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nortriptyline and Kidney Failure, Chronic

nortriptyline has been researched along with Kidney Failure, Chronic in 5 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Research Excerpts

ExcerptRelevanceReference
"For trimipramine the AUC was significantly higher in patients."2.67[Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure]. ( Degen, J; Fischer, W; Höxter, G; Pintar, P; Seiberling, M; Steinhauer, HB; Wölke, E, 1993)
"Nortriptyline kinetics were unaltered, but the elimination of the metabolites was reduced in both groups of patients."1.26Nortriptyline metabolism in chronic renal failure: metabolite elimination. ( Braithwaite, R; Dawling, S; Lynn, K; Rosser, R, 1982)
" 2 The median nortriptyline half-life was 25."1.26The pharmacokinetics of nortriptyline in patients with chronic renal failure. ( Braithwaite, R; Dawlilng, S; Lynn, K; Rosser, R, 1981)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dawling, S1
Lynn, K2
Rosser, R3
Braithwaite, R2
Dawlilng, S1
Degen, J1
Wölke, E1
Seiberling, M1
Pintar, P1
Höxter, G1
Steinhauer, HB1
Fischer, W1
Lieberman, JA1
Cooper, TB1
Suckow, RF1
Steinberg, H1
Borenstein, M1
Brenner, R1
Kane, JM1

Trials

1 trial available for nortriptyline and Kidney Failure, Chronic

ArticleYear
[Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure].
    Medizinische Klinik (Munich, Germany : 1983), 1993, Mar-15, Volume: 88, Issue:3

    Topics: Adult; Aged; Amitriptyline; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle

1993

Other Studies

4 other studies available for nortriptyline and Kidney Failure, Chronic

ArticleYear
Nortriptyline metabolism in chronic renal failure: metabolite elimination.
    Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Aged; Chromatography, Gas; Depressive Disorder; Female; Humans; Kidney Failure, C

1982
The pharmacokinetics of nortriptyline in patients with chronic renal failure.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Aged; Female; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle

1981
Depression during renal dialysis and following transplantation.
    Proceedings of the Royal Society of Medicine, 1976, Volume: 69, Issue:11

    Topics: Amitriptyline; Depression; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Mi

1976
Tricyclic antidepressant and metabolite levels in chronic renal failure.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:3

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chromatography, Liquid; Depression; Desipramine;

1985