noscapine and Influenza--Human

noscapine has been researched along with Influenza--Human* in 2 studies

Other Studies

2 other study(ies) available for noscapine and Influenza--Human

Article	Year
Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu. Pharmaceutical development and technology, 2015, Volume: 20, Issue:2 The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were subjected to in vitro intestinal drug permeability studies conducted with Ussing chambers. Vitamin E tocopherol polyethylene glycol succinate and propylene glycol based co-solvent formulations provided the maximum permeability coefficient for the drug. Inclusion complexes of the drug were prepared using hydroxypropyl-β-cyclodextrin and sulphobutylether cyclodextrins. Pharmacokinetic studies were carried out in male Sprague-Dawley rats for the selected formulations. The relative bioavailabilities of the drug with the co-solvent- and cyclodextrin-based formulations were found to be similar. Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Drug Delivery Systems; Drug Design; Excipients; Humans; Influenza, Human; Intestinal Absorption; Male; Noscapine; Rats, Sprague-Dawley; Solubility; Solvents	2015
[NO-FLU-suppositories in the treatment of influenza infections in children]. Praxis, 1968, Volume: 57, Issue:13 Topics: Acetaminophen; Child; Child, Preschool; Humans; Infant; Influenza, Human; Noscapine; Pheniramine; Respiratory Tract Infections; Salicylamides; Suppositories	1968

Article

Year

Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Pharmaceutical development and technology, 2015, Volume: 20, Issue:2

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were subjected to in vitro intestinal drug permeability studies conducted with Ussing chambers. Vitamin E tocopherol polyethylene glycol succinate and propylene glycol based co-solvent formulations provided the maximum permeability coefficient for the drug. Inclusion complexes of the drug were prepared using hydroxypropyl-β-cyclodextrin and sulphobutylether cyclodextrins. Pharmacokinetic studies were carried out in male Sprague-Dawley rats for the selected formulations. The relative bioavailabilities of the drug with the co-solvent- and cyclodextrin-based formulations were found to be similar.

Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Drug Delivery Systems; Drug Design; Excipients; Humans; Influenza, Human; Intestinal Absorption; Male; Noscapine; Rats, Sprague-Dawley; Solubility; Solvents

2015

[NO-FLU-suppositories in the treatment of influenza infections in children].

Praxis, 1968, Volume: 57, Issue:13

Topics: Acetaminophen; Child; Child, Preschool; Humans; Infant; Influenza, Human; Noscapine; Pheniramine; Respiratory Tract Infections; Salicylamides; Suppositories

1968