nortriptyline has been researched along with Migraine Disorders in 14 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with migraine, prophylaxis with atorvastatin significantly improved the frequency of headache and QOL over 24 weeks compared with placebo with no effect on the intensity of headache." | 3.11 | The preventive effect of the combination of atorvastatin and nortriptyline in migraine-type headache: a randomized, triple-blind, placebo-controlled trial. ( Mohammadi, F; Rahmany, R; Saghafi, F; Sahebnasagh, A; Sherafat, A, 2022) |
| "To determine the minimum duration of migraine prophylaxis, after patients become pain-free." | 2.79 | Analysis of the duration of migraine prophylaxis. ( Almeida, KJ; Bernardino, SN; Silva-Néto, RP, 2014) |
| "A sizeable proportion of migraineurs in need of preventive therapy do not significantly benefit from monotherapy." | 2.77 | Topiramate plus nortriptyline in the preventive treatment of migraine: a controlled study for nonresponders. ( Bigal, ME; da Cunha Jevoux, C; Krymchantowski, AV, 2012) |
| "Treatment with nortriptyline alone was not effective." | 2.74 | A double-blind randomized controlled trial of low doses of propranolol, nortriptyline, and the combination of propranolol and nortriptyline for the preventive treatment of migraine. ( Aquino, CC; Domingues, RB; Domingues, SA; Kuster, GW; Silva, AL, 2009) |
| "A sizeable proportion of migraineurs in need of preventive treatment does not significantly benefit from monotherapy." | 2.48 | Polytherapy for migraine prophylaxis. ( Casucci, G; Cologno, D; D'Onofrio, F; Villani, V, 2012) |
| "Headaches are a common entity in the ambulatory population." | 2.40 | Diagnosis, prophylaxis, and treatment of headaches in the athlete. ( Kaplan, B; Swain, RA, 1997) |
| "Our hypothesis was that adjuvant migraine medications may improve outcomes in SSNHL." | 1.62 | Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. ( Abouzari, M; Chua, JT; Djalilian, HR; Goshtasbi, K; Lin, HW; Saber, T; Sarna, B; Tan, D, 2021) |
| "In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications." | 1.56 | Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients. ( Abouzari, M; Djalilian, HR; Ghavami, Y; Goshtasbi, K; Lin, HW; Parker, EM; Sarna, B; Tan, D, 2020) |
| "The mean pre-treatment Dizziness Handicap Inventory score was 57." | 1.56 | Pharmacotherapy failure and progression to botulinum toxin injection in vestibular migraine. ( Donaldson, L; Dornhoffer, JR; Liu, YF; Macias, D; Rizk, HG, 2020) |
| "Management of MdDS as vestibular migraine can improve patients' symptoms and increase the QOL." | 1.46 | Management of mal de debarquement syndrome as vestibular migraines. ( Bhatt, J; Djalilian, HR; Ghavami, Y; Haidar, YM; Lin, HW; Moshtaghi, O; Ziai, KN, 2017) |
| "The mean frequency of migraine days decreased from 10." | 1.36 | An open pilot study assessing the benefits of quetiapine for the prevention of migraine refractory to the combination of atenolol, nortriptyline, and flunarizine. ( Jevoux, C; Krymchantowski, AV; Moreira, PF, 2010) |
| "The mean frequency of migraine days decreased from 10." | 1.35 | Quetiapine for the prevention of migraine refractory to the combination of atenolol + nortriptyline + flunarizine: an open pilot study. ( Jevoux, C; Krymchantowski, AV, 2008) |
| "The responsiveness of both migraine headaches and carotidynia to similar drugs suggests a common pathophysiologic mechanism." | 1.26 | Carotidynia. ( Prusiner, S; Raskin, NH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 4 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Sherafat, A | 1 |
| Sahebnasagh, A | 1 |
| Rahmany, R | 1 |
| Mohammadi, F | 1 |
| Saghafi, F | 1 |
| Abouzari, M | 2 |
| Tan, D | 2 |
| Sarna, B | 2 |
| Ghavami, Y | 3 |
| Goshtasbi, K | 2 |
| Parker, EM | 1 |
| Lin, HW | 4 |
| Djalilian, HR | 4 |
| Chua, JT | 1 |
| Saber, T | 1 |
| Liu, YF | 1 |
| Macias, D | 1 |
| Donaldson, L | 1 |
| Dornhoffer, JR | 1 |
| Rizk, HG | 1 |
| Haidar, YM | 2 |
| Moshtaghi, O | 2 |
| Silva-Néto, RP | 1 |
| Almeida, KJ | 1 |
| Bernardino, SN | 1 |
| Ziai, KN | 1 |
| Bhatt, J | 1 |
| Krymchantowski, AV | 3 |
| Jevoux, C | 2 |
| Moreira, PF | 1 |
| Domingues, RB | 1 |
| Silva, AL | 1 |
| Domingues, SA | 1 |
| Aquino, CC | 1 |
| Kuster, GW | 1 |
| da Cunha Jevoux, C | 1 |
| Bigal, ME | 1 |
| Casucci, G | 1 |
| Villani, V | 1 |
| Cologno, D | 1 |
| D'Onofrio, F | 1 |
| Swain, RA | 1 |
| Kaplan, B | 1 |
| Raskin, NH | 1 |
| Prusiner, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss[NCT05403229] | Phase 2 | 140 participants (Anticipated) | Interventional | 2022-10-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nortriptyline and Migraine Disorders
| Article | Year |
|---|---|
Polytherapy for migraine prophylaxis.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Fructose; Humans; Migraine Disorders; Nortripty | 2012 |
Diagnosis, prophylaxis, and treatment of headaches in the athlete.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; | 1997 |
4 trials available for nortriptyline and Migraine Disorders
| Article | Year |
|---|---|
The preventive effect of the combination of atorvastatin and nortriptyline in migraine-type headache: a randomized, triple-blind, placebo-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Atorvastatin; Constipation; Double-Blind Method; Drug Therapy, | 2022 |
Analysis of the duration of migraine prophylaxis.
Topics: Adolescent; Adult; Atenolol; Dose-Response Relationship, Drug; Female; Flunarizine; Humans; Internat | 2014 |
A double-blind randomized controlled trial of low doses of propranolol, nortriptyline, and the combination of propranolol and nortriptyline for the preventive treatment of migraine.
Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents, Tricyclic; Double-Blind Method; Drug Ther | 2009 |
Topiramate plus nortriptyline in the preventive treatment of migraine: a controlled study for nonresponders.
Topics: Adult; Analgesics; Double-Blind Method; Drug Therapy, Combination; Female; Fructose; Humans; Male; M | 2012 |
8 other studies available for nortriptyline and Migraine Disorders
| Article | Year |
|---|---|
Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Anticonvulsants; Drug Therapy, Combination; Female; Follo | 2020 |
Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss.
Topics: Administration, Oral; Adult; Aged; Dexamethasone; Drug Therapy, Combination; Female; Glucocorticoids | 2021 |
Pharmacotherapy failure and progression to botulinum toxin injection in vestibular migraine.
Topics: Adult; Aged; Aged, 80 and over; Botulinum Toxins; Dizziness; Female; Humans; Injections; Male; Middl | 2020 |
Evaluating Quality of Life in Patients With Meniere's Disease Treated as Migraine.
Topics: Chemoprevention; Female; Fructose; Humans; Male; Meniere Disease; Middle Aged; Migraine Disorders; N | 2018 |
Management of mal de debarquement syndrome as vestibular migraines.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Fructose; Genetic Predisposition to Disease; Humans; | 2017 |
Quetiapine for the prevention of migraine refractory to the combination of atenolol + nortriptyline + flunarizine: an open pilot study.
Topics: Adult; Antipsychotic Agents; Atenolol; Dibenzothiazepines; Drug Resistance; Drug Therapy, Combinatio | 2008 |
An open pilot study assessing the benefits of quetiapine for the prevention of migraine refractory to the combination of atenolol, nortriptyline, and flunarizine.
Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Atenolol | 2010 |
Carotidynia.
Topics: Adult; Aged; Carotid Artery Diseases; Dose-Response Relationship, Drug; Ergonovine; Female; Headache | 1977 |