nortriptyline has been researched along with Bipolar Disorder in 56 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Data are presented on the baseline characteristics and 2- to 3-year follow-up assessments of placebo-washout responders (PWRs) from a previously reported pharmacokinetically designed double-blind placebo-controlled trial of nortriptyline for major depressive disorder in 6- to 12-year-olds." | 5.07 | Baseline and 2- to 3-year follow-up characteristics of placebo-washout responders from the nortriptyline study of depressed 6- to 12-year-olds. ( Cooper, TB; Fox, LW; Garrity, K; Geller, B, 1992) |
| "Personality disorders are neither particularly stable nor treatment resistant." | 2.75 | Personality disorders improve in patients treated for major depression. ( Frampton, CM; Joyce, PR; Mulder, RT, 2010) |
| "Amitriptyline was found to act within seven days on the components of anxiety and on hostility in the responders, and on sleep disorder in all patients." | 2.67 | Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression. ( Bowden, CL; Casper, RC; Frazer, A; Katz, MM; Kocsis, J; Koslow, SH; Maas, JW; Secunda, S, 1991) |
| "The nortriptyline dose was therefore increased to 150 mg/day; the mean SNT rose to 402 +/- 69 nM (n = 4) and the depression disappeared." | 1.29 | Concomitant intake of nortriptyline and carbamazepine. ( Brøsen, K; Kragh-Sørensen, P, 1993) |
| " The results of the investigation were: (1) long-term treatment with nortriptyline is followed by hyposecretion or xerostomia, (2) the reduction of the secretion is reversible, (3) re-establishment of treatment with dosage leading to the same serum level of nortriptyline is immediately followed by a drop in saliva secretion, and (4) the changes in salivary secretion are useful as an indicator of side effects." | 1.26 | Saliva secretion following long-term antidepressant treatment with nortriptyline controlled by plasma levels. ( Bertram, U; Kragh-Sørensen, P; Larsen, NE; Rafaelsen, OJ, 1981) |
| " For depressive neurosis and involutional melancholia best therapeutic responses were yielded at a dosage of 50 mg, while in the treatment of manic-depressive illness, comparable results occurred at a 150 mg dosage." | 1.26 | Amitriptyline, nortriptyline plasma levels and clinical response in women with affective disorders. ( Corona, GL; Cucchi, ML; Fenoglio, L; Frattini, P; Pinelli, P; Santagostino, G; Zerbi, F, 1980) |
| " The results of the investigation were: (1) long-term treatment with nortriptyline is followed by hyposecretion or xerostomia, (2) the reduction of the secretion is reversible, (3) re-establishment of treatment with dosage leading to the same serum level of nortriptyline is immediately followed by a drop in saliva secretion, and (4) the changes in salivary secretion are useful as an indicator of side effects." | 1.26 | Saliva secretion following long-term antidepressant treatment with nortriptyline controlled by plasma levels. ( Bertram, U; Kragh-Sørensen, P; Larsen, NE; Rafaelsen, OJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (60.71) | 18.7374 |
| 1990's | 12 (21.43) | 18.2507 |
| 2000's | 7 (12.50) | 29.6817 |
| 2010's | 3 (5.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avery, DH | 1 |
| Alexander, EM | 1 |
| Wehr, TA | 1 |
| Fawcett, J | 1 |
| Rush, AJ | 1 |
| Vukelich, J | 1 |
| Diaz, SH | 1 |
| Dunklee, L | 1 |
| Romo, P | 1 |
| Yarns, BC | 1 |
| Escalona, R | 1 |
| Mulder, RT | 4 |
| Joyce, PR | 4 |
| Frampton, CM | 1 |
| Jain, V | 1 |
| Swartz, CM | 1 |
| Gilbert-Johnson, AM | 1 |
| Constantino, JN | 1 |
| RAVN, J | 1 |
| RINGEL, E | 1 |
| LANG, HB | 1 |
| Luty, SE | 3 |
| McKenzie, JM | 3 |
| Miller, AL | 2 |
| Rogers, GR | 1 |
| Kennedy, MA | 2 |
| McIntosh, VV | 1 |
| Carter, FA | 1 |
| Bulik, CM | 1 |
| Sullivan, PF | 1 |
| Porter, RJ | 1 |
| Tune, L | 1 |
| Coyle, JT | 1 |
| Extein, I | 1 |
| Gold, MS | 1 |
| Pottash, AL | 1 |
| Ansseau, M | 2 |
| Kupfer, DJ | 4 |
| Reynolds, CF | 2 |
| McEachran, AB | 1 |
| Bertram, U | 2 |
| Kragh-Sørensen, P | 3 |
| Rafaelsen, OJ | 2 |
| Larsen, NE | 3 |
| Fraser, A | 1 |
| Paramananthan, T | 1 |
| Shaw, H | 1 |
| Gibb, I | 1 |
| Alexopoulos, GS | 1 |
| Shamoian, CA | 1 |
| Razavi, D | 1 |
| Mendlewicz, J | 1 |
| Nasrallah, HA | 1 |
| Lyskowksi, J | 1 |
| Schroeder, D | 1 |
| Spiker, DG | 2 |
| Rossi, A | 1 |
| Coble, PA | 1 |
| Shaw, D | 1 |
| Ulrich, R | 1 |
| Meltzer, HY | 2 |
| Arora, RC | 1 |
| Baber, R | 1 |
| Tricou, BJ | 1 |
| Hollister, LE | 1 |
| Pfefferbaum, A | 1 |
| Davis, KL | 1 |
| Corona, GL | 1 |
| Pinelli, P | 1 |
| Zerbi, F | 1 |
| Fenoglio, L | 1 |
| Santagostino, G | 1 |
| Frattini, P | 1 |
| Cucchi, ML | 1 |
| Jungkunz, G | 1 |
| Kuss, HJ | 1 |
| Breyer-Pfaff, U | 1 |
| Nill, K | 1 |
| Entenmann, KN | 1 |
| Gaertner, HJ | 1 |
| el-Yazigi, A | 1 |
| Chaleby, K | 1 |
| Gad, A | 1 |
| Raines, DA | 1 |
| Dilsaver, SC | 1 |
| Swann, AC | 1 |
| Geller, B | 3 |
| Fox, LW | 2 |
| Clark, KA | 1 |
| Fu, C | 1 |
| Katzman, M | 1 |
| Goldbloom, DS | 1 |
| Brøsen, K | 1 |
| Maes, M | 1 |
| De Meester, I | 1 |
| Scharpe, S | 1 |
| Desnyder, R | 1 |
| Ranjan, R | 1 |
| Conforti, D | 1 |
| Borgherini, G | 1 |
| Fiorellini Bernardis, LA | 1 |
| Magni, G | 1 |
| June, R | 1 |
| Yunus, M | 1 |
| Gossman, W | 1 |
| Morita, S | 1 |
| Shimoda, K | 1 |
| Someya, T | 1 |
| Yoshimura, Y | 1 |
| Kamijima, K | 1 |
| Kato, N | 1 |
| Zimerman, B | 1 |
| Williams, M | 1 |
| Bolhofner, K | 1 |
| Craney, JL | 1 |
| Gabriel, E | 1 |
| Karobath, M | 1 |
| Lenz, G | 1 |
| Steiner, M | 1 |
| Elizur, A | 1 |
| Davidson, S | 1 |
| Bloomingdale, LM | 1 |
| Bressler, B | 1 |
| Furlong, FW | 2 |
| Sellers, EM | 1 |
| Kapur, BM | 1 |
| Cooper, TB | 1 |
| Garrity, K | 1 |
| Katz, MM | 1 |
| Koslow, SH | 2 |
| Maas, JW | 1 |
| Frazer, A | 2 |
| Kocsis, J | 1 |
| Secunda, S | 1 |
| Bowden, CL | 2 |
| Casper, RC | 1 |
| Roca, RP | 1 |
| Blackman, MR | 1 |
| Ackerley, MB | 1 |
| Harman, SM | 1 |
| Gregerman, RI | 1 |
| Hanin, I | 2 |
| Kocsis, JH | 1 |
| Brunswick, D | 1 |
| Carl, J | 1 |
| Robins, E | 1 |
| Dealy, RS | 1 |
| Weiss, JC | 1 |
| Gitlin, MJ | 1 |
| McMahon, T | 1 |
| Kragh-Sorensen, P | 1 |
| Hansen, CE | 1 |
| Nasestoft, J | 1 |
| Hvidberg, EF | 1 |
| Ogura, C | 1 |
| Okuma, T | 1 |
| Uchida, Y | 1 |
| Imai, S | 1 |
| Yogi, H | 1 |
| Pritchard, DW | 1 |
| Rump, EE | 1 |
| Grivell, PD | 1 |
| Luby, ED | 1 |
| Bechthold, HG | 1 |
| Schottky, A | 1 |
| Hrbek, J | 1 |
| Navrátil, J | 1 |
| Kammerer, T | 1 |
| Ebtinger, R | 1 |
| Gurfein, L | 1 |
| Milani, A | 1 |
| Patris, M | 1 |
| Subra, N | 1 |
| Vencovský, E | 1 |
| Sedivec, V | 1 |
| Peterová, E | 1 |
| Baudis, P | 1 |
| Valenová, Z | 1 |
| Janovský, F | 1 |
1 review available for nortriptyline and Bipolar Disorder
| Article | Year |
|---|---|
Psychopharmacologic treatment of depression.
Topics: Affective Disorders, Psychotic; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychot | 1984 |
11 trials available for nortriptyline and Bipolar Disorder
| Article | Year |
|---|---|
Personality disorders improve in patients treated for major depression.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Comorbidity; Depressive Disorder, Major; Dose-Respon | 2010 |
Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline.
Topics: Adult; Age Factors; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyc | 2003 |
Bipolar II disorder: personality and outcome in two clinical samples.
Topics: Adrenergic Uptake Inhibitors; Adult; Bipolar Disorder; Bulimia; Cognitive Behavioral Therapy; Depres | 2004 |
Reversed diurnal variation in depression: associations with a differential antidepressant response, tryptophan: large neutral amino acid ratio and serotonin transporter polymorphisms.
Topics: Adult; Affect; Alleles; Amino Acids; Antidepressive Agents; Bipolar Disorder; Circadian Rhythm; Depr | 2005 |
Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone.
Topics: Adolescent; Adult; Amitriptyline; Bipolar Disorder; Chromatography, High Pressure Liquid; Depression | 1995 |
Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children.
Topics: Adolescent; Bipolar Disorder; Child; Depressive Disorder; Double-Blind Method; Female; Follow-Up Stu | 1994 |
Baseline and 2- to 3-year follow-up characteristics of placebo-washout responders from the nortriptyline study of depressed 6- to 12-year-olds.
Topics: Bipolar Disorder; Child; Depressive Disorder; Female; Follow-Up Studies; Humans; Longitudinal Studie | 1992 |
Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression.
Topics: Affect; Amitriptyline; Arousal; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Nortrip | 1991 |
Treating delusional depressives with amitriptyline.
Topics: Adult; Amitriptyline; Bipolar Disorder; Clinical Trials as Topic; Delusions; Depressive Disorder; Dr | 1986 |
Long-term treatment of endogenous depression with nortriptyline with control of plasma levels.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Blood Specimen Collection; Chromatography, Gas; Clinical | 1974 |
Lithium in the control of mania.
Topics: Adult; Amitriptyline; Bipolar Disorder; Chlorpromazine; Clinical Trials as Topic; Desipramine; Femal | 1967 |
44 other studies available for nortriptyline and Bipolar Disorder
| Article | Year |
|---|---|
Synchrony Between Bipolar Mood Cycles and Lunar Tidal Cycles Ended After Initiation of Light Treatment and Treatment of Hypothyroidism.
Topics: Aged; Antidepressive Agents; Bipolar Disorder; Female; Humans; Hypothyroidism; Moon; Nortriptyline; | 2019 |
Clinical Experience With High-Dosage Pramipexole in Patients With Treatment-Resistant Depressive Episodes in Unipolar and Bipolar Depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Benzothiazoles; Bipolar Disorder; Bupropion; | 2016 |
Charcoal enhancement of treatment for tricyclic-induced mania.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Bipolar Disorder; Charcoal; Depres | 2002 |
Use of nortriptyline in adolescent-onset bipolar disorder.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Bipolar Disorder; Combined Modality Therapy; Drug Resi | 2002 |
[TREATMENT OF ENDOGENOUS DEPRESSIONS WITH ANTIDEPRESSIVE AGENTS AND ELECTROSHOCK AND TREATMENT BEFORE 1937].
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Electroconvulsive Thera | 1964 |
[EXPERIENCES WITH THE NEW ANTIDEPRESSIVE AGENT NORTRIPTYLINE].
Topics: Antidepressive Agents; Bipolar Disorder; Drug Therapy; Humans; Mental Disorders; Nortriptyline; Psyc | 1965 |
CLINICAL REPORT ON PARENTERAL NORTRIPTYLINE.
Topics: Antidepressive Agents; Anxiety; Anxiety Disorders; Bipolar Disorder; Depression; Depressive Disorder | 1965 |
Acute extrapyramidal side effects: serum levels of neuroleptics and anticholinergics.
Topics: Acute Disease; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Bipolar Disorder; Chlorpromazi | 1981 |
REM latency distribution in major depression: clinical characteristics associated with sleep onset REM periods.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; Double-B | 1984 |
Saliva secretion following long-term antidepressant treatment with nortriptyline controlled by plasma levels.
Topics: Aged; Bipolar Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Salivation | 1981 |
Nortriptyline and electroconvulsive therapy.
Topics: Adult; Arrhythmias, Cardiac; Bipolar Disorder; Depressive Disorder; Electroconvulsive Therapy; Femal | 1982 |
Tricyclic antidepressants and cardiac patients with pacemakers.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Female; | 1982 |
Tricyclic antidepressant plasma levels: the state of the art and clinical prospects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Bipolar Disorder; Depressive Dis | 1982 |
TCA-induced mania: differences between switchers and nonswitchers.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; | 1982 |
Nortriptyline and EEG sleep in depressed patients.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Elect | 1982 |
Serotonin uptake in blood platelets of psychiatric patients.
Topics: Adult; Analysis of Variance; Bipolar Disorder; Blood Platelets; Carbon Radioisotopes; Depressive Dis | 1981 |
Monitoring nortriptyline plasma concentrations.
Topics: Adjustment Disorders; Adult; Affective Disorders, Psychotic; Bipolar Disorder; Depression; Depressiv | 1980 |
Amitriptyline, nortriptyline plasma levels and clinical response in women with affective disorders.
Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Depressive Disorder, | 1980 |
On the relationship of nortriptyline: amitriptyline ratio to clinical improvement of amitriptyline treated depressive patients.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depression; Humans; Middle Aged; Nortriptyline; Psychiatric | 1980 |
Secretion of amitriptyline and metabolites into breast milk.
Topics: Adult; Amitriptyline; Bipolar Disorder; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; | 1995 |
Mixed mania: apparent induction by a tricyclic antidepressant in five consecutively treated patients with bipolar depression.
Topics: Adult; Bipolar Disorder; Desipramine; Female; Humans; Male; Middle Aged; Nortriptyline | 1995 |
Valproate/nortriptyline interaction.
Topics: Adult; Bipolar Disorder; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Nortrip | 1994 |
Concomitant intake of nortriptyline and carbamazepine.
Topics: Aged; Bipolar Disorder; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Female; Humans; | 1993 |
Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia: effects of antidepressants and antipsychotic drugs.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Dipeptidy | 1996 |
Extrapyramidal symptoms associated with the adjunct of nortriptyline to a venlafaxine-valproic acid combination.
Topics: Aged; Anticonvulsants; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; B | 1999 |
Neuroleptic malignant syndrome associated with nortriptyline.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Diagnosis, Differential; Emergency Treatment; Hu | 1999 |
Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: impact of CYP2D6 genotype on the hydroxylation of nortriptyline.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Alleles; Bipolar Disorder; Cytochrome P-450 CYP2D6; D | 2000 |
Bipolar disorder at prospective follow-up of adults who had prepubertal major depressive disorder.
Topics: Adolescent; Adult; Bipolar Disorder; Child; Depressive Disorder; Follow-Up Studies; Humans; Nortript | 2001 |
[The extrapyramidal symptoms in the combination of lithium long-term lithium therapy with nortriptyline. A case report on the formation of a pathogenesis hypothesis].
Topics: Adult; Basal Ganglia Diseases; Bipolar Disorder; Chlorprothixene; Clopenthixol; Dibenzazepines; Drug | 1976 |
A psychosomatic triad in a bipolar patient.
Topics: Asthma; Bipolar Disorder; Dermatitis, Seborrheic; Drug Therapy, Combination; Humans; Male; Middle Ag | 1977 |
Saliva secretion following long-term antidepressant treatment with nortriptyline controlled by plasma levels.
Topics: Aged; Ascorbic Acid; Bipolar Disorder; Carbonates; Female; Humans; Male; Middle Aged; Nortriptyline; | 1979 |
Rapid intramuscular administration of tricyclic antidepressants.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depr | 1979 |
Amitriptyline blood levels and relapse.
Topics: Administration, Oral; Adult; Amitriptyline; Bipolar Disorder; Double-Blind Method; Female; Follow-Up | 1977 |
Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism.
Topics: Adult; Bipolar Disorder; Blood Pressure; Depressive Disorder; Down-Regulation; Feedback; Female; Hal | 1990 |
Cerebrospinal fluid levels of amitriptyline, nortriptyline, imipramine and desmethylimipramine. Relationship to plasma levels and treatment outcome.
Topics: Amitriptyline; Bipolar Disorder; Depressive Disorder; Desipramine; Double-Blind Method; Female; Gas | 1985 |
L-triiodothyronine-precipitated angina and clinical response.
Topics: Angina Pectoris; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Huma | 1986 |
Bipolar affective symptoms associated with use of captopril and abrupt withdrawal of pargyline and propranolol.
Topics: Bipolar Disorder; Captopril; Drug Therapy, Combination; Female; Humans; Hypertension; Middle Aged; N | 1985 |
Internight variability of REM latency in major depression: implications for the use of REM latency as a biological correlate.
Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Electroencep | 1985 |
Combined thyroid (triiodothyronine)-tricyclic antidepressant treatment in depressive states.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents; Anxiety; Bipolar Disorder; Blood | 1974 |
Time series for symptom-clusters in a case of manic-depressive illness.
Topics: Benztropine; Bipolar Disorder; Electroconvulsive Therapy; Female; Humans; Lithium; Middle Aged; Nort | 1972 |
[Phasic depression and epilepsy. Two polar cases].
Topics: Adult; Bipolar Disorder; Chlorprothixene; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Ha | 1971 |
Pharmacotherapy in the premenstrual tension.
Topics: Adolescent; Adult; Bipolar Disorder; Chlorpromazine; Depression; Female; Humans; Imipramine; Neuroti | 1971 |
[Clinical trials of nortriptyline in 40 cases].
Topics: Adolescent; Adult; Aged; Anxiety; Bipolar Disorder; Depression; Humans; Male; Middle Aged; Neurotic | 1969 |
[Clinical experiences with nortriptyline].
Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Nortrip | 1965 |