nortriptyline has been researched along with Depression, Endogenous in 448 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke." | 9.09 | Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000) |
| "This study was designed to evaluate the comparative efficacy and safety of sertraline and nortriptyline for the treatment of major depressive disorder in older adults." | 9.09 | Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life. ( Alpert, M; Batzar, E; Bondareff, W; Clary, CM; Friedhoff, AJ; Richter, EM, 2000) |
| "To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus." | 9.07 | A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "A random assignment, double-blind, placebo-controlled study of nortriptyline in 50 prepubertal 6- to 12-year-olds with Research Diagnostic Criteria and DSM-III major depressive disorder was performed." | 9.07 | Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder. ( Cooper, TB; Fetner, HH; Geller, B; Graham, DL; Marsteller, FA; Wells, JM, 1992) |
| "The effects of four antidepressant treatments on platelet tritiated imipramine binding have been studied in 51 hospitalized patients with severe major depressive disorder." | 9.06 | Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder. ( Aberg-Wistedt, A; Asberg, M; Bertilsson, L; Mårtensson, B; Montero, D; Wägner, A, 1987) |
| "The effect of clomipramine hydrochloride in severe obsessive-compulsive disorder (OCD) was compared with that of nortriptyline hydrochloride and placebo in a five-week randomized, double-blind trial." | 9.05 | Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial. ( Asberg, M; Cronholm, B; Jörnestedt, L; Thorén, P; Träskman, L, 1980) |
| "The authors describe a patient who developed congestive heart failure and had a high plasma concentration of 10-hydroxynortriptyline." | 7.67 | Heart failure associated with high plasma 10-hydroxynortriptyline levels. ( Alexopoulos, GS; Dhar, AK; Kutt, H; Shamoian, CA; Young, RC, 1984) |
| "The presence of avoidant personality disorder (p <." | 6.71 | Psychiatric comorbidity as a predictor of clinical response to nortriptyline in treatment-resistant major depressive disorder. ( Alpert, JE; Farabaugh, AH; Fava, M; Murakami, JL; Nierenberg, AA; Papakostas, GI; Pava, JA; Petersen, TJ, 2003) |
| "Adinazolam treatment did not alter the platelet shape change response." | 6.67 | Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. ( Fleishaker, JC; Hauger, RL; Hubbell-Alberts, E; Rausch, JL; Stahl, SM, 1993) |
| "In genome-based drugs for depression (GENDEP), 811 patients with major depressive disorder treated with escitalopram or nortriptyline were assessed with the clinician-rated Montgomery-Åsberg Depression Rating Scale (MADRS), Hamilton Rating Scale for Depression (HRSD), and the self-report Beck Depression Inventory (BDI)." | 5.16 | Self-report and clinician-rated measures of depression severity: can one replace the other? ( Dernovšek, MZ; Farmer, A; Henigsberg, N; Maier, W; McGuffin, P; Mors, O; Perlis, RH; Placentino, A; Uher, R, 2012) |
| " To compare changes in body weight during treatment with different antidepressants, body weight and height were measured at baseline and after 6, 8, 12 and 26 wk treatment with escitalopram or nortriptyline in 630 adults with moderate-to-severe unipolar depression participating in GENDEP, a part-randomized open-label study." | 5.15 | Changes in body weight during pharmacological treatment of depression. ( Aitchison, KJ; Dernovsek, MZ; Farmer, A; Gray, JM; Hauser, J; Henigsberg, N; Kalember, P; Keers, R; Kozel, D; Larsen, ER; Maier, W; McGuffin, P; Mendlewicz, J; Mors, O; Placentino, A; Rietschel, M; Souery, D; Strohmaier, J; Szczepankiewicz, A; Uher, R; Zobel, A, 2011) |
| "During the 1-year follow-up period, and after adjusting for critical confounders including age, intensity of rehabilitation therapy, baseline stroke severity, and baseline Hamilton Depression Rating Scale, patients who received fluoxetine or nortriptyline had significantly greater improvement in modified Rankin Scale scores compared to patients who received placebo (t [156] = -3." | 5.15 | Effect of antidepressants on the course of disability following stroke. ( Adams, HP; Davis, PH; Jang, M; Jorge, RE; Leira, EC; Mikami, K; Robinson, RG, 2011) |
| "The authors randomly assigned nondepressed patients at least 3 months poststroke to receive nortriptyline, fluoxetine, or placebo for 3 months using double-blind methodology." | 5.12 | Risk factors for and correlates of poststroke depression following discontinuation of antidepressants. ( Fiedorowicz, JG; Robinson, RG; Takezawa, K, 2007) |
| "Fifty Caucasian inpatients with at least medium-grade depressive disorder received amitriptyline at a fixed dose of 75 mg twice a day." | 5.11 | Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy. ( Bachofer, J; Kissling, W; Leucht, S; Messner, B; Pfeiffer, H; Popp, J; Steimer, W; von Amelunxen, S; Zöpf, K, 2005) |
| "This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke." | 5.09 | Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000) |
| "This study was designed to evaluate the comparative efficacy and safety of sertraline and nortriptyline for the treatment of major depressive disorder in older adults." | 5.09 | Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life. ( Alpert, M; Batzar, E; Bondareff, W; Clary, CM; Friedhoff, AJ; Richter, EM, 2000) |
| "Nortriptyline is a promising adjunct for smoking cessation." | 5.08 | Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking. ( Frederick, S; Hall, SM; Hartz, DT; Humfleet, G; Muñoz, RF; Reus, VI; Sees, KL; Triffleman, E, 1998) |
| "To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus." | 5.07 | A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "Ninety-two middle-aged and elderly patients with disabling tinnitus participated in a double-blind randomized clinical trial comparing nortriptyline (a tricyclic antidepressant) to placebo." | 5.07 | Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit. ( Dobie, RA; Katon, WJ; Russo, J; Sakai, CS; Sullivan, MD, 1993) |
| "A random assignment, double-blind, placebo-controlled study of nortriptyline in 50 prepubertal 6- to 12-year-olds with Research Diagnostic Criteria and DSM-III major depressive disorder was performed." | 5.07 | Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder. ( Cooper, TB; Fetner, HH; Geller, B; Graham, DL; Marsteller, FA; Wells, JM, 1992) |
| "Data are presented on the baseline characteristics and 2- to 3-year follow-up assessments of placebo-washout responders (PWRs) from a previously reported pharmacokinetically designed double-blind placebo-controlled trial of nortriptyline for major depressive disorder in 6- to 12-year-olds." | 5.07 | Baseline and 2- to 3-year follow-up characteristics of placebo-washout responders from the nortriptyline study of depressed 6- to 12-year-olds. ( Cooper, TB; Fox, LW; Garrity, K; Geller, B, 1992) |
| "We performed a random assignment, double-blind, placebo-controlled study of nortriptyline (NT) in postpubertal 12- to 17-year-olds with Research Diagnostic Criteria (RDC) and DSM-III major depressive disorder." | 5.06 | Double-blind placebo-controlled study of nortriptyline in depressed adolescents using a "fixed plasma level" design. ( Bryant, DM; Cooper, TB; Geller, B; Graham, DL; Marsteller, FA, 1990) |
| "The effects of four antidepressant treatments on platelet tritiated imipramine binding have been studied in 51 hospitalized patients with severe major depressive disorder." | 5.06 | Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder. ( Aberg-Wistedt, A; Asberg, M; Bertilsson, L; Mårtensson, B; Montero, D; Wägner, A, 1987) |
| "Twenty-two subjects 6-12 years old who met Research Diagnostic Criteria and DSM-III criteria for major depressive disorder received a fixed daily dose of nortriptyline during an 8-week protocol." | 5.06 | Preliminary data on the relationship between nortriptyline plasma level and response in depressed children. ( Anker, JA; Chestnut, EC; Cooper, TB; Geller, B; Schluchter, MD, 1986) |
| "Using a simple S1S2-R paradigm, acoustically evoked potentials, CNV, and PINV were recorded in 59 patients with major depressive disorder before and during a 4 week double blind pharmacological treatment with either amitriptyline (AT) or oxaprotiline (OT)." | 5.06 | [Changes in slow evoked potentials in depressed patients treated with amitriptyline and oxaprotiline]. ( Giedke, H; Heimann, H; Rein, W, 1987) |
| "Amoxapine, a new antidepressant of the dibenzoxazepine class, was compared with amitriptyline in 80 patients with primary unipolar depressive disorders." | 5.05 | Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression. ( Click, MA; Zisook, S, 1982) |
| "The effect of clomipramine hydrochloride in severe obsessive-compulsive disorder (OCD) was compared with that of nortriptyline hydrochloride and placebo in a five-week randomized, double-blind trial." | 5.05 | Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial. ( Asberg, M; Cronholm, B; Jörnestedt, L; Thorén, P; Träskman, L, 1980) |
| "As part of a double-blind clinical trial comparing phenelzine and amitriptyline in outpatients with predominantly major depressive disorder, plasma tricyclic antidepressant drug concentrations were measured in 83 amitriptyline-treated patients." | 5.05 | Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients. ( Albright, D; Cooper, TB; Corcella, J; Howard, D; Robinson, DS, 1985) |
| "Randomized controlled trials have demonstrated the efficacy of sertraline, citalopram and nortriptyline to treat post-stroke depression." | 4.84 | Antidepressant therapy in post-stroke depression. ( Mizrahi, R; Power, BD; Starkstein, SE, 2008) |
| "Nortriptyline intoxication secondary to terbinafine treatment was observed in a woman with a major depressive disorder." | 3.71 | Pharmacokinetic interaction between nortriptyline and terbinafine. ( Kempen, RW; Van Den Heuvel, HA; Van Der Kuy, PH; Vanmolkot, LM, 2002) |
| " The authors examined the effect of total sleep deprivation (SD) in combination with nortriptyline in 20 patients with major depressive disorder (MDD)." | 3.68 | Sleep deprivation accelerates the response to nortriptyline. ( Loosen, PT; Shelton, RC, 1993) |
| " The authors measured serum levels of NT and 10-hydroxynortriptyline (10-OH-NT) using a column-switching HPLC method, and examined aging effects on NT steady-state levels to NT doses (doses/kg) ratios and NT levels to 10-OH-NT levels ratios as well as clinical response and propensity for side effects." | 3.68 | Nortriptyline response in elderly depressed patients. ( Kanba, S; Kinoshita, N; Matsumoto, K; Nibuya, M; Shintani, F; Suzuki, E; Yagi, G, 1992) |
| "The authors describe a patient who developed congestive heart failure and had a high plasma concentration of 10-hydroxynortriptyline." | 3.67 | Heart failure associated with high plasma 10-hydroxynortriptyline levels. ( Alexopoulos, GS; Dhar, AK; Kutt, H; Shamoian, CA; Young, RC, 1984) |
| "Eight adolescents with major depressive disorder were treated with nortriptyline and six adolescents with delusional depression were treated with combined nortriptyline and chlorpromazine." | 3.67 | Dose and plasma levels of nortriptyline and chlorpromazine in delusionally depressed adolescents and of nortriptyline in nondelusionally depressed adolescents. ( Chestnut, EC; Cooper, TB; Farooki, ZQ; Geller, B, 1985) |
| "The use of nortriptyline single dose kinetics to predict steady state plasma levels and suggested dose was investigated in 33 pediatric subjects who were diagnosed as having major depressive disorder." | 3.67 | Child and adolescent nortriptyline single dose kinetics predict steady state plasma levels and suggested dose: preliminary data. ( Anker, JA; Chestnut, EC; Cooper, TB; Geller, B; Price, DT; Yates, E, 1985) |
| "Children and adolescents 6 to 16 years old (N = 25), who were diagnosed as having major depressive disorder, received a fixed daily dose of nortriptyline during an 8-week period." | 3.67 | Serial monitoring and achievement of steady state nortriptyline plasma levels in depressed children and adolescents: preliminary data. ( Chestnut, EC; Cooper, TB; Geller, B, 1985) |
| "The authors investigated ECG measurements in 21 children with major depressive disorder treated with nortriptyline at plasma levels of 50-100 ng/ml." | 3.67 | Serial ECG measurements at controlled plasma levels of nortriptyline in depressed children. ( Abel, AS; Chestnut, EC; Cooper, TB; Farooki, ZQ; Geller, B, 1985) |
| "Monitoring tricyclic antidepressant concentrations in the plasma of 43 patients with major depressive disorders indicated that some responded to imipramine or desipramine but not to amitriptyline or nortriptyline, or vice versa, even though plasma levels were within therapeutic ranges." | 3.66 | The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression. ( Bagri, S; Fawcett, J; Javaid, JI; Sabelli, HC, 1983) |
| "Nortriptyline responders were the only treatment by responder status group to show no improvement in verbal learning from baseline to endpoint." | 2.77 | Change in cognitive functioning in depressed older adults following treatment with sertraline or nortriptyline. ( Culang-Reinlieb, ME; Keilp, JG; Roose, SP; Sneed, JR, 2012) |
| "Among 811 adults with moderate-to-severe depression, melancholic, atypical, anxious and anxious-somatizing depression subtypes established at baseline were evaluated as predictors of outcome of treatment with flexible dosage of the SSRI escitalopram or the tricyclic antidepressant nortriptyline." | 2.76 | Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline. ( Aitchison, KJ; Dernovsek, MZ; Farmer, A; Hauser, J; Henigsberg, N; Kalember, P; Maier, W; McGuffin, P; Mendlewicz, J; Mors, O; Placentino, A; Rietschel, M; Souery, D; Uher, R; Zobel, A, 2011) |
| "Fifty-two depressed Parkinson's disease patients were enrolled in an NIH-funded randomized, controlled trial of nortriptyline, paroxetine, and placebo." | 2.75 | The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease. ( Bienfait, KL; Dicke, A; Dobkin, RD; Gara, M; Marin, H; Mark, MH; Menza, M; Tröster, A, 2010) |
| "Nortriptyline was superior to placebo for the change in HAM-D (p < 0." | 2.74 | A controlled trial of antidepressants in patients with Parkinson disease and depression. ( Bienfait, K; Buyske, S; Dicke, A; Dobkin, RD; Gara, M; Marin, H; Mark, MH; Menza, M, 2009) |
| "In a multicentre part-randomised open-label design (the Genome Based Therapeutic Drugs for Depression (GENDEP) study) 811 adults with moderate to severe unipolar depression were allocated to flexible dosage escitalopram or nortriptyline for 12 weeks." | 2.74 | Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. ( Aitchison, KJ; Barreto, M; Dmitrzak-Weglarz, M; Elkin, A; Farmer, A; Giovannini, C; Hauser, J; Henigsberg, N; Jorgensen, L; Kalember, P; Landau, S; Maier, W; Marusic, A; McGuffin, P; Mors, O; Petrovic, A; Placentino, A; Rietschel, M; Schmael, C; Souery, D; Uher, R; Zobel, A, 2009) |
| "In a multicentre part-randomised open-label study, 811 adult patients with moderate to severe unipolar depression were allocated to flexible dosage of escitalopram or nortriptyline for 12 weeks." | 2.74 | Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial. ( Aitchison, KJ; Campbell, D; Elkin, A; Farmer, AE; Giovannini, C; Gray, J; Gunasinghe, C; Gupta, B; Hauser, J; Henigsberg, N; Jorgensen, L; Maier, W; Marusic, A; McGuffin, P; Mors, O; Perroud, N; Placentino, A; Rietschel, M; Souery, D; Strohmaier, J; Szczepankiewicz, A; Uher, R; Zobel, A, 2009) |
| "Nortriptyline was effective for over a third of patients with treatment-resistant depression, and nortriptyline should be considered as potential treatment if patients fail to respond to other antidepressants." | 2.71 | Nortriptyline for treatment-resistant depression. ( Alpert, JE; Fava, M; Iacoviello, BM; Kelly, KE; Nierenberg, AA; Papakostas, GI; Petersen, T; Tedlow, J; Worthington, JJ, 2003) |
| "Nortriptyline plasma levels were not statistically different between response groups." | 2.71 | Initial platelet serotonin (5-HT) transport kinetics predict nortriptyline treatment outcome. ( Johnson, ME; Moeller, FG; Rausch, JL, 2003) |
| "The presence of avoidant personality disorder (p <." | 2.71 | Psychiatric comorbidity as a predictor of clinical response to nortriptyline in treatment-resistant major depressive disorder. ( Alpert, JE; Farabaugh, AH; Fava, M; Murakami, JL; Nierenberg, AA; Papakostas, GI; Pava, JA; Petersen, TJ, 2003) |
| "Melancholia was associated with reduced activity in the subgenual PFC (Brodmann area 25), manifested by increased inhibitory delta activity (1." | 2.71 | Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. ( Abercrombie, HC; Benca, RM; Chung, MK; Davidson, RJ; Fox, AS; Larson, CL; Oakes, TR; Pizzagalli, DA; Schaefer, SM, 2004) |
| "nortriptyline) was done." | 2.70 | Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline. ( Clary, CM; Doraiswamy, PM; Krishnan, KR, 2001) |
| "Subjects had only recurrent, unipolar depression." | 2.70 | Initial recovery patterns may predict which maintenance therapies for depression will keep older adults well. ( Begley, A; Dew, MA; Frank, E; Houck, PR; Kupfer, DJ; Mazumdar, S; Mulsant, B; Reynolds, CF, 2001) |
| " Significant correlations were found between the numbers of alleles encoding decreased metabolism and nortriptyline plasma concentration, nortriptyline dose, and nortriptyline plasma concentration standardized for dose, indicating a gene dosage effect." | 2.70 | CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression. ( Cheuk, W; Kirshner, MA; Mulsant, BH; Murphy, GM; Pascoe, N; Pollock, BG; Reynolds, CF, 2001) |
| "Nortriptyline treatment was associated with a significantly higher rate of serious adverse cardiac events compared with paroxetine." | 2.69 | Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. ( Bigger, JT; Finkel, MS; Gaffney, A; Gergel, I; Kennedy, JS; Laghrissi-Thode, F; McCafferty, J; Narayan, M; Nelson, JC; Pollock, BG; Roose, SP, 1998) |
| "Paroxetine-treated subjects received a psychotherapy tailored for traumatic grief." | 2.69 | A post hoc comparison of paroxetine and nortriptyline for symptoms of traumatic grief. ( Houck, PR; Jacobs, S; Miller, MD; Prigerson, HG; Reynolds, CF; Shear, MK; Zygmont, M, 1998) |
| "The time to recurrence of a major depressive episode for all 3 active treatments was significantly better than for placebo." | 2.69 | Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years. ( Cornes, C; Dew, MA; Frank, E; Houck, PR; Imber, SD; Kupfer, DJ; Mazumdar, S; Miller, MD; Perel, JM; Pollock, BG; Reynolds, CF; Stack, JA, 1999) |
| "Nortriptyline was superior to placebo in achieving remission of bereavement-related major depressive episodes." | 2.69 | Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy. ( Cornes, C; Dew, MA; Frank, E; Houck, PR; Kupfer, DJ; Mazumdar, S; Miller, MD; Pasternak, RE; Perel, JM; Reynolds, CF, 1999) |
| "Sertraline treatment had a significantly more positive effect, when compared to nortriptyline, across almost all associated measures of cognitive function, energy, anxiety, and quality of life and was better tolerated than nortriptyline, with a lower attrition rate/side effect burden." | 2.69 | Comparative efficacy and safety of sertraline versus nortriptyline in major depression in patients 70 and older. ( Clary, CM; Finkel, SI; Richter, EM, 1999) |
| "Nortriptyline dose was adjusted with the use of blood-level monitoring to reach a plasma concentration of 50-150 ng/ml." | 2.69 | Treatment of major depression with nortriptyline and paroxetine in patients with ischemic heart disease. ( Gergel, I; Kennedy, JS; Laghrissi-Thode, F; McCafferty, J; Narayan, M; Nelson, JC; Nobler, MS; Pollock, BG; Robin, DW; Roose, S, 1999) |
| " It was necessary to adjust nortriptyline dosage in < 20% of patients to maintain serum levels within the postulated therapeutic window of 50-170 ng/ml." | 2.68 | Moclobemide and nortriptyline in elderly depressed patients. A randomized, multicentre trial against placebo. ( Amin, M; Holm, P; Katona, C; Klitgaard, N; Kragh-Sørensen, P; Kühn, H; Leek, CA; Nair, NP; Ng Ying Kin, NM; Stage, KB, 1995) |
| "Nortriptyline hydrochloride prescribed by primary care physicians trained in clinical guidelines specifying dosage schedules, durations, and procedures resembling those recommended by the AHCPR (Agency for Health Care Policy and Research) Depression Guideline Panel." | 2.68 | Applicability of clinical pharmacotherapy guidelines for major depression in primary care settings. ( Block, MR; Lave, J; Madonia, MJ; Rodriguez, E; Schulberg, HC; Scott, CP, 1995) |
| " Pharmacodynamic analyses showed that patients with moderate to severe anticholinergic side effects [CSE(+)] had significantly higher NT levels than those with mild or no symptoms [CSE(-)]." | 2.68 | Clinical relevance of serum nortriptyline and 10-hydroxy-nortriptyline measurements in the depressed elderly: a multicenter pharmacokinetic and pharmacodynamic study. ( Ahmed, SK; Amin, M; Holm, P; Katona, C; Kin, NM; Klitgaard, N; Kragh-Sorensen, P; Nair, NP; Schwariz, G; Stage, K, 1996) |
| "Nortriptyline levels were positively but weakly related to all-night delta-wave production during maintenance (accounting for 6." | 2.68 | Maintenance nortriptyline effects on electroencephalographic sleep in elderly patients with recurrent major depression: double-blind, placebo- and plasma-level-controlled evaluation. ( Begley, AE; Brunner, DP; Buysse, DJ; Dew, MA; Hall, M; Hoch, CC; Houck, PR; Kupfer, DJ; Mazumdar, S; Perel, JM; Reynolds, CF, 1997) |
| "Bupropion-treated patients had small but statistically significant increases in supine diastolic blood pressure of 5." | 2.67 | The cardiovascular effects of bupropion and nortriptyline in depressed outpatients. ( Batey, SR; Holloman, LC; Johnston, JA; Kiev, A; Masco, HL; Wenger, TL, 1994) |
| "These mothers are apprehensive about recurrence after later births." | 2.67 | Prevention of recurrent postpartum major depression. ( Wheeler, SB; Wisner, KL, 1994) |
| "Adinazolam treatment did not alter the platelet shape change response." | 2.67 | Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. ( Fleishaker, JC; Hauger, RL; Hubbell-Alberts, E; Rausch, JL; Stahl, SM, 1993) |
| "Nortriptyline treatment was initiated with a 75- to 125-mg dose depending on weight in 26 depressed inpatients in an open-label study." | 2.67 | High initial nortriptyline doses in the treatment of depression. ( Griffin, M; Peabody, CA; Warner, MD, 1993) |
| "Nortriptyline treatment was accompanied by marked improvements in anxiety, certain respiratory symptoms, overall physical comfort, and day-to-day function; placebo effects were negligible." | 2.67 | Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease. ( Borson, S; Deffebach, M; Gayle, T; Lakshminarayan, S; McDonald, GJ; VanTuinen, C, 1992) |
| "Amitriptyline was found to act within seven days on the components of anxiety and on hostility in the responders, and on sleep disorder in all patients." | 2.67 | Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression. ( Bowden, CL; Casper, RC; Frazer, A; Katz, MM; Kocsis, J; Koslow, SH; Maas, JW; Secunda, S, 1991) |
| "Fluoxetine was associated more frequently with nausea (p less than ." | 2.67 | Comparative efficacy and safety of nortriptyline and fluoxetine in the treatment of major depression: a clinical study. ( Fabre, LF; Itil, TM; Scharf, MB, 1991) |
| "Mean survival time without recurrence is 21." | 2.66 | Open-trial maintenance pharmacotherapy in late-life depression: survival analysis. ( Cornes, C; Frank, E; Imber, S; Kupfer, DJ; Morycz, RK; Perel, JM; Reynolds, CF; Thornton, J, 1989) |
| "There are no reports on treatment of premenstrual syndrome with antidepressants, although depression is a common symptom of the syndrome." | 2.66 | Treatment of premenstrual depression with nortriptyline: a pilot study. ( Endicott, J; Harrison, WM; Nee, J, 1989) |
| "Patients with endogenous depression responded sooner on nortriptyline than did patients with nonendogenous depression." | 2.66 | Factors affecting the delay of antidepressant effect in responders to nortriptyline and phenelzine. ( Cooper, TB; Friedhoff, A; Georgotas, A; McCue, RE; Nagachandran, N, 1989) |
| "Nortriptyline was better than phenelzine or placebo in improving middle/late insomnia." | 2.66 | Response of depressive symptoms to nortriptyline, phenelzine and placebo. ( Cooper, TB; Friedman, E; Georgotas, A; McCue, RE, 1987) |
| " A nomogram was made from the regression equations to predict the dosage required to achieve a steady state concentration within a 50 to 150 ng/ml range." | 2.66 | Prediction of individual dosage of nortriptyline in depressed elderly outpatients. ( Cooper, TB; Schneider, LS; Sloane, RB; Staples, FR, 1987) |
| "The nortriptyline-treated subjects with a PSOP of greater than or equal to 10 mm Hg had a greater improvement than those with a PSOP of less than 10 mm HG (t = -2." | 2.66 | Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression. ( Bender, M; Schneider, LS; Sloane, RB; Staples, FR, 1986) |
| " Dosage was adjusted based on plasma level with the aim of achieving a concentration of 60-180 ng/ml." | 2.65 | Amitriptyline and nortriptyline response profiles in unipolar depressed patients. ( Bowden, CL; Lehmann, LS; Redmond, FC; Stanton, BC, 1982) |
| "When evaluating the literature on the treatment of late-life depression, it is most critical to consider the methodology of each study, specifically: (1) Is the antidepressant treatment adequate with respect to dosing duration? (2) How is response defined, e." | 2.40 | Antidepressant response in late-life depression. ( Roose, SP; Suthers, KM, 1998) |
| " In many instances, a knowledge of the drug metabolism status of a patient can be helpful in the selection of a drug and its dosage regimen, and in the prediction of possible drug/drug interactions when two or more drugs have to be administered concomitantly." | 2.39 | Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping. ( Coutts, RT, 1994) |
| "Major depressive disorder is a major health concern." | 2.38 | Somatic therapy for major depressive disorder: selection of an antidepressant. ( Burke, M; Preskorn, SH, 1992) |
| "Depressive disorder is a common complication of stroke." | 2.38 | Depression and cerebrovascular disease. ( Fedoroff, JP; Morris, PL; Robinson, RG, 1990) |
| " Severe toxicity usually occurs at supratherapeutic plasma levels and might be prevented by tailoring the dosage according to the individual's drug hydroxylating capacity." | 2.37 | Clinical pharmacology of antidepressant drugs: pharmacogenetics. ( Bertilsson, L; Sjöqvist, F, 1984) |
| "It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed." | 2.37 | Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984) |
| " The clinical uses of TCA plasma level-response studies are discussed in relationship to rational dosage adjustment to increase response rates and avoid iatrogenic toxicity." | 2.37 | Nortriptyline pharmacokinetics and plasma levels: implications for clinical practice. ( Biggs, JT; Preskorn, SH; Rubin, EH, 1985) |
| " Plasma level determinations can never replace sound clinical judgment and dosage adjustment for individual patients." | 2.36 | The role of plasma concentrations in the use of tricyclic antidepressant drugs. ( Levine, RR, 1979) |
| " Multiple-dose comedication with LI160 led to a statistically significant decrease in the area under the plasma concentration-time curve within one dosing interval of amitriptyline by 22% ( p = 0." | 1.31 | Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ). ( Bauer, S; Brockmöller, J; Johne, A; Langheinrich, M; Roots, I; Schmider, J; Scholler, G; Stadelmann, AM; Störmer, E, 2002) |
| "To evaluate the CORE measure of melancholia, against the DSM-IV construct of melancholia." | 1.31 | Melancholia: definitions, risk factors, personality, neuroendocrine markers and differential antidepressant response. ( Abbott, RM; Joyce, PR; Luty, SE; McKenzie, JM; Mulder, RT; Stevens, IF; Sullivan, PF, 2002) |
| "Nortriptyline was not detected in the infants' sera." | 1.28 | Serum nortriptyline levels in nursing mothers and their infants. ( Perel, JM; Wisner, KL, 1991) |
| "Nortriptyline therapy was associated with increased QRS interval and heart rate but did not significantly affect other hemodynamic or ECG variables or cyclosporine dose requirements." | 1.28 | Nortriptyline treatment of depressed cardiac transplant recipients. ( Shapiro, PA, 1991) |
| " Using the weight-adjusted dosage schedule, 18 of the 21 patients attained plasma concentrations of nortriptyline within the presumed therapeutic range; however, no clear relationship could be established between plasma concentrations and clinical response." | 1.28 | Simulated home treatment of depression with nortriptyline. ( Hollister, L; Peabody, C; Van Norman, J; Warner, D, 1991) |
| "The drug-drug interactions with fluoxetine, a pure serotonergic reuptake blocker with a unique profile of side effects, have not been studied adequately." | 1.28 | Drug-drug interactions of fluoxetine with tricyclics. ( von Ammon Cavanaugh, S, 1990) |
| " These findings show that chronic administration of low-modest doses of tricyclic antidepressants frequently cause considerable weight gain and can significantly interfere with the ability to provide long-term maintenance therapy." | 1.27 | Weight gain. A side-effect of tricyclic antidepressants. ( Berken, GH; Stern, WC; Weinstein, DO, 1984) |
| "Twenty-one depressed patients participated in a study that assessed the predictability of amitriptyline (AT) dosage based on plasma drug concentrations after a single dose." | 1.27 | Single-dose single-point method in amitriptyline therapy. ( Khazanie, PG; Madakasira, S; Sato, TL, 1984) |
| " When DMI dosage was raised after an initial steady state had been reached, the rise in plasma DMI level was proportionately greater than the increase in dosage, suggesting saturation of DMI elimination pathways." | 1.27 | The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma. ( Cooke, RG; Persad, E; Reed, KL; Stancer, HC; Warsh, JJ, 1984) |
| "The pharmacokinetic parameters of nortriptyline in the pediatric age group following oral administration of a single dose of 25 or 50 mg were investigated from nortriptyline plasma level assays at 12, 18, 24, 36, and 48 hours postdose." | 1.27 | Nortriptyline pharmacokinetic parameters in depressed children and adolescents: preliminary data. ( Abel, AS; Anker, JA; Chestnut, E; Cooper, TB; Geller, B, 1984) |
| "Riboflavin was added to the medication to check compliance." | 1.27 | Amitriptyline metabolism in relation to antidepressive effect. ( de Wolff, FA; Edelbroek, PM; Rooymans, HG; Schreuder, JN; Zitman, FG, 1984) |
| "In nortriptyline-treated patients (N = 10, excluding one outlier), PSOP was significantly correlated with percent change in Hamilton ratings (rho = -0." | 1.27 | Pretreatment systolic orthostatic blood pressure (PSOP) and treatment response in elderly depressed inpatients. ( Hoch, CC; Houck, PR; Kupfer, DJ; Perel, JM; Reynolds, CF; Stack, JA, 1988) |
| "The debrisoquine-test appears to be a useful clinical tool for detecting in patients a genetic deficiency in the hydroxylation of AT-type drugs." | 1.27 | Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. ( Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D, 1986) |
| " The absence of correlation between clinical improvement and pharmacokinetic parameters is discussed for its possible significance." | 1.27 | Amitriptyline pharmacokinetics and clinical response: I. Free and total plasma amitriptyline and nortriptyline. ( Baumann, P; Jonzier-Perey, M; Koeb, L; Lê, PK; Schöpf, J; Tinguely, D, 1986) |
| "after all-night sleep deprivation) showed a significant inverse correlation with the increase in slow wave sleep (SWS) minutes and in SWS % from baseline to first recovery night." | 1.27 | Sleep deprivation effects in older endogenous depressed patients. ( Berman, SR; Hoch, CC; Houck, PA; Kupfer, DJ; Reynolds, CF; Stack, JA, 1987) |
| " These preliminary data suggest that smokers ideally should be dosed at the lower end of the nortriptyline therapeutic range, whereas nonsmokers should be dosed at the upper end to maximize the antidepressant effect and minimize adverse effects." | 1.27 | Effects of smoking on nortriptyline plasma concentrations in depressed patients. ( Alexander, B; Browne, JL; Perry, PJ; Prince, RA; Tsuang, MT, 1986) |
| "Nortriptyline hydrochloride is an effective antidepressant that, in depressed patients without heart disease, causes significantly less orthostatic hypotension than imipramine." | 1.27 | Nortriptyline in depressed patients with left ventricular impairment. ( Bigger, JT; Giardina, EG; Glassman, AH; Johnson, LL; Roose, SP; Walsh, BT; Woodring, S, 1986) |
| "(The debrisoquine test was performed after stopping NT treatment)." | 1.27 | Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio. ( Benitez, J; Bertilsson, L; Nordin, C; Siwers, B, 1985) |
| " Pharmacokinetic data on benzodiazepines thus in particular are important for design of dose, dose intervals and prediction (warning) about possible accumulation after repeated doses." | 1.26 | The contribution of pharmacokinetics to the best use of benzodiazepines and antidepressants. ( Gram, LF, 1982) |
| "Nortriptyline treatment did not influence serum hormone levels." | 1.26 | Nortriptyline and pituitary-thyroid function in affective disorder. ( Nordgren, L; von Schéele, C, 1981) |
| " Evaluation of free, instead of total levels did not help to clarify the relationship between clinical and pharmacokinetic variables." | 1.26 | Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels. ( Breyer-Pfaff, U; Brinkschulte, M; Gaertner, HJ; Kreuter, F; Scharek, G; Wiatr, R, 1982) |
| "Nortriptyline kinetics were unaltered, but the elimination of the metabolites was reduced in both groups of patients." | 1.26 | Nortriptyline metabolism in chronic renal failure: metabolite elimination. ( Braithwaite, R; Dawling, S; Lynn, K; Rosser, R, 1982) |
| " These dosage regimes provided a mean observed steady-state nortriptyline concentration of 104 micrograms." | 1.26 | Nortriptyline therapy in elderly patients: dosage prediction from plasma concentration at 24 hours after a single 50 mg dose. ( Crome, P; Dawling, S; Heyer, EJ; Lewis, RR, 1981) |
| "Amitriptyline and nortriptyline plasma levels were measured in depressed outpatients 24 hours after a single dose of amitriptyline and following chronic dosing to steady state." | 1.26 | Prediction of steady-state plasma levels of amitriptyline and nortriptyline from a single dose 24 hr. level in depressed patients. ( Amsterdam, J; Brunswick, DJ; Mendels, J; Rothbart, M; Sandler, K; Schless, A, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 199 (44.42) | 18.7374 |
| 1990's | 154 (34.38) | 18.2507 |
| 2000's | 74 (16.52) | 29.6817 |
| 2010's | 20 (4.46) | 24.3611 |
| 2020's | 1 (0.22) | 2.80 |
| Authors | Studies |
|---|---|
| Puzhko, S | 1 |
| Aboushawareb, SAE | 1 |
| Kudrina, I | 1 |
| Schuster, T | 1 |
| Barnett, TA | 1 |
| Renoux, C | 1 |
| Bartlett, G | 1 |
| Pimontel, MA | 1 |
| Reinlieb, ME | 1 |
| Johnert, LC | 1 |
| Garcon, E | 1 |
| Sneed, JR | 2 |
| Roose, SP | 12 |
| Al Hadithy, AF | 1 |
| Birkenhager, TK | 1 |
| Koch, BC | 1 |
| Hefner, G | 1 |
| Geschke, K | 1 |
| Hiemke, C | 1 |
| Holanda, VA | 1 |
| Medeiros, IU | 1 |
| Asth, L | 1 |
| Guerrini, R | 1 |
| Calo', G | 1 |
| Gavioli, EC | 1 |
| Malki, K | 2 |
| Tosto, MG | 1 |
| Mouriño-Talín, H | 1 |
| Rodríguez-Lorenzo, S | 1 |
| Pain, O | 1 |
| Jumhaboy, I | 1 |
| Liu, T | 1 |
| Parpas, P | 1 |
| Newman, S | 1 |
| Malykh, A | 1 |
| Carboni, L | 3 |
| Uher, R | 12 |
| McGuffin, P | 12 |
| Schalkwyk, LC | 2 |
| Bryson, K | 1 |
| Herbster, M | 1 |
| van der Hagen, EAE | 1 |
| Smeekens, KCJ | 1 |
| van 't Veer, NE | 1 |
| Boonen, KJM | 1 |
| Ermens, AAM | 1 |
| Mulder, RT | 12 |
| Frampton, CM | 2 |
| Luty, SE | 10 |
| Joyce, PR | 12 |
| Menza, M | 2 |
| Dobkin, RD | 2 |
| Marin, H | 2 |
| Mark, MH | 2 |
| Gara, M | 2 |
| Buyske, S | 1 |
| Bienfait, K | 1 |
| Dicke, A | 2 |
| Petersén, A | 1 |
| Wörtwein, G | 1 |
| Gruber, SH | 1 |
| El-Khoury, A | 1 |
| Mathé, AA | 3 |
| Maier, W | 9 |
| Hauser, J | 9 |
| Marusic, A | 3 |
| Schmael, C | 1 |
| Mors, O | 11 |
| Henigsberg, N | 11 |
| Souery, D | 10 |
| Placentino, A | 11 |
| Rietschel, M | 10 |
| Zobel, A | 10 |
| Dmitrzak-Weglarz, M | 1 |
| Petrovic, A | 2 |
| Jorgensen, L | 2 |
| Kalember, P | 5 |
| Giovannini, C | 4 |
| Barreto, M | 3 |
| Elkin, A | 2 |
| Landau, S | 1 |
| Farmer, A | 10 |
| Aitchison, KJ | 10 |
| Huezo-Diaz, P | 2 |
| Perroud, N | 5 |
| Smith, R | 2 |
| Kozel, D | 3 |
| Dernovsek, MZ | 5 |
| Schulze, TG | 2 |
| Czerski, PM | 3 |
| Larsen, ER | 5 |
| Gray, JM | 2 |
| Lewis, CM | 3 |
| Craig, I | 3 |
| Gupta, B | 2 |
| Hoda, F | 1 |
| Strohmaier, J | 3 |
| Rajewska-Rager, A | 1 |
| Szczepankiewicz, A | 2 |
| Gunasinghe, C | 1 |
| Gray, J | 1 |
| Campbell, D | 1 |
| Farmer, AE | 1 |
| Muthén, B | 1 |
| Jaracz, J | 1 |
| Ng, MY | 2 |
| Zagar, T | 1 |
| Jerman, B | 2 |
| Cohen-Woods, S | 2 |
| Pirlo, K | 1 |
| Butler, AW | 1 |
| Muglia, P | 1 |
| Barnes, MR | 1 |
| Lathrop, M | 1 |
| Breen, G | 1 |
| Bienfait, KL | 1 |
| Tröster, A | 1 |
| Becchi, S | 1 |
| Piubelli, C | 2 |
| Mallei, A | 1 |
| Giambelli, R | 1 |
| Razzoli, M | 1 |
| Popoli, M | 1 |
| Domenici, E | 2 |
| Keers, R | 1 |
| Mendlewicz, J | 3 |
| Paya-Cano, J | 1 |
| Binder, E | 1 |
| Sluyter, F | 1 |
| Craig, IW | 1 |
| Gruber, S | 1 |
| El Khoury, A | 1 |
| Macaluso, M | 1 |
| Preskorn, SH | 7 |
| Mikami, K | 1 |
| Jorge, RE | 1 |
| Adams, HP | 1 |
| Davis, PH | 1 |
| Leira, EC | 1 |
| Jang, M | 1 |
| Robinson, RG | 9 |
| Himmerich, H | 1 |
| Fulda, S | 1 |
| Sheldrick, AJ | 1 |
| Plümäkers, B | 1 |
| Rink, L | 1 |
| Hidalgo, MP | 1 |
| Caumo, W | 1 |
| Dantas, G | 1 |
| Franco, DG | 1 |
| Torres, IL | 1 |
| Pezzi, J | 1 |
| Elisabetsky, E | 1 |
| Detanico, BC | 1 |
| Piato, Â | 1 |
| Markus, RP | 1 |
| Culang-Reinlieb, ME | 1 |
| Keilp, JG | 1 |
| Perlis, RH | 1 |
| Jain, V | 1 |
| Swartz, CM | 2 |
| Solai, LK | 2 |
| Pollock, BG | 26 |
| Mulsant, BH | 16 |
| Frye, RF | 1 |
| Miller, MD | 19 |
| Sweet, RA | 5 |
| Kirshner, M | 1 |
| Sorisio, D | 1 |
| Begley, A | 3 |
| Reynolds, CF | 47 |
| Van Der Kuy, PH | 1 |
| Van Den Heuvel, HA | 1 |
| Kempen, RW | 1 |
| Vanmolkot, LM | 1 |
| Nierenberg, AA | 4 |
| Papakostas, GI | 3 |
| Petersen, T | 2 |
| Kelly, KE | 1 |
| Iacoviello, BM | 1 |
| Worthington, JJ | 2 |
| Tedlow, J | 1 |
| Alpert, JE | 3 |
| Fava, M | 3 |
| Rausch, JL | 2 |
| Moeller, FG | 1 |
| Johnson, ME | 1 |
| Scalco, MZ | 1 |
| Serro-Azul, JB | 1 |
| Giorgi, D | 1 |
| Almeida, OP | 1 |
| Wajngarten, M | 1 |
| Szanto, K | 1 |
| Houck, P | 2 |
| Dew, MA | 15 |
| McKenzie, JM | 4 |
| Rae, AM | 1 |
| Portella, MJ | 1 |
| Marcos, T | 2 |
| Rami, L | 1 |
| Navarro, V | 2 |
| Gastó, C | 2 |
| Salamero, M | 1 |
| Pava, J | 1 |
| Masson, E | 1 |
| Frampton, C | 1 |
| Watkins, WG | 1 |
| BENNETT, IF | 1 |
| CHESROW, EJ | 1 |
| KAPLITZ, SE | 1 |
| BREME, JT | 1 |
| SABATINI, R | 1 |
| VETRA, H | 1 |
| MARQUARDT, GH | 1 |
| LEAHY, MR | 1 |
| ROSE, JT | 1 |
| PELZMAN, O | 1 |
| KAST, EC | 1 |
| RAVN, J | 1 |
| KLINE, NS | 1 |
| SCHACTER, F | 1 |
| HORDERN, A | 1 |
| POLLITT, J | 1 |
| GUILMOT, P | 1 |
| RUCQUOY, G | 1 |
| HOVE, H | 1 |
| Lenze, EJ | 2 |
| Shear, MK | 5 |
| Akhondzadeh, S | 1 |
| Faraji, H | 1 |
| Sadeghi, M | 1 |
| Afkham, K | 1 |
| Fakhrzadeh, H | 1 |
| Kamalipour, A | 1 |
| Petersen, TJ | 1 |
| Farabaugh, AH | 1 |
| Murakami, JL | 1 |
| Pava, JA | 1 |
| Doraiswamy, PM | 2 |
| Krishnan, KR | 3 |
| Oxman, T | 1 |
| Jenkyn, LR | 1 |
| Coffey, DJ | 1 |
| Burt, T | 1 |
| Clary, CM | 4 |
| Pizzagalli, DA | 1 |
| Oakes, TR | 2 |
| Fox, AS | 1 |
| Chung, MK | 1 |
| Larson, CL | 2 |
| Abercrombie, HC | 2 |
| Schaefer, SM | 2 |
| Benca, RM | 2 |
| Davidson, RJ | 2 |
| Gendall, KA | 1 |
| Hackett, M | 1 |
| Anderson, C | 1 |
| House, A | 1 |
| Cloninger, CR | 1 |
| Dean, CE | 1 |
| Steimer, W | 1 |
| Zöpf, K | 1 |
| von Amelunxen, S | 1 |
| Pfeiffer, H | 1 |
| Bachofer, J | 1 |
| Popp, J | 1 |
| Messner, B | 1 |
| Kissling, W | 1 |
| Leucht, S | 1 |
| Rosenlicht, NZ | 1 |
| Riley-Lazo, KP | 1 |
| Kellner, CH | 2 |
| Fink, M | 3 |
| Knapp, R | 1 |
| Petrides, G | 2 |
| Husain, M | 1 |
| Rummans, T | 1 |
| Mueller, M | 2 |
| Bernstein, H | 1 |
| Rasmussen, K | 1 |
| O'connor, K | 1 |
| Smith, G | 1 |
| Rush, AJ | 3 |
| Biggs, M | 2 |
| McClintock, S | 1 |
| Bailine, S | 1 |
| Malur, C | 1 |
| Kurpius, MP | 1 |
| Alexander, B | 4 |
| Kok, R | 1 |
| Nolen, W | 1 |
| Heeren, T | 1 |
| Fiedorowicz, JG | 1 |
| Takezawa, K | 1 |
| Starkstein, SE | 2 |
| Mizrahi, R | 1 |
| Power, BD | 1 |
| Burch, JE | 2 |
| Hullin, RP | 1 |
| Gram, LF | 5 |
| Lipsey, JR | 3 |
| Pearlson, GD | 2 |
| Rao, K | 1 |
| Price, TR | 2 |
| Kuss, HJ | 1 |
| Jungkunz, G | 1 |
| Holsboer, F | 1 |
| Extein, I | 1 |
| Gold, MS | 2 |
| Pottash, AL | 1 |
| Hollister, LE | 2 |
| Davis, KL | 1 |
| Berger, PA | 1 |
| Berken, GH | 1 |
| Weinstein, DO | 1 |
| Stern, WC | 1 |
| Sjöqvist, F | 3 |
| Bertilsson, L | 10 |
| Kragh-Sørensen, P | 6 |
| Kristensen, CB | 2 |
| Møller, M | 2 |
| Pedersen, OL | 3 |
| Thayssen, P | 2 |
| Dixon, R | 1 |
| Cohen, J | 1 |
| White, K | 1 |
| Razani, J | 1 |
| Cadow, B | 1 |
| Gelfand, R | 1 |
| Palmer, R | 2 |
| Simpson, G | 1 |
| Sloane, RB | 6 |
| Kirstein, L | 1 |
| Othmer, SC | 1 |
| Lai, CW | 1 |
| Othmer, E | 1 |
| Cutler, NR | 1 |
| Narang, PK | 1 |
| Madakasira, S | 4 |
| Khazanie, PG | 1 |
| Sato, TL | 1 |
| Coryell, W | 2 |
| Ziegler, VE | 1 |
| Biggs, JT | 3 |
| Young, RC | 11 |
| Alexopoulos, GS | 11 |
| Manley, MW | 2 |
| Shamoian, CA | 5 |
| Dhar, AK | 9 |
| Kutt, H | 8 |
| Neppe, VM | 1 |
| Cooke, RG | 1 |
| Warsh, JJ | 1 |
| Stancer, HC | 1 |
| Reed, KL | 1 |
| Persad, E | 1 |
| Clothier, J | 1 |
| Reed, K | 2 |
| Geller, B | 13 |
| Cooper, TB | 25 |
| Chestnut, E | 1 |
| Abel, AS | 2 |
| Anker, JA | 3 |
| Browne, JL | 4 |
| Perry, PJ | 6 |
| Taylor, JW | 1 |
| Sieleni, BA | 1 |
| Kronfol, Z | 1 |
| Rowan, PR | 1 |
| Paykel, ES | 1 |
| Marks, V | 1 |
| Mould, G | 1 |
| Bhat, A | 1 |
| Ansseau, M | 3 |
| Kupfer, DJ | 30 |
| McEachran, AB | 1 |
| Yufu, N | 1 |
| Itoh, M | 1 |
| Notomi, A | 1 |
| Nakao, H | 1 |
| Lerro, FA | 1 |
| Folks, DG | 1 |
| Alexander, AI | 1 |
| Rabin, PL | 1 |
| Mattes, JA | 1 |
| Sherman, AD | 2 |
| Tsuang, MT | 3 |
| Dunner, FJ | 2 |
| Pfohl, BM | 2 |
| Miller, DD | 1 |
| Sawyer, JB | 1 |
| Duffy, JP | 1 |
| Valle-Jones, JC | 2 |
| Craven, JR | 1 |
| Wallis, TD | 1 |
| Schiff, AA | 2 |
| Murphy, GE | 3 |
| Simons, AD | 3 |
| Wetzel, RD | 2 |
| Lustman, PJ | 2 |
| Garfield, SL | 1 |
| Edelbroek, PM | 1 |
| Zitman, FG | 1 |
| Schreuder, JN | 1 |
| Rooymans, HG | 1 |
| de Wolff, FA | 1 |
| Patterson, JF | 1 |
| Georgotas, A | 14 |
| Stokes, PE | 2 |
| Krakowski, M | 1 |
| Fanelli, C | 1 |
| Cooper, T | 4 |
| Click, MA | 1 |
| Zisook, S | 1 |
| Pöldinger, W | 1 |
| Streichenwein, SM | 1 |
| Hoc, J | 1 |
| Pottash, AC | 1 |
| Nordgren, L | 1 |
| von Schéele, C | 1 |
| Bialos, D | 2 |
| Giller, E | 2 |
| Jatlow, P | 2 |
| Docherty, J | 1 |
| Harkness, L | 2 |
| Bjerre, M | 3 |
| Brixen-Rasmussen, L | 1 |
| Halgrener, J | 1 |
| Jørgensen, A | 1 |
| Gaertner, HJ | 4 |
| Kreuter, F | 2 |
| Scharek, G | 2 |
| Wiatr, G | 1 |
| Breyer-Pfaff, U | 4 |
| Brinkschulte, M | 1 |
| Wiatr, R | 1 |
| Lehmann, LS | 1 |
| Bowden, CL | 3 |
| Redmond, FC | 1 |
| Stanton, BC | 1 |
| Overø, KF | 1 |
| Asnis, GM | 1 |
| Halbreich, U | 1 |
| Nathan, RS | 1 |
| Ostrow, L | 1 |
| Novacenko, H | 1 |
| Endicott, J | 2 |
| Sachar, EJ | 1 |
| Adler, L | 1 |
| Angrist, B | 1 |
| Lautin, A | 1 |
| Rotrosen, J | 1 |
| Sabelli, HC | 1 |
| Fawcett, J | 1 |
| Javaid, JI | 1 |
| Bagri, S | 1 |
| Hyde, C | 1 |
| Goldberg, D | 1 |
| Gillin, JC | 1 |
| Coble, PA | 4 |
| Spiker, DG | 6 |
| Shaw, D | 2 |
| Holzer, B | 1 |
| Giedke, H | 3 |
| Fraser, A | 1 |
| Paramananthan, T | 1 |
| Shaw, H | 1 |
| Gibb, I | 1 |
| Johnson, DA | 1 |
| Razavi, D | 1 |
| Nasrallah, HA | 1 |
| Lyskowksi, J | 1 |
| Schroeder, D | 1 |
| Weller, R | 1 |
| Pardo, M | 1 |
| Coppen, A | 1 |
| Zeigler, VE | 1 |
| Rossi, A | 1 |
| Ulrich, R | 1 |
| Dawling, S | 3 |
| Lynn, K | 1 |
| Rosser, R | 1 |
| Braithwaite, R | 1 |
| Linnoila, M | 2 |
| George, L | 2 |
| Guthrie, S | 2 |
| Baumann, P | 7 |
| Tinguely, D | 5 |
| Koeb, L | 5 |
| Schöpf, J | 5 |
| Le, PK | 2 |
| Thomson, J | 1 |
| Rankin, H | 1 |
| Ashcroft, GW | 1 |
| Yates, CM | 1 |
| McQueen, JK | 1 |
| Cummings, SW | 1 |
| Glassman, AH | 8 |
| Walsh, BT | 3 |
| Cullen, K | 1 |
| Friedel, RO | 2 |
| Narasimhachari, N | 1 |
| Saady, JJ | 1 |
| Joseph, A | 1 |
| Ettigi, P | 1 |
| Leventhal, B | 1 |
| Corona, GL | 3 |
| Zerbi, F | 3 |
| Pinelli, P | 1 |
| Fenoglio, L | 2 |
| Frattini, P | 3 |
| Cucchi, ML | 3 |
| Santagostino, G | 3 |
| Staton, RD | 1 |
| Wilson, H | 1 |
| Brumback, RA | 1 |
| Meltzer, HY | 2 |
| Arora, RC | 1 |
| Baber, R | 1 |
| Tricou, BJ | 1 |
| Náhunek, K | 1 |
| Svestka, J | 1 |
| Cesková, E | 1 |
| Rysánek, R | 1 |
| Novotná, H | 1 |
| Crome, P | 1 |
| Heyer, EJ | 1 |
| Lewis, RR | 1 |
| Edwards, D | 1 |
| Hanin, I | 4 |
| Neil, JF | 1 |
| Brunswick, DJ | 1 |
| Amsterdam, J | 1 |
| Schless, A | 1 |
| Rothbart, M | 1 |
| Sandler, K | 1 |
| Mendels, J | 1 |
| Thorén, P | 1 |
| Asberg, M | 2 |
| Cronholm, B | 1 |
| Jörnestedt, L | 1 |
| Träskman, L | 1 |
| Maskall, DD | 1 |
| Lam, RW | 1 |
| Schmider, J | 2 |
| Deuschle, M | 2 |
| Schweiger, U | 1 |
| Körner, A | 1 |
| Gotthardt, U | 1 |
| Heuser, IJ | 1 |
| Powell, BJ | 1 |
| Campbell, JL | 1 |
| Landon, JF | 1 |
| Liskow, BI | 1 |
| Thomas, HM | 1 |
| Nickel, EJ | 1 |
| Dale, TM | 1 |
| Penick, EC | 1 |
| Samuelson, SD | 1 |
| Lacoursiere, RB | 1 |
| Apter, JT | 1 |
| Kushner, SF | 1 |
| Woolfolk, RL | 1 |
| Nair, NP | 4 |
| Amin, M | 3 |
| Holm, P | 3 |
| Katona, C | 3 |
| Klitgaard, N | 3 |
| Ng Ying Kin, NM | 1 |
| Kühn, H | 1 |
| Leek, CA | 1 |
| Stage, KB | 2 |
| el-Yazigi, A | 1 |
| Chaleby, K | 1 |
| Gad, A | 1 |
| Raines, DA | 1 |
| Altshuler, LL | 1 |
| Burt, VK | 1 |
| McMullen, M | 1 |
| Hendrick, V | 1 |
| Stack, JA | 9 |
| Paradis, CF | 3 |
| Houck, PR | 24 |
| Frank, E | 19 |
| Anderson, B | 1 |
| Mayo, AL | 1 |
| Rifai, AH | 5 |
| Perel, JM | 21 |
| Kiev, A | 1 |
| Masco, HL | 1 |
| Wenger, TL | 1 |
| Johnston, JA | 1 |
| Batey, SR | 1 |
| Holloman, LC | 1 |
| Flint, AJ | 8 |
| Rifat, SL | 7 |
| Schulberg, HC | 8 |
| Block, MR | 4 |
| Madonia, MJ | 5 |
| Rodriguez, E | 3 |
| Scott, CP | 2 |
| Lave, J | 2 |
| Wisner, KL | 2 |
| Wheeler, SB | 1 |
| Monteleone, P | 1 |
| Fabrazzo, M | 1 |
| Sullivan, M | 3 |
| Katon, W | 2 |
| Russo, J | 5 |
| Dobie, R | 3 |
| Sakai, C | 3 |
| George, CJ | 5 |
| Mann, JJ | 1 |
| Zeilmann, C | 1 |
| Arndt, S | 2 |
| Attia, E | 2 |
| Woodring, S | 4 |
| Cornes, C | 11 |
| Mazumdar, S | 26 |
| Fox, LW | 2 |
| Clark, KA | 1 |
| Nelson, JC | 4 |
| Rosen, J | 6 |
| Altieri, LP | 1 |
| Jonas, EA | 1 |
| Stahl, SM | 1 |
| Hauger, RL | 1 |
| Fleishaker, JC | 1 |
| Hubbell-Alberts, E | 1 |
| Coutts, RT | 1 |
| Lazarus, LW | 1 |
| Moberg, PJ | 1 |
| Langsley, PR | 1 |
| Lingam, VR | 1 |
| Feldman, MD | 1 |
| Sweet, R | 1 |
| Ivan, TM | 1 |
| Franco, K | 2 |
| Diehl, DJ | 1 |
| Paradis, C | 2 |
| Miller, M | 3 |
| Davis, JM | 1 |
| Shelton, RC | 1 |
| Loosen, PT | 1 |
| Dobie, RA | 3 |
| Sakai, CS | 3 |
| Sullivan, MD | 3 |
| Katon, WJ | 4 |
| Wilens, TE | 1 |
| Biederman, J | 1 |
| Spencer, T | 1 |
| Geist, DE | 1 |
| Warner, MD | 1 |
| Griffin, M | 1 |
| Peabody, CA | 1 |
| Lee, JH | 1 |
| Hoch, CC | 8 |
| Buysse, DJ | 6 |
| Greenberg, HE | 1 |
| Scharf, SM | 1 |
| Green, H | 1 |
| Terao, T | 1 |
| Hambrecht, M | 1 |
| Jerling, M | 1 |
| Kin, NM | 2 |
| Kragh-Sorensen, P | 2 |
| Schwariz, G | 1 |
| Ahmed, SK | 2 |
| Stage, K | 2 |
| Brown, C | 3 |
| Schulz, R | 1 |
| Laghrissi-Thode, F | 4 |
| Miller, MC | 1 |
| Altieri, L | 1 |
| Finkel, MS | 2 |
| Imber, SD | 4 |
| Perel, J | 1 |
| Coulehan, JL | 2 |
| Hall, M | 3 |
| Mulsant, B | 2 |
| Maes, M | 1 |
| De Meester, I | 1 |
| Scharpe, S | 1 |
| Desnyder, R | 1 |
| Ranjan, R | 1 |
| Suzuki, T | 1 |
| Kurita, H | 1 |
| Hori, T | 1 |
| Sasaki, M | 1 |
| Baba, A | 1 |
| Shiraishi, H | 1 |
| Piletz, JE | 1 |
| Bech, P | 1 |
| Larsen, JK | 1 |
| Gjerris, A | 1 |
| Griffith, LS | 1 |
| Freedland, KE | 1 |
| Clouse, RE | 1 |
| Rollman, BL | 1 |
| Pasternak, RE | 3 |
| Prigerson, H | 1 |
| Fasiczka, A | 1 |
| Byrne, S | 1 |
| Rothschild, AJ | 1 |
| Wamboldt, MZ | 2 |
| Yancey, AG | 1 |
| Roesler, TA | 1 |
| Foglia, JP | 1 |
| Lo, KH | 1 |
| Benazzi, F | 1 |
| Schwartz, G | 1 |
| Song, WY | 1 |
| West, TE | 1 |
| Begley, AE | 7 |
| Yu, K | 1 |
| Brunner, DP | 1 |
| Kennedy, JS | 2 |
| Bigger, JT | 4 |
| Gaffney, A | 1 |
| Narayan, M | 2 |
| McCafferty, J | 2 |
| Gergel, I | 2 |
| Curtiss, EI | 1 |
| Marino, L | 1 |
| Foglia, J | 1 |
| Weber, B | 1 |
| Standhardt, H | 1 |
| Lammers, CH | 1 |
| Hartmann, A | 1 |
| Heuser, I | 1 |
| Giardina, EG | 3 |
| Zygmont, M | 1 |
| Prigerson, HG | 1 |
| Jacobs, S | 1 |
| Lave, JR | 1 |
| Frank, RG | 1 |
| Kamlet, MS | 1 |
| Little, JT | 2 |
| Nebes, R | 1 |
| Kirshner, MA | 3 |
| Lecrubier, Y | 1 |
| Hall, SM | 2 |
| Reus, VI | 2 |
| Muñoz, RF | 2 |
| Sees, KL | 1 |
| Humfleet, G | 1 |
| Hartz, DT | 2 |
| Frederick, S | 1 |
| Triffleman, E | 1 |
| Suthers, KM | 1 |
| Guadagno, G | 1 |
| Finkel, SI | 1 |
| Richter, EM | 2 |
| Nobler, MS | 2 |
| Robin, DW | 1 |
| Roose, S | 1 |
| Green, TD | 1 |
| Nebes, RD | 2 |
| Stack, J | 1 |
| Bensasi, S | 1 |
| Walters, G | 1 |
| Spatz, E | 1 |
| Desai, A | 1 |
| Chibnall, JT | 1 |
| Schultz, SK | 1 |
| Castillo, C | 1 |
| Kopel, T | 1 |
| Kosier, JT | 3 |
| Newman, RM | 1 |
| Curdue, K | 1 |
| Petracca, G | 1 |
| Tsoh, JY | 1 |
| Humfleet, GL | 1 |
| Meyers, BS | 3 |
| Kalayam, B | 1 |
| Kakuma, T | 2 |
| Gabrielle, M | 1 |
| Sirey, JA | 1 |
| Hull, J | 1 |
| Wagner, WR | 1 |
| Bondareff, W | 1 |
| Alpert, M | 1 |
| Friedhoff, AJ | 2 |
| Batzar, E | 1 |
| Oslin, DW | 2 |
| Streim, JE | 2 |
| Katz, IR | 4 |
| Smith, BD | 2 |
| DiFilippo, SD | 1 |
| Ten Have, TR | 1 |
| DiFilippo, S | 1 |
| Ten Have, T | 1 |
| Taylor, MA | 1 |
| Schelde, JT | 1 |
| Ferrell, RE | 1 |
| Davis, S | 1 |
| Prohovnik, I | 1 |
| Moeller, JR | 1 |
| Louie, J | 1 |
| Van Heertum, RL | 1 |
| Sackeim, HA | 1 |
| Butters, MA | 1 |
| Becker, JT | 1 |
| Zmuda, MD | 1 |
| Hinds, NP | 1 |
| Hillier, CE | 1 |
| Wiles, CM | 1 |
| Zimerman, B | 1 |
| Williams, M | 1 |
| Bolhofner, K | 1 |
| Craney, JL | 1 |
| Pizzagalli, D | 1 |
| Pascual-Marqui, RD | 1 |
| Nitschke, JB | 1 |
| Koger, JV | 1 |
| Malhotra, S | 1 |
| Torres, X | 1 |
| Pintor, L | 1 |
| Pomara, N | 1 |
| Shao, B | 1 |
| Choi, SJ | 1 |
| Tun, H | 1 |
| Suckow, RF | 4 |
| Wagena, EJ | 1 |
| Huibers, MJ | 1 |
| van Schayck, CP | 1 |
| Chemerinski, E | 1 |
| Zubenko, GS | 1 |
| Flynn, T | 1 |
| Murphy, GM | 1 |
| Pascoe, N | 1 |
| Cheuk, W | 1 |
| Husain, MM | 1 |
| Knapp, RG | 1 |
| Rummans, TA | 1 |
| O'Connor, KM | 1 |
| Rasmussen, KG | 1 |
| Bernstein, HJ | 1 |
| Bailine, SH | 1 |
| Johne, A | 1 |
| Brockmöller, J | 1 |
| Stadelmann, AM | 1 |
| Störmer, E | 1 |
| Bauer, S | 1 |
| Scholler, G | 1 |
| Langheinrich, M | 1 |
| Roots, I | 1 |
| Oakley, F | 1 |
| Khin, NA | 1 |
| Parks, R | 1 |
| Bauer, L | 1 |
| Sunderland, T | 1 |
| Narushima, K | 1 |
| Sullivan, PF | 3 |
| Abbott, RM | 2 |
| Stevens, IF | 2 |
| Roberts, RL | 1 |
| Begg, EJ | 1 |
| Kennedy, MA | 1 |
| Gildengers, AG | 1 |
| Levine, RR | 1 |
| Sinclair, JM | 1 |
| Walsh, MR | 1 |
| Seth, R | 1 |
| Jennings, AL | 1 |
| Bindman, J | 1 |
| Phillips, J | 1 |
| Bergmann, K | 1 |
| Finelli, PF | 1 |
| Morycz, RK | 2 |
| Fadden, JS | 1 |
| Zhang, X | 1 |
| Burke, M | 1 |
| Kuhs, H | 1 |
| Schlake, HP | 1 |
| Rolf, LH | 1 |
| Rudolf, GA | 1 |
| Graham, DL | 2 |
| Fetner, HH | 1 |
| Marsteller, FA | 2 |
| Wells, JM | 1 |
| Borson, S | 1 |
| McDonald, GJ | 1 |
| Gayle, T | 1 |
| Deffebach, M | 1 |
| Lakshminarayan, S | 1 |
| VanTuinen, C | 1 |
| Bell, IR | 1 |
| Edman, JS | 1 |
| Morrow, FD | 1 |
| Marby, DW | 1 |
| Perrone, G | 1 |
| Kayne, HL | 1 |
| Greenwald, M | 1 |
| Cole, JO | 1 |
| Kanba, S | 1 |
| Matsumoto, K | 1 |
| Nibuya, M | 1 |
| Suzuki, E | 1 |
| Kinoshita, N | 1 |
| Shintani, F | 1 |
| Yagi, G | 1 |
| Badalamenti, A | 1 |
| Langs, R | 1 |
| Daamen, MJ | 1 |
| Brown, WA | 1 |
| Garrity, K | 1 |
| Chekalina, ND | 1 |
| Carra, J | 1 |
| Musgrave, J | 1 |
| Rabinowitz, J | 1 |
| Johnson, D | 1 |
| Mattis, S | 2 |
| Shindledecker, RD | 2 |
| Gabriele, M | 1 |
| Scott, AI | 1 |
| Weeks, DJ | 1 |
| McDonald, CF | 1 |
| Giesler, J | 1 |
| Reeve, E | 1 |
| Borchardt, CM | 1 |
| Otani, K | 3 |
| Dahl, ML | 2 |
| Nordin, C | 7 |
| Aberg-Wistedt, A | 4 |
| Signer, SF | 1 |
| Bebchuk, JM | 1 |
| Stewart, DE | 1 |
| Zimmer, B | 2 |
| Thornton, JE | 1 |
| Dalack, GW | 1 |
| Extein, IL | 1 |
| Rifai, H | 1 |
| Katz, MM | 1 |
| Koslow, SH | 2 |
| Maas, JW | 1 |
| Frazer, A | 2 |
| Kocsis, J | 1 |
| Secunda, S | 1 |
| Casper, RC | 1 |
| Storch, DD | 1 |
| Crompton, DR | 1 |
| Pegg, SP | 1 |
| Jellett, LB | 1 |
| Middleton, W | 1 |
| Shapiro, PA | 1 |
| Peabody, C | 1 |
| Van Norman, J | 1 |
| Hollister, L | 1 |
| Warner, D | 1 |
| Kay, J | 1 |
| Bienenfeld, D | 1 |
| Slomowitz, M | 1 |
| Burk, J | 1 |
| Zimmer, L | 1 |
| Nadolny, G | 1 |
| Marvel, NT | 1 |
| Geier, P | 1 |
| Fabre, LF | 1 |
| Scharf, MB | 1 |
| Itil, TM | 1 |
| Resul, B | 1 |
| Toresson, G | 1 |
| Schlernitzauer, M | 1 |
| Roca, RP | 1 |
| Blackman, MR | 1 |
| Ackerley, MB | 1 |
| Harman, SM | 1 |
| Gregerman, RI | 1 |
| Michals, M | 1 |
| Stanley, DA | 1 |
| Crismon, ML | 1 |
| Barrow, NE | 1 |
| Russ, MJ | 1 |
| Ackerman, SH | 1 |
| Banay-Schwartz, M | 1 |
| Smith, GP | 1 |
| Morris, PL | 1 |
| Fedoroff, JP | 1 |
| Simpson, GM | 1 |
| Curlik, SM | 1 |
| Parmelee, PA | 1 |
| Muhly, C | 1 |
| Bryant, DM | 1 |
| Schneider, LS | 5 |
| Lyness, SA | 1 |
| Haugen, C | 1 |
| Kahn, DG | 1 |
| Dietch, JT | 1 |
| Fine, M | 1 |
| Schinelli, S | 2 |
| Savoldi, F | 2 |
| Sirota, P | 1 |
| Ori, J | 1 |
| Schild, K | 1 |
| Appel, S | 1 |
| Brandis, S | 1 |
| Zahavi, I | 1 |
| Hoff, AL | 1 |
| Shukla, S | 1 |
| Helms, P | 1 |
| Aronson, TA | 1 |
| Logue, C | 1 |
| Ollo, C | 1 |
| Cook, B | 1 |
| von Ammon Cavanaugh, S | 1 |
| Bowers, WA | 1 |
| Austin, LS | 1 |
| Arana, GW | 1 |
| Ballenger, JC | 1 |
| Siwers, B | 2 |
| Hullett, FJ | 1 |
| Potkin, SG | 1 |
| Levy, AB | 1 |
| Ciasca, R | 1 |
| McCue, RE | 13 |
| Reisberg, B | 1 |
| Ferris, SH | 1 |
| Nagachandran, N | 4 |
| Chang, I | 4 |
| Mir, P | 2 |
| Imber, S | 2 |
| Thornton, J | 1 |
| Figiel, GS | 1 |
| Breitner, JC | 1 |
| Nemeroff, CB | 1 |
| Schraml, F | 1 |
| Benedetti, G | 1 |
| Hoyle, K | 1 |
| Clayton, A | 1 |
| Harrison, WM | 1 |
| Nee, J | 1 |
| Small, GW | 1 |
| Friedhoff, A | 1 |
| McCombs, HG | 1 |
| Graham, D | 1 |
| Wells, J | 1 |
| Dahl-Puustinen, ML | 1 |
| Seibyl, JP | 1 |
| Krystal, JH | 1 |
| Price, LH | 1 |
| Charney, DS | 1 |
| Nill, K | 1 |
| Abdul Basir, M | 1 |
| Go, EA | 1 |
| Forster, HS | 1 |
| Brøsen, K | 1 |
| Christensen, P | 1 |
| Wägner, A | 1 |
| Mårtensson, B | 1 |
| Montero, D | 1 |
| Cain, HI | 1 |
| Frances, A | 1 |
| Flaherty, JA | 1 |
| Møller, SE | 1 |
| Odum, K | 1 |
| Kirk, L | 1 |
| Fog-Møller, F | 1 |
| Knudsen, A | 1 |
| Shipley, JA | 1 |
| Pollock, B | 1 |
| Fernstrom, MH | 1 |
| Schweitzer, J | 1 |
| Armour, M | 1 |
| Severson, JA | 2 |
| Zemplenyi, T | 1 |
| Weissenburger, J | 1 |
| Vasavada, N | 1 |
| Orsulak, PJ | 1 |
| Fairchild, CJ | 1 |
| Hartling, OJ | 1 |
| Marving, J | 1 |
| Knudsen, P | 1 |
| Dahl, A | 1 |
| Høilund-Carlsen, PF | 1 |
| Hartling, L | 1 |
| Vandel, S | 1 |
| Bertschy, G | 1 |
| Jounet, JM | 1 |
| Allers, G | 1 |
| Kocsis, JH | 1 |
| Brunswick, D | 1 |
| Carl, J | 1 |
| Robins, E | 1 |
| Liu, P | 1 |
| Shindledecker, R | 1 |
| Curlik, S | 1 |
| Lesher, EL | 1 |
| Welkowitz, J | 2 |
| Friedman, E | 5 |
| Lidén, A | 1 |
| Spina, E | 1 |
| Harvey, NS | 1 |
| Dealy, RS | 2 |
| Weiss, JC | 2 |
| Ananth, J | 1 |
| Chestnut, EC | 5 |
| Schluchter, MD | 1 |
| Jonzier-Perey, M | 4 |
| Küpfer, A | 1 |
| Kumar, V | 1 |
| Smith, RC | 1 |
| Leelavathi, DE | 1 |
| Comincioli, V | 1 |
| Houck, PA | 1 |
| Berman, SR | 1 |
| Carr, LG | 1 |
| Warham, JE | 1 |
| Rodriguez, A | 1 |
| True, BL | 1 |
| Burns, EA | 1 |
| Staples, FR | 2 |
| Heimann, H | 1 |
| Rein, W | 1 |
| Roy, D | 1 |
| Bender, M | 1 |
| Prince, RA | 1 |
| Hapworth, W | 1 |
| Kim, OM | 1 |
| Johnson, LL | 1 |
| Garaj, V | 1 |
| Frank, V | 1 |
| Drímalová, M | 1 |
| Móric, R | 1 |
| Pullmann, R | 1 |
| Griffin, SJ | 1 |
| Soloff, PH | 1 |
| Dubovsky, SL | 1 |
| Fredrickson, ER | 1 |
| Berman, CW | 1 |
| McGrath, PJ | 1 |
| Stewart, JW | 1 |
| Waldo, M | 1 |
| Lydiard, RB | 1 |
| Rubin, EH | 1 |
| Levine, JL | 1 |
| Chisholm, DD | 1 |
| Kalin, NH | 1 |
| Weiler, SJ | 1 |
| Farooki, ZQ | 2 |
| Conti, M | 1 |
| Robinson, DS | 1 |
| Howard, D | 1 |
| Corcella, J | 1 |
| Albright, D | 1 |
| Hrdina, PD | 1 |
| Lapierre, YD | 1 |
| Koranyi, EK | 1 |
| Price, DT | 1 |
| Yates, E | 1 |
| Mac, DS | 1 |
| Kent, E | 1 |
| Benitez, J | 1 |
| Schnyder, C | 1 |
| Wertheimer, J | 1 |
| Pylko, T | 1 |
| Sicignan, J | 1 |
| Jonzier, M | 1 |
| Gustafsson, LL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Depression in Patients With Parkinson's Disease[NCT00062738] | Phase 2 | 52 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Study of Antidepressants in Parkinson's Disease[NCT00086190] | Phase 3 | 115 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens: SPHERE[NCT02625155] | Phase 4 | 14,000 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | ||
| Sequenced Treatment Alternatives to Relieve Depression[NCT00021528] | Phase 4 | 4,000 participants | Interventional | 2001-07-31 | Completed | ||
| Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939] | 15 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | |||
| Measurement of GABA and Neurosteroid Levels in Women With Menopausal Major Depression Before and After Treatment With Estrogen Alone, Fluoxetine Alone, or Estrogen and Fluoxetine and Normal Controls Before and After Treatment With Estrogen[NCT00626340] | Phase 4 | 18 participants (Actual) | Interventional | 1999-07-31 | Completed | ||
| A Prospective Study of Pregnant and Postpartum Women With and Without Mood Disorders[NCT03615794] | 400 participants (Anticipated) | Observational | 2017-10-01 | Recruiting | |||
| [NCT00005461] | 0 participants | Observational | 1991-04-30 | Completed | |||
| Randomized Trial of KEEP-P, a Preventive Intervention for Foster Preschoolers[NCT03106636] | 442 participants (Actual) | Interventional | 2014-05-20 | Completed | |||
| Adapting Marital Therapy in Older Adults With Depression[NCT00612807] | Phase 1/Phase 2 | 42 participants (Actual) | Interventional | 2006-07-31 | Completed | ||
| Coping After Loss Through Mindfulness Training in Grieving Adults With Prolonged Grief Disorder - A Neuroimaging Pilot Study[NCT06017765] | 30 participants (Anticipated) | Interventional | 2023-08-30 | Enrolling by invitation | |||
| Maintenance Therapies in Late-Life Depression[NCT00000377] | 0 participants | Interventional | 1989-03-31 | Completed | |||
| Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction[NCT02386475] | Phase 4 | 39 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Pathways Linking Late-Life Depression to MCI & Dementia[NCT00178087] | 331 participants (Actual) | Observational | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
total score on HDRS (0-54 higher score is worse) (NCT00062738)
Timeframe: 8 weeks
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Nortriptyline | 10.84 |
| Paroxetine | 12.45 |
| Placebo | 15.81 |
Percent of patients who had a 50% decrease in total HDRS at 8 weeks (NCT00062738)
Timeframe: 8 weeks
| Intervention | percent of patients who were responders (Number) |
|---|---|
| Nortriptyline | 53 |
| Paroxetine | 11 |
| Placebo | 24 |
Beck Depression Inventory II ranges from 0-63. Higher score indicates more severe depression. 0-13 minimal depression, 14-19 mild depression, 20-28 moderate depression, 29-63 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in BDI-II score (Mean) |
|---|---|
| Paroxetine | -9.7 |
| Venlafaxine Extended Release | -9.6 |
| Placebo | -5.2 |
Brief Psychiatric Rating Scale. Maximum score 126. Higher score indicates greater psychiatric difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in BPRS score (Mean) |
|---|---|
| Paroxetine | -9.0 |
| Venlafaxine Extended Release | -9.8 |
| Placebo | -4.4 |
Geriatric Depression Scale ranges from 0-30. Higher score indicates more severe depression. 0-9 normal, 10-19 mild depression, 20-30 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in GDS score (Mean) |
|---|---|
| Paroxetine | -6.9 |
| Venlafaxine Extended Release | -6.9 |
| Placebo | -2.8 |
Change in Hamilton Rating Scale for Depression over 12 weeks. Hamilton Depression Rating Scale ranges from 0-50. Higher scores represent more significant depression. Mild depression ranges from 8-13, moderate depression from 14-18, severe 19-22 and very severe any score over 23. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in HAM-D score (Mean) |
|---|---|
| Paroxetine | -13.0 |
| Venlafaxine Extended Release | -11.0 |
| Placebo | -6.8 |
Montgomery-Asberg Depression Rating Scale ranges from 0-60. Higher score indicates more severe depression. 0-6 normal, 7-19 mild depression, 20-34 moderate depression, greater than 34 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in MADRS score (Mean) |
|---|---|
| Paroxetine | -13.6 |
| Venlafaxine Extended Release | -10.9 |
| Placebo | -6.6 |
Parkinson's Disease Questionnaire (PDQ-39) - Emotional Well-Being maximum score 24, minimum score of 0.Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in PDQ-39 Emotional score (Mean) |
|---|---|
| Paroxetine | -21.4 |
| Venlafaxine Extended Release | -20.7 |
| Placebo | -10.9 |
Parkinson's Disease Questionnaire (PDQ-39) Total. Range 0-100. Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in PDQ-39 score (Mean) |
|---|---|
| Paroxetine | -8.0 |
| Venlafaxine Extended Release | -8.4 |
| Placebo | -5.3 |
Pittsburgh Sleep Quality Index scores range from 0-21, with higher scores indicating severe sleep difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in PQSI score (Mean) |
|---|---|
| Paroxetine | -2.1 |
| Venlafaxine Extended Release | -2.6 |
| Placebo | -1.1 |
Short Form 36 Health Survey. Range 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in SF-36 mental score (Mean) |
|---|---|
| Paroxetine | 11.4 |
| Venlafaxine Extended Release | 9.5 |
| Placebo | 4.8 |
Short Form 36 Health Survey - Mental Health subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in SF-36 Mental Health score (Mean) |
|---|---|
| Paroxetine | 16.7 |
| Venlafaxine Extended Release | 17.4 |
| Placebo | 9.7 |
Short Form 36 Health Survey - Emotional subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in SF-36 Role score (Mean) |
|---|---|
| Paroxetine | 39.5 |
| Venlafaxine Extended Release | 26.9 |
| Placebo | 12.7 |
Short Form 36 Health Survey - Vitality subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in SF-36 vitality score (Mean) |
|---|---|
| Paroxetine | 13.5 |
| Venlafaxine Extended Release | 9.1 |
| Placebo | 4.7 |
Snaith Clinical Anxiety Scale. Range 0-21. Higher scores indicate increased anxiety. Score greater than 8 indicates clinical anxiety. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in CAS score (Mean) |
|---|---|
| Paroxetine | -3.6 |
| Venlafaxine Extended Release | -3.2 |
| Placebo | -2.4 |
Unified Parkinson's Disease Rating Scale. Higher score indicates more severe Parkinson's disease symptoms. Total maximum = 176. Mental maximum = 52, Activities of Daily Living maximum = 52, Motor maximum = 72. Minimum = 0. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in UPDRS score (Mean) |
|---|---|
| Paroxetine | -8.7 |
| Venlafaxine Extended Release | -7.0 |
| Placebo | -4.3 |
Unified Parkinson's Disease Rating Scale - Bulbar maximum score 24, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in UPDRS-Bulbar score (Mean) |
|---|---|
| Paroxetine | -1.4 |
| Venlafaxine Extended Release | -1.4 |
| Placebo | -0.5 |
Unified Parkinson's Disease Rating Scale - Motor has a maximum score of 72, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in UPDRS-motor score (Mean) |
|---|---|
| Paroxetine | -4.3 |
| Venlafaxine Extended Release | -2.0 |
| Placebo | -1.0 |
Unified Parkinson's Disease Rating Scale - Tremor subscale ranges from 0-23. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase
| Intervention | Change in UPDRS-tremor score (Mean) |
|---|---|
| Paroxetine | 0.4 |
| Venlafaxine Extended Release | 0.5 |
| Placebo | -0.6 |
"This study was conducted at Yale University almost two decades ago. Our group at the University of Pennsylvania only has very basic information about this study. This includes the number of participants, which was 18, and the fact that no adverse events occurred. Staff members at the University of Pennsylvania do not have access to any additional study data. The contact person who initially entered this study protocol information is no longer at the University of Pennsylvania and we are unable to contact for additional information.~We only know that 18 participants completed, but as far as we know data was never analyzed for these 18 participants." (NCT00626340)
Timeframe: Healthy controls will undergo scans pre and post 3 weeks of estrogen treatment. Women with depression will undergo scans pre and post 6 weeks of treatment with estrogen alone, estrogen and fluoxetine, or fluoxetine alone
| Intervention | () |
|---|---|
| All Participants | 0 |
"The FOI-adapted Parenting Sense of Competence (PSOC) questionnaire is filled out by the caregiver to assess parents' sense of competence and enjoyment of parenting. This is an adapted version of the PSOC (original PSOC has 17 items, Johnston & Mash, 1989), with 18 items and simplified language for lower reading levels.~Items are answered on a 4-point Likert scale ranging from strongly agree to strongly disagree. Nine items (#s 2,3,4,5,8,9,13,15 and 17) are reverse coded so that, for all items, higher scores indicate greater parenting self-esteem.~Total score of parent's perceived sense of competency is calculated by summing up scores of all the 18 items, ranging from 18 to 72." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 49.42 | 51.6 | 2.14 |
| KEEP-P+ | 49.82 | 50.15 | 0.3 |
"The Attachment Diary (ADRY) is a 47-item measure in which caregivers report how the child reacts when hurt, frightened, or separated from the caregiver by placing check marks on a behavior list. All the checked behaviors are coded into three categories, proximity seeking/contact maintenance, avoidance, and resistance, to assess individual differences in child's attachment behaviors. Thus, there are no total scores for the ADRY, only subscale scores for the three categories.~Outcomes include scores for proximity seeking/contact maintenance (range from 0 to 14), scores for avoidance (range from 0 to 18), and scores for resistance (range from 0 to 6), which are generated by counting the number of checked behaviors in corresponding subscales. Higher scores indicate higher levels of behaviors correspondingly." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline Proximity | Endpoint Proximity | Change Proximity | Baseline Avoidance | Endpoint Avoidance | Change Avoidance | Baseline Resistance | Endpoint Resistance | Change Resistance | |
| KEEP-P | 7.53 | 7.75 | 0.22 | 1.84 | 1.78 | -0.03 | 0.72 | 0.57 | -0.08 |
| KEEP-P+ | 8.42 | 7.87 | -0.49 | 1.95 | 2.06 | -0.04 | 0.88 | 0.70 | -0.21 |
"The Kansas Reflection-Impulsivity Scale for Preschoolers (KRISP) presents children with a target picture and 4-6 similar pictures. Children were asked to identify an exact match of the target picture.~Fifteen test trials were administered following a single practice trial. Each item was scored based on the number of incorrect responses, up to 3 errors. Final score is calculated as the number of errors subtracted from the total errors possible (45), ranging from 0 to 45. Higher score indicates better executive functioning." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 35.76 | 37.81 | 2.16 |
| KEEP-P+ | 33.52 | 35.8 | 3.96 |
"The Child Behavior Checklist (CBCL) is a 100-item questionnaire to assess emotional and behavioral problems in children. Caregivers are asked to rate how often their child displayed certain behaviors in the past two months on a 3-point Likert scale (0 = Not True, 1 = Somewhat/Sometimes True, 2 = Very True/Often True).~Subscales include: Internalizing symptoms - Emotionally Reactive: 21, 46, 82, 83, 92, 97, 99; Anxious/Depressed: 10, 33, 37, 43, 47, 68, 87, 90; Somatic Complaints: 1, 7, 39, 45, 78, 86, 93; Withdrawn: 2, 4, 12, 19, 23, 62, 67, 70, 71, 98 Externalizing symptoms - Attention Problems: 5, 6, 24, 48, 51, 56, 59, 64, 95; Aggressive Behavior: 8, 14, 15, 16, 17, 18, 20, 22, 27, 28, 29, 35, 40, 42, 44, 53, 58, 66, 69, 74, 81, 84, 85, 88, 96 Raw scores for each subscale were calculated by summing up item scores correspondingly and then normalized to T-scores. The means are anchored to 50, with a standard deviation of 10 points. Higher T score indicates more behavior problems." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | T-score (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 59.6 | 57.18 | -3.24 |
| KEEP-P+ | 61.65 | 57.47 | -3.76 |
"The Ages and Stages Questionnaires: Social-Emotional Development Screening Tool (ASQ:SE) is a caregiver-report questionnaire about children's social-emotional development.~The ASQ:SE has 29 questions, of which 26 questions are scored from 0-15, the others are open-ended. Therefore the total score (the sum of the 26 item scores) ranges from 0 to 390. Lower scores indicate more pocitive outcomes, i.e. better social-emotional development." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 121.35 | 105 | -14.33 |
| KEEP-P+ | 125.81 | 119.13 | -2.39 |
The total number of phases passed in the DCCS. A phase was passed if 4/6 trials were correct. Children only proceeded to the next phase if they passed the previous phase. 5 phases total. Higher score indicates better executive functioning. (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | number of phases passed (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 1.76 | 2.12 | 0.48 |
| KEEP-P+ | 1.61 | 2.05 | 0.43 |
"The Family Routines Questionnaire (FRQ) is a 28-item measure of the frequency and rated importance of family routines. Scores are calculated based on the how frequent the family's routines are and how important the routines are to them. The frequency of family routines construct was reported in the results.~To rate each endorsed routine by the frequency of its performance by the family, daily performance is assigned a weight of 3, a somewhat less frequency performance of 3-5 times a week is assigned a weight of 2; and an even less frequent performance of l-2 times a week is assigned a weight of 1. The 'almost never' category is taken to mean that the family does not participate in the particular routine, and it is therefore assigned a value of 0 in computing the total inventory score. By summing up frequency scores of all the 28 items, the total frequency score ranges from 0 to 84. Higher scores indicate higher frequency of family routines." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 51.66 | 52.63 | 1.37 |
| KEEP-P+ | 50.43 | 52.09 | 1.3 |
"The Interpersonal Mindfulness in Parenting (IEMP) scale is a 10-item measure to investigate the quality of interpersonal mindfulness in parenting.~Items are answered on a 5-point Likert scale ranging from never true to always true. Four items (#s 1,5,9, and 10) are reverse coded.~Total score is the sum of all the item scores, ranging from 10 to 50. Higher scores indicate higher quality of Mindful parenting." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 37.87 | 38.8 | 0.81 |
| KEEP-P+ | 37.17 | 37.56 | 0.69 |
"In the Bear/Dragon Task, children were presented with a nice bear and a mean dragon and instructed to do what the bear says (e.g., touch your nose), but not to do what the dragon says.~Children's compliance was scored on a 4-point scale on 5 bear trials (0 = failure to move; 1 = a wrong movement; 2 = a partial movement; 3 = a full correct movement) and 5 dragon trials (0 = a full commanded movement; 1 = a partial commanded movement; 2 = a flinch or wrong movement; 3 = no movement). Scores of each trial are summed up to produce a total score ranging from 0 to 30. A higher score indicates better inhibitory control." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | total score (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 21.52 | 23.6 | 1.56 |
| KEEP-P+ | 20.42 | 22.42 | 3.24 |
"In the Delay Choice Paradigm, children were asked to make choices between getting one penny/sticker/treat now or four (or more) to bring home for nine times.~Total score is the total times when the child chooses the bring home option (ranges from 0 to 9). Higher score indicates better ability for child to delay gratification, i.e. better inhibitory control." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 4.86 | 5.24 | 0.19 |
| KEEP-P+ | 5.55 | 4.54 | -0.89 |
"In the Spin the Pots Task, several visually distinct boxes were arranged on a rotating tray (2.5-year -olds: 8 boxes; 3-year-olds: 9 boxes; 3.5 year olds: 10 boxes; 4-year-olds; 11 boxes). Children watched the experimenter hide colourful stickers inside all but two boxes, cover the boxes with a cloth, and rotate a tray for a few seconds to mark the beginning of a search trial. The cloth was removed and children were instructed to select a box to find a sticker. If a sticker was found, children were allowed to keep it. After each search attempt, the tray was covered and rotated again to mark the beginning of the next search trial. The task was completed once children found all hidden stickers or after the allotted number of trials (2.5-year -olds: 12 trials; 3-year-olds: 14 trials; 3.5 year olds: 16 trials; 4-year-olds; 18 trials).~Ratio of stickers found to number of trials ranges from 0 to 1. A higher score indicates better working memory." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | Ratio of stickers found to trials (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 0.58 | 0.62 | 0.05 |
| KEEP-P+ | 0.55 | 0.59 | 0.06 |
"The Parenting Interactions with Children: Checklist of Observations Linked to Outcomes (PICCOLO) is an observational measure which rates developmentally-supportive parenting across four domains: affection, responsiveness, encouragement, and teaching.~It is a checklist of 29 items reflecting positive parent-child interaction behaviors. Each behavior is rated according to their frequency as 0 (absent, no behavior observed), 1 (barely, minor or emerging behavior) and 2 (clearly, definitive, strong and frequent behavior). Higher scores indicating higher levels of positive parenting.~PICCOLO total score is calculated by summing up scores of all the 29 items, ranging from 0 to 58. " (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 42.58 | 42.85 | 0.14 |
| KEEP-P+ | 43.36 | 43.08 | -0.76 |
"The Parent Daily Report (PDR) is a caregiver-report measure assessing child behaviour problems and associated parental stress occurring in the past 24 hours. The measure has several versions. The version used in the present research is the Oregon Social Learning Center Community Programs PDR which has 39 questions with only negative child behaviors, targeting to children from 3 to 6 years.~Caregivers rate each child behavior as 0 = Did Not Occur, 1 = Occurred & Not Stressful, 2 = Occurred & Stressful. The PDR was administered 3 times per wave. For each response, total score of stressful behaviors was calculated by counting the number of behaviors rated as 2 = Occurred & Stressful. Then the three total scores was averaged to get the mean of stressful behaviors (ranges from 0 to 39) as a indicator of parental stress. Higher score indicates higher level of parental stress." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 6.56 | 4.48 | -1.9 |
| KEEP-P+ | 7.26 | 4.58 | -2.8 |
"The Parenting Stress Index IV (PSI-IV) Short Form evaluates the magnitude of stress in the parent-child relationship based on the parent's perception of the child's characteristics, the personal characteristics of the parent, and the interaction between the parent and child.~It is a 5-point Likert scale ranging from strongly agree to strongly disagree with 36 items. Item 32 is the only item which is reverse coded. For all the other items, higher scores indicate higher levels of stress.~Total parenting stress score is calculated by summing up scores of all the 36 items, ranging from 36 to 180." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 80.87 | 74.62 | -5.29 |
| KEEP-P+ | 86.18 | 80.8 | -5.72 |
"Caregivers perception of their child's behaviors via the Preschool and Kindergarten Behavior Scales (PKBS). Items are on a 4-point scale ranging from never to often. Higher scores indicate more behavior problems.~PKBS total score (76 items) sum score ranging between 0-228." (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | total score on scale (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 55.86 | 50.6 | -3.44 |
| KEEP-P+ | 54.63 | 52.39 | -3.09 |
Proportion of animals sorted correctly after rule switch. Higher score indicates better executive functioning. (NCT03106636)
Timeframe: Change from baseline at endpoint (3-4 months post-baseline)
| Intervention | proportion correct (Mean) | ||
|---|---|---|---|
| Baseline | Endpoint | Change | |
| KEEP-P | 0.64 | 0.67 | 0.05 |
| KEEP-P+ | 0.61 | 0.71 | 0.1 |
The DAS is a self-report measure of marital adjustment that includes questions about agreement on lifestyle and household decisions, level of conflict, level of cooperation, and affection. Scores range from 0 to 151, with higher scores representing better relationship functioning. (NCT00612807)
Timeframe: pre-treatment, monthly, post-treatment, 6 month follow-up
| Intervention | Score on DAS measure (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline assessment (Depressed spouse) | Post-test assessment (Depressed spouse) | Follow-up assessment (Depressed spouse) | Baseline assessment (Non-depressed spouse) | Post-test assessment (Non-depressed spouse) | Follow-up assessment (Non-depressed spouse) | |
| Semi-weekly Medication Management | 72.14 | 84.17 | 89.67 | 91.0 | 93.33 | 104.17 |
| Semi-weekly Medication Management + Weekly Marital Therapy | 84.43 | 92.27 | 91.07 | 88.29 | 97.57 | 98.31 |
The HDRS is a semi-structured interview administered by a trained independent evaluator, and used for rating the severity of depressive symptoms. Scores range from 0 to 50, with higher scores indicating greater severity of depression. (NCT00612807)
Timeframe: pre-treatment, monthly, post-treatment, 6 month follow-up
| Intervention | Score on HDRS (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline assessment (Depressed spouse) | Post-test assessment (Depressed spouse) | Follow-up assessment (Depressed spouse) | Baseline assessment (Non-depressed spouse) | Post-test assessment (Non-depressed spouse) | Follow-up assessment (Non-depressed spouse) | |
| Semi-weekly Medication Management | 17.86 | 5.00 | 9.17 | 5.14 | 5.33 | 3.83 |
| Semi-weekly Medication Management + Weekly Marital Therapy | 19.0 | 7.29 | 8.14 | 8.86 | 3.29 | 5.71 |
29 reviews available for nortriptyline and Depression, Endogenous
| Article | Year |
|---|---|
Excess body weight as a predictor of response to treatment with antidepressants in patients with depressive disorder.
Topics: Adult; Antidepressive Agents; Body Weight; Citalopram; Depressive Disorder; Humans; Nortriptyline | 2020 |
CYP 2D6 PM status and antidepressant response to nortriptyline and venlafaxine: is it more than just drug metabolism?
Topics: Antidepressive Agents; Catalysis; Cyclohexanols; Cytochrome P-450 CYP2D6; Depressive Disorder; Human | 2011 |
THE ANTIDEPRESSANT DRUGS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Depression; Depressive Diso | 1965 |
Antidepressant therapy in post-stroke depression.
Topics: Antidepressive Agents; Citalopram; Controlled Clinical Trials as Topic; Depressive Disorder; Humans; | 2008 |
Psychopharmacologic treatment of depression.
Topics: Affective Disorders, Psychotic; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychot | 1984 |
Clinical pharmacology of antidepressant drugs: pharmacogenetics.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Depressive Disorder | 1984 |
Plasma level monitoring of antidepressants: theoretical basis and clinical application.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Genetic Variatio | 1984 |
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde | 1984 |
Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depres | 1994 |
Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping.
Topics: Clomipramine; Cytochromes; Dealkylation; Depressive Disorder; Desipramine; Dextromethorphan; Drug In | 1994 |
A primary care perspective on management of acute and long-term depression.
Topics: Acute Disease; Adult; Aged; Depressive Disorder; Drug Administration Schedule; Drug Therapy, Combina | 1993 |
Cardiovascular effects of tricyclic antidepressants in childhood asthma: a case series and review.
Topics: Adolescent; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Asthma; B | 1997 |
The impact of comorbidity on the treatment of panic disorder.
Topics: Agoraphobia; Anxiety Disorders; Comorbidity; Depressive Disorder; Humans; Mental Disorders; Nortript | 1998 |
Antidepressant response in late-life depression.
Topics: 1-Naphthylamine; Age Factors; Aged; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depr | 1998 |
Treatment of depression in patients with heart disease.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Comorbidity; | 1999 |
Monitoring of antidepressant drug plasma levels: the next ten years.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Monitoring, Ph | 1979 |
The role of plasma concentrations in the use of tricyclic antidepressant drugs.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Dr | 1979 |
Drug-induced Creutzfeldt-Jakob like syndrome.
Topics: Creutzfeldt-Jakob Syndrome; Dementia; Depressive Disorder; Electroencephalography; Humans; Lithium; | 1992 |
Somatic therapy for major depressive disorder: selection of an antidepressant.
Topics: 1-Naphthylamine; Antidepressive Agents; Bupropion; Depressive Disorder; Humans; Nortriptyline; Sertr | 1992 |
[Blood levels of tricyclic antidepressants and their clinical effectiveness (review of the literature)].
Topics: Amitriptyline; Cardiovascular Diseases; Depressive Disorder; Dose-Response Relationship, Drug; Human | 1991 |
Depression and cerebrovascular disease.
Topics: Cerebrovascular Disorders; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Male; Nortr | 1990 |
Tricyclic antidepressants for medically ill geriatric patients.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Doxepin; Geriatrics; Human | 1989 |
E-10-hydroxynortriptyline: effects and disposition of a potential novel antidepressant.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Humans; Nortriptyline | 1989 |
Use of antidepressants in the frail elderly. When, why, and how.
Topics: Age Factors; Aged; Antidepressive Agents; Dementia; Depressive Disorder; Diagnosis, Differential; Hu | 1988 |
Psychiatric disorders in parkinsonism. 1. Functional illnesses and personality.
Topics: Antidepressive Agents; Clozapine; Depressive Disorder; Dopamine; Electroconvulsive Therapy; Female; | 1986 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry.
Topics: Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Clinical Trials as Topic; Depressive Diso | 1985 |
Tricyclic-resistant depression: treatment resistance or inadequate treatment?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dose-Response Rel | 1985 |
Nortriptyline pharmacokinetics and plasma levels: implications for clinical practice.
Topics: Age Factors; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Half-Life; Humans; Kinetic | 1985 |
182 trials available for nortriptyline and Depression, Endogenous
| Article | Year |
|---|---|
The external validity of MRI-defined vascular depression.
Topics: Age Factors; Aged; Aged, 80 and over; Antidepressive Agents; Cerebrovascular Disorders; Depressive D | 2013 |
Eighteen months of drug treatment for depression: predicting relapse and recovery.
Topics: Adolescent; Adult; Analysis of Variance; Antidepressive Agents; Depressive Disorder; Dose-Response R | 2009 |
A controlled trial of antidepressants in patients with Parkinson disease and depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Co | 2009 |
A controlled trial of antidepressants in patients with Parkinson disease and depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Co | 2009 |
A controlled trial of antidepressants in patients with Parkinson disease and depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Co | 2009 |
A controlled trial of antidepressants in patients with Parkinson disease and depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Co | 2009 |
Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Depressive Disorder; Female; Humans; Mal | 2009 |
Moderation of antidepressant response by the serotonin transporter gene.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Antidepressive Agents, Tricyclic; | 2009 |
Adverse reactions to antidepressants.
Topics: Adult; Aged; Antidepressive Agents; Citalopram; Depressive Disorder; Female; Humans; Male; Middle Ag | 2009 |
Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Citalopram; Depressive Disorder; Female; | 2009 |
Trajectories of change in depression severity during treatment with antidepressants.
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Europe; Female; Follow-Up Studies; Ge | 2010 |
The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease.
Topics: Adult; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepre | 2010 |
Changes in body weight during pharmacological treatment of depression.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Body Mass Index; Body Weight; Citalopram; Depressive | 2011 |
Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
Topics: Adult; Aged; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Female; Gene Expressio | 2011 |
Effect of antidepressants on the course of disability following stroke.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depre | 2011 |
Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety Disorders | 2011 |
Change in cognitive functioning in depressed older adults following treatment with sertraline or nortriptyline.
Topics: Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents; Attention; Cognition; Depressive Disorder | 2012 |
Self-report and clinician-rated measures of depression severity: can one replace the other?
Topics: Adult; Aged; Antidepressive Agents; Citalopram; Depressive Disorder; Depressive Disorder, Major; Fem | 2012 |
Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.
Topics: Adrenergic Agents; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; | 2002 |
Nortriptyline for treatment-resistant depression.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Antidepressive Agents; Antidepressive Agents, Second-Gener | 2003 |
Initial platelet serotonin (5-HT) transport kinetics predict nortriptyline treatment outcome.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Biological Transport; Biomarkers; Blood Platelets; Ca | 2003 |
The relationship of personality disorders to treatment outcome in depressed outpatients.
Topics: Adult; Age Factors; Ambulatory Care; Antidepressive Agents; Chronic Disease; Comorbidity; Depressive | 2003 |
Occurrence and course of suicidality during short-term treatment of late-life depression.
Topics: Aged; Combined Modality Therapy; Depressive Disorder; Depressive Disorder, Major; Female; Humans; Ma | 2003 |
A differential response to nortriptyline and fluoxetine in melancholic depression: the importance of age and gender.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Age Factors; Antidepressive Agents, Second-Generati | 2003 |
Relationships among measures of treatment outcome in depressed patients.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disord | 2003 |
Age may affect response to antidepressants with serotonergic and noradrenergic actions.
Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agent | 2003 |
Good treatment outcomes in late-life depression with comorbid anxiety.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Antidepressive Agents, Second-Generation; Antidepressi | 2003 |
Double-blind comparison of fluoxetine and nortriptyline in the treatment of moderate to severe major depression.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disord | 2003 |
Psychiatric comorbidity as a predictor of clinical response to nortriptyline in treatment-resistant major depressive disorder.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder; Drug Re | 2003 |
Does antidepressant therapy improve cognition in elderly depressed patients?
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Cognition; Cognition Disorders; Confidence Intervals | 2003 |
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia.
Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Blood Glucose; Brain Mapping; Depress | 2004 |
Thyroid indices and response to fluoxetine and nortriptyline in major depression.
Topics: Adolescent; Adult; Antidepressive Agents; Depressive Disorder; Female; Fluoxetine; Humans; Male; Mid | 2003 |
Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochr | 2005 |
Risk factors for and correlates of poststroke depression following discontinuation of antidepressants.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Second-Gen | 2007 |
Antidepressant treatment is associated with a reduction in suicidal ideation and suicide attempts.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepres | 2008 |
Nortriptyline treatment of post-stroke depression: a double-blind study.
Topics: Brain; Cerebral Hemorrhage; Cerebrovascular Disorders; Clinical Trials as Topic; Depressive Disorder | 1984 |
Amitriptyline: looking through the therapeutic window.
Topics: Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Kinetics; | 1984 |
The demethylation of amitriptyline: a cross-over study of steady-state plasma levels of amitriptyline and nortriptyline in depressed patients.
Topics: Aged; Amitriptyline; Biotransformation; Depressive Disorder; Female; Humans; Kinetics; Male; Metabol | 1983 |
Tranylcypromine vs nortriptyline vs placebo in depressed outpatients: a controlled trial.
Topics: Adolescent; Adult; Ambulatory Care; Clinical Trials as Topic; Depression; Depressive Disorder; Doubl | 1984 |
Tricyclic-induced electroencephalogram abnormalities and plasma drug concentrations.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bupropion; Depr | 1984 |
Mixed anxiety/depressive illness in general practice. A therapeutic comparison of nomifensine with fluphenazine/nortriptyline.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Drug Combinati | 1983 |
Cognitive therapy and pharmacotherapy. Singly and together in the treatment of depression.
Topics: Adult; Ambulatory Care; Behavior Therapy; Cognition; Combined Modality Therapy; Depressive Disorder; | 1984 |
The process of change in cognitive therapy and pharmacotherapy for depression. Changes in mood and cognition.
Topics: Adult; Ambulatory Care; Behavior Therapy; Cognition; Combined Modality Therapy; Depressive Disorder; | 1984 |
Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression.
Topics: Adolescent; Adult; Ambulatory Care; Amitriptyline; Amoxapine; Clinical Trials as Topic; Depressive D | 1982 |
A clinical trial comparing nomifensine and nortriptyline.
Topics: Adolescent; Adult; Age Factors; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1982 |
The clinical efficacy and side-effects of mianserin and nortriptyline in depressed out-patients: a double-blind randomized trial.
Topics: Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Depression; Depressive Disorder; Dibenzazepi | 1982 |
Recurrence of depression after discontinuation of long-term amitriptyline treatment.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Long-Term Care; Male; Middle Aged; | 1982 |
Dose-dependent kinetics of imipramine in elderly patients.
Topics: Aged; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; M | 1981 |
Amitriptyline and nortriptyline response profiles in unipolar depressed patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1982 |
Studies of depressive symptoms in schizophrenia.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; | 1981 |
The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo.
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Drug Therapy, Combination; Family Pract | 1982 |
Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial.
Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Obsessiv | 1980 |
Amitriptyline metabolism in elderly depressed patients and normal controls in relation to hypothalamic-pituitary-adrenal system function.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; | 1995 |
A double-blind, placebo-controlled study of nortriptyline and bromocriptine in male alcoholics subtyped by comorbid psychiatric disorders.
Topics: Adult; Alcoholism; Antisocial Personality Disorder; Anxiety Disorders; Bromocriptine; Comorbidity; D | 1995 |
Moclobemide and nortriptyline in elderly depressed patients. A randomized, multicentre trial against placebo.
Topics: Aged; Antidepressive Agents; Benzamides; Depressive Disorder; Dose-Response Relationship, Drug; Doub | 1995 |
Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone.
Topics: Adolescent; Adult; Amitriptyline; Bipolar Disorder; Chromatography, High Pressure Liquid; Depression | 1995 |
The cardiovascular effects of bupropion and nortriptyline in depressed outpatients.
Topics: Adult; Aged; Blood Pressure; Bupropion; Cardiovascular System; Depressive Disorder; Dose-Response Re | 1994 |
Applicability of clinical pharmacotherapy guidelines for major depression in primary care settings.
Topics: Adult; Ambulatory Care; Clinical Protocols; Depressive Disorder; Female; Humans; Male; Nortriptyline | 1995 |
Prevention of recurrent postpartum major depression.
Topics: Antidepressive Agents; Depressive Disorder; Female; Humans; Nortriptyline; Odds Ratio; Pregnancy; Ps | 1994 |
Prevention of recurrent postpartum major depression.
Topics: Antidepressive Agents; Depressive Disorder; Female; Humans; Nortriptyline; Odds Ratio; Pregnancy; Ps | 1994 |
Prevention of recurrent postpartum major depression.
Topics: Antidepressive Agents; Depressive Disorder; Female; Humans; Nortriptyline; Odds Ratio; Pregnancy; Ps | 1994 |
Prevention of recurrent postpartum major depression.
Topics: Antidepressive Agents; Depressive Disorder; Female; Humans; Nortriptyline; Odds Ratio; Pregnancy; Ps | 1994 |
Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Diso | 1994 |
Coping and marital support as correlates of tinnitus disability.
Topics: Adaptation, Psychological; Aged; Depressive Disorder; Disability Evaluation; Double-Blind Method; Fe | 1994 |
Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia.
Topics: Age Factors; Aged; Comorbidity; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Female | 1994 |
Treatment of consecutive episodes of major depression in the elderly.
Topics: Age Factors; Aged; Combined Modality Therapy; Depressive Disorder; Female; Humans; Male; Middle Aged | 1994 |
Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children.
Topics: Adolescent; Bipolar Disorder; Child; Depressive Disorder; Double-Blind Method; Female; Follow-Up Stu | 1994 |
Treatment of nortriptyline's side effects in elderly patients: a double-blind study of bethanechol.
Topics: Aged; Bethanechol; Bethanechol Compounds; Depressive Disorder; Double-Blind Method; Female; Humans; | 1993 |
Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Biomarkers; Blood Platelets; Body Tempe | 1993 |
A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms.
Topics: Aged; Audiometry, Pure-Tone; Chronic Disease; Depression; Depressive Disorder; Disabled Persons; Dou | 1993 |
Nortriptyline in the hospitalized elderly: tolerance and side effect reduction.
Topics: Aged; Bethanechol Compounds; Depressive Disorder; Double-Blind Method; Drug Tolerance; Female; Human | 1993 |
Pretreatment systolic orthostatic blood pressure and treatment response in geriatric depression: a revisit.
Topics: Aged; Blood Pressure; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; N | 1993 |
Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit.
Topics: Aged; Depressive Disorder; Disabled Persons; Female; Humans; Loudness Perception; Male; Middle Aged; | 1993 |
High initial nortriptyline doses in the treatment of depression.
Topics: Adult; Body Weight; Depressive Disorder; Drug Administration Schedule; Female; Hospitalization; Huma | 1993 |
Electroencephalographic sleep in recently remitted, elderly depressed patients in double-blind placebo-maintenance therapy.
Topics: Aged; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle | 1993 |
Clinical relevance of serum nortriptyline and 10-hydroxy-nortriptyline measurements in the depressed elderly: a multicenter pharmacokinetic and pharmacodynamic study.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged | 1996 |
Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders.
Topics: Adolescent; Adult; Antidepressive Agents; Anxiety Disorders; Combined Modality Therapy; Comorbidity; | 1996 |
Changes in perceived health status of depressed elderly patients treated until remission.
Topics: Age Factors; Aged; Attitude to Health; Clinical Protocols; Combined Modality Therapy; Depressive Dis | 1996 |
Double-blind comparison of paroxetine and nortriptyline on the postural stability of late-life depressed patients.
Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disorde | 1995 |
Treating major depression in primary care practice. Eight-month clinical outcomes.
Topics: Adult; Combined Modality Therapy; Depressive Disorder; Female; Health Policy; Humans; Male; Nortript | 1996 |
High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression.
Topics: Age Factors; Age of Onset; Aged; Antidepressive Agents; Combined Modality Therapy; Depressive Disord | 1996 |
Longitudinal effects of nortriptyline on EEG sleep and the likelihood of recurrence in elderly depressed patients.
Topics: Aged; Depressive Disorder; Electroencephalography; Female; Humans; Longitudinal Studies; Male; Middl | 1996 |
Clinical presentations of major depression by African Americans and whites in primary medical care practice.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Attitude to Health; Black or African American; | 1996 |
The Major Depression Rating Scale (MDS). Inter-rater reliability and validity across different settings in randomized moclobemide trials. Danish University Antidepressant Group.
Topics: Antidepressive Agents; Benzamides; Clomipramine; Depressive Disorder; Drug Therapy, Combination; Hum | 1997 |
The course of major depression in diabetes.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Blood Glucose; Comorbidity; Depressive Di | 1997 |
Anxious depression in elderly patients. Response to antidepressant treatment.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety Disorders; Combined Modality Therapy; Depres | 1997 |
Symptoms of major depression and tricyclic side effects in primary care patients.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Cognition Disorders | 1997 |
Phenomenology and severity of major depression and comorbid lifetime anxiety disorders in primary medical care practice.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Anxiety Disorders; Comorbidity; Depressiv | 1996 |
Treating depressed primary care patients improves their physical, mental, and social functioning.
Topics: Adolescent; Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Clinical Protocols; Cohor | 1997 |
The posttreatment illness course of depression in bereaved elders. High relapse/recurrence rates.
Topics: Aged; Antidepressive Agents, Tricyclic; Bereavement; Combined Modality Therapy; Depressive Disorder; | 1997 |
The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients.
Topics: Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Depressive Disorder; Drug Interactions | 1997 |
The dexamethasone suppression test and treatment outcome in elderly depressed patients participating in a placebo-controlled multicenter trial involving moclobemide and nortriptyline.
Topics: Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzamides; Depressive Disorder; Dexa | 1997 |
Does lorazepam impair the antidepressant response to nortriptyline and psychotherapy?
Topics: Age Factors; Aged; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Combined Modality Therapy; | 1997 |
Maintenance nortriptyline effects on electroencephalographic sleep in elderly patients with recurrent major depression: double-blind, placebo- and plasma-level-controlled evaluation.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Electroencephalogr | 1997 |
Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease.
Topics: Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, | 1998 |
Long-term ECG changes in depressed elderly patients treated with nortriptyline. A double-blind, randomized, placebo-controlled evaluation.
Topics: Age Factors; Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Depressive Disorder; Doub | 1998 |
Nortriptyline pulse loading in depressed patients.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Male; Nortriptyline | 1998 |
The treatment of psychotic depression in later life: a comparison of pharmacotherapy and ECT.
Topics: Age Distribution; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Antipsychotic Agents; D | 1998 |
A post hoc comparison of paroxetine and nortriptyline for symptoms of traumatic grief.
Topics: Adjustment Disorders; Adult; Aged; Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive D | 1998 |
Cost-effectiveness of treatments for major depression in primary care practice.
Topics: Adult; Combined Modality Therapy; Cost-Benefit Analysis; Depressive Disorder; Female; Health Care Co | 1998 |
How common is resistance to treatment in recurrent, nonpsychotic geriatric depression?
Topics: Academic Medical Centers; Aged; Antidepressive Agents; Combined Modality Therapy; Depressive Disorde | 1998 |
Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline.
Topics: Aged; Cholinergic Antagonists; Depressive Disorder; Humans; Nortriptyline; Paroxetine; Radioligand A | 1998 |
Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cognitive Behavioral Therapy; Combined Modality Thera | 1998 |
Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years.
Topics: Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Dep | 1999 |
Melancholia with onset during treatment with SSRIs.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety Dis | 1998 |
Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy.
Topics: Aged; Antidepressive Agents, Tricyclic; Bereavement; Combined Modality Therapy; Depressive Disorder; | 1999 |
Comparative efficacy and safety of sertraline versus nortriptyline in major depression in patients 70 and older.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Antidepressive Agents; Cognition; Depressive Disorder | 1999 |
Recurrence of first-episode geriatric depression after discontinuation of maintenance antidepressants.
Topics: Aged; Antidepressive Agents; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Middle Ag | 1999 |
Treatment of major depression with nortriptyline and paroxetine in patients with ischemic heart disease.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder; | 1999 |
Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Male; Nortriptyline; Tr | 1999 |
Accelerating antidepressant response in geriatric depression: a post hoc comparison of combined sleep deprivation and paroxetine versus monotherapy with paroxetine, nortriptyline, or placebo.
Topics: Aged; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Depressive Disorder; Double-Blind | 1999 |
A double-blind randomized comparison of nortriptyline and paroxetine in the treatment of late-life depression: 6-week outcome.
Topics: Age Factors; Age of Onset; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Depressive Disor | 1999 |
Continuation and maintenance pharmacotherapy in geriatric depression: an open-trial comparison of paroxetine and nortriptyline in patients older than 70 years.
Topics: Age Factors; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Drug | 1999 |
Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study.
Topics: Activities of Daily Living; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disord | 2000 |
Executive dysfunction and long-term outcomes of geriatric depression.
Topics: Age Factors; Aged; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disorder; Femal | 2000 |
Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; beta-Thromboglobulin; Co | 2000 |
Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life.
Topics: Age Factors; Age of Onset; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Depressive Disor | 2000 |
Heuristic comparison of sertraline with nortriptyline for the treatment of depression in frail elderly patients.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Dru | 2000 |
Drug treatment of depression in frail elderly nursing home residents.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Dementia; Depressive Disorder; Dose-Respo | 2000 |
Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression.
Topics: Adrenergic alpha-Agonists; Aged; Alleles; Antidepressive Agents, Tricyclic; Carrier Proteins; Depres | 2000 |
Regional cerebral blood flow in mood disorders, V.: Effects of antidepressant medication in late-life depression.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Antidepressive Agents; Brain; Brain Mapping; Cerebrov | 2000 |
Changes in cognitive functioning following treatment of late-life depression.
Topics: Aged; Antidepressive Agents; Cognition Disorders; Comorbidity; Dementia; Depressive Disorder; Female | 2000 |
Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline.
Topics: Age of Onset; Aged; Antidepressive Agents; Anxiety; Cardiovascular Diseases; Comorbidity; Depressive | 2001 |
Initial recovery patterns may predict which maintenance therapies for depression will keep older adults well.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Depressive Dis | 2001 |
Citalopram versus nortriptyline in late-life depression: a 12-week randomized single-blind study.
Topics: Age of Onset; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cita | 2001 |
Sex-related differences in nortriptyline-induced side-effects among depressed patients.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Constipation; Depressive Disorder; Double-Blind Metho | 2001 |
The effect of remission of poststroke depression on activities of daily living in a double-blind randomized treatment study.
Topics: Activities of Daily Living; Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Doub | 2001 |
A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life.
Topics: Affective Disorders, Psychotic; Age Factors; Aged; Antidepressive Agents, Tricyclic; Antipsychotic A | 2001 |
CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression.
Topics: Aged; Aged, 80 and over; Alleles; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Depress | 2001 |
ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antimanic Agents; Depressive Disorder; Electroconvuls | 2001 |
Comparison between noradrenergic and serotonergic medications using the social adjustment scale: is drive enhancement necessary for recovery of social functioning?
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; An | 2001 |
Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment.
Topics: Age Factors; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Dep | 2002 |
Improvement in activities of daily living in elderly following treatment for post-bereavement depression.
Topics: Activities of Daily Living; Aged; Antidepressive Agents; Bereavement; Depressive Disorder; Double-Bl | 2002 |
Preventing poststroke depression: a 12-week double-blind randomized treatment trial and 21-month follow-up.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; | 2002 |
Patterns and predictors of remission, response and recovery in major depression treated with fluoxetine or nortriptyline.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disord | 2002 |
A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; ATP Binding Casse | 2002 |
Treatment of anxiety/depressive conditions in the elderly: a double-blind comparative study of Motival and amitriptyline.
Topics: Aged; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1975 |
Somatization, co-morbidity, and the quality of life: measuring the effect of depression upon chronic medical illness.
Topics: Activities of Daily Living; Audiometry, Pure-Tone; Chronic Disease; Comorbidity; Depressive Disorder | 1992 |
Combined pharmacotherapy and psychotherapy in the acute and continuation treatment of elderly patients with recurrent major depression: a preliminary report.
Topics: Age Factors; Aged; Aged, 80 and over; Ambulatory Care; Combined Modality Therapy; Depressive Disorde | 1992 |
Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Meth | 1992 |
Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder.
Topics: Child; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; M | 1992 |
Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease.
Topics: Activities of Daily Living; Affect; Attitude to Health; Chronic Disease; Depressive Disorder; Dyspne | 1992 |
Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.
Topics: Aged; Cognition Disorders; Depressive Disorder; Drug Therapy, Combination; Female; Folic Acid; Human | 1992 |
Antidepressant treatment of tinnitus patients. Interim report of a randomized clinical trial.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Hearing Tests; Humans; I | 1992 |
Baseline and 2- to 3-year follow-up characteristics of placebo-washout responders from the nortriptyline study of depressed 6- to 12-year-olds.
Topics: Bipolar Disorder; Child; Depressive Disorder; Female; Follow-Up Studies; Humans; Longitudinal Studie | 1992 |
Effects of nortriptyline on memory self-assessment and performance in recovered elderly depressives.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Female; Humans; Male; Memory; Middle Aged; Nortriptyli | 1991 |
Sleep in late-life recurrent depression. Changes during early continuation therapy with nortriptyline.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; H | 1991 |
Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression.
Topics: Affect; Amitriptyline; Arousal; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Nortrip | 1991 |
Comparative efficacy and safety of nortriptyline and fluoxetine in the treatment of major depression: a clinical study.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Huma | 1991 |
Acute open-trial nortriptyline therapy of bereavement-related depression in late life.
Topics: Age Factors; Aged; Death; Depressive Disorder; Drug Administration Schedule; Female; Follow-Up Studi | 1991 |
Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects.
Topics: Adolescent; Adult; Amino Acids; Blood-Brain Barrier; Depressive Disorder; Desipramine; Double-Blind | 1990 |
Pharmacologic treatment of major depression for elderly patients in residential care settings.
Topics: Age Factors; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Homes for the | 1990 |
Double-blind placebo-controlled study of nortriptyline in depressed adolescents using a "fixed plasma level" design.
Topics: Adolescent; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Nortriptyline; Randomize | 1990 |
Rapid response of patients simultaneously treated with lithium and nortriptyline.
Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Drug Therapy, Combination; Female; Hospitaliza | 1990 |
The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.
Topics: Affect; Aged; Aged, 80 and over; Cognition Disorders; Depressive Disorder; Double-Blind Method; Fema | 1989 |
Open-trial maintenance pharmacotherapy in late-life depression: survival analysis.
Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Female; Follow-Up Studies; Humans; Long-Term Ca | 1989 |
10-Hydroxynortriptyline and treatment effects in elderly depressed patients.
Topics: Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Personality Inventory; | 1989 |
Treatment of premenstrual depression with nortriptyline: a pilot study.
Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Middle Aged; Nortriptyline; Ou | 1989 |
Factors affecting the delay of antidepressant effect in responders to nortriptyline and phenelzine.
Topics: Aged; Blood Platelets; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Dr | 1989 |
Double-blind, placebo-controlled study of nortriptyline in depressed children using a "fixed plasma level" design.
Topics: Child; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Nor | 1989 |
A placebo-controlled comparison of nortriptyline and phenelzine in maintenance therapy of elderly depressed patients.
Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Nort | 1989 |
Validation of a therapeutic plasma level range in amitriptyline treatment of depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyl | 1989 |
Plasma levels of nortriptyline and 10-hydroxynortriptyline and treatment-related electrocardiographic changes in the elderly depressed.
Topics: Aged; Ambulatory Care; Depressive Disorder; Electrocardiography; Female; Heart; Humans; Isomerism; M | 1989 |
Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder.
Topics: Adult; Aged; Alanine; Antidepressive Agents; Blood Platelets; Carrier Proteins; Depressive Disorder; | 1987 |
Integrating research projects into clinical service settings.
Topics: Antipsychotic Agents; Clinical Trials as Topic; Community Mental Health Centers; Depressive Disorder | 1988 |
Antidepressant-induced weight gain: a comparison study of four medications.
Topics: Adult; Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Female; Humans; Male; | 1988 |
Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients.
Topics: Blood Platelets; Carrier Proteins; Clonidine; Depressive Disorder; Double-Blind Method; Humans; Imid | 1987 |
Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Dose-R | 1988 |
Dexamethasone suppression test status does not predict differential response to nortriptyline versus amitriptyline.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Dexamethasone; Double-Blind Met | 1988 |
Clinical predictors of response to antidepressants in elderly patients.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; | 1987 |
A placebo-controlled comparison of the effect of nortriptyline and phenelzine on orthostatic hypotension in elderly depressed patients.
Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotensio | 1987 |
How effective and safe is continuation therapy in elderly depressed patients? Factors affecting relapse rate.
Topics: Age Factors; Aged; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nortri | 1988 |
Treating delusional depressives with amitriptyline.
Topics: Adult; Amitriptyline; Bipolar Disorder; Clinical Trials as Topic; Delusions; Depressive Disorder; Dr | 1986 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
Preliminary data on the relationship between nortriptyline plasma level and response in depressed children.
Topics: Age Factors; Child; Clinical Trials as Topic; Depressive Disorder; Drug Administration Schedule; Fem | 1986 |
Electrocardiographic effects of nortriptyline, phenelzine, and placebo under optimal treatment conditions.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Depressive Disorder; Electrocardiography; Heart; Heart Con | 1987 |
Response of depressive symptoms to nortriptyline, phenelzine and placebo.
Topics: Aged; Circadian Rhythm; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; | 1987 |
Prediction of individual dosage of nortriptyline in depressed elderly outpatients.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Middle Aged; | 1987 |
[Changes in slow evoked potentials in depressed patients treated with amitriptyline and oxaprotiline].
Topics: Adult; Amitriptyline; Anthracenes; Antidepressive Agents; Contingent Negative Variation; Depressive | 1987 |
Application of an individually predicted dosage of amitriptyline to the treatment of depression.
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; M | 1987 |
Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression.
Topics: Aged; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotension, Orthostatic; Male; Midd | 1986 |
Comparative efficacy and safety of MAOIs versus TCAs in treating depression in the elderly.
Topics: Aged; Depressive Disorder; Dizziness; Female; Humans; Male; Middle Aged; Nortriptyline; Phenelzine; | 1986 |
The pharmacological treatment of delusional depression: Part II.
Topics: Amitriptyline; Delusions; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Human | 1986 |
Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry.
Topics: Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Clinical Trials as Topic; Depressive Diso | 1985 |
Long-term amitriptyline in chronic depression.
Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1985 |
Cognitive therapy and pharmacotherapy for depression. Sustained improvement over one year.
Topics: Adolescent; Adult; Attitude; Behavior Therapy; Cognition; Combined Modality Therapy; Depressive Diso | 1986 |
Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Humans; Kinetics; Middle Aged; Nortriptyline | 1985 |
[The use of low-dose amitriptyline in psychogeriatrics. A clinical, pharmacokinetic and pharmacogenetic study].
Topics: Aged; Amitriptyline; Debrisoquin; Depressive Disorder; Dose-Response Relationship, Drug; Female; Hum | 1985 |
239 other studies available for nortriptyline and Depression, Endogenous
| Article | Year |
|---|---|
Cytochrome P450 2D6 poor metabolism, curvilinearity, and response: an intriguing observation requiring integration of psychopharmacology into pharmacogenetics.
Topics: Antidepressive Agents; Cyclohexanols; Cytochrome P-450 CYP2D6; Depressive Disorder; Humans; Nortript | 2013 |
Severe adverse drug events under combination of nortriptyline and melperone due to pharmacokinetic interaction.
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Butyrophenones; Cytochrome P-450 CYP2D6; Dep | 2014 |
Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cycloheptanes; Depressive Disorder; Disease Models | 2016 |
Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression.
Topics: Animals; Antidepressive Agents; Citalopram; Cyclic AMP Response Element-Binding Protein; Depression; | 2017 |
Interference in Na+ measurements on the Siemens RAPIDPoint® 500 after nortriptyline intoxication: a case report.
Topics: Blood Chemical Analysis; Blood Gas Analysis; Depressive Disorder; Electrocardiography; Female; Human | 2017 |
Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Cell Count; Cell Proliferation; Depressive | 2009 |
Genetic predictors of response to antidepressants in the GENDEP project.
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Humans; Linkage Disequilibrium; Norep | 2009 |
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder; De | 2010 |
Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression.
Topics: Animals; Biomarkers; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Citalopram; Corticostero | 2010 |
Nortriptyline influences protein pathways involved in carbohydrate metabolism and actin-related processes in a rat gene-environment model of depression.
Topics: Actins; Animals; Antidepressive Agents; Brain; Carbohydrate Metabolism; Cytoskeletal Proteins; Depre | 2011 |
IFN-gamma reduction by tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexa | 2010 |
6‐Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Biomarkers; Depressive Disorder; Female; Humans; Me | 2011 |
Charcoal enhancement of treatment for tricyclic-induced mania.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Bipolar Disorder; Charcoal; Depres | 2002 |
Pharmacokinetic interaction between nortriptyline and terbinafine.
Topics: Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Depre | 2002 |
Effect of nortriptyline on the day-night systolic blood pressure difference in hypertensive and normotensive elderly depressed women.
Topics: Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circa | 2003 |
Residual cognitive impairment in late-life depression after a 12-month period follow-up.
Topics: Aged; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2003 |
Hopelessness and suicidal ideation in outpatients with treatment-resistant depression: prevalence and impact on treatment outcome.
Topics: Adolescent; Adult; Affective Symptoms; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Depr | 2003 |
The constellation of depression: its treatment with nortriptyline. I. Criteria for true antidepressant activity.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Nortriptyline | 1962 |
NORTRIPTYLINE FOR THE TREATMENT OF ANXIETY AND DEPRESSION IN CHRONICALLY ILL AND GERIATRIC PATIENTS.
Topics: Aged; Alcoholism; Antidepressive Agents; Anxiety; Cerebrovascular Disorders; Chronic Disease; Depres | 1964 |
A PRELIMINARY STUDY OF NORTRIPTYLINE IN DEPRESSION.
Topics: Antidepressive Agents; Biomedical Research; Depression; Depressive Disorder; Nortriptyline; Thiorida | 1964 |
NORTRIPTYLINE, AN ANTIDEPRESSANT.
Topics: Alcoholism; Antidepressive Agents; Depression; Depressive Disorder; Depressive Disorder, Major; Drug | 1964 |
OBSERVATIONS OF PSYCHOMOTOR BEHAVIOR AS AN INDEX OF PSYCHOPHARMACOLOGIC ACTION.
Topics: Antidepressive Agents; Biomedical Research; Depression; Depressive Disorder; Dextroamphetamine; Drug | 1964 |
[TREATMENT OF ENDOGENOUS DEPRESSIONS WITH ANTIDEPRESSIVE AGENTS AND ELECTROSHOCK AND TREATMENT BEFORE 1937].
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Electroconvulsive Thera | 1964 |
NORTRIPTYLINE IN PRIVATE PRACTICE.
Topics: Antidepressive Agents; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Drug Therapy; No | 1965 |
THE DIAGNOSIS AND MANAGEMENT OF DEPRESSION.
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Classification; Depression; Depre | 1965 |
[NORTRIPTYLINE IN TREATMENT OF THE DEPRESSIVE SYNDROME].
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Nortriptyline | 1964 |
[MEDICAL ANTIDEPRESSIVE TREATMENT. NORTRIPTYLINE EVALUATED IN COMPARISON WITH AMITRIPTYLINE AND IMIPRAMINE].
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Geriatrics; Imipr | 1965 |
Selective serotonin reuptake inhibitors and the tricyclic antidepressant nortriptyline in the treatment of post stroke depression.
Topics: Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depressive Disorder; Humans; Nortriptyli | 2004 |
Atypical depression, atypical temperament and a differential antidepressant response to fluoxetine and nortriptyline.
Topics: Adult; Age Factors; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depr | 2004 |
Mortality and poststroke depression.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Comorbidity; Depressive Disorder; Fluoxeti | 2004 |
Interactions of cyclobenzaprine and tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal | 2005 |
Relief of expressed suicidal intent by ECT: a consortium for research in ECT study.
Topics: Adult; Combined Modality Therapy; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; In | 2005 |
Rates of in vivo methylation of desipramine and nortriptyline.
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive Disorder; Desipra | 2006 |
Cardiovascular changes associated with venlafaxine in the treatment of late-life depression.
Topics: Aged; Antidepressive Agents, Second-Generation; Blood Pressure; Cyclohexanols; Delayed-Action Prepar | 2007 |
Amitriptyline pharmacokinetics. Lentizol and ordinary amitriptyline tablets compared in a cross-over study of steady state plasma drug levels in depressed patients.
Topics: Adult; Aged; Amitriptyline; Delayed-Action Preparations; Depressive Disorder; Female; Humans; Intest | 1982 |
The contribution of pharmacokinetics to the best use of benzodiazepines and antidepressants.
Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Depressive Di | 1982 |
Subtypes of depression based on excretion of MHPG and response to nortriptyline.
Topics: Adult; Depressive Disorder; Glycols; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; M | 1980 |
Weight gain. A side-effect of tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Depressive Disorder; | 1984 |
Steady state plasma concentration profiles and therapeutic response in anxious-depressed outpatients after administration of a chlordiazepoxide-amitriptyline combination.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Dep | 1983 |
Neuroendocrine dysfunction and response to tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dexamethasone; Evaluation Studie | 1984 |
Single-dose single-point method in amitriptyline therapy.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; P | 1984 |
Symptoms as predictors of response to amitriptyline and nortriptyline -- the plasma level variable.
Topics: Amitriptyline; Depressive Disorder; Humans; Nortriptyline; Psychiatric Status Rating Scales | 1980 |
Treatment outcome in elderly depressives: plasma nortriptyline concentration and pretreatment dexamethasone suppression test.
Topics: Aged; Depressive Disorder; Dexamethasone; Humans; Middle Aged; Nortriptyline; Prognosis | 1984 |
Propranolol, depression, and nortriptyline interaction.
Topics: Depressive Disorder; Drug Interactions; Humans; Nortriptyline; Propranolol | 1984 |
The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Chromatography, High Pressure Liquid; | 1984 |
Targeting therapeutic plasma levels of nortriptyline from test dose plasma concentrations.
Topics: Computers; Depressive Disorder; Humans; Kinetics; Models, Biological; Nortriptyline | 1984 |
The occurrence and treatment of poststroke mood disorders.
Topics: Cerebrovascular Disorders; Delirium; Depressive Disorder; Dominance, Cerebral; Humans; Male; Middle | 1984 |
Nortriptyline pharmacokinetic parameters in depressed children and adolescents: preliminary data.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Depressive Disorder; Female; Half-Life; Hum | 1984 |
Nortriptyline capacity-limited metabolism: a case report.
Topics: Blood Proteins; Depressive Disorder; Female; Half-Life; Humans; Kinetics; Middle Aged; Nortriptyline | 1984 |
Serum levels and response to amitriptyline in depressed out-patients.
Topics: Adult; Aged; Ambulatory Care; Amitriptyline; Depressive Disorder; Double-Blind Method; Follow-Up Stu | 1984 |
REM latency distribution in major depression: clinical characteristics associated with sleep onset REM periods.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; Double-B | 1984 |
Simultaneous measurement of various antidepressants in the plasma of depressed patients by high performance liquid chromatography.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents; Chromatography, High Pressure Liquid; Clomip | 1984 |
Abdominal distention syndrome in a patient receiving cimetidine-nortriptyline therapy.
Topics: Cimetidine; Depressive Disorder; Drug Synergism; Female; Gastric Emptying; Gastritis; Humans; Middle | 1983 |
Psychiatric disturbance in Hodgkin's disease.
Topics: Adult; Depressive Disorder; Hodgkin Disease; Humans; Male; Middle Aged; Nortriptyline; Retrospective | 1983 |
Disputing preliminary findings on methylphenidate-desipramine responses.
Topics: Depressive Disorder; Desipramine; Humans; Methylphenidate; Nortriptyline; Probability | 1983 |
Pharmacokinetic protocol for predicting plasma nortriptyline levels.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Female; Humans; Kinetics; Male; Middle Aged; Minicompu | 1983 |
Cimetidine's effect on steady-state serum nortriptyline concentrations.
Topics: Cimetidine; Depressive Disorder; Drug Interactions; Humans; Male; Middle Aged; Nortriptyline; Peptic | 1983 |
Heart failure associated with high plasma 10-hydroxynortriptyline levels.
Topics: Aged; Depressive Disorder; Heart Failure; Humans; Hydroxylation; Male; Nortriptyline | 1984 |
Amitriptyline metabolism in relation to antidepressive effect.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Humans; Mal | 1984 |
Plasma 10-hydroxynortriptyline in elderly depressed patients.
Topics: Adolescent; Adult; Aged; Aging; Creatinine; Depressive Disorder; Female; Humans; Male; Middle Aged; | 1984 |
Psychosis after discontinuation of nortriptyline.
Topics: Adult; Depressive Disorder; Humans; Male; Nortriptyline; Psychoses, Substance-Induced; Substance Wit | 1984 |
Hypothalamic-pituitary-adrenocortical function in geriatric depression: diagnostic and treatment implications.
Topics: Aged; Depressive Disorder; Dexamethasone; Diagnosis, Differential; Female; Humans; Hydrocortisone; M | 1984 |
Depression: diagnosis and treatment with tricyclic antidepressants.
Topics: Age Factors; Antidepressive Agents, Tricyclic; Black People; Chromatography, High Pressure Liquid; D | 1981 |
Nortriptyline and pituitary-thyroid function in affective disorder.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Pituitary Gland; | 1981 |
Amitriptyline and nortriptyline excretion in human breast milk.
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Milk, Human; Nortriptyline; Pregnancy; Pu | 1982 |
Do urinary MHPG and plasma drug levels correlate with response to amitriptyline therapy?
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Glycols; Humans; Male; Methoxyhydroxyphenyl | 1982 |
Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels.
Topics: Adult; Aged; Amitriptyline; Biotransformation; Blood Proteins; Depressive Disorder; Female; Humans; | 1982 |
Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect--a phase II study.
Topics: Adult; Citalopram; Depressive Disorder; Drug Evaluation; Electroconvulsive Therapy; Female; Humans; | 1982 |
The dexamethasone suppression test in depressive illness: clinical correlates.
Topics: Depressive Disorder; Desipramine; Dexamethasone; Diagnosis, Differential; Double-Blind Method; Doxep | 1982 |
Pharmacologic treatment of childhood depressive disorders.
Topics: Child; Depressive Disorder; Humans; Imipramine; Nortriptyline | 1983 |
Differential effects of tricyclic antidepressants on mean arterial pressure in a hypertensive patient.
Topics: Blood Pressure; Depressive Disorder; Humans; Hypertension; Hypotension, Orthostatic; Imipramine; Mal | 1983 |
The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Desipramine; Emotions; Humans; Imipramine; Me | 1983 |
Labelling and drug effects in the treatment of neurotic affective disorders: an experimental investigation.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Depressive Disorder; Diazepam; Double-Blind Method; Fema | 1983 |
REM sleep, naps, and depression.
Topics: Adult; Amitriptyline; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Nortriptyline; Sl | 1981 |
Plasma levels, psychophysiological variables, and clinical response to amitriptyline.
Topics: Adult; Aged; Amitriptyline; Arousal; Depressive Disorder; Female; Galvanic Skin Response; Habituatio | 1982 |
Nortriptyline and electroconvulsive therapy.
Topics: Adult; Arrhythmias, Cardiac; Bipolar Disorder; Depressive Disorder; Electroconvulsive Therapy; Femal | 1982 |
Plasma concentrations of tricyclic antidepressants in clinical practice.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Depressive Disorder; Desipramine | 1982 |
Tricyclic antidepressants and cardiac patients with pacemakers.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Female; | 1982 |
Tricyclic antidepressant plasma levels: the state of the art and clinical prospects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Bipolar Disorder; Depressive Dis | 1982 |
TCA-induced mania: differences between switchers and nonswitchers.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; | 1982 |
Single dose prediction of steady state plasma levels of amitriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; F | 1982 |
Early improvement as a predictor of response to amitriptyline and nortriptyline: a comparison of 2 patient samples.
Topics: Age Factors; Amitriptyline; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Nortriptylin | 1982 |
Nortriptyline and EEG sleep in depressed patients.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Elect | 1982 |
Nortriptyline metabolism in chronic renal failure: metabolite elimination.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Depressive Disorder; Female; Humans; Kidney Failure, C | 1982 |
Plasma concentrations of tricyclic antidepressants in clinical practice.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Nortriptyline; Research Design | 1982 |
Interaction between antidepressants and perphenazine in psychiatric inpatients.
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; Drug | 1982 |
On the relationship between free plasma and saliva amitriptyline and nortriptyline.
Topics: Amitriptyline; Depressive Disorder; Humans; Hydrogen-Ion Concentration; Nortriptyline; Saliva; Time | 1982 |
Reversible loss of nocturnal penile tumescence during depression: a preliminary report.
Topics: Aged; Depressive Disorder; Erectile Dysfunction; Humans; Imipramine; Libido; Male; Middle Aged; Nort | 1982 |
The relationship of therapeutic response to antidepressant plasma levels: an update.
Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Biological Availability; Depressive | 1982 |
Evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans.
Topics: Amitriptyline; Biotransformation; Depressive Disorder; Desipramine; Humans; Imipramine; Methylation; | 1982 |
Effect of alcohol consumption and cigarette smoking on antidepressant levels of depressed patients.
Topics: Adult; Alcohol Drinking; Amitriptyline; Depressive Disorder; Female; Humans; Nortriptyline; Smoking | 1981 |
Amitriptyline and nortriptyline plasma levels monitoring. Perspective in clinical practice.
Topics: Amitriptyline; Depressive Disorder; Female; Humans; Nortriptyline; Psychiatric Status Rating Scales | 1980 |
Tricyclic antidepressants: clinical use of plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Confusion; Depressive Disorder; Electrocardi | 1981 |
Cognitive improvement associated with tricyclic antidepressant treatment of childhood major depressive illness.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Cognition; Depressive Disorder; | 1981 |
Serotonin uptake in blood platelets of psychiatric patients.
Topics: Adult; Analysis of Variance; Bipolar Disorder; Blood Platelets; Carbon Radioisotopes; Depressive Dis | 1981 |
[Comparison of the effectiveness of tranylcypromine, nortriptyline, thioridazine and amitriptyline in two syndromological types of endogenous depression (author's transl)].
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Thiorid | 1981 |
Nortriptyline therapy in elderly patients: dosage prediction from plasma concentration at 24 hours after a single 50 mg dose.
Topics: Aged; Depressive Disorder; Drug Administration Schedule; Female; Humans; Nortriptyline | 1981 |
Urinary MHPG and clinical response to amitriptyline in depressed patients.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Glycols; Humans; Male; Methoxyhydroxy | 1980 |
Prediction of steady-state plasma levels of amitriptyline and nortriptyline from a single dose 24 hr. level in depressed patients.
Topics: Amitriptyline; Delayed-Action Preparations; Depressive Disorder; Female; Humans; Male; Nortriptyline | 1980 |
Midodrine for TCA-induced orthostatic hypotension.
Topics: Adult; Blood Pressure; Depressive Disorder; Drug Therapy, Combination; Female; Heart Rate; Humans; H | 1993 |
Bupropion/nortriptyline combination for refractory depression.
Topics: Bupropion; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 1994 |
Breastfeeding and sertraline: a 24-hour analysis.
Topics: 1-Naphthylamine; Adult; Breast Feeding; Child Development; Depressive Disorder; Female; Humans; Infa | 1995 |
Does recruitment method make a difference? Effects on protocol retention and treatment outcome in elderly depressed patients.
Topics: Adjustment Disorders; Aged; Bias; Combined Modality Therapy; Depressive Disorder; Female; Humans; Li | 1995 |
A prospective study of lithium augmentation in antidepressant-resistant geriatric depression.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Dru | 1994 |
Hopelessness in suicide attempters after acute treatment of major depression in late life.
Topics: Age Factors; Aged; Depressive Disorder; Female; Follow-Up Studies; Geriatric Assessment; Humans; Mal | 1994 |
Initiation of tricyclic treatment at full dose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administrati | 1994 |
Methylphenidate and nortriptyline in the treatment of poststroke depression: a retrospective comparison.
Topics: Aged; Cerebrovascular Disorders; Depressive Disorder; Drug Monitoring; Female; Humans; Male; Methylp | 1994 |
Therapeutic blood monitoring of tricyclic antidepressants.
Topics: Adult; Depressive Disorder; Drug Monitoring; Female; Humans; Nortriptyline | 1994 |
Poststroke pathological laughing and crying.
Topics: Biogenic Amines; Cerebrovascular Disorders; Crying; Depressive Disorder; Humans; Laughter; Nortripty | 1994 |
Reply to "Question the experts".
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Nortriptyline | 1993 |
Modern tricyclic antidepressant drugs are hardly distinguishable in efficacy or safety for treatment of depressive mood disorders in controlled clinical trials.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Nortriptyline; Randomized Controlled | 1993 |
Sleep deprivation accelerates the response to nortriptyline.
Topics: Adult; Combined Modality Therapy; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyl | 1993 |
A retrospective study of serum levels and electrocardiographic effects of nortriptyline in children and adolescents.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Child, P | 1993 |
Nortriptyline-induced depression of ventilatory control in a patient with chronic obstructive pulmonary disease.
Topics: Aged; Depression, Chemical; Depressive Disorder; Female; Humans; Lung Diseases, Obstructive; Nortrip | 1993 |
Combination treatment of depression.
Topics: Depressive Disorder; Drug Therapy, Combination; Humans; Nortriptyline; Selective Serotonin Reuptake | 1993 |
[Toxic tricyclic drug plasma level caused by fluoxetine].
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressiv | 1995 |
Treatment of late-onset agoraphobia secondary to depression.
Topics: 1-Naphthylamine; Adaptation, Psychological; Aged; Aged, 80 and over; Agoraphobia; Antidepressive Age | 1995 |
Dosing of antidepressants--the unknown art.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Depress | 1995 |
The effect of sequential antidepressant treatment on geriatric depression.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Clinical Protocols; Combined Modality Therapy; Demen | 1996 |
Quality of life in elderly patients with recurrent major depression: a factor analysis of the General Life Functioning Scale.
Topics: Adaptation, Psychological; Age of Onset; Aged; Antidepressive Agents; Depressive Disorder; Factor An | 1996 |
Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia: effects of antidepressants and antipsychotic drugs.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Dipeptidy | 1996 |
The Pisa syndrome (pleurothotonus) during antidepressant therapy.
Topics: Amitriptyline; Antidepressive Agents; Biperiden; Depressive Disorder; Dose-Response Relationship, Dr | 1997 |
Psychiatrists' responses to failure of maintenance therapy with antidepressants.
Topics: 1-Naphthylamine; Adult; Antidepressive Agents; Attitude of Health Personnel; Depressive Disorder; Do | 1997 |
Venlafaxine-fluoxetine-nortriptyline interaction.
Topics: Aged; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Drug Interactions; Drug Therapy, Co | 1997 |
Effect of demographic and clinical variables on time to antidepressant response in geriatric depression.
Topics: Aged; Aged, 80 and over; Anxiety; Chi-Square Distribution; Cross-Sectional Studies; Depressive Disor | 1997 |
Effect of sertraline on plasma nortriptyline levels in depressed elderly.
Topics: 1-Naphthylamine; Aged; Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; Dru | 1997 |
Cardiovascular effects of fluoxetine in depressed patients with heart disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Blood Pressure; Comorbidity; Depressive Disorder; Dru | 1998 |
Effects of age at onset of first lifetime episode of recurrent major depression on treatment response and illness course in elderly patients.
Topics: Age Factors; Age of Onset; Aged; Combined Modality Therapy; Depressive Disorder; Female; Humans; Lif | 1998 |
Psychiatry and cigarettes.
Topics: Antidepressive Agents, Tricyclic; Cognitive Behavioral Therapy; Combined Modality Therapy; Depressiv | 1998 |
Dysthymia. Treating mild depression's major effects.
Topics: Adult; Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder; Dysthymic Disorder; | 1999 |
Comparative efficacy and safety of sertraline versus nortriptyline in major depression in patients 70 and older.
Topics: Aged; Depressive Disorder; Humans; Nortriptyline; Psychiatric Status Rating Scales; Sertraline | 1999 |
Development of major depression after treatment for smoking cessation.
Topics: Adult; Central Nervous System Stimulants; Chewing Gum; Combined Modality Therapy; Comorbidity; Depre | 2000 |
Medication treatment versus cognitive behavior therapy.
Topics: Ambulatory Care; Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder; Humans; I | 2000 |
Incomplete recovery among endogenously depressed patients: an ethological analysis.
Topics: Adult; Aged; Aged, 80 and over; Depressive Disorder; Electroconvulsive Therapy; Ethology; Female; Ho | 2000 |
Possible serotonin syndrome arising from an interaction between nortriptyline and selegiline in a lady with parkinsonism.
Topics: Antidepressive Agents, Tricyclic; Antiparkinson Agents; Depressive Disorder; Drug Interactions; Fema | 2000 |
Bipolar disorder at prospective follow-up of adults who had prepubertal major depressive disorder.
Topics: Adolescent; Adult; Bipolar Disorder; Child; Depressive Disorder; Follow-Up Studies; Humans; Nortript | 2001 |
Anterior cingulate activity as a predictor of degree of treatment response in major depression: evidence from brain electrical tomography analysis.
Topics: Adult; Antidepressive Agents, Tricyclic; Brain Mapping; Depressive Disorder; Electroencephalography; | 2001 |
Poststroke depression.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Fluoxetine; Humans; Middle Aged; Nortri | 2001 |
Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorde | 2001 |
Antidepressants in the treatment of patients with COPD: possible associations between smoking cigarettes, COPD and depression.
Topics: Antidepressive Agents; Bupropion; Depressive Disorder; Humans; Lung Diseases, Obstructive; Nortripty | 2001 |
Diagnosing and treating depression in the elderly.
Topics: Age Factors; Age of Onset; Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Co | 2001 |
Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Sch | 2002 |
Melancholia: definitions, risk factors, personality, neuroendocrine markers and differential antidepressant response.
Topics: Age Factors; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive | 2002 |
Course and rate of antidepressant response in the very old.
Topics: Age Factors; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Second-Generatio | 2002 |
Combination treatment with noradrenalin and serotonin reuptake inhibitors in resistant depression.
Topics: 1-Naphthylamine; Adult; Aged; Aged, 80 and over; Depressive Disorder; Drug Therapy, Combination; Fem | 1992 |
Nifedipine and nonresponse to antidepressants.
Topics: Depressive Disorder; Drug Interactions; Esophageal Spasm, Diffuse; Humans; Nifedipine; Nortriptyline | 1992 |
[Serum concentrations of amitriptyline and its metabolites and clinical effect in depressive patients].
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; M | 1992 |
Nortriptyline: a model drug in geriatric depression.
Topics: Aged; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Nortriptyline | 1992 |
Nortriptyline and weight change in depressed patients over 60.
Topics: Aged; Aging; Body Weight; Depressive Disorder; Humans; Nortriptyline; Psychiatric Status Rating Scal | 1992 |
Nortriptyline response in elderly depressed patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Depressive Disorder; Fe | 1992 |
Stochastic analysis of the duration of the speaker role in the psychotherapy of an AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Adult; Communication; Depressive Disorder; HIV Seropositivity; H | 1992 |
Single-dose fluoxetine in management of premenstrual syndrome.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Nortriptyl | 1992 |
Pharmacotherapy and psychotherapy for major depression in a man with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Combined Modality Therapy; Depressive Disorder; Humans; M | 1992 |
Verbal memory and plasma drug concentrations in elderly depressives treated with nortriptyline.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Female; Humans; Male; Memory; Nortriptyline; Psychiatr | 1991 |
Continuation electroconvulsive therapy: preliminary guidelines and an illustrative case report.
Topics: Aged; Combined Modality Therapy; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Nor | 1991 |
Low dose tricyclic tachycardia.
Topics: Adolescent; Depressive Disorder; Desipramine; Electrocardiography, Ambulatory; Female; Humans; Nortr | 1991 |
Stereoselective efflux of (E)-10-hydroxynortriptyline enantiomers from the cerebrospinal fluid of depressed patients.
Topics: Adult; Amitriptyline; Biological Transport, Active; Depressive Disorder; Female; Humans; Middle Aged | 1991 |
Controlling agitation in patients with cognitive impairment.
Topics: Aphasia, Broca; Carbamazepine; Depressive Disorder; Drug Therapy, Combination; Epilepsy, Temporal Lo | 1991 |
Serum nortriptyline levels in nursing mothers and their infants.
Topics: Breast Feeding; Depressive Disorder; Humans; Infant; Infant, Newborn; Nortriptyline; Puerperal Disor | 1991 |
Drug interaction between rifampin and nortriptyline: a case report.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Metabolic Cl | 1991 |
Treatment choice after one antidepressant fails: a survey of northeastern psychiatrists.
Topics: Antidepressive Agents; Attitude of Health Personnel; Bupropion; Decision Making; Depressive Disorder | 1991 |
Adjunctive lithium carbonate in nortriptyline-resistant elderly depressed patients.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Drug Resistance; Drug Therapy, Combination; Female; Hu | 1991 |
Tricyclics and heart failure.
Topics: Aged; Depressive Disorder; Doxepin; Heart Failure; Humans; Male; Myocardial Contraction; Nortriptyli | 1991 |
Recent fluoxetine treatment and complications of tricyclic therapy.
Topics: Depressive Disorder; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female | 1991 |
Caution with use of tricyclics in patients with AIDS.
Topics: Adult; AIDS Dementia Complex; Depressive Disorder; Diagnosis, Differential; Humans; Male; Nortriptyl | 1991 |
Altered pharmacokinetics of tricyclic antidepressants in burns.
Topics: Adult; Amitriptyline; Burns; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; | 1991 |
Nortriptyline treatment of depressed cardiac transplant recipients.
Topics: Adult; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography; Female; Heart Rate; Heart Tra | 1991 |
Simulated home treatment of depression with nortriptyline.
Topics: Adult; Blood Pressure; Depressive Disorder; Female; Home Care Services; Humans; Hypotension; Male; M | 1991 |
Use of tricyclic antidepressants in recipients of heart transplants.
Topics: Adaptation, Psychological; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disord | 1991 |
Treatment of depression with E-10-hydroxynortriptyline--a pilot study on biochemical effects and pharmacokinetics.
Topics: Adult; Antidepressive Agents; Biogenic Amines; Depressive Disorder; Female; Humans; Male; Methoxyhyd | 1991 |
Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism.
Topics: Adult; Bipolar Disorder; Blood Pressure; Depressive Disorder; Down-Regulation; Feedback; Female; Hal | 1990 |
Elevated tricyclic antidepressant plasma concentrations associated with fluoxetine: two case reports.
Topics: Adult; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male | 1990 |
Relationship of hydroxynortriptyline to nortriptyline concentration and creatinine clearance in depressed elderly outpatients.
Topics: Aged; Aged, 80 and over; Creatinine; Depressive Disorder; Female; Humans; Kidney Function Tests; Mal | 1990 |
Increased plasma nortriptyline concentration in a patient cotreated with fluoxetine.
Topics: Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Dyspnea; Fatigue; Fluoxetine; Hum | 1990 |
The effect of nortriptyline in elderly patients with cardiac conduction disease.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depressive Disorder | 1990 |
Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression.
Topics: Adult; Aged; Aging; Amitriptyline; Body Weight; Depressive Disorder; Female; Humans; Middle Aged; Mo | 1990 |
Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels.
Topics: Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography, Ambulato | 1990 |
The effects of nortriptyline on cognition in elderly depressed patients.
Topics: Aged; Aged, 80 and over; Arousal; Attention; Depressive Disorder; Dose-Response Relationship, Drug; | 1990 |
Drug-drug interactions of fluoxetine with tricyclics.
Topics: Depressive Disorder; Desipramine; Drug Synergism; Drug Therapy, Combination; Fluoxetine; Humans; Met | 1990 |
Treatment of depressed in-patients. Cognitive therapy plus medication, relaxation plus medication, and medication alone.
Topics: Adult; Chronic Disease; Cognitive Behavioral Therapy; Combined Modality Therapy; Depressive Disorder | 1990 |
Clinical and biochemical effects during treatment of depression with nortriptyline: the role of 10-hydroxynortriptyline.
Topics: Administration, Oral; Adult; Aged; Depressive Disorder; Female; Humans; Hydroxyindoleacetic Acid; Ma | 1987 |
Depression associated with nifedipine-induced calcium channel blockade.
Topics: Aged; Angina Pectoris; Depressive Disorder; Female; Humans; Ion Channels; Male; Middle Aged; Nifedip | 1988 |
Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases | 1989 |
Fluoxetine and nortriptyline combination therapy.
Topics: Adult; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Male; | 1989 |
Use of yohimbine to counteract nortriptyline-induced orthostatic hypotension.
Topics: Blood Pressure; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Hypotension, Orthost | 1989 |
Naproxen reversal of nortriptyline-induced orthostatic hypotension.
Topics: Aged; Depressive Disorder; Female; Humans; Hypotension, Orthostatic; Naproxen; Nortriptyline | 1989 |
Open-trial maintenance nortriptyline in geriatric depression: survival analysis and preliminary data on the use of REM latency as a predictor of recurrence.
Topics: Aged; Depressive Disorder; Humans; Nortriptyline; Recurrence; Sleep, REM | 1989 |
Premenstrual syndrome treatments.
Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Nortriptyline; Premenstrual Syndrome | 1989 |
Steady-state plasma levels of E- and Z-10-OH-nortriptyline in nortriptyline-treated patients: significance of concurrent medication and the sparteine oxidation phenotype.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, Thin Layer; Depressive Disorder; Drug Interactions; | 1989 |
Treatment of depressed tinnitus patients with nortriptyline.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Drug Evaluation; Humans; Middle Aged; Nortriptyline; T | 1989 |
Elderly widow develops panic attacks, followed by depression.
Topics: Aged; Anxiety Disorders; Depressive Disorder; Fear; Female; Humans; Nortriptyline; Panic; Psychother | 1989 |
Plasma tyrosine/neutral amino acid ratio correlated with clinical response to nortriptyline in endogenously depressed patients.
Topics: Adult; Amino Acids; Biological Availability; Depressive Disorder; Female; Humans; Male; Middle Aged; | 1985 |
Antidepressants and EEG sleep: search for specificity.
Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Humans; Nortriptyline; Sleep | 1987 |
The effect of the tricyclic antidepressant drug, nortriptyline on left ventricular ejection fraction and left ventricular volumes.
Topics: Adult; Blood Pressure; Depressive Disorder; Female; Heart; Humans; Male; Middle Aged; Nortriptyline; | 1987 |
Valpromide increases the plasma concentrations of amitriptyline and its metabolite nortriptyline in depressive patients.
Topics: Adult; Amitriptyline; Anticonvulsants; Depressive Disorder; Drug Therapy, Combination; Female; Human | 1988 |
Cerebrospinal fluid levels of amitriptyline, nortriptyline, imipramine and desmethylimipramine. Relationship to plasma levels and treatment outcome.
Topics: Amitriptyline; Bipolar Disorder; Depressive Disorder; Desipramine; Double-Blind Method; Female; Gas | 1985 |
[Relation of plasma levels and clinical response to amitriptyline in treating endogenous depression].
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline | 1988 |
Plasma 10-hydroxynortriptyline and therapeutic response in geriatric depression.
Topics: Aged; Depressive Disorder; Humans; Middle Aged; Nortriptyline; Time Factors | 1988 |
Antidepressant metabolism in the elderly.
Topics: Aged; Depressive Disorder; Humans; Middle Aged; Nortriptyline | 1988 |
Pretreatment systolic orthostatic blood pressure (PSOP) and treatment response in elderly depressed inpatients.
Topics: Aged; Aged, 80 and over; Blood Pressure; Blood Pressure Determination; Depressive Disorder; Drug Adm | 1988 |
Isomers of 10-hydroxynortriptyline in geriatric depression.
Topics: Aged; Chromatography, High Pressure Liquid; Depressive Disorder; Humans; Isomerism; Middle Aged; Nor | 1988 |
Alprazolam does not inhibit the metabolism of nortriptyline in depressed patients or inhibit the metabolism of desipramine in human liver microsomes.
Topics: Adult; Alprazolam; Depressive Disorder; Desipramine; Drug Interactions; Female; Humans; Hydroxylatio | 1988 |
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; I | 1986 |
Amitriptyline pharmacokinetics and clinical response: I. Free and total plasma amitriptyline and nortriptyline.
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Kinetic | 1986 |
New aspects in research on blood levels and bioavailability of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Biological Availability; Debrisoquin; Depressive Disorder; Hum | 1986 |
No interaction of diazepam on amitriptyline disposition in depressed patients.
Topics: Adult; Amitriptyline; Depressive Disorder; Diazepam; Drug Interactions; Female; Humans; Middle Aged; | 1987 |
Plasma levels and effects of nortriptyline in geriatric depressed patients.
Topics: Age Factors; Aged; Blood Pressure; Depressive Disorder; Dose-Response Relationship, Drug; Electrocar | 1987 |
Amitriptyline and nortriptyline plasma levels, urinary 3-methoxy-4-hydroxyphenylglycol and clinical response in depressed women.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Glycols; Humans; Methoxyhydroxyphenylglycol | 1986 |
Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment.
Topics: Aged; Cognition Disorders; Depressive Disorder; Electroconvulsive Therapy; Humans; Nortriptyline; Pr | 1987 |
Sleep deprivation effects in older endogenous depressed patients.
Topics: Affect; Depressive Disorder; Electroconvulsive Therapy; Humans; Nortriptyline; Psychiatric Status Ra | 1987 |
Prospective study of scheduled withdrawal from nortriptyline in children and adolescents.
Topics: Adolescent; Child; Depressive Disorder; Female; Gastrointestinal Diseases; Humans; Male; Nortriptyli | 1987 |
Profound hypoglycemia with the addition of a tricyclic antidepressant to maintenance sulfonylurea therapy.
Topics: Aged; Chlorpropamide; Depressive Disorder; Diabetes Complications; Diabetes Mellitus; Doxepin; Drug | 1987 |
Plasma 10-hydroxynortriptyline and renal function in elderly depressives.
Topics: Aged; Aged, 80 and over; Aging; Creatinine; Depressive Disorder; Humans; Kidney; Kidney Function Tes | 1987 |
Effects of smoking on nortriptyline plasma concentrations in depressed patients.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Female; Half-Life; Humans; Kinetics; Male; Middle Aged | 1986 |
Nortriptyline in depressed patients with left ventricular impairment.
Topics: Aged; Aged, 80 and over; Blood Pressure; Depressive Disorder; Female; Heart Diseases; Humans; Male; | 1986 |
[Relation of plasma amitriptyline and nortriptyline levels to the therapeutic response in endogenous depression].
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nort | 1986 |
Severe nortriptyline intoxication due to change from a generic to a trade preparation.
Topics: Adult; Biological Availability; Depressive Disorder; Humans; Male; Nortriptyline; Patient Compliance | 1987 |
3H-imipramine binding in depressed elderly: relationship to family history and clinical response.
Topics: Aged; Blood Platelets; Depressive Disorder; Female; Humans; Imipramine; Male; Middle Aged; Nortripty | 1986 |
Doses and blood levels of tricyclic antidepressants.
Topics: Adult; Depressive Disorder; Drug Administration Schedule; Female; Humans; Imipramine; Middle Aged; N | 1987 |
Prediction of response to nortriptyline and phenelzine by platelet MAO activity.
Topics: Aged; Blood Platelets; Depressive Disorder; Female; Humans; Male; Middle Aged; Monoamine Oxidase; No | 1987 |
Tricyclic antidepressants in depressed patients with cardiac conduction disease.
Topics: Antidepressive Agents, Tricyclic; Bundle-Branch Block; Depressive Disorder; Electrocardiography; Fem | 1987 |
Change in serum antidepressant level at a constant dose of medication.
Topics: Depressive Disorder; Drug Tolerance; Female; Humans; Middle Aged; Nortriptyline; Recurrence | 1986 |
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia.
Topics: Amitriptyline; Antidepressive Agents; Dementia; Depressive Disorder; Dexamethasone; Humans; Hydrocor | 1985 |
Dose and plasma levels of nortriptyline and chlorpromazine in delusionally depressed adolescents and of nortriptyline in nondelusionally depressed adolescents.
Topics: Adolescent; Child; Chlorpromazine; Delusions; Depressive Disorder; Drug Interactions; Drug Therapy, | 1985 |
"Paradoxical" shortening of REM latency on first recording night in major depressive disorder: clinical and polysomnographic correlates.
Topics: Adaptation, Physiological; Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Female; Huma | 1985 |
Internight variability of REM latency in major depression: implications for the use of REM latency as a biological correlate.
Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Electroencep | 1985 |
Interindividual differences in the binding of antidepressives to plasma proteins: the role of the variants of alpha 1-acid glycoprotein.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Proteins; Depressive Disorder; Female; Humans; Ma | 1985 |
Altered amitriptyline kinetics in a depressed patient with porto-caval anastomosis.
Topics: Administration, Oral; Adult; Amitriptyline; Depressive Disorder; Half-Life; Humans; Kinetics; Liver | 1985 |
Child and adolescent nortriptyline single dose kinetics predict steady state plasma levels and suggested dose: preliminary data.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Depressive Disorder; Female; Humans; Kinetics; Mal | 1985 |
Plasma levels of amitriptyline: effect of age and sex.
Topics: Adult; Age Factors; Aged; Amitriptyline; Depressive Disorder; Drug Administration Schedule; Female; | 1985 |
Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients.
Topics: Age Factors; Aged; Arrhythmias, Cardiac; Depressive Disorder; Dose-Response Relationship, Drug; Elec | 1985 |
Serial monitoring and achievement of steady state nortriptyline plasma levels in depressed children and adolescents: preliminary data.
Topics: Adolescent; Child; Depressive Disorder; Female; Humans; Male; Nortriptyline; Time Factors | 1985 |
Serial ECG measurements at controlled plasma levels of nortriptyline in depressed children.
Topics: Age Factors; Body Weight; Child; Child, Preschool; Depressive Disorder; Electrocardiography; Female; | 1985 |
Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
Topics: Debrisoquin; Depressive Disorder; Humans; Hydroxylation; Isoquinolines; Nortriptyline | 1985 |
Nortriptyline in the treatment of a monosymptomatic delusion.
Topics: Delusions; Depressive Disorder; Female; Humans; Middle Aged; Nortriptyline; Parasites | 1985 |
Determination of compliance with riboflavin in an antidepressive therapy.
Topics: Adult; Amitriptyline; Creatinine; Depressive Disorder; Drug Combinations; Female; Half-Life; Humans; | 1985 |
Relationship of free nortriptyline levels to therapeutic response.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Kine | 1985 |
Diagnosis and clinical management of post-stroke depression.
Topics: Aphasia; Cerebrovascular Disorders; Depression; Depressive Disorder; Dexamethasone; Frontal Lobe; Hu | 1985 |
Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Depressive Disorder; Drug Thera | 1985 |