Page last updated: 2024-11-01

nortriptyline and Hypotension, Orthostatic

nortriptyline has been researched along with Hypotension, Orthostatic in 18 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin was shown to be equally efficacious but was better tolerated compared to nortriptyline and can be considered a suitable alternative for the treatment of PHN."6.72Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. ( Chandra, K; Gupta, S; Malhotra, S; Pandhi, P; Shafiq, N, 2006)
"Gabapentin was shown to be equally efficacious but was better tolerated compared to nortriptyline and can be considered a suitable alternative for the treatment of PHN."2.72Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. ( Chandra, K; Gupta, S; Malhotra, S; Pandhi, P; Shafiq, N, 2006)
" At the end of each study week, the steady-state pharmacokinetic parameters of nortriptyline or paroxetine were determined within the dose interval."2.70Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. ( Andersson, K; Bertilsson, L; Härtter, S; Laine, K; Svensson, JO; Tybring, G; Widén, J, 2001)
"Bupropion-treated patients had small but statistically significant increases in supine diastolic blood pressure of 5."2.67The cardiovascular effects of bupropion and nortriptyline in depressed outpatients. ( Batey, SR; Holloman, LC; Johnston, JA; Kiev, A; Masco, HL; Wenger, TL, 1994)
"Nortriptyline treatment was initiated with a 75- to 125-mg dose depending on weight in 26 depressed inpatients in an open-label study."2.67High initial nortriptyline doses in the treatment of depression. ( Griffin, M; Peabody, CA; Warner, MD, 1993)
"The nortriptyline-treated subjects with a PSOP of greater than or equal to 10 mm Hg had a greater improvement than those with a PSOP of less than 10 mm HG (t = -2."2.66Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression. ( Bender, M; Schneider, LS; Sloane, RB; Staples, FR, 1986)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19907 (38.89)18.7374
1990's6 (33.33)18.2507
2000's4 (22.22)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jensen, BP1
Roberts, RL2
Vyas, R1
Bonke, G1
Jardine, DL1
Begg, EJ2
Chandra, K1
Shafiq, N1
Pandhi, P1
Gupta, S1
Malhotra, S1
Roose, SP4
Glassman, AH3
Siris, SG1
Walsh, BT2
Bruno, RL1
Wright, LB1
Adler, L1
Angrist, B1
Lautin, A1
Rotrosen, J1
Maskall, DD1
Lam, RW1
Kiev, A1
Masco, HL1
Wenger, TL1
Johnston, JA1
Batey, SR1
Holloman, LC1
Nelson, JC1
Warner, MD1
Griffin, M1
Peabody, CA1
Attia, E1
Woodring, S2
Giardina, EG2
Bigger, JT2
Spatz, E1
Scalco, MZ1
de Almeida, OP1
Hachul, DT1
Castel, S1
Serro-Azul, J1
Wajngarten, M1
Laine, K1
Tybring, G1
Härtter, S1
Andersson, K1
Svensson, JO1
Widén, J1
Bertilsson, L1
Joyce, PR1
Mulder, RT1
Kennedy, MA1
Seibyl, JP1
Krystal, JH1
Price, LH1
Charney, DS1
Forster, HS1
Georgotas, A1
McCue, RE1
Friedman, E1
Cooper, TB1
Schneider, LS1
Sloane, RB1
Staples, FR1
Bender, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662]Phase 450 participants (Anticipated)Interventional2015-02-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nortriptyline and Hypotension, Orthostatic

ArticleYear
Treatment of depression in patients with heart disease.
    The Journal of clinical psychiatry, 1999, Volume: 60 Suppl 20

    Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Comorbidity;

1999

Trials

7 trials available for nortriptyline and Hypotension, Orthostatic

ArticleYear
Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial.
    International journal of clinical pharmacology and therapeutics, 2006, Volume: 44, Issue:8

    Topics: Aged; Amines; Analgesics; Capsules; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; D

2006
The cardiovascular effects of bupropion and nortriptyline in depressed outpatients.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1994, Volume: 6, Issue:2

    Topics: Adult; Aged; Blood Pressure; Bupropion; Cardiovascular System; Depressive Disorder; Dose-Response Re

1994
High initial nortriptyline doses in the treatment of depression.
    The Journal of clinical psychiatry, 1993, Volume: 54, Issue:2

    Topics: Adult; Body Weight; Depressive Disorder; Drug Administration Schedule; Female; Hospitalization; Huma

1993
Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4

    Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors

2001
A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression.
    The pharmacogenomics journal, 2002, Volume: 2, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; ATP Binding Casse

2002
A placebo-controlled comparison of the effect of nortriptyline and phenelzine on orthostatic hypotension in elderly depressed patients.
    Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:6

    Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotensio

1987
Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression.
    Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:3

    Topics: Aged; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotension, Orthostatic; Male; Midd

1986

Other Studies

10 other studies available for nortriptyline and Hypotension, Orthostatic

ArticleYear
Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Area Under Curve; ATP Binding Cassette Transpor

2012
Comparison of imipramine- and nortriptyline-induced orthostatic hypotension: a meaningful difference.
    Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:5

    Topics: Humans; Hypotension, Orthostatic; Imipramine; Middle Aged; Nortriptyline; Receptors, Adrenergic, alp

1981
Differential effects of tricyclic antidepressants on mean arterial pressure in a hypertensive patient.
    Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2

    Topics: Blood Pressure; Depressive Disorder; Humans; Hypertension; Hypotension, Orthostatic; Imipramine; Mal

1983
Midodrine for TCA-induced orthostatic hypotension.
    Journal of psychiatry & neuroscience : JPN, 1993, Volume: 18, Issue:5

    Topics: Adult; Blood Pressure; Depressive Disorder; Drug Therapy, Combination; Female; Heart Rate; Humans; H

1993
Initiation of tricyclic treatment at full dose.
    The Journal of clinical psychiatry, 1994, Volume: 55, Issue:6

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administrati

1994
Cardiovascular effects of fluoxetine in depressed patients with heart disease.
    The American journal of psychiatry, 1998, Volume: 155, Issue:5

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Comorbidity; Depressive Disorder; Dru

1998
Comparison of risk of orthostatic hypotension in elderly depressed hypertensive women treated with nortriptyline and thiazides versus elderly depressed normotensive women treated with nortriptyline.
    The American journal of cardiology, 2000, May-01, Volume: 85, Issue:9

    Topics: Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Case-Control Studies; Depression; Female; Hu

2000
Use of yohimbine to counteract nortriptyline-induced orthostatic hypotension.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:1

    Topics: Blood Pressure; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Hypotension, Orthost

1989
Naproxen reversal of nortriptyline-induced orthostatic hypotension.
    The Journal of clinical psychiatry, 1989, Volume: 50, Issue:9

    Topics: Aged; Depressive Disorder; Female; Humans; Hypotension, Orthostatic; Naproxen; Nortriptyline

1989
Tricyclic antidepressants in depressed patients with cardiac conduction disease.
    Archives of general psychiatry, 1987, Volume: 44, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Bundle-Branch Block; Depressive Disorder; Electrocardiography; Fem

1987