norvancomycin and Keratitis

Efficacy of norvancomycin (NVCM) through continuous topical ocular instillation drug delivery (CTOIDD) system for treating severe acute bacterial keratitis infection with. Rabbits with bacterial keratitis were treated using CTOIDD with NVCM (n=13), topical NVCM eye drops (n=11), and CTOIDD with saline (n=8). Clinical signs of keratitis in all groups were assessed consecutively for a week. Bacterial quantification of excised corneas was counted on the fourth and eighth days. Histopathologic examinations were performed to assess inflammatory cell infiltration on the eighth day.. All signs of bacterial keratitis were alleviated in CTOIDD with NVCM according to criteria, and the CTOIDD-NVCM group had significantly less inflammation than CTOIDD-saline (. CTOIDD with NVCM effectively reduced the severity and treated acute bacterial

Topics: Acute Disease; Administration, Ophthalmic; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Eye Infections, Bacterial; Female; Keratitis; Microbial Sensitivity Tests; Molecular Structure; Ophthalmic Solutions; Rabbits; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin