nortriptyline has been researched along with Kidney Failure, Chronic in 5 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For trimipramine the AUC was significantly higher in patients." | 2.67 | [Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure]. ( Degen, J; Fischer, W; Höxter, G; Pintar, P; Seiberling, M; Steinhauer, HB; Wölke, E, 1993) |
| "Nortriptyline kinetics were unaltered, but the elimination of the metabolites was reduced in both groups of patients." | 1.26 | Nortriptyline metabolism in chronic renal failure: metabolite elimination. ( Braithwaite, R; Dawling, S; Lynn, K; Rosser, R, 1982) |
| " 2 The median nortriptyline half-life was 25." | 1.26 | The pharmacokinetics of nortriptyline in patients with chronic renal failure. ( Braithwaite, R; Dawlilng, S; Lynn, K; Rosser, R, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawling, S | 1 |
| Lynn, K | 2 |
| Rosser, R | 3 |
| Braithwaite, R | 2 |
| Dawlilng, S | 1 |
| Degen, J | 1 |
| Wölke, E | 1 |
| Seiberling, M | 1 |
| Pintar, P | 1 |
| Höxter, G | 1 |
| Steinhauer, HB | 1 |
| Fischer, W | 1 |
| Lieberman, JA | 1 |
| Cooper, TB | 1 |
| Suckow, RF | 1 |
| Steinberg, H | 1 |
| Borenstein, M | 1 |
| Brenner, R | 1 |
| Kane, JM | 1 |
1 trial available for nortriptyline and Kidney Failure, Chronic
| Article | Year |
|---|---|
[Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure].
Topics: Adult; Aged; Amitriptyline; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle | 1993 |
4 other studies available for nortriptyline and Kidney Failure, Chronic
| Article | Year |
|---|---|
Nortriptyline metabolism in chronic renal failure: metabolite elimination.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Depressive Disorder; Female; Humans; Kidney Failure, C | 1982 |
The pharmacokinetics of nortriptyline in patients with chronic renal failure.
Topics: Adolescent; Adult; Aged; Female; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle | 1981 |
Depression during renal dialysis and following transplantation.
Topics: Amitriptyline; Depression; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Mi | 1976 |
Tricyclic antidepressant and metabolite levels in chronic renal failure.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chromatography, Liquid; Depression; Desipramine; | 1985 |