nortriptyline has been researched along with Neuroleptic Malignant Syndrome in 3 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "As well as neuroleptic malignant syndrome, the SS may cause cerebellar degeneration, probably due to sustained hyperpyrexia." | 1.31 | [Progressive cerebellar atrophy following acute antidepressant intoxication]. ( Fujino, Y; Shimoji, E; Takahashi, M; Tsuboi, Y; Yamada, T, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fink, M | 1 |
| June, R | 1 |
| Yunus, M | 1 |
| Gossman, W | 1 |
| Fujino, Y | 1 |
| Tsuboi, Y | 1 |
| Shimoji, E | 1 |
| Takahashi, M | 1 |
| Yamada, T | 1 |
3 other studies available for nortriptyline and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Toxic serotonin syndrome or neuroleptic malignant syndrome?
Topics: Antidepressive Agents, Tricyclic; Central Nervous System Diseases; Electroconvulsive Therapy; Female | 1996 |
Neuroleptic malignant syndrome associated with nortriptyline.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Diagnosis, Differential; Emergency Treatment; Hu | 1999 |
[Progressive cerebellar atrophy following acute antidepressant intoxication].
Topics: Adult; Antidepressive Agents, Tricyclic; Atrophy; Cerebellar Ataxia; Cerebellum; Female; Humans; Mal | 2000 |