novobiocin and Burkitt-Lymphoma

novobiocin has been researched along with Burkitt-Lymphoma* in 2 studies

Other Studies

2 other study(ies) available for novobiocin and Burkitt-Lymphoma

Article	Year
Unique sensitivity of nitrogen mustard-resistant human Burkitt lymphoma cells to novobiocin. Biochemical pharmacology, 1988, Nov-15, Volume: 37, Issue:22 Topics: Burkitt Lymphoma; Cell Line; Cell Survival; Cells, Cultured; DNA Topoisomerases, Type II; Drug Synergism; Humans; Mechlorethamine; Novobiocin	1988
Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells. NCI monographs : a publication of the National Cancer Institute, 1987, Issue:4 A human Burkitt's lymphoma cell line (Raji-HN2) made resistant to nitrogen mustard, a bifunctional alkylating agent, was used to study the mechanism of resistance to nitrogen mustard. A comparative study of Raji-HN2 and the parental sensitive Raji cell lines revealed the following: (1) The DNA of Raji-HN2 cells was crosslinked by nitrogen mustard to a lower extent than Raji DNA; (2) once interstrand crosslinks were formed, they were repaired at the same rate in both cell lines; (3) DNA crosslink formation in Raji-HN2, but not in Raji cells, was enhanced by novobiocin, a topoisomerase II inhibitor; (4) Raji-HN2 cells had elevated topoisomerase II activity and were hypersensitive to topoisomerase inhibitors (amsacrine, novobiocin, teniposide); (5) similar amounts of topoisomerase I were found in both cell lines; and (6) the chromatin of Raji-HN2 but not of Raji cells, was hypersensitive to DNase I digestion. The relationship between DNA repair, topoisomerase II activity, chromatin structure and drug resistance is discussed. Topics: Amsacrine; Burkitt Lymphoma; Cell Line; Cell Survival; Chromatin; DNA Topoisomerases, Type II; Drug Resistance; Humans; Kinetics; Mechlorethamine; Novobiocin; Podophyllotoxin; Teniposide; Tumor Stem Cell Assay	1987

Article

Year

Unique sensitivity of nitrogen mustard-resistant human Burkitt lymphoma cells to novobiocin.

Biochemical pharmacology, 1988, Nov-15, Volume: 37, Issue:22

Topics: Burkitt Lymphoma; Cell Line; Cell Survival; Cells, Cultured; DNA Topoisomerases, Type II; Drug Synergism; Humans; Mechlorethamine; Novobiocin

1988

Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells.

NCI monographs : a publication of the National Cancer Institute, 1987, Issue:4

A human Burkitt's lymphoma cell line (Raji-HN2) made resistant to nitrogen mustard, a bifunctional alkylating agent, was used to study the mechanism of resistance to nitrogen mustard. A comparative study of Raji-HN2 and the parental sensitive Raji cell lines revealed the following: (1) The DNA of Raji-HN2 cells was crosslinked by nitrogen mustard to a lower extent than Raji DNA; (2) once interstrand crosslinks were formed, they were repaired at the same rate in both cell lines; (3) DNA crosslink formation in Raji-HN2, but not in Raji cells, was enhanced by novobiocin, a topoisomerase II inhibitor; (4) Raji-HN2 cells had elevated topoisomerase II activity and were hypersensitive to topoisomerase inhibitors (amsacrine, novobiocin, teniposide); (5) similar amounts of topoisomerase I were found in both cell lines; and (6) the chromatin of Raji-HN2 but not of Raji cells, was hypersensitive to DNase I digestion. The relationship between DNA repair, topoisomerase II activity, chromatin structure and drug resistance is discussed.

Topics: Amsacrine; Burkitt Lymphoma; Cell Line; Cell Survival; Chromatin; DNA Topoisomerases, Type II; Drug Resistance; Humans; Kinetics; Mechlorethamine; Novobiocin; Podophyllotoxin; Teniposide; Tumor Stem Cell Assay

1987