novobiocin; Sarcoma, Experimental

1983