nortriptyline has been researched along with Disease Models, Animal in 32 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In concurrence with clinical findings proposing alleviation of withdrawal states as a possible mechanism of bupropion and nortriptyline's smoking cessation action, both drugs were found to ameliorate somatic signs of nicotine withdrawal in rodents." | 7.74 | Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. ( Shoaib, M; Wing, VC, 2007) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 7.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| "We therefore superimposed maternal separation (MS) onto a genetic rat model (Flinders-sensitive and -resistant lines, FSL/FRL) of depression, treated these rats with antidepressants (escitalopram and nortriptyline) and measured CGRP-LI in selected brain regions." | 3.91 | CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment. ( Angelucci, F; El Khoury, A; Ellenbroek, BA; Mathé, AA, 2019) |
| "This study was to characterize the neuroprotective effects of nortriptyline, a tricyclic antidepressant, in mouse models of chronic neurodegeneration [amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)]." | 3.74 | Nortriptyline delays disease onset in models of chronic neurodegeneration. ( Cormier, K; Ferrante, RJ; Friedlander, RM; Guan, Y; Huo, C; Kristal, BS; Smith, K; Stavrovskaya, IG; Wang, H; Wang, X; Zhu, S, 2007) |
| "In concurrence with clinical findings proposing alleviation of withdrawal states as a possible mechanism of bupropion and nortriptyline's smoking cessation action, both drugs were found to ameliorate somatic signs of nicotine withdrawal in rodents." | 3.74 | Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. ( Shoaib, M; Wing, VC, 2007) |
| " Amiodarone is recommended for treatment of wide complex tachycardia, but its hemodynamic effects in wide complex tachycardia induced by tricyclic antidepressant poisoning are unknown." | 3.73 | Effects of amiodarone in a swine model of nortriptyline [corrected] toxicity. ( Barrueto, F; Brewer, K; Meggs, W; Meltzer, A; Murr, I, 2006) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 3.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| "Presence of leptomeningeal metastases is indicative of poor prognosis." | 1.56 | Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy. ( Ben-David, Y; Chung, PED; Croul, S; Dubuc, A; Garzia, L; Gendoo, DMA; Ghanbari-Azarnier, R; Haibe-Kains, B; Ho, B; Huang, A; Jiang, Z; Kang, SG; Li, B; Liu, JC; Remke, M; Shih, D; Taylor, MD; Tsui, J; Wang, DY; Xiao, X; Zacksenhaus, E, 2020) |
| "One of its consequences is neuropathic pain which is often chronic and difficult to treat." | 1.40 | The antiallodynic action of nortriptyline and terbutaline is mediated by β(2) adrenoceptors and δ opioid receptors in the ob/ob model of diabetic polyneuropathy. ( Barrot, M; Choucair-Jaafar, N; Freund-Mercier, MJ; Salvat, E, 2014) |
| "We used a murine model of neuropathic pain induced by sciatic nerve constriction to study the antiallodynic properties of a chronic treatment with the tricyclic antidepressants nortriptyline and amitriptyline." | 1.35 | Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. ( Barrot, M; Benbouzid, M; Freund-Mercier, MJ; Gavériaux-Ruff, C; Kieffer, BL; Muller, A; Tessier, LH; Waltisperger, E; Yalcin, I, 2008) |
| "Amitriptyline was studied in greater detail and caused a dose-related (0." | 1.30 | Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Bis-Humbert, C | 1 |
| García-Cabrerizo, R | 1 |
| García-Fuster, MJ | 1 |
| Chung, PED | 1 |
| Gendoo, DMA | 1 |
| Ghanbari-Azarnier, R | 1 |
| Liu, JC | 1 |
| Jiang, Z | 1 |
| Tsui, J | 1 |
| Wang, DY | 1 |
| Xiao, X | 1 |
| Li, B | 1 |
| Dubuc, A | 1 |
| Shih, D | 1 |
| Remke, M | 1 |
| Ho, B | 1 |
| Garzia, L | 1 |
| Ben-David, Y | 1 |
| Kang, SG | 1 |
| Croul, S | 1 |
| Haibe-Kains, B | 1 |
| Huang, A | 1 |
| Taylor, MD | 1 |
| Zacksenhaus, E | 1 |
| Carboni, L | 4 |
| Pischedda, F | 1 |
| Piccoli, G | 1 |
| Lauria, M | 1 |
| Musazzi, L | 1 |
| Popoli, M | 2 |
| Mathé, AA | 5 |
| Domenici, E | 3 |
| Kim, JH | 1 |
| Lee, J | 1 |
| Park, KS | 1 |
| Hong, SW | 1 |
| Gho, YS | 1 |
| Ceredig, RA | 1 |
| Pierre, F | 1 |
| Doridot, S | 1 |
| Alduntzin, U | 1 |
| Salvat, E | 2 |
| Yalcin, I | 3 |
| Gaveriaux-Ruff, C | 2 |
| Barrot, M | 4 |
| Massotte, D | 1 |
| Angelucci, F | 1 |
| Ellenbroek, BA | 1 |
| El Khoury, A | 2 |
| Jansen, T | 1 |
| Hoegberg, LCG | 1 |
| Eriksen, T | 1 |
| Dalhoff, KP | 1 |
| Belhage, B | 1 |
| Johansen, SS | 1 |
| Holanda, VAD | 1 |
| Pacifico, S | 1 |
| Azevedo Neto, J | 1 |
| Finetti, L | 1 |
| Lobão-Soares, B | 1 |
| Calo, G | 1 |
| Gavioli, EC | 3 |
| Ruzza, C | 1 |
| Choucair-Jaafar, N | 2 |
| Freund-Mercier, MJ | 3 |
| de Moura, JC | 1 |
| Noroes, MM | 1 |
| Rachetti, Vde P | 1 |
| Soares, BL | 1 |
| Preti, D | 1 |
| Nassini, R | 1 |
| Materazzi, S | 1 |
| Marone, IM | 1 |
| Minocci, D | 1 |
| Geppetti, P | 1 |
| André, E | 1 |
| Holanda, VA | 1 |
| Medeiros, IU | 1 |
| Asth, L | 1 |
| Guerrini, R | 1 |
| Calo', G | 1 |
| Yazdani, I | 1 |
| Ghazi-Khansari, M | 1 |
| Saeedi Saravi, SS | 1 |
| Nobakht, M | 1 |
| Majdani, R | 1 |
| Rezayat, SM | 1 |
| Mousavi, SE | 1 |
| Yari, A | 1 |
| Dehpour, AR | 1 |
| Marcon, M | 1 |
| Herrmann, AP | 1 |
| Mocelin, R | 1 |
| Rambo, CL | 1 |
| Koakoski, G | 1 |
| Abreu, MS | 1 |
| Conterato, GM | 1 |
| Kist, LW | 1 |
| Bogo, MR | 1 |
| Zanatta, L | 1 |
| Barcellos, LJ | 1 |
| Piato, AL | 1 |
| Malki, K | 2 |
| Tosto, MG | 1 |
| Mouriño-Talín, H | 1 |
| Rodríguez-Lorenzo, S | 1 |
| Pain, O | 1 |
| Jumhaboy, I | 1 |
| Liu, T | 1 |
| Parpas, P | 1 |
| Newman, S | 1 |
| Malykh, A | 1 |
| Uher, R | 2 |
| McGuffin, P | 2 |
| Schalkwyk, LC | 2 |
| Bryson, K | 1 |
| Herbster, M | 1 |
| Petersén, A | 1 |
| Wörtwein, G | 1 |
| Gruber, SH | 1 |
| El-Khoury, A | 1 |
| Becchi, S | 1 |
| Piubelli, C | 2 |
| Mallei, A | 1 |
| Giambelli, R | 1 |
| Razzoli, M | 1 |
| Gruber, S | 1 |
| Lourdusamy, A | 1 |
| Binder, E | 1 |
| Payá-Cano, J | 1 |
| Sluyter, F | 1 |
| Craig, I | 1 |
| Keers, R | 1 |
| Wang, H | 1 |
| Guan, Y | 1 |
| Wang, X | 1 |
| Smith, K | 1 |
| Cormier, K | 1 |
| Zhu, S | 1 |
| Stavrovskaya, IG | 1 |
| Huo, C | 1 |
| Ferrante, RJ | 1 |
| Kristal, BS | 1 |
| Friedlander, RM | 1 |
| Wing, VC | 1 |
| Shoaib, M | 1 |
| Benbouzid, M | 2 |
| Waltisperger, E | 2 |
| Tessier, LH | 1 |
| Muller, A | 2 |
| Kieffer, BL | 1 |
| Barrueto, F | 1 |
| Murr, I | 1 |
| Meltzer, A | 1 |
| Brewer, K | 1 |
| Meggs, W | 1 |
| Telner, JI | 2 |
| Singhal, RL | 2 |
| Lapierre, YD | 1 |
| Hilberg, T | 1 |
| Bugge, A | 1 |
| Beylich, KM | 1 |
| Ingum, J | 1 |
| Bjørneboe, A | 1 |
| Mørland, J | 1 |
| Dahlin, KL | 1 |
| Lâstbom, L | 1 |
| Blomgren, B | 1 |
| Ryrfeldt, A | 1 |
| McCabe, JL | 1 |
| Cobaugh, DJ | 1 |
| Menegazzi, JJ | 1 |
| Fata, J | 1 |
| Nakamura, K | 1 |
| Kurasawa, M | 1 |
| Otani, K | 1 |
| Kaneko, S | 1 |
| Bertilsson, L | 1 |
32 other studies available for nortriptyline and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Dose-dependent opposite effects of nortriptyline on affective-like behavior in adolescent rats: Comparison with adult rats.
Topics: Adolescent; Adult; Affective Symptoms; Age Factors; Animals; Antidepressive Agents; Behavior, Animal | 2021 |
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Topics: Animals; Autophagosomes; Autophagy; Cluster Analysis; Disease Models, Animal; Gene Deletion; Germ-Li | 2020 |
Depression-Associated Gene
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Cell Adhesion Molecules, Ne | 2020 |
Drug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram-Negative Bacterial Outer Membrane Vesicles.
Topics: Albuterol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Repositioning; Ex | 2018 |
Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Duloxetine Hydrochloride; Female; | 2018 |
CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment.
Topics: Amygdala; Animals; Antidepressive Agents; Brain; Calcitonin Gene-Related Peptide; Citalopram; Depres | 2019 |
Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion-a randomized controlled animal poisoning model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antidotes; Charcoal; Chromatography, High | 2019 |
Modulation of the NOP receptor signaling affects resilience to acute stress.
Topics: Animals; Behavior, Animal; Benzimidazoles; Cycloheptanes; Depression; Disease Models, Animal; Dose-R | 2019 |
The antiallodynic action of nortriptyline and terbutaline is mediated by β(2) adrenoceptors and δ opioid receptors in the ob/ob model of diabetic polyneuropathy.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Animals; Diabetic Neuropathies; D | 2014 |
The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice.
Topics: Acetanilides; Acrolein; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Anim | 2014 |
Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cycloheptanes; Depressive Disorder; Disease Models | 2016 |
Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion.
Topics: Adrenergic Uptake Inhibitors; Animals; Apoptosis; Caspase 3; Catalase; Cytoprotection; Disease Model | 2017 |
Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bromazepam; Cyclooxygenase 2; | 2016 |
Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression.
Topics: Animals; Antidepressive Agents; Citalopram; Cyclic AMP Response Element-Binding Protein; Depression; | 2017 |
Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Cell Count; Cell Proliferation; Depressive | 2009 |
Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression.
Topics: Animals; Biomarkers; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Citalopram; Corticostero | 2010 |
Nortriptyline influences protein pathways involved in carbohydrate metabolism and actin-related processes in a rat gene-environment model of depression.
Topics: Actins; Animals; Antidepressive Agents; Brain; Carbohydrate Metabolism; Cytoskeletal Proteins; Depre | 2011 |
Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Disease Models, Animal; Hippocampus; Mice; N | 2012 |
Nortriptyline delays disease onset in models of chronic neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antidepressive Agents, Tricyclic; Apoptosis; Brain; Chronic | 2007 |
Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal.
Topics: Animals; Antidepressive Agents; Bupropion; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Dose-Response Rela | 2008 |
Effects of amiodarone in a swine model of nortriptyline [corrected] toxicity.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Bl | 2006 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Effects of nortriptyline treatment on learned helplessness in the rat.
Topics: Animals; Avoidance Learning; Depression; Disease Models, Animal; Electroshock; Humans; Male; Nortrip | 1981 |
Reversal of learned helplessness by nortriptyline.
Topics: Animals; Depression; Disease Models, Animal; Escape Reaction; Humans; Male; Nortriptyline; Rats; Rat | 1981 |
An animal model of postmortem amitriptyline redistribution.
Topics: Amitriptyline; Animals; Disease Models, Animal; Drug Overdose; Liver; Lung; Male; Nortriptyline; Pos | 1993 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose- | 1997 |
Experimental tricyclic antidepressant toxicity: a randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Buffers; Disease Models, Animal; Electroc | 1998 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bro | 2001 |
Studies on active transport of (E)-10-hydroxynortriptyline in the kidney and brain of rats: effects of propranolol and quinidine.
Topics: Animals; Biological Transport, Active; Brain; Disease Models, Animal; Kidney; Male; Metabolic Cleara | 1991 |