nortriptyline has been researched along with Arrhythmia in 21 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 to 7 mg base per kilogram caused significantly more arrhythmias than did E-10-hydroxynortriptyline (E-10-OH-NT) but was not significantly different from Z-10-hydroxynortriptyline (Z-10-OH-NT) in this effect." | 3.68 | Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites. ( Everett, G; Perel, JM; Pollock, BG, 1992) |
| "The effect of nortriptyline against ventricular arrhythmias was determined in 16 cardiac patients with 30 or more ventricular premature depolarizations per hour." | 3.67 | The antiarrhythmic effect of nortriptyline in cardiac patients with ventricular premature depolarizations. ( Barnard, T; Bigger, JT; Giardina, EG; Johnson, L; Louie, M; Saroff, AL, 1986) |
| " In 1 patient, acute myocardial infarction developed after two 10-mg doses of nortriptyline." | 3.66 | Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged. ( Oei, LS; Rodstein, M, 1979) |
| "Nortriptyline was effective for his depressive as well as for obsessive symptoms." | 1.33 | [A case of Brugada syndrome with convulsive seizure during antidepressant administration: relation of antidepressant agents and arrhythmia leading to sudden death]. ( Aihara, H; Aonuma, K; Asada, T; Endo, G; Hori, T; Tanimukai, S, 2006) |
| "Nortriptyline therapy was associated with increased QRS interval and heart rate but did not significantly affect other hemodynamic or ECG variables or cyclosporine dose requirements." | 1.28 | Nortriptyline treatment of depressed cardiac transplant recipients. ( Shapiro, PA, 1991) |
| "Five of the 10 patients had arrhythmias and two of these died." | 1.25 | Cardiac abnormalities in poisoning with tricyclic antidepressants. ( Beattie, RR; Freeman, JW; Mundy, GR; Ryan, C, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (76.19) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, G | 1 |
| Hori, T | 1 |
| Tanimukai, S | 1 |
| Aihara, H | 1 |
| Aonuma, K | 1 |
| Asada, T | 1 |
| Tacconi, MT | 1 |
| Bonaccorsi, A | 1 |
| Cini, M | 1 |
| Spina, AM | 1 |
| Bizzi, A | 1 |
| Fraser, A | 1 |
| Paramananthan, T | 1 |
| Shaw, H | 1 |
| Gibb, I | 1 |
| Ziegler, VE | 1 |
| Co, BT | 1 |
| Biggs, JT | 1 |
| Rodstein, M | 1 |
| Oei, LS | 1 |
| Baum, T | 1 |
| Peters, JR | 1 |
| Butz, F | 1 |
| Much, DR | 1 |
| Pollock, BG | 1 |
| Everett, G | 1 |
| Perel, JM | 1 |
| Shapiro, PA | 1 |
| Dietch, JT | 1 |
| Fine, M | 1 |
| Sirota, P | 1 |
| Ori, J | 1 |
| Schild, K | 1 |
| Appel, S | 1 |
| Brandis, S | 1 |
| Zahavi, I | 1 |
| Schneider, LS | 1 |
| Cooper, TB | 1 |
| Severson, JA | 1 |
| Zemplenyi, T | 1 |
| Sloane, RB | 1 |
| Giardina, EG | 2 |
| Barnard, T | 1 |
| Johnson, L | 1 |
| Saroff, AL | 1 |
| Bigger, JT | 2 |
| Louie, M | 1 |
| Johnson, LL | 1 |
| Vita, J | 1 |
| Brem, RF | 1 |
| Young, RC | 1 |
| Alexopoulos, GS | 1 |
| Shamoian, CA | 1 |
| Kent, E | 1 |
| Dhar, AK | 1 |
| Kutt, H | 1 |
| Freeman, JW | 2 |
| Loughhead, MG | 1 |
| Plowman, PE | 1 |
| Thomas, WJ | 1 |
| Brown, TC | 1 |
| Barker, GA | 1 |
| Dunlop, ME | 1 |
| Loughnan, PM | 1 |
| Duke, WW | 1 |
| Horton, JP | 1 |
| Sedal, L | 1 |
| Korman, MG | 1 |
| Williams, PO | 1 |
| Mushin, G | 1 |
| Slovis, TL | 1 |
| Ott, JE | 1 |
| Teitebaum, DT | 1 |
| Lipscomb, W | 1 |
| Mundy, GR | 1 |
| Beattie, RR | 1 |
| Ryan, C | 1 |
2 trials available for nortriptyline and Arrhythmia
| Article | Year |
|---|---|
Plasma nortriptyline levels and ECG findings.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Depression; Electrocardiography; Electr | 1977 |
Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Dose-R | 1988 |
19 other studies available for nortriptyline and Arrhythmia
| Article | Year |
|---|---|
[A case of Brugada syndrome with convulsive seizure during antidepressant administration: relation of antidepressant agents and arrhythmia leading to sudden death].
Topics: Adult; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Brugada Syndrome; Death, Sudden, Card | 2006 |
Effect of carnitine on heart alterations caused by tricyclic antidepressants.
Topics: Animals; Arrhythmias, Cardiac; Carnitine; Heart; Male; Nortriptyline; Rabbits | 1981 |
Nortriptyline and electroconvulsive therapy.
Topics: Adult; Arrhythmias, Cardiac; Bipolar Disorder; Depressive Disorder; Electroconvulsive Therapy; Femal | 1982 |
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; | 1979 |
Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Dogs | 1976 |
Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Blood Proteins; Cardiac Output, Low; Chromatography, | 1992 |
Nortriptyline treatment of depressed cardiac transplant recipients.
Topics: Adult; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography; Female; Heart Rate; Heart Tra | 1991 |
The effect of nortriptyline in elderly patients with cardiac conduction disease.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depressive Disorder | 1990 |
Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels.
Topics: Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography, Ambulato | 1990 |
The antiarrhythmic effect of nortriptyline in cardiac patients with ventricular premature depolarizations.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Female; Half-Life; Humans; Male; Middle Aged; Nor | 1986 |
Effect of imipramine and nortriptyline on left ventricular function and blood pressure in patients treated for arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Drug Administration Schedule; Electrocardiography | 1985 |
Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients.
Topics: Age Factors; Aged; Arrhythmias, Cardiac; Depressive Disorder; Dose-Response Relationship, Drug; Elec | 1985 |
Beta blockade in the treatment of tricyclic antidepressant overdosage.
Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Amitriptyline; Antidepressive Agen | 1973 |
Tricylic antidepressants and cardiac dysrhythmias during dental anaesthesia.
Topics: Adult; Anesthesia, Dental; Anesthesia, General; Arrhythmia, Sinus; Arrhythmias, Cardiac; Blood Press | 1974 |
The use of sodium bicarbonate in the treatment of tricyclic antidepressant-induced arrhythmias.
Topics: Acid-Base Equilibrium; Acidosis; Amitriptyline; Animals; Antidepressive Agents; Arrhythmias, Cardiac | 1973 |
Nortriptyline (Aventyl) overdosage.
Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Epilepsy, Tonic-Clonic; Female; Humans; Nortriptyl | 1969 |
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block; | 1972 |
Physostigmine therapy in acute tricyclic antidepressant poisoning.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Barbiturates; Blood P | 1971 |
Cardiac abnormalities in poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Electrocardiography; | 1969 |