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nortriptyline and Arrhythmia

nortriptyline has been researched along with Arrhythmia in 21 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Research Excerpts

ExcerptRelevanceReference
"5 to 7 mg base per kilogram caused significantly more arrhythmias than did E-10-hydroxynortriptyline (E-10-OH-NT) but was not significantly different from Z-10-hydroxynortriptyline (Z-10-OH-NT) in this effect."3.68Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites. ( Everett, G; Perel, JM; Pollock, BG, 1992)
"The effect of nortriptyline against ventricular arrhythmias was determined in 16 cardiac patients with 30 or more ventricular premature depolarizations per hour."3.67The antiarrhythmic effect of nortriptyline in cardiac patients with ventricular premature depolarizations. ( Barnard, T; Bigger, JT; Giardina, EG; Johnson, L; Louie, M; Saroff, AL, 1986)
" In 1 patient, acute myocardial infarction developed after two 10-mg doses of nortriptyline."3.66Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged. ( Oei, LS; Rodstein, M, 1979)
"Nortriptyline was effective for his depressive as well as for obsessive symptoms."1.33[A case of Brugada syndrome with convulsive seizure during antidepressant administration: relation of antidepressant agents and arrhythmia leading to sudden death]. ( Aihara, H; Aonuma, K; Asada, T; Endo, G; Hori, T; Tanimukai, S, 2006)
"Nortriptyline therapy was associated with increased QRS interval and heart rate but did not significantly affect other hemodynamic or ECG variables or cyclosporine dose requirements."1.28Nortriptyline treatment of depressed cardiac transplant recipients. ( Shapiro, PA, 1991)
"Five of the 10 patients had arrhythmias and two of these died."1.25Cardiac abnormalities in poisoning with tricyclic antidepressants. ( Beattie, RR; Freeman, JW; Mundy, GR; Ryan, C, 1969)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199016 (76.19)18.7374
1990's4 (19.05)18.2507
2000's1 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Endo, G1
Hori, T1
Tanimukai, S1
Aihara, H1
Aonuma, K1
Asada, T1
Tacconi, MT1
Bonaccorsi, A1
Cini, M1
Spina, AM1
Bizzi, A1
Fraser, A1
Paramananthan, T1
Shaw, H1
Gibb, I1
Ziegler, VE1
Co, BT1
Biggs, JT1
Rodstein, M1
Oei, LS1
Baum, T1
Peters, JR1
Butz, F1
Much, DR1
Pollock, BG1
Everett, G1
Perel, JM1
Shapiro, PA1
Dietch, JT1
Fine, M1
Sirota, P1
Ori, J1
Schild, K1
Appel, S1
Brandis, S1
Zahavi, I1
Schneider, LS1
Cooper, TB1
Severson, JA1
Zemplenyi, T1
Sloane, RB1
Giardina, EG2
Barnard, T1
Johnson, L1
Saroff, AL1
Bigger, JT2
Louie, M1
Johnson, LL1
Vita, J1
Brem, RF1
Young, RC1
Alexopoulos, GS1
Shamoian, CA1
Kent, E1
Dhar, AK1
Kutt, H1
Freeman, JW2
Loughhead, MG1
Plowman, PE1
Thomas, WJ1
Brown, TC1
Barker, GA1
Dunlop, ME1
Loughnan, PM1
Duke, WW1
Horton, JP1
Sedal, L1
Korman, MG1
Williams, PO1
Mushin, G1
Slovis, TL1
Ott, JE1
Teitebaum, DT1
Lipscomb, W1
Mundy, GR1
Beattie, RR1
Ryan, C1

Trials

2 trials available for nortriptyline and Arrhythmia

ArticleYear
Plasma nortriptyline levels and ECG findings.
    The American journal of psychiatry, 1977, Volume: 134, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Depression; Electrocardiography; Electr

1977
Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients.
    Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:6

    Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Dose-R

1988

Other Studies

19 other studies available for nortriptyline and Arrhythmia

ArticleYear
[A case of Brugada syndrome with convulsive seizure during antidepressant administration: relation of antidepressant agents and arrhythmia leading to sudden death].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2006, Volume: 108, Issue:8

    Topics: Adult; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Brugada Syndrome; Death, Sudden, Card

2006
Effect of carnitine on heart alterations caused by tricyclic antidepressants.
    The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Carnitine; Heart; Male; Nortriptyline; Rabbits

1981
Nortriptyline and electroconvulsive therapy.
    The New Zealand medical journal, 1982, Aug-11, Volume: 95, Issue:713

    Topics: Adult; Arrhythmias, Cardiac; Bipolar Disorder; Depressive Disorder; Electroconvulsive Therapy; Femal

1982
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
    Journal of the American Geriatrics Society, 1979, Volume: 27, Issue:5

    Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System;

1979
Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity.
    European journal of pharmacology, 1976, Volume: 39, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Dogs

1976
Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 6, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Blood Proteins; Cardiac Output, Low; Chromatography,

1992
Nortriptyline treatment of depressed cardiac transplant recipients.
    The American journal of psychiatry, 1991, Volume: 148, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography; Female; Heart Rate; Heart Tra

1991
The effect of nortriptyline in elderly patients with cardiac conduction disease.
    The Journal of clinical psychiatry, 1990, Volume: 51, Issue:2

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depressive Disorder

1990
Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels.
    Biological psychiatry, 1990, May-01, Volume: 27, Issue:9

    Topics: Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography, Ambulato

1990
The antiarrhythmic effect of nortriptyline in cardiac patients with ventricular premature depolarizations.
    Journal of the American College of Cardiology, 1986, Volume: 7, Issue:6

    Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Female; Half-Life; Humans; Male; Middle Aged; Nor

1986
Effect of imipramine and nortriptyline on left ventricular function and blood pressure in patients treated for arrhythmias.
    American heart journal, 1985, Volume: 109, Issue:5 Pt 1

    Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Drug Administration Schedule; Electrocardiography

1985
Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients.
    The American journal of psychiatry, 1985, Volume: 142, Issue:7

    Topics: Age Factors; Aged; Arrhythmias, Cardiac; Depressive Disorder; Dose-Response Relationship, Drug; Elec

1985
Beta blockade in the treatment of tricyclic antidepressant overdosage.
    The Medical journal of Australia, 1973, Jun-23, Volume: 1, Issue:25

    Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Amitriptyline; Antidepressive Agen

1973
Tricylic antidepressants and cardiac dysrhythmias during dental anaesthesia.
    Anaesthesia, 1974, Volume: 29, Issue:5

    Topics: Adult; Anesthesia, Dental; Anesthesia, General; Arrhythmia, Sinus; Arrhythmias, Cardiac; Blood Press

1974
The use of sodium bicarbonate in the treatment of tricyclic antidepressant-induced arrhythmias.
    Anaesthesia and intensive care, 1973, Volume: 1, Issue:3

    Topics: Acid-Base Equilibrium; Acidosis; Amitriptyline; Animals; Antidepressive Agents; Arrhythmias, Cardiac

1973
Nortriptyline (Aventyl) overdosage.
    Southern medical journal, 1969, Volume: 62, Issue:11

    Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Epilepsy, Tonic-Clonic; Female; Humans; Nortriptyl

1969
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.
    The Medical journal of Australia, 1972, Jul-08, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block;

1972
Physostigmine therapy in acute tricyclic antidepressant poisoning.
    Clinical toxicology, 1971, Volume: 4, Issue:3

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Barbiturates; Blood P

1971
Cardiac abnormalities in poisoning with tricyclic antidepressants.
    British medical journal, 1969, Jun-07, Volume: 2, Issue:5657

    Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Electrocardiography;

1969