novobiocin and Jaundice

Topics: Adult; Altitude; Bilirubin; Biological Transport; Erythrocyte Aging; Female; Hemolysis; Hepatitis B; Hexosyltransferases; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Infant, Newborn; Jaundice; Liver; Novobiocin; Portacaval Shunt, Surgical; Pregnancy; Vitamin K

Topics: Bilirubin; Coloring Agents; Glucosyltransferases; Glucuronates; Glycine; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Indocyanine Green; Indoles; Infant, Newborn; Jaundice; Jaundice, Chronic Idiopathic; Jaundice, Neonatal; Liver; Metabolic Diseases; Novobiocin; Serum Albumin

Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptive Agents; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Halothane; Humans; Isoniazid; Jaundice; Liver; Liver Cirrhosis; Metabolism, Inborn Errors; Methotrexate; Methoxyflurane; Methyldopa; Necrosis; Novobiocin

The novobiocin and luminal test application increases the possibilities to differentiate premicrosome from postmicrosome jaundice and extends the knowledge on hyperbilirubinemia pathobiochemistry. Novobiocin (an antibiotic) inhibits the conjugation and glucuronidizing of bile pigments. Accordingly, the novobiocin test is strongly positive in any premicrosome jaundice form--Gilberts's disease, posthepatitis hyperbilirubinemia (PHHB) and hemolytic jaundice. It is negative in hepatocellular and hepatocanalicular jaundice, and in Dubin-Johnson's syndrome. In premicrosome jaundice with fluctuating bilirubinemia and normal bilirubin level at the time of examination, the novobiocin test may bring about manifestation of a latent or temporary compensated defect which proves to be most helpful in diagnosing. It is assumed that hemolytic jaundice is caused, apart from bile pigments hyperproduction, also by concomitant disorders in the intrahepatal transport of bile pigments. The latter hypothesis is corroborated by the data of the study. The luminal test is likewise markedly positive in premicrosome jaundice, and negative--in chronic hepatocellular and hepatocanalicular jaundice. In some instances with slight defect in the intrahepatal transport of pigments, the luminal test accounts for normalization of bilirubinemia and of the direct to total bilirubin ratio. The test is moderately positive in the syndrome of Dubin-Johnson. The latter fact supports the hypothesis that luminal, alongside the effect on transport mechanisms, exerts influence on bile pigments excretion also.

Topics: Bile; Biological Transport; Chronic Disease; Humans; Jaundice; Liver; Novobiocin; Phenobarbital; Pigments, Biological

Topics: Adult; Female; Humans; Jaundice; Male; Novobiocin

Topics: Chronic Disease; Ethanol; Female; Humans; Hyperbilirubinemia, Hereditary; Jaundice; Middle Aged; Novobiocin; Sulfobromophthalein

Topics: Humans; Hyperbilirubinemia; Jaundice; Liver; Novobiocin

A case of novobiocin-induced jaundice is described in which the main feature was elevated unconjugated bilirubin in the serum. No evidence of hemolysis or hepato-cellular failure was demonstrated.The effect of novobiocin on serum bilirubin was studied by administering 2 g. of the drug daily in four divided oral doses for two days. An increase in serum unconjugated bilirubin was nearly always observed in the normal subjects and in patients with cirrhosis of the liver. This rise was particularly significant in three patients with hemolytic anemia and in two patients with Gilbert's disease. After an oral dose of 500 mg. the BSP clearance was decreased after one hour and it was close to normal after three hours. Since hemolysis is not responsible for this elevation of serum unconjugated bilirubin, the novobiocin-induced hyperbilirubinemia appears to be due to a direct effect of the drug upon the liver.

Topics: Adult; Bilirubin; Humans; Hyperbilirubinemia; Jaundice; Liver; Male; Novobiocin

Topics: Adult; Child; Female; Furunculosis; Humans; Jaundice; Male; Novobiocin; Pelvic Inflammatory Disease

Topics: Humans; Jaundice; Male; Middle Aged; Novobiocin; Proteus Infections; Urinary Tract Infections

Topics: Bilirubin; Chemical and Drug Induced Liver Injury; Child; Hepatitis A; Humans; Hyperbilirubinemia; Jaundice; Novobiocin; Toxicology

Topics: Bilirubin; Humans; Infant; Jaundice; Novobiocin; Toxicology

Topics: Analgesics; Analgesics, Non-Narcotic; Anemia; Anemia, Hemolytic; Antimalarials; Antipyretics; Erythroblastosis, Fetal; Female; Fetal Diseases; Glucosephosphate Dehydrogenase Deficiency; Glucosephosphates; Humans; Hyperbilirubinemia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Jaundice; Jaundice, Neonatal; Maternal-Fetal Exchange; North Carolina; Novobiocin; Pregnancy; Salicylates; Sulfisoxazole; Toxicology; Vitamin K

Topics: Animals; Animals, Newborn; Bilirubin; Enzyme Inhibitors; Glucuronates; Guinea Pigs; Jaundice; Liver; Liver Glycogen; Metabolism; NAD; Novobiocin; Oxidoreductases; Pharmacology; Rats; Research; Transferases

Topics: Bilirubin; Enzyme Inhibitors; Humans; Infant; Infant, Newborn; Jaundice; Liver; Novobiocin; Pharmacology; Progestins; Rats; Research; Transferases; Vitamin K

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Child; Dermatologic Agents; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Jaundice; Novobiocin

Topics: Humans; Jaundice; Novobiocin

Topics: Anti-Bacterial Agents; Humans; Jaundice; Novobiocin; Pigmentation

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Humans; Jaundice; Novobiocin