nortriptyline has been researched along with Polyneuropathy, Acquired in 2 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barohn, RJ | 1 |
| Gajewski, B | 1 |
| Pasnoor, M | 1 |
| Brown, A | 1 |
| Herbelin, LL | 1 |
| Kimminau, KS | 1 |
| Mudaranthakam, DP | 1 |
| Jawdat, O | 1 |
| Dimachkie, MM | 1 |
| Iyadurai, S | 1 |
| Stino, A | 1 |
| Kissel, J | 1 |
| Pascuzzi, R | 1 |
| Brannagan, T | 1 |
| Wicklund, M | 1 |
| Ahmed, A | 1 |
| Walk, D | 1 |
| Smith, G | 1 |
| Quan, D | 1 |
| Heitzman, D | 1 |
| Tobon, A | 1 |
| Ladha, S | 1 |
| Wolfe, G | 1 |
| Pulley, M | 1 |
| Hayat, G | 1 |
| Li, Y | 1 |
| Thaisetthawatkul, P | 1 |
| Lewis, R | 1 |
| Biliciler, S | 1 |
| Sharma, K | 1 |
| Salajegheh, K | 1 |
| Trivedi, J | 1 |
| Mallonee, W | 1 |
| Burns, T | 1 |
| Jacoby, M | 1 |
| Bril, V | 1 |
| Vu, T | 1 |
| Ramchandren, S | 1 |
| Bazant, M | 1 |
| Austin, S | 1 |
| Karam, C | 1 |
| Hussain, Y | 1 |
| Kutz, C | 1 |
| Twydell, P | 1 |
| Scelsa, S | 1 |
| Kushlaf, H | 1 |
| Wymer, J | 1 |
| Hehir, M | 1 |
| Kolb, N | 1 |
| Ralph, J | 1 |
| Barboi, A | 1 |
| Verma, N | 1 |
| Ahmed, M | 1 |
| Memon, A | 1 |
| Saperstein, D | 1 |
| Lou, JS | 1 |
| Swenson, A | 1 |
| Cash, T | 1 |
| Kaeser, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)[NCT02260388] | Phase 4 | 402 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Higher scores for fatigue represents worse outcome (more fatigue). T-score metric: 50 is the mean of a relevant reference population and 10 is the standard deviation (SD) of that population.~On the T-score metric: A score of 40 is one SD lower than the mean of the reference population; A score of 60 is one SD higher than the mean of the reference population." (NCT02260388)
Timeframe: 12 Weeks
| Intervention | T-Score (Mean) |
|---|---|
| Nortriptyline | 53.6 |
| Duloxetine | 55.4 |
| Pregabalin | 56.7 |
| Mexiletine | 51.6 |
"Higher scores for pain interference represents worse outcome (more pain interference) T-score metric: 50 is the mean of a relevant reference population and 10 is the standard deviation (SD) of that population.~On the T-score metric: A score of 40 is one SD lower than the mean of the reference population; A score of 60 is one SD higher than the mean of the reference population." (NCT02260388)
Timeframe: 12 weeks
| Intervention | T-Score (Mean) |
|---|---|
| Nortriptyline | 56.4 |
| Duloxetine | 56.5 |
| Pregabalin | 60.0 |
| Mexiletine | 54.5 |
"Higher scores for sleep disturbance represents worse outcome (more sleep disturbance).~T-score metric: 50 is the mean of a relevant reference population and 10 is the standard deviation (SD) of that population.~On the T-score metric: A score of 40 is one SD lower than the mean of the reference population; A score of 60 is one SD higher than the mean of the reference population.~Higher scores equals more of the concept being measured" (NCT02260388)
Timeframe: 12 weeks
| Intervention | T-Score (Mean) |
|---|---|
| Nortriptyline | 58.9 |
| Duloxetine | 58.9 |
| Pregabalin | 58.3 |
| Mexiletine | 59.1 |
"SF-12v2® Health Survey Standard The Optum™ SF-12v2® Health Survey is a shorter version of the SF-36v2® Health Survey that uses just 12 questions to measure functional health and well-being from the patient's point of view.~Survey provides psychometrically-based physical component summary (PCS) and mental component summary (MCS) scores.~Scores are calibrated so that 50 is the average score or norm, standard deviation = 10.~Higher scores indicate better health for both mental and physical component summary scores." (NCT02260388)
Timeframe: 12 weeks
| Intervention | Norm-Based Standardization Score (Mean) | |
|---|---|---|
| Mental Component Score | Physical Component Score | |
| Duloxetine | 50.9 | 42.1 |
| Mexiletine | 51.3 | 43.7 |
| Nortriptyline | 51.0 | 42.8 |
| Pregabalin | 47.2 | 40.0 |
1 trial available for nortriptyline and Polyneuropathy, Acquired
| Article | Year |
|---|---|
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial.
Topics: Adult; Aged; Analgesics; Bayes Theorem; Comparative Effectiveness Research; Duloxetine Hydrochloride | 2021 |
1 other study available for nortriptyline and Polyneuropathy, Acquired
| Article | Year |
|---|---|
[Therapy of polyneuritides].
Topics: Butyrophenones; Chlorpromazine; Glucocorticoids; Humans; Hypoxia; Imipramine; Methotrimeprazine; Nor | 1971 |