Page last updated: 2024-11-01

nortriptyline and Cognition Disorders

nortriptyline has been researched along with Cognition Disorders in 21 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke."9.09Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000)
"This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke."5.09Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000)
"Patients with major (n=33) or minor (n=14) depression participated in a double-blind treatment study with nortriptyline or placebo."5.09Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial. ( Kimura, M; Kosier, JT; Robinson, RG, 2000)
"Fifty-two depressed Parkinson's disease patients were enrolled in an NIH-funded randomized, controlled trial of nortriptyline, paroxetine, and placebo."2.75The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease. ( Bienfait, KL; Dicke, A; Dobkin, RD; Gara, M; Marin, H; Mark, MH; Menza, M; Tröster, A, 2010)
"The A."2.68A randomized trial of dementia care in nursing homes. ( Folstein, MF; Rovner, BW; Shmuely, Y; Steele, CD, 1996)
"Depression is a highly prevalent concomitant of dementia."2.40Depression and dementia: comorbidities, identification, and treatment. ( Meyers, BS, 1998)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19903 (14.29)18.7374
1990's6 (28.57)18.2507
2000's10 (47.62)29.6817
2010's2 (9.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dobkin, RD1
Menza, M1
Bienfait, KL1
Gara, M1
Marin, H1
Mark, MH1
Dicke, A1
Tröster, A1
Keers, R1
Uher, R1
Gupta, B1
Rietschel, M1
Schulze, TG1
Hauser, J1
Skibinska, M1
Henigsberg, N1
Kalember, P1
Maier, W1
Zobel, A1
Mors, O1
Kristensen, AS1
Kozel, D1
Giovannini, C1
Mendlewicz, J1
Kumar, S1
McGuffin, P1
Farmer, AE1
Aitchison, KJ1
Portella, MJ1
Marcos, T1
Rami, L1
Navarro, V1
Gastó, C1
Salamero, M1
Adeoye, OM1
Ferrell, RE1
Kirshner, MA1
Mulsant, BH3
Seligman, K1
Begley, AE1
Reynolds, CF4
Pollock, BG3
Doraiswamy, PM1
Krishnan, KR1
Oxman, T1
Jenkyn, LR1
Coffey, DJ1
Burt, T1
Clary, CM1
Houck, PR1
Mazumdar, S1
Koru-Sengul, T1
Tang, G1
Narushima, K1
Paradiso, S1
Moser, DJ1
Jorge, R1
Robinson, RG3
Jocic, Z1
Staton, RD1
Rovner, BW1
Steele, CD1
Shmuely, Y1
Folstein, MF1
Rollman, BL1
Block, MR1
Schulberg, HC1
Meyers, BS2
Schultz, SK1
Castillo, C1
Kopel, T1
Kosier, JT2
Newman, RM1
Curdue, K1
Petracca, G1
Starkstein, SE1
Alexopoulos, GS1
Young, RC1
Kalayam, B1
Kakuma, T1
Gabrielle, M1
Sirey, JA1
Hull, J1
Kimura, M1
Butters, MA1
Becker, JT1
Nebes, RD1
Zmuda, MD1
House, A1
Anderson, C1
Hackett, M1
Bell, IR1
Edman, JS1
Morrow, FD1
Marby, DW1
Perrone, G1
Kayne, HL1
Greenwald, M1
Cole, JO1
Bartlomé, P1
King, KS1
Matsuo, F1
Wood, JS1
Georgotas, A1
McCue, RE1
Reisberg, B1
Ferris, SH1
Nagachandran, N1
Chang, I1
Mir, P1
Perel, JM1
Kupfer, DJ1
Zimmer, B1
Stack, JA1
Hoch, CC1
Thomasová, E1
Mlcáková, K1
Kümpel, Q1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Depression in Patients With Parkinson's Disease[NCT00062738]Phase 252 participants (Actual)Interventional2003-06-30Completed
Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction[NCT02386475]Phase 439 participants (Actual)Interventional2015-01-31Completed
Pathways Linking Late-Life Depression to MCI & Dementia[NCT00178087]331 participants (Actual)Observational2005-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Hamilton Depression Scale

total score on HDRS (0-54 higher score is worse) (NCT00062738)
Timeframe: 8 weeks

Interventionunits on a scale (Least Squares Mean)
Nortriptyline10.84
Paroxetine12.45
Placebo15.81

Percent Responders

Percent of patients who had a 50% decrease in total HDRS at 8 weeks (NCT00062738)
Timeframe: 8 weeks

Interventionpercent of patients who were responders (Number)
Nortriptyline53
Paroxetine11
Placebo24

Reviews

1 review available for nortriptyline and Cognition Disorders

ArticleYear
Depression and dementia: comorbidities, identification, and treatment.
    Journal of geriatric psychiatry and neurology, 1998,Winter, Volume: 11, Issue:4

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cog

1998

Trials

13 trials available for nortriptyline and Cognition Disorders

ArticleYear
The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease.
    The Journal of neuropsychiatry and clinical neurosciences, 2010,Spring, Volume: 22, Issue:2

    Topics: Adult; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepre

2010
Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP.
    Journal of affective disorders, 2010, Volume: 127, Issue:1-3

    Topics: Adult; Affect; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra

2010
Does antidepressant therapy improve cognition in elderly depressed patients?
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2003, Volume: 58, Issue:12

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Cognition; Cognition Disorders; Confidence Intervals

2003
Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods.
    Psychiatry research, 2004, Dec-15, Volume: 129, Issue:2

    Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cognition Disorder

2004
Effect of antidepressant therapy on executive function after stroke.
    The British journal of psychiatry : the journal of mental science, 2007, Volume: 190

    Topics: Aged; Antidepressive Agents; Cognition Disorders; Double-Blind Method; Female; Fluoxetine; Humans; M

2007
A randomized trial of dementia care in nursing homes.
    Journal of the American Geriatrics Society, 1996, Volume: 44, Issue:1

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Baltimore; Cognitio

1996
Symptoms of major depression and tricyclic side effects in primary care patients.
    Journal of general internal medicine, 1997, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Cognition Disorders

1997
Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study.
    The American journal of psychiatry, 2000, Volume: 157, Issue:3

    Topics: Activities of Daily Living; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disord

2000
Executive dysfunction and long-term outcomes of geriatric depression.
    Archives of general psychiatry, 2000, Volume: 57, Issue:3

    Topics: Age Factors; Aged; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disorder; Femal

2000
Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial.
    Stroke, 2000, Volume: 31, Issue:7

    Topics: Affect; Aged; Antidepressive Agents, Tricyclic; Cognition; Cognition Disorders; Depression; Double-B

2000
Changes in cognitive functioning following treatment of late-life depression.
    The American journal of psychiatry, 2000, Volume: 157, Issue:12

    Topics: Aged; Antidepressive Agents; Cognition Disorders; Comorbidity; Dementia; Depressive Disorder; Female

2000
Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.
    Journal of the American College of Nutrition, 1992, Volume: 11, Issue:2

    Topics: Aged; Cognition Disorders; Depressive Disorder; Drug Therapy, Combination; Female; Folic Acid; Human

1992
The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.
    International psychogeriatrics, 1989,Fall, Volume: 1, Issue:2

    Topics: Affect; Aged; Aged, 80 and over; Cognition Disorders; Depressive Disorder; Double-Blind Method; Fema

1989

Other Studies

7 other studies available for nortriptyline and Cognition Disorders

ArticleYear
Residual cognitive impairment in late-life depression after a 12-month period follow-up.
    International journal of geriatric psychiatry, 2003, Volume: 18, Issue:7

    Topics: Aged; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl

2003
alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics.
    Journal of geriatric psychiatry and neurology, 2003, Volume: 16, Issue:4

    Topics: Aged; Aged, 80 and over; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, T

2003
Reduplication after right middle cerebral artery infarction.
    Brain and cognition, 1993, Volume: 23, Issue:2

    Topics: Aged; Brain; Brain Diseases; Cognition Disorders; Functional Laterality; Hemianopsia; Humans; Magnet

1993
Authors should be accurate when describing study design.
    Stroke, 2001, Volume: 32, Issue:4

    Topics: Cognition Disorders; Duplicate Publications as Topic; Humans; Meta-Analysis as Topic; Nortriptyline;

2001
Cognitive decline with nortriptyline use in a patient with dementia of the Alzheimer's type.
    The Western journal of medicine, 1992, Volume: 156, Issue:1

    Topics: Aged; Alzheimer Disease; Attention; Cognition Disorders; Depression; Humans; Intelligence; Male; Mem

1992
Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment.
    Psychiatry research, 1987, Volume: 21, Issue:2

    Topics: Aged; Cognition Disorders; Depressive Disorder; Electroconvulsive Therapy; Humans; Nortriptyline; Pr

1987
Confusional states in elderly mental patients treated with antidepressants.
    Activitas nervosa superior, 1974, Volume: 16, Issue:3

    Topics: Aged; Amitriptyline; Cognition Disorders; Confusion; Depression; Drug Therapy, Combination; Female;

1974