Page last updated: 2024-11-01

nortriptyline and Genetic Predisposition

nortriptyline has been researched along with Genetic Predisposition in 5 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Research Excerpts

ExcerptRelevanceReference
" A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation."2.74Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project. ( Aitchison, KJ; Bonvicini, C; Craig, I; Farmer, AE; Gray, J; Gupta, B; Hauser, J; Henigsberg, N; Huezo-Diaz, P; Jorgensen, L; Kalember, P; Kapelski, P; Lewis, CM; Maier, W; Marusic, A; McGuffin, P; Mors, O; Perroud, N; Petrovic, A; Placentino, A; Rietschel, M; Schulze, TG; Smith, R; Souery, D; Uher, R; Zobel, A, 2009)
"Risk factors such as borderline personality disorder and childhood abuse experiences were systematically assessed, and patients were genotyped for polymorphisms of GNbeta3."2.72Genetic, developmental and personality correlates of self-mutilation in depressed patients. ( Joyce, PR; Kennedy, MA; Luty, SE; McKenzie, JM; Miller, AL; Mulder, RT; Sullivan, PF, 2006)
"Management of MdDS as vestibular migraine can improve patients' symptoms and increase the QOL."1.46Management of mal de debarquement syndrome as vestibular migraines. ( Bhatt, J; Djalilian, HR; Ghavami, Y; Haidar, YM; Lin, HW; Moshtaghi, O; Ziai, KN, 2017)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Fjær, R1
Marciniak, K1
Sundnes, O1
Hjorthaug, H1
Sheng, Y1
Hammarström, C1
Sitek, JC1
Vigeland, MD1
Backe, PH1
Øye, AM1
Fosse, JH1
Stav-Noraas, TE1
Uchiyama, Y1
Matsumoto, N1
Comi, A1
Pevsner, J1
Haraldsen, G1
Selmer, KK1
Zwicker, A1
Fabbri, C1
Rietschel, M2
Hauser, J2
Mors, O2
Maier, W2
Zobel, A2
Farmer, A1
Aitchison, KJ2
McGuffin, P2
Lewis, CM2
Uher, R2
Ghavami, Y1
Haidar, YM1
Ziai, KN1
Moshtaghi, O1
Bhatt, J1
Lin, HW1
Djalilian, HR1
Perroud, N1
Smith, R1
Huezo-Diaz, P1
Marusic, A1
Placentino, A1
Henigsberg, N1
Souery, D1
Kapelski, P1
Bonvicini, C1
Jorgensen, L1
Petrovic, A1
Kalember, P1
Schulze, TG1
Gupta, B1
Gray, J1
Farmer, AE1
Craig, I1
Joyce, PR1
McKenzie, JM1
Mulder, RT1
Luty, SE1
Sullivan, PF1
Miller, AL1
Kennedy, MA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Genetics of Self-injurious Behaviour[NCT05563324]234 participants (Actual)Observational2014-05-09Completed
Influences on and Prevention of Self-harm Behaviour Among the Most At-risk Adolescents[NCT05765864]400 participants (Anticipated)Observational2023-03-23Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for nortriptyline and Genetic Predisposition

ArticleYear
Genetic disposition to inflammation and response to antidepressants in major depressive disorder.
    Journal of psychiatric research, 2018, Volume: 105

    Topics: Adrenergic Uptake Inhibitors; Adult; C-Reactive Protein; Citalopram; Depressive Disorder, Major; Fem

2018
Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:12

    Topics: Adult; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Citalopram; Depressive Disorder, Ma

2009
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
    The Australian and New Zealand journal of psychiatry, 2006, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl

2006
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
    The Australian and New Zealand journal of psychiatry, 2006, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl

2006
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
    The Australian and New Zealand journal of psychiatry, 2006, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl

2006
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
    The Australian and New Zealand journal of psychiatry, 2006, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl

2006

Other Studies

2 other studies available for nortriptyline and Genetic Predisposition

ArticleYear
A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome.
    Human molecular genetics, 2021, 10-13, Volume: 30, Issue:21

    Topics: Adolescent; Adult; Child; DNA Mutational Analysis; Exome Sequencing; Gene Frequency; Genetic Associa

2021
Management of mal de debarquement syndrome as vestibular migraines.
    The Laryngoscope, 2017, Volume: 127, Issue:7

    Topics: Adult; Aged; Drug Therapy, Combination; Female; Fructose; Genetic Predisposition to Disease; Humans;

2017