nosiheptide and Liver-Neoplasms

nosiheptide has been researched along with Liver-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for nosiheptide and Liver-Neoplasms

ArticleYear
[Preparation of nosiheptide liposomes and its inhibitory effect on hepatitics B virus in vitro].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:5

    To prepare liposomes of nosiheptide and study its ability to inhibit hepatitis B virus HBsAg and HBeAg secreted.. Liposomes of nosiheptide was prepared by sodium deoxycholate dialysis and sonication. Nosheptide was determined by HPLC and partical size was determined by using laser light scattering instrument. Transmission electron microscopy (TEM) was used to examine the morphology of liposomes. Its actions to inhibit hepatitis B virus HBsAg and HBeAg secreted was studied by a HBV-transfectted cell line (HepG2 2. 2. 15 ).. Encapsulation efficiency of liposomes by chloroform:methanol (2:1, v/v) was higher than that by dioxane. With the increase of the ratio of nosiheptide: PC (W/W), the encapsulation efficiency of liposomes decreased with the increase of ratio of sodium deoxycholate: PC, the liposomes partical size decreased. The liposomes kept stable at -20 degrees C after 2 years. The drug concentrations of liposomes that inhibit HBsAg secreted by (46.9 +/- 2. 6) %, (55.4 +/- 1.2) %, (65 +/- 3) % and HBeAg secreted by (15.1 +/- 2.3) %, (36.2 +/- 1.7) %, (36.8 +/- 2.5) % were 1.25, 2.5, 5.0 microg x mL(-1), respectively.. Liposomes of nosheptide can be prepared by sodium deoxycholate dialysis and sonication, which ability to inhibit hepatitis B virus HBsAg and HBeAg secreted is better than nosheptide.

    Topics: Antiviral Agents; Cell Line, Tumor; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Stability; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatoblastoma; Humans; Liposomes; Liver Neoplasms; Particle Size; Thiazoles

2005