Page last updated: 2024-11-01

nortriptyline and Depressive Disorder, Treatment-Resistant

nortriptyline has been researched along with Depressive Disorder, Treatment-Resistant in 4 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)

Research Excerpts

ExcerptRelevanceReference
" By study phase, Eight of 27 (30%) patients remitted with initial dosing of tranylcypromine up to 60 mg/d, 6/18 (33%) remitted with above PDR dosing of tranylcypromine up to 120 mg/d, and 1/6 (17%) to adding dextroamphetamine."2.79How treatable is refractory depression? ( Deliyannides, DA; McGrath, PJ; Stewart, JW, 2014)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Ebell, MH1
Cristancho, P1
Lenard, E1
Lenze, EJ1
Miller, JP1
Brown, PJ1
Roose, SP1
Montes-Garcia, C1
Blumberger, DM1
Mulsant, BH1
Lavretsky, H1
Rollman, BL1
Reynolds, CF1
Karp, JF1
Stewart, JW1
Deliyannides, DA1
McGrath, PJ1
Fawcett, J1
Rush, AJ1
Vukelich, J1
Diaz, SH1
Dunklee, L1
Romo, P1
Yarns, BC1
Escalona, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of Treatment for Refractory Depression With Sequential Trials of Tranylcypromine, Tranylcypromine Plus Dextroamphetamine, Tranylcypromine Plus Triiodothyronine.[NCT00296686]Phase 431 participants (Actual)Interventional2001-09-30Terminated (stopped due to Study is no longer funded.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for nortriptyline and Depressive Disorder, Treatment-Resistant

ArticleYear
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019, Volume: 27, Issue:10

    Topics: Aged; Antidepressive Agents; Aripiprazole; Bupropion; Depressive Disorder, Treatment-Resistant; Huma

2019
How treatable is refractory depression?
    Journal of affective disorders, 2014, Volume: 167

    Topics: Adult; Antidepressive Agents; Central Nervous System Stimulants; Depressive Disorder, Major; Depress

2014

Other Studies

2 other studies available for nortriptyline and Depressive Disorder, Treatment-Resistant

ArticleYear
Augmentation With Aripiprazole or Bupropion, or a Switch to Nortriptyline, Effective for Treatment-Resistant Depression in Older Adults.
    American family physician, 2023, Volume: 108, Issue:3

    Topics: Aged; Aripiprazole; Bupropion; Depression; Depressive Disorder, Treatment-Resistant; Humans; Nortrip

2023
Clinical Experience With High-Dosage Pramipexole in Patients With Treatment-Resistant Depressive Episodes in Unipolar and Bipolar Depression.
    The American journal of psychiatry, 2016, Feb-01, Volume: 173, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Benzothiazoles; Bipolar Disorder; Bupropion;

2016