nothofagin has been researched along with Hypokalemia* in 1 studies
1 other study(ies) available for nothofagin and Hypokalemia
| Article | Year |
|---|---|
Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats.
Active constituents from natural origin have long been used for the treatment of patients suffering from cardiovascular and renal diseases. This study therefore aimed to investigate the diuretic and natriuretic properties of nothofagin, a dihydrochalcone isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats. Male Wistar normotensive rats were orally treated with vehicle (1 ml/kg); hydrochlorothiazide (HCTZ; 25 mg/kg); ethyl acetate fraction from L. dasytricha (EALD; 3-30 mg/kg) and nothofagin (NOT; 0.3-3 mg/kg). Spontaneously hypertensive rats (SHR) received NOT (1 mg/kg), HCTZ (25 mg/kg) or vehicle. The cumulative diuretic index, urinary electrolytes excretion (Na Topics: Animals; Antioxidants; Cell Line; Chalcones; Diuretics, Potassium Sparing; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Melastomataceae; Mice; Natriuretic Agents; Nitric Oxide; Nitrites; Potassium; Prostaglandins; Rats, Wistar; Receptors, Muscarinic | 2017 |