novobiocin and Endocarditis--Bacterial

Topics: Deafness; Drug Eruptions; Drug Hypersensitivity; Drug Resistance, Microbial; Endocarditis, Bacterial; Enterocolitis, Pseudomembranous; Fever; Humans; Novobiocin; Sepsis; Staphylococcal Infections; Vancomycin

The effectiveness of ciprofloxacin and/or novobiocin therapy was assessed for experimental endocarditis caused by three strains of Enterococcus faecium resistant to ampicillin, vancomycin, and aminoglycosides. Rabbits with endocarditis caused by two of the strains had a significant decrease in bacterial counts in vegetations when treated with both antibiotics. Further studies using combination therapy with ciprofloxacin plus novobiocin for multidrug resistant strains of E. faecium are warranted.

Topics: Animals; Ciprofloxacin; Drug Therapy, Combination; Endocarditis, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Microbial Sensitivity Tests; Novobiocin; Rabbits

Topics: Acute Disease; Anti-Infective Agents; Cephalosporins; Chronic Disease; Czechoslovakia; Drug Evaluation; Endocarditis, Bacterial; Erythromycin; Fusidic Acid; Gentamicins; Humans; Lincomycin; Novobiocin; Osteomyelitis; Penicillins; Recurrence; Rifamycins; Staphylococcal Infections; Sulfamethoxazole; Trimethoprim; Vancomycin

Topics: Ampicillin; Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Drug Synergism; Endocarditis, Bacterial; Erythromycin; Leucomycins; Lincomycin; Microbial Sensitivity Tests; Neomycin; Novobiocin; Penicillin G; Streptococcus; Streptomycin; Tetracycline; Vancomycin

Topics: Drug Resistance, Microbial; Endocarditis, Bacterial; Fusidic Acid; Humans; Novobiocin; Staphylococcal Infections; Vancomycin

Topics: Animals; Dihydrostreptomycin Sulfate; Dog Diseases; Dogs; Endocarditis, Bacterial; Erythrocyte Count; Hematocrit; Hemoglobinometry; Leukocyte Count; Novobiocin; Penicillin G Procaine; Prednisolone; Tetracycline

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Endocarditis, Bacterial; Erythromycin; Female; Fusidic Acid; Humans; Infant; Infant, Newborn; Male; Methicillin; Middle Aged; Novobiocin; Penicillin Resistance; Pneumonia, Staphylococcal; Rifampin; Sepsis; Staphylococcal Infections

Topics: Anti-Bacterial Agents; Bacitracin; Candidiasis; Cardiac Surgical Procedures; Child; Endocarditis; Endocarditis, Bacterial; Heart, Artificial; Humans; Methicillin; Novobiocin; Penicillins; Pneumonia; Postoperative Complications; Preventive Medicine; Pulmonary Atelectasis; Sepsis; Streptomycin; Surgical Wound Infection; Thoracic Surgery; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Endocarditis; Endocarditis, Bacterial; In Vitro Techniques; Micrococcus; Novobiocin; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus