nortriptyline has been researched along with Huntington Disease in 1 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was to characterize the neuroprotective effects of nortriptyline, a tricyclic antidepressant, in mouse models of chronic neurodegeneration [amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)]." | 3.74 | Nortriptyline delays disease onset in models of chronic neurodegeneration. ( Cormier, K; Ferrante, RJ; Friedlander, RM; Guan, Y; Huo, C; Kristal, BS; Smith, K; Stavrovskaya, IG; Wang, H; Wang, X; Zhu, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Guan, Y | 1 |
| Wang, X | 1 |
| Smith, K | 1 |
| Cormier, K | 1 |
| Zhu, S | 1 |
| Stavrovskaya, IG | 1 |
| Huo, C | 1 |
| Ferrante, RJ | 1 |
| Kristal, BS | 1 |
| Friedlander, RM | 1 |
1 other study available for nortriptyline and Huntington Disease
| Article | Year |
|---|---|
Nortriptyline delays disease onset in models of chronic neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antidepressive Agents, Tricyclic; Apoptosis; Brain; Chronic | 2007 |