nortriptyline has been researched along with Chronic Disease in 28 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus." | 9.07 | A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 9.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
| "To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus." | 5.07 | A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "This study describes the correlations between several measures of functional disability and Hamilton depression scores in two groups of patients with major depression and depressive symptoms (D-NOS) who were patients enrolled in a 12-week placebo-controlled, double-blind trial of nortriptyline." | 5.07 | Depressive symptoms and measures of disability: a prospective study. ( Dobie, R; Katon, W; Russo, J; Sakai, C; Sullivan, M, 1993) |
| "The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 5.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
| "Objective To evaluate the short- and long-term effects of tricyclic antidepressants (TCAs) and gabapentin in the treatment of unexplained chronic cough (UCC)." | 3.88 | Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough. ( Adessa, M; Benninger, MS; Bowen, AJ; Bryson, PC; Contrera, K; Kaltenbach, J; Milstein, CF; Nowacki, AS; Taliercio, R; Trask, D, 2018) |
| "Although this is a small study, it appears that gabapentin and nortriptyline are effective in the treatment of idiopathic chronic orchialgia but not post-vasectomy pain." | 3.74 | Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery. ( Lee, LK; Miller, B; Sinclair, AM, 2007) |
| "This study was to characterize the neuroprotective effects of nortriptyline, a tricyclic antidepressant, in mouse models of chronic neurodegeneration [amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)]." | 3.74 | Nortriptyline delays disease onset in models of chronic neurodegeneration. ( Cormier, K; Ferrante, RJ; Friedlander, RM; Guan, Y; Huo, C; Kristal, BS; Smith, K; Stavrovskaya, IG; Wang, H; Wang, X; Zhu, S, 2007) |
| "Nortriptyline treatment was accompanied by marked improvements in anxiety, certain respiratory symptoms, overall physical comfort, and day-to-day function; placebo effects were negligible." | 2.67 | Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease. ( Borson, S; Deffebach, M; Gayle, T; Lakshminarayan, S; McDonald, GJ; VanTuinen, C, 1992) |
| "Headaches are a common entity in the ambulatory population." | 2.40 | Diagnosis, prophylaxis, and treatment of headaches in the athlete. ( Kaplan, B; Swain, RA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 14 (50.00) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bowen, AJ | 1 |
| Nowacki, AS | 1 |
| Contrera, K | 1 |
| Trask, D | 1 |
| Kaltenbach, J | 1 |
| Milstein, CF | 1 |
| Adessa, M | 1 |
| Benninger, MS | 1 |
| Taliercio, R | 1 |
| Bryson, PC | 1 |
| Wind, LA | 1 |
| Chavannes, NH | 1 |
| Kaper, J | 1 |
| Frijling, BD | 1 |
| van der Laan, JR | 1 |
| Wiersma, T | 1 |
| Goudswaard, AN | 1 |
| Reed, BD | 1 |
| Cantor, LE | 1 |
| Johnstone, JM | 1 |
| Luty, SE | 2 |
| Carter, JD | 1 |
| Mulder, RT | 2 |
| Frampton, CM | 1 |
| Joyce, PR | 2 |
| Jensen, TS | 1 |
| Finnerup, NB | 1 |
| CHESROW, EJ | 1 |
| KAPLITZ, SE | 1 |
| BREME, JT | 1 |
| SABATINI, R | 1 |
| VETRA, H | 1 |
| MARQUARDT, GH | 1 |
| Yi, BA | 1 |
| Nirenberg, MJ | 1 |
| Goldstein, SM | 1 |
| Berger, TG | 1 |
| Cohen, SP | 1 |
| Sireci, A | 1 |
| Wu, CL | 1 |
| Larkin, TM | 1 |
| Williams, KA | 1 |
| Hurley, RW | 1 |
| Khoromi, S | 1 |
| Cui, L | 1 |
| Nackers, L | 1 |
| Max, MB | 1 |
| Sinclair, AM | 1 |
| Miller, B | 1 |
| Lee, LK | 1 |
| Wang, H | 1 |
| Guan, Y | 1 |
| Wang, X | 1 |
| Smith, K | 1 |
| Cormier, K | 1 |
| Zhu, S | 1 |
| Stavrovskaya, IG | 1 |
| Huo, C | 1 |
| Ferrante, RJ | 1 |
| Kristal, BS | 1 |
| Friedlander, RM | 1 |
| Benbouzid, M | 1 |
| Choucair-Jaafar, N | 1 |
| Yalcin, I | 1 |
| Waltisperger, E | 1 |
| Muller, A | 1 |
| Freund-Mercier, MJ | 1 |
| Barrot, M | 1 |
| Sullivan, M | 3 |
| Katon, W | 2 |
| Russo, J | 3 |
| Dobie, R | 3 |
| Sakai, C | 3 |
| Swain, RA | 1 |
| Kaplan, B | 1 |
| Lofland, JH | 1 |
| Szarlej, D | 1 |
| Buttaro, T | 1 |
| Shermock, S | 1 |
| Jalali, S | 1 |
| Holroyd, KA | 1 |
| O'Donnell, FJ | 1 |
| Stensland, M | 1 |
| Lipchik, GL | 1 |
| Cordingley, GE | 1 |
| Carlson, BW | 1 |
| Stolar, AG | 1 |
| Stewart, JT | 1 |
| Katon, WJ | 2 |
| Borson, S | 1 |
| McDonald, GJ | 1 |
| Gayle, T | 1 |
| Deffebach, M | 1 |
| Lakshminarayan, S | 1 |
| VanTuinen, C | 1 |
| Walker, EA | 1 |
| Roy-Byrne, PP | 1 |
| Jemelka, R | 1 |
| Bowers, WA | 1 |
| Edelbroek, PM | 1 |
| Linssen, AC | 1 |
| Zitman, FG | 1 |
| Rooymans, HG | 1 |
| de Wolff, FA | 1 |
| Giller, E | 1 |
| Bialos, D | 1 |
| Harkness, L | 1 |
| Jatlow, P | 1 |
| Waldo, M | 1 |
| Rawlins, MD | 1 |
| Berner, P | 1 |
| Kryspin-Exner, K | 1 |
| Poeldinger, W | 1 |
| Morley, WN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Radiofrequency Thoracic Sympathectomy for Chronic Postmastectomy Pain; Randomized Placebo Controlled Study[NCT03494426] | 70 participants (Actual) | Interventional | 2018-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nortriptyline and Chronic Disease
| Article | Year |
|---|---|
Diagnosis, prophylaxis, and treatment of headaches in the athlete.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; | 1997 |
Variability in response to drugs.
Topics: Acute Disease; Acylation; Chlorthalidone; Chronic Disease; Depression; Diazoxide; Digoxin; Dose-Resp | 1974 |
12 trials available for nortriptyline and Chronic Disease
| Article | Year |
|---|---|
Childhood neglect and abuse as predictors of antidepressant response in adult depression.
Topics: Adult; Age of Onset; Antidepressive Agents; Child; Child Abuse; Child Abuse, Sexual; Chronic Disease | 2009 |
The relationship of personality disorders to treatment outcome in depressed outpatients.
Topics: Adult; Age Factors; Ambulatory Care; Antidepressive Agents; Chronic Disease; Comorbidity; Depressive | 2003 |
Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain.
Topics: Adult; Aged; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Chronic Disease; Cross-Over Studi | 2007 |
A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms.
Topics: Aged; Audiometry, Pure-Tone; Chronic Disease; Depression; Depressive Disorder; Disabled Persons; Dou | 1993 |
Depressive symptoms and measures of disability: a prospective study.
Topics: Adaptation, Psychological; Aged; Chronic Disease; Depression; Disability Evaluation; Double-Blind Me | 1993 |
Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Cognitive | 2001 |
Somatization, co-morbidity, and the quality of life: measuring the effect of depression upon chronic medical illness.
Topics: Activities of Daily Living; Audiometry, Pure-Tone; Chronic Disease; Comorbidity; Depressive Disorder | 1992 |
Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease.
Topics: Activities of Daily Living; Affect; Attitude to Health; Chronic Disease; Depressive Disorder; Dyspne | 1992 |
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; | 1986 |
Long-term amitriptyline in chronic depression.
Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1985 |
Therapy possibilities for therapy-resistant depressions.
Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipra | 1974 |
Nortriptyline in the treatment of chronic urticaria.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nortriptyline; | 1969 |
14 other studies available for nortriptyline and Chronic Disease
| Article | Year |
|---|---|
Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough.
Topics: Adult; Aged; Amitriptyline; Chronic Disease; Cohort Studies; Cough; Dose-Response Relationship, Drug | 2018 |
[Summary of the practice guideline 'Smoking cessation' from the Dutch College of General Practitioners].
Topics: Bupropion; Chronic Disease; Family Practice; Female; Humans; Male; Motivation; Netherlands; Nicotine | 2008 |
Vulvodynia in preadolescent girls.
Topics: Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Disease; Female; Humans; Nortript | 2008 |
Neuropathic pain treatment: a further step forward.
Topics: Amines; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Cyclohexanecarboxylic Acids; | 2009 |
NORTRIPTYLINE FOR THE TREATMENT OF ANXIETY AND DEPRESSION IN CHRONICALLY ILL AND GERIATRIC PATIENTS.
Topics: Aged; Alcoholism; Antidepressive Agents; Anxiety; Cerebrovascular Disorders; Chronic Disease; Depres | 1964 |
Chronic neuropathic pain associated with imiquimod: report of 2 cases.
Topics: Aminoquinolines; Antiviral Agents; Chronic Disease; Female; Humans; Imiquimod; Male; Middle Aged; No | 2005 |
Pulsed radiofrequency of the dorsal root ganglia is superior to pharmacotherapy or pulsed radiofrequency of the intercostal nerves in the treatment of chronic postsurgical thoracic pain.
Topics: Adult; Amines; Analgesics; Anticonvulsants; Carbamazepine; Catheter Ablation; Chronic Disease; Cyclo | 2006 |
Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amines; Calcium Channel Blockers; Chronic Disease; Cycloh | 2007 |
Nortriptyline delays disease onset in models of chronic neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antidepressive Agents, Tricyclic; Apoptosis; Brain; Chronic | 2007 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination; | 2001 |
Nortriptyline for depression and vulvodynia.
Topics: Aged; Chronic Disease; Depressive Disorder, Major; Female; Humans; Neuralgia; Nortriptyline; Treatme | 2002 |
An open trial of nortriptyline in women with chronic pelvic pain.
Topics: Abdominal Pain; Adult; Chronic Disease; Female; Genital Diseases, Female; Humans; Nortriptyline; Pat | 1991 |
Treatment of depressed in-patients. Cognitive therapy plus medication, relaxation plus medication, and medication alone.
Topics: Adult; Chronic Disease; Cognitive Behavioral Therapy; Combined Modality Therapy; Depressive Disorder | 1990 |