nortriptyline has been researched along with Depressive Disorder, Treatment-Resistant in 4 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| " By study phase, Eight of 27 (30%) patients remitted with initial dosing of tranylcypromine up to 60 mg/d, 6/18 (33%) remitted with above PDR dosing of tranylcypromine up to 120 mg/d, and 1/6 (17%) to adding dextroamphetamine." | 2.79 | How treatable is refractory depression? ( Deliyannides, DA; McGrath, PJ; Stewart, JW, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebell, MH | 1 |
| Cristancho, P | 1 |
| Lenard, E | 1 |
| Lenze, EJ | 1 |
| Miller, JP | 1 |
| Brown, PJ | 1 |
| Roose, SP | 1 |
| Montes-Garcia, C | 1 |
| Blumberger, DM | 1 |
| Mulsant, BH | 1 |
| Lavretsky, H | 1 |
| Rollman, BL | 1 |
| Reynolds, CF | 1 |
| Karp, JF | 1 |
| Stewart, JW | 1 |
| Deliyannides, DA | 1 |
| McGrath, PJ | 1 |
| Fawcett, J | 1 |
| Rush, AJ | 1 |
| Vukelich, J | 1 |
| Diaz, SH | 1 |
| Dunklee, L | 1 |
| Romo, P | 1 |
| Yarns, BC | 1 |
| Escalona, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Treatment for Refractory Depression With Sequential Trials of Tranylcypromine, Tranylcypromine Plus Dextroamphetamine, Tranylcypromine Plus Triiodothyronine.[NCT00296686] | Phase 4 | 31 participants (Actual) | Interventional | 2001-09-30 | Terminated (stopped due to Study is no longer funded.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nortriptyline and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized.
Topics: Aged; Antidepressive Agents; Aripiprazole; Bupropion; Depressive Disorder, Treatment-Resistant; Huma | 2019 |
How treatable is refractory depression?
Topics: Adult; Antidepressive Agents; Central Nervous System Stimulants; Depressive Disorder, Major; Depress | 2014 |
2 other studies available for nortriptyline and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
Augmentation With Aripiprazole or Bupropion, or a Switch to Nortriptyline, Effective for Treatment-Resistant Depression in Older Adults.
Topics: Aged; Aripiprazole; Bupropion; Depression; Depressive Disorder, Treatment-Resistant; Humans; Nortrip | 2023 |
Clinical Experience With High-Dosage Pramipexole in Patients With Treatment-Resistant Depressive Episodes in Unipolar and Bipolar Depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Benzothiazoles; Bipolar Disorder; Bupropion; | 2016 |