nortriptyline has been researched along with Amyotrophic Lateral Sclerosis in 1 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was to characterize the neuroprotective effects of nortriptyline, a tricyclic antidepressant, in mouse models of chronic neurodegeneration [amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)]." | 3.74 | Nortriptyline delays disease onset in models of chronic neurodegeneration. ( Cormier, K; Ferrante, RJ; Friedlander, RM; Guan, Y; Huo, C; Kristal, BS; Smith, K; Stavrovskaya, IG; Wang, H; Wang, X; Zhu, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Guan, Y | 1 |
| Wang, X | 1 |
| Smith, K | 1 |
| Cormier, K | 1 |
| Zhu, S | 1 |
| Stavrovskaya, IG | 1 |
| Huo, C | 1 |
| Ferrante, RJ | 1 |
| Kristal, BS | 1 |
| Friedlander, RM | 1 |
1 other study available for nortriptyline and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Nortriptyline delays disease onset in models of chronic neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antidepressive Agents, Tricyclic; Apoptosis; Brain; Chronic | 2007 |