nortriptyline has been researched along with Depression in 276 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bupropion SR treatment is an efficacious aid to smoking cessation in patients with COPD." | 9.11 | Efficacy of bupropion and nortriptyline for smoking cessation among people at risk for or with chronic obstructive pulmonary disease. ( Huibers, MJ; Knipschild, PG; van Schayck, CP; Wagena, EJ; Wouters, EF, 2005) |
| "The authors examined 1) effects of nortriptyline (NT) on electroencephalographic (EEG) sleep measures in elderly patients with bereavement-related depression in remission under randomized, double-blind, placebo-controlled conditions, and 2) the effects of clinical remission on sleep after discontinuation of medication." | 9.09 | EEG sleep measures in later-life bereavement depression. A randomized, double-blind, placebo-controlled evaluation of nortriptyline. ( Dew, MA; Frank, E; Houck, PR; Kupfer, DJ; Mazumdar, S; Reynolds, CF; Taylor, MP, 1999) |
| "OBJECTIVE (BACKGROUND): Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN)." | 9.08 | Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. ( Chipman, M; Reed, K; Vernich, L; Watson, CP, 1998) |
| "The effectiveness of amitriptyline in relieving neuropathic pain following treatment of breast cancer was studied in 15 patients in a randomised, double-blind placebo-controlled crossover study." | 9.08 | Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. ( Eija, K; J, NP; Tiina, T, 1996) |
| "Nortriptyline was superior to placebo by multivariate analysis of covariance for depression (10." | 9.07 | A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "Sixteen patients with primary depression were treated for 4 wk with amitriptyline." | 9.04 | Amitriptyline plasma levels and clinical response in primary depression. ( Coble, P; Grau, T; Hanin, I; Kupfer, DJ; Spiker, DG, 1977) |
| "The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached." | 9.04 | The practical significance of nortriptyline plasma control. A prospective evaluation under routine conditions in endogenous depression. ( Hvidberg, EF; Kragh-Sørensen, P; Larsen, NE; Sørensen, B, 1978) |
| "Patients suffering from mixed anxiety/depressive states referred to a psychiatric out-patient clinic completed a four course of either a once-daily table of 30 mg nortriptyline with 1-5 mag fluphenazine, or a sustained release capsule of 50 mg amitriptyline once daily, on a double-blind basis." | 9.04 | Once-daily treatment for mixed anxiety/depressive states: a comparison of slow release amitriptyline and fluphenazine with nortriptyline. ( Magnus, RV; Schiff, AA, 1977) |
| "A double-blind study involving sixty-two patients, aged 65 years or over, treated for twenty-eight days, showed that fluphenazine 0-5 mg/nortriptyline 10 mg three times daily was superior to promazine 50 mg three times daily in relieving symptoms of anxiety and was associated with a lower incidence of side-effects." | 9.04 | Anxiety/depression in elderly patients. A double-blind comparative study of fluphenazine/nortriptyline and promazine. ( Brodie, NH; McGhie, RL; O'Hara, H; Schiff, AA; Valle-Jones, JC, 1975) |
| "Patients suffering from mixed anxiety/depressive reactions, referred to the out-patient department of a large psychiatric hospital, were treated with either amitriptyline tablets or fluphenazine with nortriptyline (f/n) tablets for a period of four weeks." | 9.04 | A comparison of amitriptyline and a fluphenazine/nortriptyline preparation in anxiety-depressive states. ( Bennie, EH; Schiff, AA, 1976) |
| "Treatment of endogenous depression with nortriptyline (NT), at a daily dose of 150 mg, resulted in a pronounced improvement of seven of ten patients investigated." | 7.67 | Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. ( Aberg-Wistedt, A; Bertilsson, L; Malmgren, R, 1987) |
| "Out of 24 patients with endogenous depression, 21 completed the treatment with nortriptyline 150 mg as once-a-day dosage." | 7.66 | Therapeutic effect and side effects in patients with endogenous depression treated with oral nortriptyline once a day. ( Pedersen, JH; Sørensen, JL, 1980) |
| "In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs." | 7.66 | Prolonged delirium without anticholinergic signs following amitriptyline overdose. ( Gomolin, IH; Melmed, CA, 1983) |
| "In an open, uncontrolled trial flupenthixol was administered to 45 patients with endogenous depression." | 7.65 | Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients. ( Baba, O; Fujiwara, J; Hanaoka, M; Ishino, H; Sasaki, K, 1976) |
| " A sustained remission rate of 50% over 2 years in patients with severe major depression who were treated with nortriptyline monotherapy after successful ECT is encouraging." | 5.69 | Clinical characteristics associated with relapse 2 years after electroconvulsive therapy for major depression. ( Birkenhäger, TK; Kamperman, AM; Pluijms, EM; Vinther, PT, 2023) |
| "In older adults with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole improved well-being significantly more over 10 weeks than a switch to bupropion and was associated with a numerically higher incidence of remission." | 5.69 | Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression. ( Blumberger, DM; Brown, PJ; Cristancho, P; Flint, AJ; Gebara, MA; Gettinger, TR; Karp, JF; Lavretsky, H; Lenard, E; Lenze, EJ; Miller, JP; Mulsant, BH; Nicol, GE; Oughli, HA; Pham, VT; Reynolds, CF; Rollman, BL; Roose, SP; Yang, L, 2023) |
| "Weekly antidepressant dose was measured in 380 men and women with major depression treated with escitalopram or nortriptyline for 12 weeks as part of the Genome Based Therapeutic Drugs for Depression (GENDEP) study." | 5.34 | Estimating dose-response for time to remission with instrumental variable adjustment: the obscuring effects of drug titration in Genome Based Therapeutic Drugs for Depression Trial (GENDEP): clinical trial data. ( Emsley, R; Hellier, J; Pickles, A, 2020) |
| "Bupropion SR treatment is an efficacious aid to smoking cessation in patients with COPD." | 5.11 | Efficacy of bupropion and nortriptyline for smoking cessation among people at risk for or with chronic obstructive pulmonary disease. ( Huibers, MJ; Knipschild, PG; van Schayck, CP; Wagena, EJ; Wouters, EF, 2005) |
| "Treatment with fluoxetine or nortriptyline for 12 weeks during the first 6 months poststroke significantly increased the survival of both depressed and nondepressed patients." | 5.10 | Mortality and poststroke depression: a placebo-controlled trial of antidepressants. ( Arndt, S; Jorge, RE; Robinson, RG; Starkstein, S, 2003) |
| "Patients whose poststroke depression remitted (predominantly associated with nortriptyline treatment) had significantly greater recovery in cognitive function over the course of the treatment study than patients whose mood disorder did not remit (predominantly associated with placebo treatment)." | 5.09 | Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial. ( Kimura, M; Kosier, JT; Robinson, RG, 2000) |
| "The authors examined 1) effects of nortriptyline (NT) on electroencephalographic (EEG) sleep measures in elderly patients with bereavement-related depression in remission under randomized, double-blind, placebo-controlled conditions, and 2) the effects of clinical remission on sleep after discontinuation of medication." | 5.09 | EEG sleep measures in later-life bereavement depression. A randomized, double-blind, placebo-controlled evaluation of nortriptyline. ( Dew, MA; Frank, E; Houck, PR; Kupfer, DJ; Mazumdar, S; Reynolds, CF; Taylor, MP, 1999) |
| "The effectiveness of amitriptyline in relieving neuropathic pain following treatment of breast cancer was studied in 15 patients in a randomised, double-blind placebo-controlled crossover study." | 5.08 | Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. ( Eija, K; J, NP; Tiina, T, 1996) |
| "OBJECTIVE (BACKGROUND): Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN)." | 5.08 | Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. ( Chipman, M; Reed, K; Vernich, L; Watson, CP, 1998) |
| "Twenty-two female patients with anorexia nervosa, restricted type, 14-35 years old, were treated with a 4-month course of combined cognitive-behavioral therapy, nutritional counselling and antidepressant drugs (nortriptyline for 7, fluoxetine for 15)." | 5.08 | Combined cognitive-behavioral, psychopharmacological and nutritional therapy in eating disorders. 1. Anorexia nervosa--restricted type. ( Brambilla, F; Brunetta, M; Draisci, A; Peirone, A, 1995) |
| "Nortriptyline was superior to placebo by multivariate analysis of covariance for depression (10." | 5.07 | A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "This study describes the correlations between several measures of functional disability and Hamilton depression scores in two groups of patients with major depression and depressive symptoms (D-NOS) who were patients enrolled in a 12-week placebo-controlled, double-blind trial of nortriptyline." | 5.07 | Depressive symptoms and measures of disability: a prospective study. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "Patients suffering from mixed anxiety/depressive states referred to a psychiatric out-patient clinic completed a four course of either a once-daily table of 30 mg nortriptyline with 1-5 mag fluphenazine, or a sustained release capsule of 50 mg amitriptyline once daily, on a double-blind basis." | 5.04 | Once-daily treatment for mixed anxiety/depressive states: a comparison of slow release amitriptyline and fluphenazine with nortriptyline. ( Magnus, RV; Schiff, AA, 1977) |
| "A double-blind study comparing the effects of nomifensine and nortriptyline, which was carried out exclusively on outpatients with retarded depressions, showed nomifensine to have a distinctive antidepressive and activating effect." | 5.04 | Differences in effect between nomifensine and nortriptyline. ( Gammel, G; Pöldinger, W, 1978) |
| "The clinical effect of a sustained release preparation of amitriptyline has been compared with that of conventional amitriptyline tablets in a double-blind cross-over study with 24 patients suffering from endogenous depression." | 5.04 | A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline. ( Amdisen, A; Jørgensen, A; Liisberg, P; Mose, H; Petersen, HE, 1978) |
| "Below the toxic plasma level of nortriptyline (NT) an upper therapeutic limit has been postulated in patients with endogenous depression." | 5.04 | Self-inhibiting action of nortriptylin's antidepressive effect at high plasma levels: a randomized double-blind study controlled by plasma concentrations in patients with endogenous depression. ( Baastrup, PC; Hansen, CE; Hvidberg, EF; Kragh-Sorensen, P, 1976) |
| "Sixteen patients with primary depression were treated for 4 wk with amitriptyline." | 5.04 | Amitriptyline plasma levels and clinical response in primary depression. ( Coble, P; Grau, T; Hanin, I; Kupfer, DJ; Spiker, DG, 1977) |
| "Patients suffering from mixed anxiety/depressive reactions, referred to the out-patient department of a large psychiatric hospital, were treated with either amitriptyline tablets or fluphenazine with nortriptyline (f/n) tablets for a period of four weeks." | 5.04 | A comparison of amitriptyline and a fluphenazine/nortriptyline preparation in anxiety-depressive states. ( Bennie, EH; Schiff, AA, 1976) |
| "A double-blind study involving sixty-two patients, aged 65 years or over, treated for twenty-eight days, showed that fluphenazine 0-5 mg/nortriptyline 10 mg three times daily was superior to promazine 50 mg three times daily in relieving symptoms of anxiety and was associated with a lower incidence of side-effects." | 5.04 | Anxiety/depression in elderly patients. A double-blind comparative study of fluphenazine/nortriptyline and promazine. ( Brodie, NH; McGhie, RL; O'Hara, H; Schiff, AA; Valle-Jones, JC, 1975) |
| " In a 14-week randomized trial comparing pramipexole with sertraline in depressed patients without motor complications, the Hamilton Depression Rating Scale score decreased in both groups; however, in the pramipexole group, the proportion of patients who recovered was significantly higher." | 4.87 | Treatment of depressive symptoms in Parkinson's disease. ( Barone, P, 2011) |
| " Our studies have suggested that older patients appear to benefit as much, though perhaps more slowly, than mid-life patients from acute combined treatment (nortriptyline+interpersonal psychotherapy) of major depression." | 4.79 | Treatment of major depression in later life: a life cycle perspective. ( Reynolds, CF, 1997) |
| "We therefore superimposed maternal separation (MS) onto a genetic rat model (Flinders-sensitive and -resistant lines, FSL/FRL) of depression, treated these rats with antidepressants (escitalopram and nortriptyline) and measured CGRP-LI in selected brain regions." | 3.91 | CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment. ( Angelucci, F; El Khoury, A; Ellenbroek, BA; Mathé, AA, 2019) |
| "We explored the links between both P450 genotype and serum concentrations of antidepressant with antidepressant side effects, using data from the Genome-Based Therapeutic Drugs for Depression Project (GENDEP), which is a large (n = 868), pharmacogenetic study of depressed individuals treated with escitalopram or nortriptyline." | 3.81 | Exploring the role of drug-metabolising enzymes in antidepressant side effects. ( Aitchison, KJ; Craig, IW; Dernovšek, MZ; Dobson, RJ; Farmer, AE; Hauser, J; Henigsberg, N; Hodgson, K; Maier, W; McGuffin, P; Mors, O; Placentino, A; Rietschel, M; Souery, D; Tansey, KE; Uher, R, 2015) |
| "Amitriptyline is a tricyclic antidepressant widely used in the treatment of depression." | 3.74 | Massive intoxication involving unusual high concentration of amitriptyline. ( Barroso, M; Gallardo, E; Margalho, C; Monsanto, P; Vieira, DN, 2007) |
| "Treatment of endogenous depression with nortriptyline (NT), at a daily dose of 150 mg, resulted in a pronounced improvement of seven of ten patients investigated." | 3.67 | Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. ( Aberg-Wistedt, A; Bertilsson, L; Malmgren, R, 1987) |
| "The plasma concentrations of prolactin and nortriptyline were determined in 17 patients with endogenous depression treated for 4 weeks with nortriptyline once a day." | 3.66 | Plasma prolactin during treatment with nortriptyline. ( Nielsen, JL, 1980) |
| "In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs." | 3.66 | Prolonged delirium without anticholinergic signs following amitriptyline overdose. ( Gomolin, IH; Melmed, CA, 1983) |
| "In 21 patients suffering from endogenous depression and given nortriptyline 150 mg/day for 4 weeks in a once-a-day dosage an electrocardiographic study was made with ECG recordings at different times during the treatment." | 3.66 | ECG changes during treatment with nortriptyline in a once-a-day dosage. ( Nielsen, JL, 1980) |
| "Steady-state plasma tricyclic antidepressant levels were determined in 65 patients undergoing treatment for depression with either amitriptyline hydrochloride or nortriptyline hydrochloride to determine if common factors such as age, race, sex, or smoking status were predictors of steady-state drug levels that have been shown to vary up to 36-fold." | 3.65 | Tricyclic plasma levels. Effect of age, race, sex, and smoking. ( Biggs, JT; Ziegler, VE, 1977) |
| "In an open, uncontrolled trial flupenthixol was administered to 45 patients with endogenous depression." | 3.65 | Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients. ( Baba, O; Fujiwara, J; Hanaoka, M; Ishino, H; Sasaki, K, 1976) |
| "Fifty-three patients suffering from depressive illness were classified as 'responders' or 'non-responders' on the basis of an "amelioration score" of the Hamilton Rating Scale for depression after six weeks treatment with nortriptyline hydrochloride at 150 mgs." | 3.65 | Rating scales as predictors of response to tricyclic antidepressants. ( Burrows, GD; Davies, B; Foenander, G; Scoggins, BA, 1976) |
| "With nortriptyline the increase in impedance was reduced by 29% after ADP induction (p=0." | 2.75 | Antiplatelet effects of antidepressant treatment: a randomized comparison between escitalopram and nortriptyline. ( Bauriedel, G; Flöck, A; Hammerstingl, C; Höfels, S; Maier, W; Nickenig, G; Schuhmacher, A; Skowasch, D; Tuleta, I; Zobel, A, 2010) |
| "It suggests that successfully treating depression in PD leads to important, sustained improvements in these outcomes and that patients who improve on antidepressants are less likely to relapse than are patients who initially improve on placebo." | 2.74 | The impact of treatment of depression on quality of life, disability and relapse in patients with Parkinson's disease. ( Bienfait, K; Buyske, S; Dicke, A; Dobkin, RD; Gara, M; Marin, H; Mark, MH; Menza, M, 2009) |
| "The A." | 2.68 | A randomized trial of dementia care in nursing homes. ( Folstein, MF; Rovner, BW; Shmuely, Y; Steele, CD, 1996) |
| "The authors suggest the depression in Parkinson's disease to be of both reactive and endogenous origins." | 2.65 | Anti-depressive treatment in Parkinson's disease. A controlled trial of the effect of nortriptyline in patients with Parkinson's disease treated with L-DOPA. ( Aabro, E; Andersen, J; Gulmann, N; Hjelmsted, A; Pedersen, HE, 1980) |
| " Plasma level determinations after 2 and 6 weeks of treatment revealed that moderately significant correlations existed between AT plasma levels and clinical improvement, dosage intake, age, weight, sex, and coffee intake." | 2.65 | Tricyclic plasma levels in depressed outpatients treated with amitriptyline. ( Case, G; Hucker, H; Rickels, K; Weise, C, 1983) |
| "Nortriptyline-treated patients on a mean dose of 117 mg/day had a mean nortriptyline level of 141 ng/ml." | 2.64 | A comparison study of amitriptyline and nortriptyline with plasma levels. ( Biggs, JT; Clayton, PJ; Ziegler, VE, 1977) |
| "However, this major comorbidity in COPD is rarely managed effectively." | 2.58 | Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease. ( Carson-Chahhoud, KV; Pollok, J; van Agteren, JE, 2018) |
| "Antidepressant drugs have been used to treat tinnitus in patients with and without depressive symptoms." | 2.48 | Antidepressants for patients with tinnitus. ( Baldo, P; Cecco, S; Doree, C; McFerran, D; Molin, P, 2012) |
| "Depression is a highly prevalent concomitant of dementia." | 2.40 | Depression and dementia: comorbidities, identification, and treatment. ( Meyers, BS, 1998) |
| "The treatment with nortriptyline and venlafaxine (both at 30 mg/kg, intraperitoneally) blocked dexamethasone-induced increase in the immobility time and the latency to self-care." | 1.51 | Venlafaxine and nortriptyline reverse acute dexamethasone-induced depressive-like behaviors in male and female mice. ( Cagni, FC; Costa, LRF; de Souza, IBMB; Gavioli, EC; Lima, RH; Silva Junior, ED; Tiago, PRF, 2019) |
| " Improvement from sub- or supratherapeutically dosed patients to correctly dosed patients was simulated, assuming that genotyping would prevent under- or overdosing of patients." | 1.43 | A Model Based Cost-Effectiveness Analysis of Routine Genotyping for CYP2D6 among Older, Depressed Inpatients Starting Nortriptyline Pharmacotherapy. ( Berm, EJ; Gout-Zwart, JJ; Luttjeboer, J; Postma, MJ; Wilffert, B, 2016) |
| "Data collected included demographics, cancer and co-morbid diagnoses, and compliance to antidepressant medication using medication possession ratio (MPR) by patient, medication class, and individual agents." | 1.37 | Evaluation of medication compliance in patients on antidepressants at an outpatient tertiary cancer center setting. ( Adamus, A; Arbuckle, R; DaCosta Byfield, S; Feng, C; Hung, F; Lal, LS; Miller, LA; Zhuang, A, 2011) |
| " Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B." | 1.32 | A case report of a poor metabolizer of CYP2D6 presented with unusual responses to nortriptyline medication. ( Hong, KS; Ki, CS; Kim, JW; Lee, SY, 2004) |
| "The linearity of the (AMT) kinetics of amitriptyline has been tested in 135 depressed dosed twice daily by measuring plasma." | 1.28 | Amitriptyline: linear or nonlinear kinetics in every day practice? ( Allers, G; Bertschy, G; Vandel, B; Vandel, S; Volmat, R, 1989) |
| " Compared to the recommended therapeutic ranges, wild inter-individual differences were observed in plasma drug concentration, even when corrections for dosage were made." | 1.26 | Monitoring of tricyclic antidepressant therapy. ( Dawling, S, 1982) |
| "Nortriptyline is a preferential noradrenaline uptake inhibitor, while the dimethylated compound, chlorimipramine also has a profound influence on serotonin neurons." | 1.26 | Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects. ( Asberg, M, 1976) |
| "Two cases of depression are presented: One which responded to psychotherapy and the other which responded to medication." | 1.26 | Repertory grid and biochemical characterization of depression: a comparison of case reports. ( Berger, PA; Slater, P; Yesavage, JA, 1979) |
| "The authors describe a technique that enables a physician to determine individual patient dosage requirements for nortriptyline from a single 24-hour blood sample." | 1.26 | Prediction of individual dosage of nortriptyline. ( Cooper, TB; Simpson, GM, 1978) |
| " This fraction is higher than that reported previously when intravenous nortriptyline was used as the reference dosage form." | 1.26 | First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma. ( Alván, G; Borga, O; Lind, M; Palmér, L; Siwers, B, 1977) |
| "In imipramine-treated patients this finding was associated with a decreased rate of drug elimination from plasma." | 1.26 | Relationship between age and tricyclic antidepressant plasma levels. ( Cooper, TB; Friedman, MJ; Green, R; Ives, JO; Nies, A; Ravaris, CL; Robinson, DS, 1977) |
| "Steady-state nortriptyline plasma levels were determined in eight patients at 9 AM, 12 PM, 3 PM, and 6 PM during treatment with nortriptyline hydrochloride administered as a single daily bedtime (hs) dose at 10 PM and repeated after changing the dosage schedule to three times a day (tid) with divided doses at 10 AM, 4 PM, and 10 PM." | 1.26 | Sampling time, dosage schedule, and nortriptyline plasma levels. ( Biggs, JT; Knesevich, JW; Wylie, LT; Ziegler, VE, 1977) |
| "Fifteen depressed patients were treated with amitriptyline in a dosage ranging from 75 mg to 200 mg/day for a minimum of three weeks, two of which were at a fixed dosage." | 1.26 | Electrocardiographic findings in patients undergoing amitriptyline treatment. ( Biggs, JT; Ziegler, VE, 1977) |
| "A combined pharmacodynamic and pharmacokinetic approach was made to study the pharmacodynamic half-life (Pd1/2) of amitriptyline (AT)." | 1.26 | Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life. ( Ghose, K, 1980) |
| " For depressive neurosis and involutional melancholia best therapeutic responses were yielded at a dosage of 50 mg, while in the treatment of manic-depressive illness, comparable results occurred at a 150 mg dosage." | 1.26 | Amitriptyline, nortriptyline plasma levels and clinical response in women with affective disorders. ( Corona, GL; Cucchi, ML; Fenoglio, L; Frattini, P; Pinelli, P; Santagostino, G; Zerbi, F, 1980) |
| " From such kowledge it should be possible to individualize drug dosage regimes so as to maximize antidepressant action, while at the same time minimizing the risk of toxicity." | 1.26 | The prediction of tricyclic antidepressant plasma concentrations. ( Braithwaite, RA; Dawling, S; McAuley, R; Montgomery, SA, 1980) |
| " The fluctuation between maximal and minimal drug levels within the dosage interval was found to be more pronounced than with a t." | 1.26 | Pharmacokinetic aspects on once-daily nortriptyline administration. ( Overø, KF, 1980) |
| " The large individual variation in the pharmacokinetics of the tricyclic antidepressants makes prediction of plasma level from dosage in a given individual virtually impossible without knowledge of rate of elimination and apparent volume of distribution." | 1.25 | Relationship between plasma level and therapeutic effect of nortriptyline. ( Asberg, M; Crönholm, B; Sjöqvist, F; Tuck, D, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 207 (75.00) | 18.7374 |
| 1990's | 25 (9.06) | 18.2507 |
| 2000's | 19 (6.88) | 29.6817 |
| 2010's | 20 (7.25) | 24.3611 |
| 2020's | 5 (1.81) | 2.80 |
| Authors | Studies |
|---|---|
| Lenze, EJ | 1 |
| Mulsant, BH | 3 |
| Roose, SP | 2 |
| Lavretsky, H | 1 |
| Reynolds, CF | 8 |
| Blumberger, DM | 1 |
| Brown, PJ | 1 |
| Cristancho, P | 1 |
| Flint, AJ | 1 |
| Gebara, MA | 1 |
| Gettinger, TR | 1 |
| Lenard, E | 1 |
| Miller, JP | 1 |
| Nicol, GE | 1 |
| Oughli, HA | 1 |
| Pham, VT | 1 |
| Rollman, BL | 1 |
| Yang, L | 1 |
| Karp, JF | 1 |
| Pluijms, EM | 1 |
| Vinther, PT | 1 |
| Kamperman, AM | 1 |
| Birkenhäger, TK | 1 |
| Ebell, MH | 1 |
| Hellier, J | 1 |
| Emsley, R | 1 |
| Pickles, A | 1 |
| Carboni, L | 3 |
| Pischedda, F | 1 |
| Piccoli, G | 1 |
| Lauria, M | 1 |
| Musazzi, L | 1 |
| Popoli, M | 1 |
| Mathé, AA | 3 |
| Domenici, E | 2 |
| Ayres, ASFSJ | 1 |
| Santos, WB | 1 |
| Junqueira-Ayres, DD | 1 |
| Costa, GM | 1 |
| Ramos, FA | 1 |
| Castellanos, L | 1 |
| Alves, JSF | 1 |
| Asth, L | 1 |
| Medeiros, IU | 1 |
| Zucolotto, SM | 1 |
| Gavioli, EC | 4 |
| Angelucci, F | 1 |
| Ellenbroek, BA | 1 |
| El Khoury, A | 2 |
| Pollok, J | 1 |
| van Agteren, JE | 1 |
| Carson-Chahhoud, KV | 1 |
| de Souza, IBMB | 1 |
| Costa, LRF | 1 |
| Tiago, PRF | 1 |
| Cagni, FC | 1 |
| Lima, RH | 1 |
| Silva Junior, ED | 1 |
| Holanda, VAD | 1 |
| Pacifico, S | 1 |
| Azevedo Neto, J | 1 |
| Finetti, L | 1 |
| Lobão-Soares, B | 1 |
| Calo, G | 1 |
| Ruzza, C | 1 |
| Kofune, M | 1 |
| Kofune, T | 1 |
| Ohkubo, K | 1 |
| Watanabe, I | 1 |
| de Moura, JC | 1 |
| Noroes, MM | 1 |
| Rachetti, Vde P | 1 |
| Soares, BL | 1 |
| Preti, D | 1 |
| Nassini, R | 1 |
| Materazzi, S | 1 |
| Marone, IM | 1 |
| Minocci, D | 1 |
| Geppetti, P | 1 |
| André, E | 1 |
| Urbanavicius, J | 1 |
| Lagos, P | 1 |
| Torterolo, P | 1 |
| Scorza, C | 1 |
| Hodgson, K | 1 |
| Tansey, KE | 1 |
| Uher, R | 3 |
| Dernovšek, MZ | 1 |
| Mors, O | 1 |
| Hauser, J | 1 |
| Souery, D | 1 |
| Maier, W | 2 |
| Henigsberg, N | 1 |
| Rietschel, M | 1 |
| Placentino, A | 1 |
| Craig, IW | 1 |
| Aitchison, KJ | 1 |
| Farmer, AE | 1 |
| Dobson, RJ | 1 |
| McGuffin, P | 3 |
| Malki, K | 2 |
| Tosto, MG | 1 |
| Mouriño-Talín, H | 1 |
| Rodríguez-Lorenzo, S | 1 |
| Pain, O | 1 |
| Jumhaboy, I | 1 |
| Liu, T | 1 |
| Parpas, P | 1 |
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| Andersen, J | 1 |
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| Valle-Jones, JC | 3 |
| O'Hara, J | 2 |
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| Schiff, AA | 7 |
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| Coble, PA | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "A Prospective, Randomized Study of the Possible Pain Relieving and Scar Tissue Modifying Properties of Lipotransplantation in a Post Breast Therapy Pain Syndrome Setting"[NCT01888419] | 18 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| Comparative Evaluation of Osteopathy Treatment Efficacy in Pain Support After Breast Surgery in Oncology[NCT01403168] | 28 participants (Actual) | Interventional | 2011-04-30 | Terminated (stopped due to Recruitment difficulties) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for nortriptyline and Depression
| Article | Year |
|---|---|
Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease.
Topics: Antidepressive Agents, Tricyclic; Depression; Dizziness; Dyspnea; Exercise Tolerance; Forced Expirat | 2018 |
Treatment of depressive symptoms in Parkinson's disease.
Topics: Antidepressive Agents, Tricyclic; Antiparkinson Agents; Benzothiazoles; Depression; Desipramine; Dop | 2011 |
Antidepressants for patients with tinnitus.
Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Nortriptyline; Paroxetine; Randomized Cont | 2012 |
THE ANTIDEPRESSANT DRUGS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Depression; Depressive Diso | 1965 |
The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Doxepin; Heart; Humans; Im | 1980 |
Pharmacokinetics and clinical response to tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Humans; Imipr | 1980 |
Measurement of serum drug levels in the assessment of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Imipramine; Nortriptyline | 1980 |
Treatment of major depression in later life: a life cycle perspective.
Topics: Aged; Antidepressive Agents; Anxiety; Bereavement; Clinical Trials as Topic; Combined Modality Thera | 1997 |
Depression and dementia: comorbidities, identification, and treatment.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cog | 1998 |
Tricyclic antidepressants (first of two parts).
Topics: Aged; Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Chemical Phenomena; Chemistry; Child; | 1978 |
Blood levels of tricyclic antidepressant drugs: assay procedures, reproducibility and relationship to therapeutic outcome and side effects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Double-Blind | 1977 |
Relationship between antidepressant effect and plasma level of nortriptyline. Clinical studies.
Topics: Depression; Humans; Nortriptyline; Time Factors | 1976 |
Contribution of the variants of alpha 1-acid glycoprotein to its binding of drugs.
Topics: Amitriptyline; Depression; Dialysis; Genetic Variation; Humans; Nortriptyline; Orosomucoid; Pharmace | 1989 |
Editorial: Pharmacogenetics and mental disease.
Topics: Acetylation; Adjuvants, Anesthesia; Adult; Anticonvulsants; Antidepressive Agents; Attention Deficit | 1974 |
Variability in response to drugs.
Topics: Acute Disease; Acylation; Chlorthalidone; Chronic Disease; Depression; Diazoxide; Digoxin; Dose-Resp | 1974 |
Individualization of treatment with tricyclic compounds.
Topics: Animals; Antidepressive Agents; Chromatography, Gas; Clomipramine; Depression; Drug Interactions; El | 1974 |
89 trials available for nortriptyline and Depression
| Article | Year |
|---|---|
Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.
Topics: Aged; Antidepressive Agents; Aripiprazole; Bupropion; Depression; Drug Therapy, Combination; Humans; | 2023 |
Clinical characteristics associated with relapse 2 years after electroconvulsive therapy for major depression.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Electroconvulsive Therapy; Humans; No | 2023 |
Estimating dose-response for time to remission with instrumental variable adjustment: the obscuring effects of drug titration in Genome Based Therapeutic Drugs for Depression Trial (GENDEP): clinical trial data.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricy | 2020 |
The impact of treatment of depression on quality of life, disability and relapse in patients with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depression; Disability Evaluation; Double-Bli | 2009 |
Antiplatelet effects of antidepressant treatment: a randomized comparison between escitalopram and nortriptyline.
Topics: Adult; Antidepressive Agents; Blood Platelets; Citalopram; Depression; Female; Humans; Male; Middle | 2010 |
Quantitative approaches for assessment of white matter hyperintensities in elderly populations.
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Brain; Brain Mapping; Depression; Double-Blin | 2011 |
Mortality and poststroke depression: a placebo-controlled trial of antidepressants.
Topics: Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2003 |
Efficacy of bupropion and nortriptyline for smoking cessation among people at risk for or with chronic obstructive pulmonary disease.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Depression; D | 2005 |
Aggressive behavior in patients with stroke: association with psychopathology and results of antidepressant treatment on aggression.
Topics: Aged; Aggression; Analysis of Variance; Antidepressive Agents, Tricyclic; Depression; Double-Blind M | 2006 |
ECT in the treatment of depressed elderly: lessons from a terminated clinical trial.
Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Electroconvulsive Therapy; Fear; Feasibility Stu | 2007 |
Tricyclic plasma levels in depressed outpatients treated with amitriptyline.
Topics: Amitriptyline; Caffeine; Depression; Female; Humans; Male; Nortriptyline; Smoking | 1983 |
Tranylcypromine vs nortriptyline vs placebo in depressed outpatients: a controlled trial.
Topics: Adolescent; Adult; Ambulatory Care; Clinical Trials as Topic; Depression; Depressive Disorder; Doubl | 1984 |
Amitriptyline stimulates weight gain in hemodialysis patients.
Topics: Adult; Aged; Amitriptyline; Anorexia Nervosa; Blood Pressure; Body Weight; Clinical Trials as Topic; | 1982 |
The clinical efficacy and side-effects of mianserin and nortriptyline in depressed out-patients: a double-blind randomized trial.
Topics: Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Depression; Depressive Disorder; Dibenzazepi | 1982 |
A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzothiepins; Dothiepin; Double-Blind | 1980 |
Pharmacokinetics and clinical response to tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Humans; Imipr | 1980 |
Anti-depressive treatment in Parkinson's disease. A controlled trial of the effect of nortriptyline in patients with Parkinson's disease treated with L-DOPA.
Topics: Aged; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Therapy, Combination; Female; | 1980 |
Flupenthixol versus combined fluphenazine-nortriptyline in depressive illness.
Topics: Adult; Aged; Clinical Trials as Topic; Depression; Drug Combinations; Female; Flupenthixol; Fluphena | 1981 |
Doctor's versus patient's judgement in the assessment of mixed anxiety/depressive illness. Implications for measurement of therapeutic response.
Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Drug Combinations; Female; | 1981 |
Combined cognitive-behavioral, psychopharmacological and nutritional therapy in eating disorders. 1. Anorexia nervosa--restricted type.
Topics: Adolescent; Adult; Anorexia Nervosa; Antidepressive Agents, Second-Generation; Antidepressive Agents | 1995 |
Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone.
Topics: Adolescent; Adult; Amitriptyline; Bipolar Disorder; Chromatography, High Pressure Liquid; Depression | 1995 |
Metabolic and physiologic consequences of nortriptyline treatment in the elderly.
Topics: Aged; Aged, 80 and over; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1994 |
A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms.
Topics: Aged; Audiometry, Pure-Tone; Chronic Disease; Depression; Depressive Disorder; Disabled Persons; Dou | 1993 |
Depressive symptoms and measures of disability: a prospective study.
Topics: Adaptation, Psychological; Aged; Chronic Disease; Depression; Disability Evaluation; Double-Blind Me | 1993 |
A randomized trial of dementia care in nursing homes.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Baltimore; Cognitio | 1996 |
Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anxiety; Breast Neoplasms; Cross-Over Studies; | 1996 |
Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anxiety; Breast Neoplasms; Cross-Over Studies; | 1996 |
Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anxiety; Breast Neoplasms; Cross-Over Studies; | 1996 |
Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anxiety; Breast Neoplasms; Cross-Over Studies; | 1996 |
Using interpersonal psychotherapy (IPT) in a combined psychotherapy/medication research protocol with depressed elders. A descriptive report with case vignettes.
Topics: Aged; Aging; Antidepressive Agents, Tricyclic; Depression; Female; Geriatric Psychiatry; Humans; Mal | 1997 |
Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial.
Topics: Aged; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Cross-Over Studies; Depre | 1998 |
The severity of major depression and choice of treatment in primary care practice.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Depression; Female; Guidelines as Topic; Humans | 1998 |
EEG sleep measures in later-life bereavement depression. A randomized, double-blind, placebo-controlled evaluation of nortriptyline.
Topics: Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Bereavement; Depression; Double-Blind | 1999 |
Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial.
Topics: Affect; Aged; Antidepressive Agents, Tricyclic; Cognition; Cognition Disorders; Depression; Double-B | 2000 |
A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients.
Topics: Aged; Alzheimer Disease; Antidepressive Agents, Tricyclic; Depression; Double-Blind Method; Female; | 2001 |
Continuation treatment of delusional depression in older adults.
Topics: Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Combined Modality Therapy; Delusions; | 2001 |
Amitriptyline plasma-concentration and clinical effect. A World Health Organisation Collaborative Study.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Denmark; Depression; Drug Evaluation; England; | 1978 |
Antidepressant drug levels and clinical response.
Topics: Adult; Amitriptyline; Antidepressive Agents; Biological Availability; Clinical Trials as Topic; Depr | 1978 |
The practical significance of nortriptyline plasma control. A prospective evaluation under routine conditions in endogenous depression.
Topics: Aged; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1978 |
Plasma tricyclic drug levels in amitriptyline-treated depressed patients.
Topics: Adult; Aged; Amitriptyline; Depression; Double-Blind Method; Erythrocytes; Evaluation Studies as Top | 1979 |
Plasma nortriptyline levels and ECG findings.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Depression; Electrocardiography; Electr | 1977 |
Blood levels of tricyclic antidepressant drugs: assay procedures, reproducibility and relationship to therapeutic outcome and side effects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Double-Blind | 1977 |
Differences in effect between nomifensine and nortriptyline.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Isoquinolines; Mal | 1978 |
Plasma and erythrocyte levels of tricyclic antidepressants in depressed patients.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Biopharmaceutics; Clinical Trials as Topic; | 1978 |
[A double-blind nomifensine-nortriptyline trial in ambulatory patients conducted by psychiatrists in private practice: results and comments].
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Depression; Double-Blind M | 1978 |
A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Delayed-Action Preparations; Depre | 1978 |
Amitriptyline nortriptyline plasma levels and therapeutic response in depressed women.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Humans; Middle Aged; Nortr | 1977 |
Clinical response and plasma concentration of amitriptyline and its metabolite nortriptyline.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortr | 1978 |
Maprotiline and fluphenazine/nortriptyline in depression.
Topics: Adult; Aged; Anthracenes; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Therapy, C | 1978 |
Changes in weight during treatment for depression.
Topics: Adult; Amitriptyline; Appetite; Body Weight; Depression; Female; Humans; Nortriptyline; Placebos | 1979 |
Self-inhibiting action of nortriptylin's antidepressive effect at high plasma levels: a randomized double-blind study controlled by plasma concentrations in patients with endogenous depression.
Topics: Adult; Aged; Clinical Trials as Topic; Depression; Female; Humans; Kinetics; Male; Middle Aged; Nort | 1976 |
[Double-blind multicenter trial in general practice on fluphenthixol versus nortriptyline in patients with anxiety-depression-asthenia (the "ADA"-syndrome)].
Topics: Adult; Anxiety; Clinical Trials as Topic; Depression; Female; Flupenthixol; Humans; Male; Middle Age | 1976 |
Nortriptyline plasma levels and therapeutic response.
Topics: Adult; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortriptyline; Psych | 1976 |
A comparison of amitriptyline and a fluphenazine/nortriptyline preparation in anxiety-depressive states.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Drug Combinat | 1976 |
A comparison study of amitriptyline and nortriptyline with plasma levels.
Topics: Administration, Oral; Adult; Amitriptyline; Depression; Dose-Response Relationship, Drug; Drug Evalu | 1977 |
Once-daily treatment for mixed anxiety/depressive states: a comparison of slow release amitriptyline and fluphenazine with nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Depression; Drug Combinations; Fluphenazine; Humans | 1977 |
Amitriptyline plasma levels and clinical response in primary depression.
Topics: Adult; Amitriptyline; Depression; Female; Humans; Male; Nortriptyline; Psychiatric Status Rating Sca | 1977 |
The relationship between nortriptyline plasms levels and clinical effects.
Topics: Clinical Trials as Topic; Depression; Humans; Nortriptyline | 1975 |
Anxiety/depression in elderly patients. A double-blind comparative study of fluphenazine/nortriptyline and promazine.
Topics: Age Factors; Aged; Anxiety; Clinical Trials as Topic; Depression; Fluphenazine; Humans; Nitrazepam; | 1975 |
Hostility, somatic symptoms and recovery with antidepressants.
Topics: Depression; Dibenzocycloheptenes; Hostility; Humans; Nortriptyline; Personality Inventory; Protripty | 1975 |
Depression treatment in Parkinson's disease.
Topics: Antidepressive Agents, Tricyclic; Carbidopa; Depression; Double-Blind Method; Drug Interactions; Dru | 1991 |
Separate and combined anxiolytic and anti-depressant treatment of mixed anxiety/depression. A double-blind, placebo controlled comparison. Sussex Clinical Trials Group.
Topics: Adolescent; Adult; Aged; Anxiety; Depression; Double-Blind Method; Drug Combinations; Female; Fluphe | 1985 |
Monitoring plasma concentration of nortriptyline. Methodological, pharmakokinetic and clinical aspects.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Kinetics; Monitori | 1985 |
Plasma-nortriptyline levels in endogenous depression.
Topics: Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Humans; Male; Nortriptyline; Plac | 1973 |
Plasma-nortriptyline levels in depression.
Topics: Clinical Trials as Topic; Depression; Humans; Nortriptyline; Placebos | 1973 |
Long-term treatment of endogenous depression with nortriptyline with control of plasma levels.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Blood Specimen Collection; Chromatography, Gas; Clinical | 1974 |
A study of the effects of Aventyl HCl (nortriptyline hydrochloride) in the treatment of patients with depressive symptoms.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; No | 1968 |
Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression.
Topics: Clomipramine; Depression; Dibenzazepines; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglyc | 1974 |
An evaluation of fluphenazine with nortriptyline in anxiety and depression.
Topics: Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Drug Combinations; Fluphenazine; Human | 1972 |
Ophthalmological effects of nortriptyline--relationship to plasma level.
Topics: Accommodation, Ocular; Adult; Aged; Clinical Trials as Topic; Depression; Female; Humans; Male; Midd | 1972 |
Plasma levels of nortriptyline in the treatment of endogenous depression.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Clinical Trials as Topic; Depression; Drug Evaluation; | 1973 |
A review of clinical studies with combinations of fluphenazine and nortriptyline.
Topics: Amitriptyline; Anxiety; Central Nervous System; Clinical Trials as Topic; Depression; Diazepam; Doxe | 1972 |
Plasma nortriptyline levels--relationship to clinical effects.
Topics: Adjustment Disorders; Antidepressive Agents; Blood Proteins; Clinical Trials as Topic; Depression; D | 1974 |
A sequential trial comparing two plasma levels of nortriptyline.
Topics: Adult; Analysis of Variance; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged | 1974 |
Plasma nortriptyline and clinical response.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Clinical Trials as Topic; Depression; Emotions | 1974 |
Therapy possibilities for therapy-resistant depressions.
Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipra | 1974 |
Motival in the treatment of anxious depression.
Topics: Adult; Antidepressive Agents; Anxiety; Clinical Trials as Topic; Depression; Drug Synergism; Female; | 1972 |
[Treatment of depressive conditions with nortriptyline].
Topics: Aged; Anxiety; Arteriosclerosis; Clinical Trials as Topic; Depression; Humans; Nortriptyline; Thiori | 1966 |
Double-blind comparison of nortriptyline and amitriptyline in depressive illness.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Hospitals, Psychiatric; Hu | 1967 |
Comparative trial of nortriptyline and amitriptyline in 100 depressed patients.
Topics: Amitriptyline; Analysis of Variance; Clinical Trials as Topic; Depression; Female; Humans; Male; Mid | 1968 |
A comparative trial of desipramine and nortriptyline in depression.
Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Depression; Desipramine; Electroconvulsi | 1968 |
Prediction in anti-depressant therapy.
Topics: Adjustment Disorders; Amitriptyline; Clinical Trials as Topic; Depression; Female; Humans; Male; Mid | 1968 |
A comparative investigation of desipramine and nortriptyline in the treatment of depression.
Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Male; Middl | 1968 |
A blind comparative trial of nortriptyline and isocarboxazid in depressed outpatients.
Topics: Clinical Trials as Topic; Depression; Humans; Isocarboxazid; Nortriptyline; Outpatient Clinics, Hosp | 1969 |
Verbal behaviour changes with depression treatment.
Topics: Adolescent; Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Clinical Trials as To | 1969 |
A controlled study of nortriptyline and imipramine.
Topics: Anxiety; Body Weight; Clinical Trials as Topic; Depression; Female; Humans; Imipramine; Nortriptylin | 1970 |
[Clinical trial of a new antidepressant: nortriptyline chlorhydrate or Psychostyl].
Topics: Adult; Aged; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1968 |
Are antidepressants better than placebo?
Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Clinical Trials as | 1971 |
A pharmacokinetic approach to the treatment of depression.
Topics: Barbiturates; Biotransformation; Blood Pressure; Chromatography, Gas; Clinical Trials as Topic; Deal | 1971 |
Aventyl--another antidepressant.
Topics: Antidepressive Agents; Anxiety; Clinical Trials as Topic; Depression; Humans; Nortriptyline | 1965 |
Desipramine and nortriptyline in mental depression.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depression; Desipramine; Humans; Nortriptyline | 1966 |
[Comparative evaluation of nortriptyline, amitriptyline and of a placebo in the treatment of anxiety and depressive disorders].
Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Mental Disorders; Middle Aged; Nortriptyl | 1969 |
173 other studies available for nortriptyline and Depression
| Article | Year |
|---|---|
Augmentation With Aripiprazole or Bupropion, or a Switch to Nortriptyline, Effective for Treatment-Resistant Depression in Older Adults.
Topics: Aged; Aripiprazole; Bupropion; Depression; Depressive Disorder, Treatment-Resistant; Humans; Nortrip | 2023 |
Depression-Associated Gene
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Cell Adhesion Molecules, Ne | 2020 |
Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis.
Topics: Acetates; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive A | 2017 |
CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment.
Topics: Amygdala; Animals; Antidepressive Agents; Brain; Calcitonin Gene-Related Peptide; Citalopram; Depres | 2019 |
Venlafaxine and nortriptyline reverse acute dexamethasone-induced depressive-like behaviors in male and female mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Dexamethasone; Female; Hypothalamo-Hyp | 2019 |
Modulation of the NOP receptor signaling affects resilience to acute stress.
Topics: Animals; Behavior, Animal; Benzimidazoles; Cycloheptanes; Depression; Disease Models, Animal; Dose-R | 2019 |
Electrocardiographic changes upon tricyclic antidepressant administration mimicking Brugada syndrome.
Topics: Antidepressive Agents, Tricyclic; Brugada Syndrome; Bundle-Branch Block; Clomipramine; Depression; E | 2013 |
The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice.
Topics: Acetanilides; Acrolein; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Anim | 2014 |
Prodepressive effect induced by microinjections of MCH into the dorsal raphe: time course, dose dependence, effects on anxiety-related behaviors, and reversion by nortriptyline.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Central | 2014 |
Exploring the role of drug-metabolising enzymes in antidepressant side effects.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricy | 2015 |
Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression.
Topics: Animals; Antidepressive Agents; Citalopram; Cyclic AMP Response Element-Binding Protein; Depression; | 2017 |
A Model Based Cost-Effectiveness Analysis of Routine Genotyping for CYP2D6 among Older, Depressed Inpatients Starting Nortriptyline Pharmacotherapy.
Topics: Cost-Benefit Analysis; Cytochrome P-450 CYP2D6; Decision Trees; Depression; Dose-Response Relationsh | 2016 |
Inhibition of CYP2D6 with low dose (5 mg) paroxetine in patients with high 10-hydroxynortriptyline serum levels - a review of routine practice.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Cytochrome P-450 CYP2D6 Inhibitors; Depression; Drug Inte | 2017 |
Evaluation of medication compliance in patients on antidepressants at an outpatient tertiary cancer center setting.
Topics: Aged; Antidepressive Agents; Cancer Care Facilities; Depression; Electronic Health Records; Female; | 2011 |
Nortriptyline influences protein pathways involved in carbohydrate metabolism and actin-related processes in a rat gene-environment model of depression.
Topics: Actins; Animals; Antidepressive Agents; Brain; Carbohydrate Metabolism; Cytoskeletal Proteins; Depre | 2011 |
Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study.
Topics: Aged; Antidepressive Agents; Case-Control Studies; Citalopram; Death, Sudden, Cardiac; Denmark; Depr | 2012 |
Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Disease Models, Animal; Hippocampus; Mice; N | 2012 |
The constellation of depression: its treatment with nortriptyline. I. Criteria for true antidepressant activity.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Nortriptyline | 1962 |
NORTRIPTYLINE FOR THE TREATMENT OF ANXIETY AND DEPRESSION IN CHRONICALLY ILL AND GERIATRIC PATIENTS.
Topics: Aged; Alcoholism; Antidepressive Agents; Anxiety; Cerebrovascular Disorders; Chronic Disease; Depres | 1964 |
A PRELIMINARY STUDY OF NORTRIPTYLINE IN DEPRESSION.
Topics: Antidepressive Agents; Biomedical Research; Depression; Depressive Disorder; Nortriptyline; Thiorida | 1964 |
COMPARATIVE TRIAL OF NORTRIPTYLINE AND AMITRIPTYLINE.
Topics: Amitriptyline; Antidepressive Agents; Biomedical Research; Depression; Drug Therapy; Geriatrics; Nor | 1964 |
NORTRIPTYLINE, AN ANTIDEPRESSANT.
Topics: Alcoholism; Antidepressive Agents; Depression; Depressive Disorder; Depressive Disorder, Major; Drug | 1964 |
OBSERVATIONS OF PSYCHOMOTOR BEHAVIOR AS AN INDEX OF PSYCHOPHARMACOLOGIC ACTION.
Topics: Antidepressive Agents; Biomedical Research; Depression; Depressive Disorder; Dextroamphetamine; Drug | 1964 |
NORTRIPTYLINE IN PRIVATE PRACTICE.
Topics: Antidepressive Agents; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Drug Therapy; No | 1965 |
THE DIAGNOSIS AND MANAGEMENT OF DEPRESSION.
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Classification; Depression; Depre | 1965 |
[NORTRIPTYLINE IN TREATMENT OF THE DEPRESSIVE SYNDROME].
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Nortriptyline | 1964 |
CLINICAL REPORT ON PARENTERAL NORTRIPTYLINE.
Topics: Antidepressive Agents; Anxiety; Anxiety Disorders; Bipolar Disorder; Depression; Depressive Disorder | 1965 |
[MEDICAL ANTIDEPRESSIVE TREATMENT. NORTRIPTYLINE EVALUATED IN COMPARISON WITH AMITRIPTYLINE AND IMIPRAMINE].
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Geriatrics; Imipr | 1965 |
Those high-cholesterol blues.
Topics: Antidepressive Agents; Cholesterol; Depression; Fluoxetine; Humans; Hypercholesterolemia; Nortriptyl | 2003 |
Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers.
Topics: Adult; Aged; Alleles; Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases | 2004 |
A case report of a poor metabolizer of CYP2D6 presented with unusual responses to nortriptyline medication.
Topics: Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Depression; Genotype; Humans; Male; Middl | 2004 |
Using trajectories from a bivariate growth curve as predictors in a Cox regression model.
Topics: Aged; Antidepressive Agents, Tricyclic; Computer Simulation; Depression; Forecasting; Humans; Nortri | 2007 |
Statistical analysis of longitudinal psychiatric data with dropouts.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depression; Humans; Likelihood Functions; Longitudi | 2007 |
Recurrent hyponatremia after substitution of citalopram with duloxetine.
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Citalopram; Depression; Duloxetine Hydrochlorid | 2007 |
Massive intoxication involving unusual high concentration of amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Diazepam; Female; Forensic Toxic | 2007 |
[Comparative clinical experiences with Protriptyline in depressive conditions of various origins].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; N | 1966 |
[Clinical studies of a new antidepressive agent, nortriptyline].
Topics: Adolescent; Adult; Aged; Amitriptyline; Depression; Desipramine; Humans; Imipramine; Middle Aged; Ne | 1967 |
[Place of nortriptyline in the group of antidepressants; clinical and electroencephalographic considerations].
Topics: Amitriptyline; Depression; Humans; Imipramine; Nortriptyline | 1967 |
Side-effects of nortriptyline treatment for post-stroke depression.
Topics: Cerebrovascular Disorders; Delirium; Depression; Humans; Nortriptyline | 1984 |
Nortriptyline for post-stroke depression.
Topics: Cerebrovascular Disorders; Delirium; Depression; Humans; Nortriptyline | 1984 |
Prolonged delirium without anticholinergic signs following amitriptyline overdose.
Topics: Amitriptyline; Delirium; Depression; Female; Humans; Nortriptyline; Parasympatholytics; Physostigmin | 1983 |
Peripheral serotonergic and adrenergic responses in depression.
Topics: Affective Symptoms; Amitriptyline; Blood Platelets; Blood Pressure; Depression; Female; Humans; Male | 1980 |
Monitoring of tricyclic antidepressant therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Depression; Female; Humans; Kinetics; Male; Mid | 1982 |
EEG sleep and tricyclic blood levels: acute and chronic administration in depression.
Topics: Adult; Age Factors; Amitriptyline; Depression; Female; Humans; Male; Nortriptyline; Personality Asse | 1982 |
Effects of nortriptyline treatment on learned helplessness in the rat.
Topics: Animals; Avoidance Learning; Depression; Disease Models, Animal; Electroshock; Humans; Male; Nortrip | 1981 |
Reversal of learned helplessness by nortriptyline.
Topics: Animals; Depression; Disease Models, Animal; Escape Reaction; Humans; Male; Nortriptyline; Rats; Rat | 1981 |
Monitoring nortriptyline plasma concentrations.
Topics: Adjustment Disorders; Adult; Affective Disorders, Psychotic; Bipolar Disorder; Depression; Depressiv | 1980 |
Pharmacokinetics of nortriptyline in elderly depressed patients and prediction of optimal dosage regimes [proceedings].
Topics: Aged; Depression; Drug Administration Schedule; Humans; Kinetics; Nortriptyline | 1980 |
Pharmacokinetic aspects on once-daily nortriptyline administration.
Topics: Adult; Depression; Drug Administration Schedule; Female; Humans; Kinetics; Male; Middle Aged; Nortri | 1980 |
Therapeutic effect and side effects in patients with endogenous depression treated with oral nortriptyline once a day.
Topics: Administration, Oral; Adult; Depression; Drug Evaluation; Female; Humans; Male; Middle Aged; Nortrip | 1980 |
ECG changes during treatment with nortriptyline in a once-a-day dosage.
Topics: Depression; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Nortriptyline | 1980 |
Plasma prolactin during treatment with nortriptyline.
Topics: Adult; Depression; Female; Humans; Male; Middle Aged; Nortriptyline; Prolactin | 1980 |
Reliability of commercially available tricyclic antidepressant levels.
Topics: Amitriptyline; Depression; Humans; Nortriptyline | 1980 |
Amitriptyline in human breast milk and the nursing infant's serum.
Topics: Adult; Amitriptyline; Depression; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Pregn | 1980 |
Quantitative analysis for tricyclic antidepressant drugs in plasma or serum by gas chromatography-chemical-ionization mass spectrometry.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Female; Gas Chromat | 1980 |
The prediction of tricyclic antidepressant plasma concentrations.
Topics: Depression; Drug Tolerance; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Nortriptyline | 1980 |
Plasma levels and clinical improvement--a comparative study of clomipramine and amitriptyline in depression.
Topics: Amitriptyline; Clomipramine; Depression; Female; Humans; Male; Nortriptyline | 1980 |
Amitriptyline, nortriptyline plasma levels and clinical response in women with affective disorders.
Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Depressive Disorder, | 1980 |
On the relationship of nortriptyline: amitriptyline ratio to clinical improvement of amitriptyline treated depressive patients.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depression; Humans; Middle Aged; Nortriptyline; Psychiatric | 1980 |
Pharmacokinetics and the effects of nortriptyline in geriatric depressed patients.
Topics: Adult; Aged; Depression; Humans; Kinetics; Middle Aged; Nortriptyline | 1980 |
Cardiovascular effects of nortriptyline in geriatric patients.
Topics: Adult; Aged; Blood Pressure; Depression; Dose-Response Relationship, Drug; Electrocardiography; Fema | 1980 |
Nortriptyline therapy in elderly patients: dosage prediction after single dose pharmacokinetic study.
Topics: Administration, Oral; Age Factors; Aged; Depression; Female; Humans; Kinetics; Metabolic Clearance R | 1980 |
Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life.
Topics: Adult; Amitriptyline; Blood Pressure; Depression; Drug Interactions; Female; Half-Life; Humans; Male | 1980 |
Sudden chest pain with sertraline.
Topics: 1-Naphthylamine; Antidepressive Agents; Aspirin; Chest Pain; Coronary Disease; Depression; Humans; M | 1994 |
Antidepressants and tinnitus.
Topics: Antidepressive Agents; Depression; Humans; Nortriptyline; Tinnitus | 1994 |
Is a "palliative" patient always a palliative patient? Two case studies.
Topics: Acute Kidney Injury; Adaptation, Psychological; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-In | 1997 |
Nortriptyline for the treatment of depression in progressive supranuclear palsy.
Topics: Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, | 1997 |
Elevated levels of erythropoietin in cerebrospinal fluid of depressed patients.
Topics: Antidepressive Agents, Tricyclic; Cerebrovascular Disorders; Depression; Erythropoietin; Female; Hum | 1998 |
The hypertensive elderly male with prostatism.
Topics: Aged; Antidepressive Agents, Tricyclic; Constriction, Pathologic; Depression; Humans; Hypertension; | 1999 |
Comparison of risk of orthostatic hypotension in elderly depressed hypertensive women treated with nortriptyline and thiazides versus elderly depressed normotensive women treated with nortriptyline.
Topics: Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Case-Control Studies; Depression; Female; Hu | 2000 |
Post-stroke depression impedes recovery.
Topics: Antidepressive Agents, Tricyclic; Depression; Humans; Nortriptyline; Stroke; Stroke Rehabilitation | 2000 |
An 82-year-old woman with mood changes following a stroke, 1 year later.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Antidepressive Agents; Depression; Female; Huma | 2001 |
Salmon calcitonin potentiates the analgesia induced by antidepressants.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Antidepress | 2001 |
Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Homovanillic Acid; Humans; Hydroxyindole | 1976 |
Interaction between amitriptyline and phenothiazine in man: effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antipsychotic Agents; Depression; Drug Interactions; Female; | 1979 |
Letter: Do tricyclic antidepressants work?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Humans; Nortriptyline | 1976 |
Amitriptyline and its demethylation-rate.
Topics: Adult; Aged; Amitriptyline; Depression; Humans; Middle Aged; Nortriptyline | 1978 |
EEG sleep and tricyclic plasma levels in primary depression.
Topics: Adult; Amitriptyline; Depression; Dose-Response Relationship, Drug; Electroencephalography; Female; | 1979 |
Noradrenaline, depressive illness, and the action of amitriptyline.
Topics: Adult; Aged; Amitriptyline; Blood Pressure; Depression; Female; Humans; Male; Middle Aged; Norepinep | 1977 |
Amitriptyline plasma concentration and clinical response.
Topics: Amitriptyline; Depression; Humans; Nortriptyline | 1979 |
Chronic amitriptyline toxicity.
Topics: Amitriptyline; Depression; Humans; Liver; Male; Middle Aged; Nortriptyline | 1979 |
Repertory grid and biochemical characterization of depression: a comparison of case reports.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1979 |
Monitoring tricyclic antidepressant plasma concentrations.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Humans; Imiprami | 1979 |
Rapid intramuscular administration of tricyclic antidepressants.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depr | 1979 |
Amitriptyline plasma concentrations and clinical response.
Topics: Amitriptyline; Depression; Dose-Response Relationship, Drug; Humans; Nortriptyline; Psychiatric Stat | 1979 |
Guidelines for clinical use in interpreting tricyclic plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Human | 1979 |
Tricyclic plasma levels. Effect of age, race, sex, and smoking.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Black People; Depression; Female; Humans; Male; Nor | 1977 |
High serum concentrations of antidepressants in elderly patients.
Topics: Aged; Amitriptyline; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1977 |
Prediction of individual dosage of nortriptyline.
Topics: Adult; Depression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; M | 1978 |
Nortriptyline in depressed patients with high plasma levels. II.
Topics: Adult; Aged; Depression; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Time Factors | 1978 |
High plasma nortriptyline levels in the treatment of depression. I.
Topics: Adult; Aged; Depression; Double-Blind Method; Female; Humans; Kinetics; Male; Middle Aged; Nortripty | 1978 |
Implications of dose regimen and protein binding for plasma nortriptyline estimations.
Topics: Adult; Biological Availability; Blood Proteins; Depression; Drug Administration Schedule; Female; Fl | 1978 |
Amitriptyline plasma levels and clinical response in primary depression: II.
Topics: Adult; Amitriptyline; Chromatography, Gas; Depression; Female; Humans; Male; Mass Spectrometry; Meth | 1978 |
Correlation between plasma levels of nortriptyline and clinical effects.
Topics: Adult; Aged; Depression; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline | 1978 |
[Blood levels of tricyclics and evolution of depressive syndrome during therapy].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Humans; Imipramine; Nortriptyline | 1978 |
Depression during renal dialysis and following transplantation.
Topics: Amitriptyline; Depression; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Mi | 1976 |
First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma.
Topics: Administration, Oral; Biological Availability; Depression; Humans; Hydroxylation; Injections, Intram | 1977 |
Relationship between age and tricyclic antidepressant plasma levels.
Topics: Administration, Oral; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Bod | 1977 |
Plasma nortriptyline and clinical response--a study using changing plasma levels.
Topics: Administration, Oral; Adult; Depression; Drug Evaluation; Female; Humans; Male; Middle Aged; Nortrip | 1977 |
Sampling time, dosage schedule, and nortriptyline plasma levels.
Topics: Depression; Drug Administration Schedule; Humans; Nortriptyline; Time Factors | 1977 |
Routine nortriptyline levels in treatment of depression.
Topics: Adult; Aged; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1977 |
Electrocardiographic findings in patients undergoing amitriptyline treatment.
Topics: Adolescent; Adult; Amitriptyline; Depression; Electrocardiography; Female; Humans; Male; Middle Aged | 1977 |
Amitriptyline dosage schedule, sampling time and tricyclic plasma levels.
Topics: Amitriptyline; Depression; Drug Administration Schedule; Humans; Nortriptyline; Time Factors | 1977 |
Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Clomipramine; Depre | 1976 |
Therapeutic control of plasma concentrations and long-term effect of nortriptyline in recurrent affective disorders.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Depression; Female; Humans; Male; Middle Aged; Nortriptyli | 1976 |
Tricyclic antidepressants and depletion of brain catecholamines. Preclinical and clinical studies with L-DOPA [proceedings].
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Humans; Levod | 1976 |
Plasma nortriptyline and clinical response.
Topics: Adolescent; Adult; Depression; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 1975 |
Rating scales as predictors of response to tricyclic antidepressants.
Topics: Adult; Age Factors; Depression; Female; Humans; Male; Manifest Anxiety Scale; Middle Aged; Nortripty | 1976 |
Letter: Effective dosage of tricyclic antidepressants.
Topics: Amitriptyline; Depression; Dose-Response Relationship, Drug; Humans; Nortriptyline | 1975 |
Patterns of symptom change in anxious depressed outpatients treated with different drugs.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Depression; Desipra | 1975 |
Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression.
Topics: Amitriptyline; Biogenic Amines; Depression; Desipramine; Dextroamphetamine; Humans; Hydroxyindoleace | 1975 |
[Antidepressive treatment with nortriptyline].
Topics: Administration, Oral; Adult; Aged; Depression; Depressive Disorder, Major; Female; Humans; Male; Mid | 1975 |
[Primary health care and ambulatory psychiatric care. Diagnosis is the most important part in treatment of depression].
Topics: Ambulatory Care; Antidepressive Agents; Depression; Humans; Nortriptyline; Primary Health Care | 1992 |
Depression in elderly is common but undertreated, says expert panel.
Topics: Age Factors; Aged; Antidepressive Agents; Depression; Desipramine; Humans; Nortriptyline | 1992 |
From the Alcohol, Drug Abuse, and Mental Health Administration.
Topics: Alcohol Drinking; Animals; Brain; Carrier Proteins; Cocaine; Depression; Heart Transplantation; Huma | 1991 |
Cognitive decline with nortriptyline use in a patient with dementia of the Alzheimer's type.
Topics: Aged; Alzheimer Disease; Attention; Cognition Disorders; Depression; Humans; Intelligence; Male; Mem | 1992 |
Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine.
Topics: Alleles; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debris | 1991 |
Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites.
Topics: Adult; Blood Platelets; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kin | 1987 |
Amitriptyline: linear or nonlinear kinetics in every day practice?
Topics: Amitriptyline; Biotransformation; Depression; Humans; Linear Models; Nortriptyline | 1989 |
Neutropenia with cross-intolerance between two tricyclic antidepressant agents.
Topics: Adult; Agranulocytosis; Cross Reactions; Depression; Female; Humans; Imipramine; Neutropenia; Nortri | 1987 |
Depression in Southeast Asian refugees.
Topics: Antidepressive Agents; Asia, Southeastern; Depression; Humans; Nortriptyline; Psychiatric Status Rat | 1987 |
A simplified radioimmunoassay of plasma nortriptyline in depressed patients compared with high-pressure liquid chromatography and gas-liquid chromatography.
Topics: Antidepressive Agents; Buffers; Charcoal; Chromatography, Gas; Chromatography, High Pressure Liquid; | 1986 |
Cardiac antiarrhythmic effect of nortriptyline.
Topics: Anti-Arrhythmia Agents; Depression; Electrocardiography; Humans; Male; Middle Aged; Nortriptyline | 1986 |
Tricyclic antidepressant and metabolite levels in chronic renal failure.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chromatography, Liquid; Depression; Desipramine; | 1985 |
Diagnosis and clinical management of post-stroke depression.
Topics: Aphasia; Cerebrovascular Disorders; Depression; Depressive Disorder; Dexamethasone; Frontal Lobe; Hu | 1985 |
CSF and plasma levels of nortriptyline and its 10-hydroxy metabolite.
Topics: Aged; Depression; Humans; Middle Aged; Nortriptyline | 1985 |
Plasma concentration of nortriptyline and clinical response in depressive illness.
Topics: Administration, Oral; Adolescent; Adult; Depression; Female; Follow-Up Studies; Humans; Kidney; Kidn | 1972 |
Plasma levels on antidepressants and clinical response.
Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Nortriptyline | 1973 |
Clinical significance of plasma levels of tricyclic antidepressant drugs in the treatment of depression.
Topics: Amitriptyline; Depression; Humans; Nortriptyline | 1973 |
Letter: Antidepressant teratogenicity?
Topics: Abnormalities, Multiple; Depression; Female; Fetus; Humans; Infant, Newborn; Male; Nortriptyline; Pr | 1974 |
Sleep and depression. IV. Longitudinal studies.
Topics: Adult; Depression; Desipramine; Electroconvulsive Therapy; Ethynodiol Diacetate; Female; Hospitaliza | 1971 |
Development of a rating scale for depressive illness.
Topics: Antidepressive Agents; Anxiety; Depression; Drug Evaluation; Electroconvulsive Therapy; Humans; Nort | 1974 |
Confusional states in elderly mental patients treated with antidepressants.
Topics: Aged; Amitriptyline; Cognition Disorders; Confusion; Depression; Drug Therapy, Combination; Female; | 1974 |
Letter: Variability in response to drugs.
Topics: Administration, Oral; Depression; Humans; Nortriptyline | 1974 |
Combined thyroid (triiodothyronine)-tricyclic antidepressant treatment in depressive states.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents; Anxiety; Bipolar Disorder; Blood | 1974 |
L-dopa and tricyclic antidepressants in affective disorders. A pilot study.
Topics: Adult; Amitriptyline; Depression; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodo | 1974 |
Elamol and Motival-new psychotropic drugs?
Topics: Animals; Anxiety; Depression; Fluphenazine; Humans; Nortriptyline; Orphenadrine | 1972 |
Toward a biochemical classification of depression.
Topics: Antidepressive Agents; Biogenic Amines; Brain; Brain Stem; Depression; Dopamine; Homovanillic Acid; | 1974 |
5-Hydroxytryptamine in depression.
Topics: Aged; Amitriptyline; Antidepressive Agents; Biogenic Amines; Blood Platelets; Depression; Dibenzazep | 1974 |
Differential diagnosis and treatment of depression in the elderly.
Topics: Adjustment Disorders; Aged; Antidepressive Agents; Circadian Rhythm; Dementia; Depression; Diagnosis | 1974 |
[Neuropsychiatric aspects of male sterility].
Topics: Amitriptyline; Depression; Dibenzazepines; Frustration; Humans; Imipramine; Infertility, Male; Male; | 1972 |
Urinary retention in a neonate secondary to maternal ingestion of nortriptyline.
Topics: Adult; Depression; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal | 1972 |
[Connection between the kinetics and the therapeutic effects of tricyclic antidepressive agents. A review and results obtained with nortriptyline (Sensival)].
Topics: Adolescent; Adult; Aged; Depression; Female; Humans; Kinetics; Middle Aged; Nortriptyline; Placebos | 1972 |
Pharmacotherapy in the premenstrual tension.
Topics: Adolescent; Adult; Bipolar Disorder; Chlorpromazine; Depression; Female; Humans; Imipramine; Neuroti | 1971 |
The correlation of subjective side-effects with plasma concentrations of nortriptyline.
Topics: Depression; Humans; Nortriptyline | 1970 |
Fatal amitriptytine poisoning. Determination of the drug in forensic-chemical material.
Topics: Adult; Amitriptyline; Depression; Female; Forensic Medicine; Humans; Liver; Nortriptyline; Spectroph | 1969 |
[Clinical trials of nortriptyline in 40 cases].
Topics: Adolescent; Adult; Aged; Anxiety; Bipolar Disorder; Depression; Humans; Male; Middle Aged; Neurotic | 1969 |
[Current problems of endogenous depression].
Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Convulsive Therapy; Depression; Desipramine; F | 1970 |
[Clinical antidepressant drug therapy].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; N | 1970 |
Noveril (dibenzepin)--another new antidepressive.
Topics: Amitriptyline; Antidepressive Agents; Depression; Dibenzazepines; Humans; Imipramine; Nortriptyline | 1970 |
Antianxiety and anti-depressant drugs.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Depression; Desipramine; Dibenzoxep | 1970 |
[Complications caused by anonymous preclinical medication].
Topics: Amitriptyline; Antidepressive Agents; Barbiturates; Bromides; Cannabis; Chlordiazepoxide; Delirium; | 1970 |
Relationship between plasma level and therapeutic effect of nortriptyline.
Topics: Adult; Age Factors; Aged; Amines; Depression; Depression, Chemical; Female; Humans; Male; Middle Age | 1971 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug | 1971 |
[Evaluation of the therapeutic action of nortriptyline in depressive syndromes].
Topics: Adult; Depression; Humans; Male; Middle Aged; Nortriptyline | 1967 |
[To the indication spectrum of intensive impulse thymoleptics in the therapy of depressive states. Exemplified by the effect of spectrum of nortriptyline].
Topics: Adult; Aged; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1967 |
[Remarks on the use of Nortriptyline in the pharmacotherapy of depression].
Topics: Aged; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1968 |
[Remarks on therapeutic action and side effects of nortriptyline].
Topics: Adult; Aged; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1968 |
[A new drug in the treatment of depressions: nortriptyline].
Topics: Depression; Humans; Nortriptyline | 1968 |
[Trial of nortriptyline: a new tricyclic antidepressant].
Topics: Adult; Aged; Depression; Female; Humans; Male; Middle Aged; Nortriptyline; Sex Factors | 1968 |
[Nortriptyline, an antidepressant].
Topics: Adult; Depression; Female; Humans; Middle Aged; Nortriptyline | 1968 |
Masked depression and the use of antidepressants in general practice.
Topics: Adult; Age Factors; Amitriptyline; Antidepressive Agents; Depression; Family Practice; Female; Human | 1969 |
Extrinsic factors influencing responses to psychotherapeutic drugs.
Topics: Adult; Amitriptyline; Analysis of Variance; Black or African American; Chlorpromazine; Depression; D | 1969 |
Desipramine.
Topics: Amitriptyline; Depression; Desipramine; Humans; Nortriptyline | 1965 |
[Clinical experiences with nortriptyline].
Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Nortrip | 1965 |
A comparison of nortriptyline and amitriptyline in depression.
Topics: Amitriptyline; Antidepressive Agents; Depression; Female; Humans; Male; Nortriptyline | 1965 |
A pilot trial of nortryptiline in the treatment of mentally disturbed patients in general practice.
Topics: Adolescent; Adult; Antidepressive Agents; Anxiety; Child; Depression; Family Practice; Female; Human | 1965 |
Results of nortriptyline treatment of depressive conditions.
Topics: Adult; Aged; Antidepressive Agents; Depression; Electroencephalography; Female; Humans; Male; Middle | 1965 |
A new antidepressant of the tricyclic group: nortriptyline hydrochloride (aventyl hydrochloride).
Topics: Adolescent; Adult; Antidepressive Agents; Child; Child, Preschool; Depression; Humans; Nortriptyline | 1965 |
A new antidepressant, nortriptyline hydrochloride. A preliminary report.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Anxiety; Depression; Female; Humans; Male; Middle Ag | 1966 |
[Patients with endogenous depressions treated with nortriptyline].
Topics: Adult; Aged; Depression; Female; Humans; Middle Aged; Nortriptyline | 1966 |
Diagnosis and treatment of depressive reactions.
Topics: Antidepressive Agents; Depression; Desipramine; Humans; Nortriptyline | 1966 |
[Effects of dibenzocycloheptadienic derivatives in treatment of depressive syndromes].
Topics: Amitriptyline; Anxiety Disorders; Depression; Humans; Nortriptyline; Schizophrenia | 1966 |