nortriptyline has been researched along with Cognition Disorders in 21 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke." | 9.09 | Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000) |
| "This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke." | 5.09 | Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000) |
| "Patients with major (n=33) or minor (n=14) depression participated in a double-blind treatment study with nortriptyline or placebo." | 5.09 | Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial. ( Kimura, M; Kosier, JT; Robinson, RG, 2000) |
| "Fifty-two depressed Parkinson's disease patients were enrolled in an NIH-funded randomized, controlled trial of nortriptyline, paroxetine, and placebo." | 2.75 | The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease. ( Bienfait, KL; Dicke, A; Dobkin, RD; Gara, M; Marin, H; Mark, MH; Menza, M; Tröster, A, 2010) |
| "The A." | 2.68 | A randomized trial of dementia care in nursing homes. ( Folstein, MF; Rovner, BW; Shmuely, Y; Steele, CD, 1996) |
| "Depression is a highly prevalent concomitant of dementia." | 2.40 | Depression and dementia: comorbidities, identification, and treatment. ( Meyers, BS, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dobkin, RD | 1 |
| Menza, M | 1 |
| Bienfait, KL | 1 |
| Gara, M | 1 |
| Marin, H | 1 |
| Mark, MH | 1 |
| Dicke, A | 1 |
| Tröster, A | 1 |
| Keers, R | 1 |
| Uher, R | 1 |
| Gupta, B | 1 |
| Rietschel, M | 1 |
| Schulze, TG | 1 |
| Hauser, J | 1 |
| Skibinska, M | 1 |
| Henigsberg, N | 1 |
| Kalember, P | 1 |
| Maier, W | 1 |
| Zobel, A | 1 |
| Mors, O | 1 |
| Kristensen, AS | 1 |
| Kozel, D | 1 |
| Giovannini, C | 1 |
| Mendlewicz, J | 1 |
| Kumar, S | 1 |
| McGuffin, P | 1 |
| Farmer, AE | 1 |
| Aitchison, KJ | 1 |
| Portella, MJ | 1 |
| Marcos, T | 1 |
| Rami, L | 1 |
| Navarro, V | 1 |
| Gastó, C | 1 |
| Salamero, M | 1 |
| Adeoye, OM | 1 |
| Ferrell, RE | 1 |
| Kirshner, MA | 1 |
| Mulsant, BH | 3 |
| Seligman, K | 1 |
| Begley, AE | 1 |
| Reynolds, CF | 4 |
| Pollock, BG | 3 |
| Doraiswamy, PM | 1 |
| Krishnan, KR | 1 |
| Oxman, T | 1 |
| Jenkyn, LR | 1 |
| Coffey, DJ | 1 |
| Burt, T | 1 |
| Clary, CM | 1 |
| Houck, PR | 1 |
| Mazumdar, S | 1 |
| Koru-Sengul, T | 1 |
| Tang, G | 1 |
| Narushima, K | 1 |
| Paradiso, S | 1 |
| Moser, DJ | 1 |
| Jorge, R | 1 |
| Robinson, RG | 3 |
| Jocic, Z | 1 |
| Staton, RD | 1 |
| Rovner, BW | 1 |
| Steele, CD | 1 |
| Shmuely, Y | 1 |
| Folstein, MF | 1 |
| Rollman, BL | 1 |
| Block, MR | 1 |
| Schulberg, HC | 1 |
| Meyers, BS | 2 |
| Schultz, SK | 1 |
| Castillo, C | 1 |
| Kopel, T | 1 |
| Kosier, JT | 2 |
| Newman, RM | 1 |
| Curdue, K | 1 |
| Petracca, G | 1 |
| Starkstein, SE | 1 |
| Alexopoulos, GS | 1 |
| Young, RC | 1 |
| Kalayam, B | 1 |
| Kakuma, T | 1 |
| Gabrielle, M | 1 |
| Sirey, JA | 1 |
| Hull, J | 1 |
| Kimura, M | 1 |
| Butters, MA | 1 |
| Becker, JT | 1 |
| Nebes, RD | 1 |
| Zmuda, MD | 1 |
| House, A | 1 |
| Anderson, C | 1 |
| Hackett, M | 1 |
| Bell, IR | 1 |
| Edman, JS | 1 |
| Morrow, FD | 1 |
| Marby, DW | 1 |
| Perrone, G | 1 |
| Kayne, HL | 1 |
| Greenwald, M | 1 |
| Cole, JO | 1 |
| Bartlomé, P | 1 |
| King, KS | 1 |
| Matsuo, F | 1 |
| Wood, JS | 1 |
| Georgotas, A | 1 |
| McCue, RE | 1 |
| Reisberg, B | 1 |
| Ferris, SH | 1 |
| Nagachandran, N | 1 |
| Chang, I | 1 |
| Mir, P | 1 |
| Perel, JM | 1 |
| Kupfer, DJ | 1 |
| Zimmer, B | 1 |
| Stack, JA | 1 |
| Hoch, CC | 1 |
| Thomasová, E | 1 |
| Mlcáková, K | 1 |
| Kümpel, Q | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Depression in Patients With Parkinson's Disease[NCT00062738] | Phase 2 | 52 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction[NCT02386475] | Phase 4 | 39 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Pathways Linking Late-Life Depression to MCI & Dementia[NCT00178087] | 331 participants (Actual) | Observational | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
total score on HDRS (0-54 higher score is worse) (NCT00062738)
Timeframe: 8 weeks
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Nortriptyline | 10.84 |
| Paroxetine | 12.45 |
| Placebo | 15.81 |
Percent of patients who had a 50% decrease in total HDRS at 8 weeks (NCT00062738)
Timeframe: 8 weeks
| Intervention | percent of patients who were responders (Number) |
|---|---|
| Nortriptyline | 53 |
| Paroxetine | 11 |
| Placebo | 24 |
1 review available for nortriptyline and Cognition Disorders
| Article | Year |
|---|---|
Depression and dementia: comorbidities, identification, and treatment.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cog | 1998 |
13 trials available for nortriptyline and Cognition Disorders
| Article | Year |
|---|---|
The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease.
Topics: Adult; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepre | 2010 |
Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP.
Topics: Adult; Affect; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra | 2010 |
Does antidepressant therapy improve cognition in elderly depressed patients?
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Cognition; Cognition Disorders; Confidence Intervals | 2003 |
Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods.
Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cognition Disorder | 2004 |
Effect of antidepressant therapy on executive function after stroke.
Topics: Aged; Antidepressive Agents; Cognition Disorders; Double-Blind Method; Female; Fluoxetine; Humans; M | 2007 |
A randomized trial of dementia care in nursing homes.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Baltimore; Cognitio | 1996 |
Symptoms of major depression and tricyclic side effects in primary care patients.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Cognition Disorders | 1997 |
Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study.
Topics: Activities of Daily Living; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disord | 2000 |
Executive dysfunction and long-term outcomes of geriatric depression.
Topics: Age Factors; Aged; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disorder; Femal | 2000 |
Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial.
Topics: Affect; Aged; Antidepressive Agents, Tricyclic; Cognition; Cognition Disorders; Depression; Double-B | 2000 |
Changes in cognitive functioning following treatment of late-life depression.
Topics: Aged; Antidepressive Agents; Cognition Disorders; Comorbidity; Dementia; Depressive Disorder; Female | 2000 |
Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.
Topics: Aged; Cognition Disorders; Depressive Disorder; Drug Therapy, Combination; Female; Folic Acid; Human | 1992 |
The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.
Topics: Affect; Aged; Aged, 80 and over; Cognition Disorders; Depressive Disorder; Double-Blind Method; Fema | 1989 |
7 other studies available for nortriptyline and Cognition Disorders
| Article | Year |
|---|---|
Residual cognitive impairment in late-life depression after a 12-month period follow-up.
Topics: Aged; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2003 |
alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics.
Topics: Aged; Aged, 80 and over; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, T | 2003 |
Reduplication after right middle cerebral artery infarction.
Topics: Aged; Brain; Brain Diseases; Cognition Disorders; Functional Laterality; Hemianopsia; Humans; Magnet | 1993 |
Authors should be accurate when describing study design.
Topics: Cognition Disorders; Duplicate Publications as Topic; Humans; Meta-Analysis as Topic; Nortriptyline; | 2001 |
Cognitive decline with nortriptyline use in a patient with dementia of the Alzheimer's type.
Topics: Aged; Alzheimer Disease; Attention; Cognition Disorders; Depression; Humans; Intelligence; Male; Mem | 1992 |
Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment.
Topics: Aged; Cognition Disorders; Depressive Disorder; Electroconvulsive Therapy; Humans; Nortriptyline; Pr | 1987 |
Confusional states in elderly mental patients treated with antidepressants.
Topics: Aged; Amitriptyline; Cognition Disorders; Confusion; Depression; Drug Therapy, Combination; Female; | 1974 |