nortriptyline has been researched along with Hypotension, Orthostatic in 18 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabapentin was shown to be equally efficacious but was better tolerated compared to nortriptyline and can be considered a suitable alternative for the treatment of PHN." | 6.72 | Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. ( Chandra, K; Gupta, S; Malhotra, S; Pandhi, P; Shafiq, N, 2006) |
| "Gabapentin was shown to be equally efficacious but was better tolerated compared to nortriptyline and can be considered a suitable alternative for the treatment of PHN." | 2.72 | Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. ( Chandra, K; Gupta, S; Malhotra, S; Pandhi, P; Shafiq, N, 2006) |
| " At the end of each study week, the steady-state pharmacokinetic parameters of nortriptyline or paroxetine were determined within the dose interval." | 2.70 | Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. ( Andersson, K; Bertilsson, L; Härtter, S; Laine, K; Svensson, JO; Tybring, G; Widén, J, 2001) |
| "Bupropion-treated patients had small but statistically significant increases in supine diastolic blood pressure of 5." | 2.67 | The cardiovascular effects of bupropion and nortriptyline in depressed outpatients. ( Batey, SR; Holloman, LC; Johnston, JA; Kiev, A; Masco, HL; Wenger, TL, 1994) |
| "Nortriptyline treatment was initiated with a 75- to 125-mg dose depending on weight in 26 depressed inpatients in an open-label study." | 2.67 | High initial nortriptyline doses in the treatment of depression. ( Griffin, M; Peabody, CA; Warner, MD, 1993) |
| "The nortriptyline-treated subjects with a PSOP of greater than or equal to 10 mm Hg had a greater improvement than those with a PSOP of less than 10 mm HG (t = -2." | 2.66 | Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression. ( Bender, M; Schneider, LS; Sloane, RB; Staples, FR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jensen, BP | 1 |
| Roberts, RL | 2 |
| Vyas, R | 1 |
| Bonke, G | 1 |
| Jardine, DL | 1 |
| Begg, EJ | 2 |
| Chandra, K | 1 |
| Shafiq, N | 1 |
| Pandhi, P | 1 |
| Gupta, S | 1 |
| Malhotra, S | 1 |
| Roose, SP | 4 |
| Glassman, AH | 3 |
| Siris, SG | 1 |
| Walsh, BT | 2 |
| Bruno, RL | 1 |
| Wright, LB | 1 |
| Adler, L | 1 |
| Angrist, B | 1 |
| Lautin, A | 1 |
| Rotrosen, J | 1 |
| Maskall, DD | 1 |
| Lam, RW | 1 |
| Kiev, A | 1 |
| Masco, HL | 1 |
| Wenger, TL | 1 |
| Johnston, JA | 1 |
| Batey, SR | 1 |
| Holloman, LC | 1 |
| Nelson, JC | 1 |
| Warner, MD | 1 |
| Griffin, M | 1 |
| Peabody, CA | 1 |
| Attia, E | 1 |
| Woodring, S | 2 |
| Giardina, EG | 2 |
| Bigger, JT | 2 |
| Spatz, E | 1 |
| Scalco, MZ | 1 |
| de Almeida, OP | 1 |
| Hachul, DT | 1 |
| Castel, S | 1 |
| Serro-Azul, J | 1 |
| Wajngarten, M | 1 |
| Laine, K | 1 |
| Tybring, G | 1 |
| Härtter, S | 1 |
| Andersson, K | 1 |
| Svensson, JO | 1 |
| Widén, J | 1 |
| Bertilsson, L | 1 |
| Joyce, PR | 1 |
| Mulder, RT | 1 |
| Kennedy, MA | 1 |
| Seibyl, JP | 1 |
| Krystal, JH | 1 |
| Price, LH | 1 |
| Charney, DS | 1 |
| Forster, HS | 1 |
| Georgotas, A | 1 |
| McCue, RE | 1 |
| Friedman, E | 1 |
| Cooper, TB | 1 |
| Schneider, LS | 1 |
| Sloane, RB | 1 |
| Staples, FR | 1 |
| Bender, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nortriptyline and Hypotension, Orthostatic
| Article | Year |
|---|---|
Treatment of depression in patients with heart disease.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Comorbidity; | 1999 |
7 trials available for nortriptyline and Hypotension, Orthostatic
| Article | Year |
|---|---|
Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial.
Topics: Aged; Amines; Analgesics; Capsules; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; D | 2006 |
The cardiovascular effects of bupropion and nortriptyline in depressed outpatients.
Topics: Adult; Aged; Blood Pressure; Bupropion; Cardiovascular System; Depressive Disorder; Dose-Response Re | 1994 |
High initial nortriptyline doses in the treatment of depression.
Topics: Adult; Body Weight; Depressive Disorder; Drug Administration Schedule; Female; Hospitalization; Huma | 1993 |
Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.
Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors | 2001 |
A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; ATP Binding Casse | 2002 |
A placebo-controlled comparison of the effect of nortriptyline and phenelzine on orthostatic hypotension in elderly depressed patients.
Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotensio | 1987 |
Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression.
Topics: Aged; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotension, Orthostatic; Male; Midd | 1986 |
10 other studies available for nortriptyline and Hypotension, Orthostatic
| Article | Year |
|---|---|
Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Area Under Curve; ATP Binding Cassette Transpor | 2012 |
Comparison of imipramine- and nortriptyline-induced orthostatic hypotension: a meaningful difference.
Topics: Humans; Hypotension, Orthostatic; Imipramine; Middle Aged; Nortriptyline; Receptors, Adrenergic, alp | 1981 |
Differential effects of tricyclic antidepressants on mean arterial pressure in a hypertensive patient.
Topics: Blood Pressure; Depressive Disorder; Humans; Hypertension; Hypotension, Orthostatic; Imipramine; Mal | 1983 |
Midodrine for TCA-induced orthostatic hypotension.
Topics: Adult; Blood Pressure; Depressive Disorder; Drug Therapy, Combination; Female; Heart Rate; Humans; H | 1993 |
Initiation of tricyclic treatment at full dose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administrati | 1994 |
Cardiovascular effects of fluoxetine in depressed patients with heart disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Comorbidity; Depressive Disorder; Dru | 1998 |
Comparison of risk of orthostatic hypotension in elderly depressed hypertensive women treated with nortriptyline and thiazides versus elderly depressed normotensive women treated with nortriptyline.
Topics: Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Case-Control Studies; Depression; Female; Hu | 2000 |
Use of yohimbine to counteract nortriptyline-induced orthostatic hypotension.
Topics: Blood Pressure; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Hypotension, Orthost | 1989 |
Naproxen reversal of nortriptyline-induced orthostatic hypotension.
Topics: Aged; Depressive Disorder; Female; Humans; Hypotension, Orthostatic; Naproxen; Nortriptyline | 1989 |
Tricyclic antidepressants in depressed patients with cardiac conduction disease.
Topics: Antidepressive Agents, Tricyclic; Bundle-Branch Block; Depressive Disorder; Electrocardiography; Fem | 1987 |