nortriptyline has been researched along with Drug Overdose in 23 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 7.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| " Therefore, in these cases, pharmacokinetic values derived from routine dosing should not be used to make clinical decisions (such as timing of discontinuation of sodium bicarbonate infusion)." | 6.66 | Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment. ( Eche, IM; Elsamadisi, P; Sclafani, A, 2020) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 3.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| " Therefore, in these cases, pharmacokinetic values derived from routine dosing should not be used to make clinical decisions (such as timing of discontinuation of sodium bicarbonate infusion)." | 2.66 | Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment. ( Eche, IM; Elsamadisi, P; Sclafani, A, 2020) |
| "Amitriptyline was the most frequent agent followed by Nortriptyline." | 1.37 | Tricyclic antidepressants intoxication in Tehran, Iran: epidemiology and associated factors. ( Dianat, S; Hassanian-Moghaddam, H; Rahimian, R; Rashidi-Ranjbar, N; Rasouli, MR; Zarei, MR, 2011) |
| " Mechanisms of desipramine toxicity and its dosage recommendations are discussed." | 1.32 | Excess fatality from desipramine and dosage recommendations. ( Amitai, Y; Frischer, H, 2004) |
| "Amitriptyline was studied in greater detail and caused a dose-related (0." | 1.30 | Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997) |
| "Nortriptyline was not detected in most cases, suggesting that it may degrade more rapidly than desipramine." | 1.29 | The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions. ( Wahba, WW; Winek, CL; Zaveri, NR, 1993) |
| "No correlation between coma grade or QRS duration and cerebral spinal fluid concentration of amitriptyline was found." | 1.28 | Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. ( Heath, A; Hultén, BA; Knudsen, K; Mårtensson, E; Nyberg, G; Starmark, JE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (52.17) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Özütemiz, C | 1 |
| Roshan, SK | 1 |
| Kroll, NJ | 1 |
| Rykken, JB | 1 |
| Ott, F | 1 |
| McKinney, AM | 1 |
| Elsamadisi, P | 1 |
| Sclafani, A | 1 |
| Eche, IM | 1 |
| De Roock, S | 1 |
| Beauloye, C | 1 |
| De Bauwer, I | 1 |
| Vancraynest, D | 1 |
| Gurne, O | 1 |
| Gerber, B | 1 |
| Hantson, P | 1 |
| Dianat, S | 1 |
| Zarei, MR | 1 |
| Hassanian-Moghaddam, H | 1 |
| Rashidi-Ranjbar, N | 1 |
| Rahimian, R | 1 |
| Rasouli, MR | 1 |
| Clement, A | 1 |
| Raney, JJ | 1 |
| Wasserman, GS | 1 |
| Lowry, JA | 1 |
| Jain, V | 1 |
| Swartz, CM | 1 |
| Franssen, EJ | 1 |
| Kunst, PW | 1 |
| Bet, PM | 1 |
| Strack van Schijndel, RJ | 1 |
| van Loenen, AC | 1 |
| Wilhelm, AJ | 1 |
| Amitai, Y | 1 |
| Frischer, H | 1 |
| Avella, J | 1 |
| Katz, M | 1 |
| Lehrer, M | 1 |
| Agrawal, P | 1 |
| Nadel, ES | 1 |
| Brown, DF | 1 |
| Pounder, DJ | 1 |
| Owen, V | 1 |
| Quigley, C | 1 |
| Lipper, B | 2 |
| Gaynor, BD | 1 |
| Bell, A | 1 |
| Gaynor, B | 1 |
| Winek, CL | 1 |
| Zaveri, NR | 1 |
| Wahba, WW | 1 |
| Hilberg, T | 1 |
| Bugge, A | 1 |
| Beylich, KM | 1 |
| Ingum, J | 1 |
| Bjørneboe, A | 1 |
| Mørland, J | 1 |
| Lee, DC | 1 |
| Klachko, MN | 1 |
| Dahlin, KL | 1 |
| Lâstbom, L | 1 |
| Blomgren, B | 1 |
| Ryrfeldt, A | 1 |
| Moriya, F | 1 |
| Hashimoto, Y | 1 |
| Tada, H | 1 |
| Sticherling, C | 1 |
| Oral, H | 1 |
| Morady, F | 1 |
| Wrenn, K | 1 |
| Smith, BA | 1 |
| Slovis, CM | 1 |
| Hultén, BA | 2 |
| Heath, A | 2 |
| Knudsen, K | 2 |
| Nyberg, G | 2 |
| Starmark, JE | 1 |
| Mårtensson, E | 2 |
| Svensson, C | 1 |
| Wimbish, G | 1 |
| Shores, J | 1 |
| Spiehler, V | 1 |
1 review available for nortriptyline and Drug Overdose
| Article | Year |
|---|---|
Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment.
Topics: Antidepressive Agents, Tricyclic; Cardiotoxicity; Drug Overdose; Electrocardiography; Humans; Male; | 2020 |
22 other studies available for nortriptyline and Drug Overdose
| Article | Year |
|---|---|
Concomitant Acute Toxic Leukoencephalopathy and Posterior Reversible Encephalopathy Syndrome.
Topics: Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Leukoencephalopathies; Magnetic Resonance Im | 2018 |
Tako-tsubo syndrome following nortriptyline overdose.
Topics: Antidepressive Agents, Tricyclic; Drug Overdose; Electrocardiography; Female; Follow-Up Studies; Hum | 2008 |
Tricyclic antidepressants intoxication in Tehran, Iran: epidemiology and associated factors.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Cross-Sectional Studies; Drug Overdose; Fema | 2011 |
Chronic amitriptyline overdose in a child.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Drug Overdose; Electrocardiography; Female; | 2012 |
Charcoal enhancement of treatment for tricyclic-induced mania.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Bipolar Disorder; Charcoal; Depres | 2002 |
Toxicokinetics of nortriptyline and amitriptyline: two case reports.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Drug O | 2003 |
Excess fatality from desipramine and dosage recommendations.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Databases, Factual; Desipramine; Drug Overdose; Hum | 2004 |
Assessing free and total morphine following heroin overdose when complicated by the presence of toxic amitriptyline levels.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interactions; Drug Overdose; Fatal Outc | 2007 |
Tricyclic antidepressant overdose.
Topics: Antidepressive Agents, Tricyclic; Drug Overdose; Electrocardiography; Emergency Medicine; Female; Hu | 2008 |
Postmortem changes in blood amitriptyline concentration.
Topics: Adult; Amitriptyline; Body Fluids; Chromatography, High Pressure Liquid; Drug Overdose; Humans; Male | 1994 |
Value of serum tricyclic antidepressant levels with massive nortriptyline overdose and persistent hypotension.
Topics: Drug Overdose; Female; Humans; Hypotension; Nortriptyline; Prognosis; Respiratory Distress Syndrome | 1995 |
Recurrent hypotension immediately after seizures in nortriptyline overdose.
Topics: Biological Availability; Blood Pressure; Drug Overdose; Female; Heart; Humans; Hypotension; Midazola | 1994 |
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
Topics: Amitriptyline; Cryopreservation; Desipramine; Drug Overdose; Drug Stability; Embalming; Evaluation S | 1993 |
An animal model of postmortem amitriptyline redistribution.
Topics: Amitriptyline; Animals; Disease Models, Animal; Drug Overdose; Liver; Lung; Male; Nortriptyline; Pos | 1993 |
Falsely elevated lithium levels in plasma samples obtained in lithium containing tubes.
Topics: Adult; Drug Overdose; False Positive Reactions; Female; Humans; Infant; Lithium; Lithium Carbonate; | 1996 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose- | 1997 |
Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Autopsy; Central Nervous System Sti | 1999 |
Brugada syndrome mimicked by tricyclic antidepressant overdose.
Topics: Adult; Antidepressive Agents, Tricyclic; Bundle-Branch Block; Drug Overdose; Electrocardiography; Hu | 2001 |
Profound alkalemia during treatment of tricyclic antidepressant overdose: a potential hazard of combined hyperventilation and intravenous bicarbonate.
Topics: Adult; Aged; Alkalosis; Antidepressive Agents, Tricyclic; Bicarbonates; Critical Care; Doxepin; Drug | 1992 |
Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics.
Topics: Amitriptyline; Coma; Drug Overdose; Electrocardiography; Erythrocytes; Half-Life; Humans; Intubation | 1992 |
Amitriptyline and amitriptyline metabolites in blood and cerebrospinal fluid following human overdose.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Dialysis; Drug Overdose; Erythrocytes; F | 1992 |
A comparison of three computer models for prediction of dose in acute amitriptyline overdose.
Topics: Amitriptyline; Animals; Chi-Square Distribution; Computer Simulation; Discriminant Analysis; Dogs; D | 1991 |