nortriptyline has been researched along with Muscle Contraction in 15 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that amitriptyline and nortriptyline could act as adrenoceptor antagonists and direct inhibitors of smooth muscle contraction of human mesenteric arteries, whereas sertraline might principally exert its action only as direct inhibitor of smooth muscle contraction." | 3.70 | Relaxant effects of antidepressants on human isolated mesenteric arteries. ( Flor, B; Lluch, P; Lluch, S; Medina, P; Pallardó, F; Segarra, G; Vila, JM, 1999) |
| " These results show that the adaptative changes of alpha-adrenoceptors in the rat anococcygeus muscle following long-term administration may depend on the efficiency to inhibit the neuronal uptake and the ability to antagonize alpha 1-adrenoceptors." | 1.28 | Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle. ( Badia, A; Sallés, J; Vila, E, 1990) |
| " Concurrently the effect of nortriptyline low dosage therapy was studied in 21 women suffering from motor or sensory urgency and urge incontinence." | 1.27 | Selective effect of nortriptyline on smooth muscle as an anticholinergic drug: a pharmacological and clinical study. ( Cohen, S; Katz, A; Nissenkorn, I; Rubinstein, R, 1986) |
| "Nortriptyline was found to have anticholinergic properties." | 1.25 | Nortriptyline hydrochloride in urology. ( Nissenkorn, I; Servadio, C; Zeigler, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doggrell, SA | 6 |
| Rubinstein, R | 2 |
| Nissenkorn, I | 3 |
| Cohen, S | 2 |
| Vila, JM | 1 |
| Medina, P | 1 |
| Segarra, G | 1 |
| Lluch, P | 1 |
| Pallardó, F | 1 |
| Flor, B | 1 |
| Lluch, S | 1 |
| Paton, DM | 2 |
| Servadio, C | 1 |
| Zeigler, M | 1 |
| Vila, E | 1 |
| Sallés, J | 1 |
| Badia, A | 1 |
| Katz, A | 1 |
| Chinn, C | 1 |
| Weber, LJ | 1 |
| Oxenkrug, GF | 1 |
| Lapin, IP | 1 |
| Elonen, E | 1 |
| Mattila, MJ | 1 |
| Saarnivaara, L | 1 |
| Maxwell, RA | 1 |
| Eckhardt, SB | 1 |
| Hite, G | 1 |
15 other studies available for nortriptyline and Muscle Contraction
| Article | Year |
|---|---|
The assessment of pre- and postsynaptic alpha-adrenoceptor blocking activity of drugs using the rat anococcygeus muscle.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Hydroxydopamines; In Vit | 1980 |
Effect of mianserin on noradrenergic transmission in the rat anococcygeus muscle.
Topics: Animals; Dibenzazepines; Hydroxydopamines; In Vitro Techniques; Male; Mianserin; Muscle Contraction; | 1980 |
Affinity of nortriptyline to muscarinic receptors in the bladder and ileum of man and guinea-pig.
Topics: Animals; Bethanechol Compounds; Carbachol; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mu | 1984 |
Relaxant effects of antidepressants on human isolated mesenteric arteries.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second- | 1999 |
Effects of pyroxamidine and guanethidine on contractile responses to field stimulation and to noradrenaline in the anococcygeus muscle and vas deferens of the rat.
Topics: Amidines; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Electric Stimulation; | 1979 |
Mianserin potentiates responses to acetylcholine in the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Carbachol; Dibenzazepines; Drug Synergism; Hydroxydopamines; In Vitro Techni | 1979 |
Effects of prazosin and phentolamine on responses to field stimulation and to noradrenaline in vas deferens and anococcygeus muscle of the rat.
Topics: Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; | 1978 |
Release of noradrenaline by labetalol in the rat anococcygeus muscle.
Topics: Animals; Ethanolamines; Hydroxydopamines; In Vitro Techniques; Labetalol; Male; Muscle Contraction; | 1978 |
Nortriptyline hydrochloride in urology.
Topics: Acetylcholine; Animals; Circadian Rhythm; Female; Humans; Muscle Contraction; Muscle Tonus; Nortript | 1975 |
Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Antidepressive Agents; Cocaine; Desipramine; Electric Stimulation; Male; Mianserin; Muscle | 1990 |
Selective effect of nortriptyline on smooth muscle as an anticholinergic drug: a pharmacological and clinical study.
Topics: Bethanechol Compounds; Carbachol; Dose-Response Relationship, Drug; Female; Humans; Ileum; Muscle Co | 1986 |
The actions of several psychoactive agents upon the muscarinic mechanisms in the superior cervical ganglion of the cat.
Topics: Alkynes; Animals; Atropine; Carbamates; Cats; Desipramine; Dimethylphenylpiperazinium Iodide; Electr | 1974 |
Effect of dimethyl and monomethyl tricyclic antidepressants on central 5-hydroxytryptamine processes in the frog.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anura; Brain; Desipramine; Dibenzazepines; Imipramine | 1971 |
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits.
Topics: Amitriptyline; Animals; Antidepressive Agents; Aorta; Blood Pressure; Depression, Chemical; Dibenzoc | 1974 |
Kinetic and thermodynamic considerations regarding the inhibition by tricyclic antidepressants of the uptake of tritiated norepinephrine by the adrenergic nerves in rabbit aortic strips.
Topics: Animals; Antidepressive Agents; Aorta; Desipramine; Energy Transfer; Female; Imipramine; Kinetics; M | 1970 |