nortriptyline has been researched along with Aging in 19 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therapeutic drug monitoring data for nortriptyline (674 analyses from 578 patients) were evaluated with the nonparametric maximum likelihood (NPML) method in order to determine the population kinetic parameters of this drug and their relation to age, body weight and duration of treatment." | 3.69 | Population pharmacokinetics of nortriptyline during monotherapy and during concomitant treatment with drugs that inhibit CYP2D6--an evaluation with the nonparametric maximum likelihood method. ( Jerling, M; Mallet, A; Mentré, F; Merlé, Y, 1994) |
| " The authors measured serum levels of NT and 10-hydroxynortriptyline (10-OH-NT) using a column-switching HPLC method, and examined aging effects on NT steady-state levels to NT doses (doses/kg) ratios and NT levels to 10-OH-NT levels ratios as well as clinical response and propensity for side effects." | 3.68 | Nortriptyline response in elderly depressed patients. ( Kanba, S; Kinoshita, N; Matsumoto, K; Nibuya, M; Shintani, F; Suzuki, E; Yagi, G, 1992) |
| "It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed." | 2.37 | Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984) |
| " The actual dosing levels at the second treatment were compared with estimates based on HA." | 1.35 | Seizure threshold in a large sample: implications for stimulus dosing strategies in bilateral electroconvulsive therapy: a report from CORE. ( Bailine, S; Braga, RJ; Fink, M; Husain, M; Kellner, C; Knapp, R; Malur, C; Mueller, M; O'Connor, K; Petrides, G; Rummans, T, 2009) |
| "2." | 1.26 | Plasma nortriptyline and cardiac responses in young and old rats. ( Bonaccorsi, A; Franco, R; Garattini, S; Morselli, PL; Pita, E, 1977) |
| "For nortriptyline there is an inverse ratio, with more nortriptyline and desmethylnortriptyline in the older animals than in the young ones." | 1.26 | [Proceedings: Age and sex specificity of organ distribution and metabolism of chlorprothixene and nortriptyline in the rat (author's transl)]. ( Dell, HD; Fassbender, W; Kamp, R; Lorenz, D, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 9 (47.37) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrides, G | 1 |
| Braga, RJ | 1 |
| Fink, M | 1 |
| Mueller, M | 1 |
| Knapp, R | 1 |
| Husain, M | 1 |
| Rummans, T | 1 |
| Bailine, S | 1 |
| Malur, C | 1 |
| O'Connor, K | 1 |
| Kellner, C | 1 |
| Brickman, AM | 1 |
| Sneed, JR | 1 |
| Provenzano, FA | 1 |
| Garcon, E | 1 |
| Johnert, L | 1 |
| Muraskin, J | 1 |
| Yeung, LK | 1 |
| Zimmerman, ME | 1 |
| Roose, SP | 1 |
| Lenze, EJ | 1 |
| Mulsant, BH | 1 |
| Dew, MA | 1 |
| Shear, MK | 1 |
| Houck, P | 1 |
| Pollock, BG | 2 |
| Reynolds, CF | 3 |
| Cutler, NR | 1 |
| Narang, PK | 1 |
| Young, RC | 2 |
| Alexopoulos, GS | 2 |
| Shamoian, CA | 1 |
| Manley, MW | 1 |
| Dhar, AK | 2 |
| Kutt, H | 2 |
| Schmider, J | 1 |
| Deuschle, M | 1 |
| Schweiger, U | 1 |
| Körner, A | 1 |
| Gotthardt, U | 1 |
| Heuser, IJ | 1 |
| Monteleone, P | 1 |
| Fabrazzo, M | 1 |
| Jerling, M | 1 |
| Merlé, Y | 1 |
| Mentré, F | 1 |
| Mallet, A | 1 |
| Amitai, Y | 1 |
| Kennedy, EJ | 1 |
| DeSandre, P | 1 |
| Frischer, H | 1 |
| Miller, MD | 2 |
| Wolfson, L | 1 |
| Frank, E | 1 |
| Cornes, C | 1 |
| Silberman, R | 1 |
| Ehrenpreis, L | 1 |
| Zaltman, J | 1 |
| Malloy, J | 1 |
| Bonaccorsi, A | 2 |
| Garattini, S | 2 |
| Franco, R | 1 |
| Morselli, PL | 1 |
| Pita, E | 1 |
| Dell, HD | 1 |
| Fassbender, W | 1 |
| Kamp, R | 1 |
| Lorenz, D | 1 |
| Paradis, CF | 1 |
| Stack, JA | 1 |
| George, CJ | 1 |
| Rifai, AH | 1 |
| Mazumdar, S | 1 |
| Perel, JM | 1 |
| Kanba, S | 1 |
| Matsumoto, K | 1 |
| Nibuya, M | 1 |
| Suzuki, E | 1 |
| Kinoshita, N | 1 |
| Shintani, F | 1 |
| Yagi, G | 1 |
| Fukuchi, H | 1 |
| Kitaura, T | 1 |
| Miyake, K | 1 |
| Kimura, M | 1 |
| Kimura, Y | 1 |
| Sarai, K | 1 |
| Nakahara, T | 1 |
| Corona, GL | 1 |
| Cucchi, ML | 1 |
| Frattini, P | 1 |
| Santagostino, G | 1 |
| Schinelli, S | 1 |
| Zerbi, F | 1 |
| Savoldi, F | 1 |
| Asberg, M | 1 |
| Evans, DA | 1 |
| Sjöqvist, F | 1 |
2 reviews available for nortriptyline and Aging
| Article | Year |
|---|---|
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde | 1984 |
Cardiac effects of nortriptyline and other tricyclic antidepressant drugs.
Topics: Aged; Aging; Animals; Antidepressive Agents, Tricyclic; Electrocardiography; Heart; Heart Diseases; | 1978 |
5 trials available for nortriptyline and Aging
| Article | Year |
|---|---|
Quantitative approaches for assessment of white matter hyperintensities in elderly populations.
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Brain; Brain Mapping; Depression; Double-Blin | 2011 |
Good treatment outcomes in late-life depression with comorbid anxiety.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Antidepressive Agents, Second-Generation; Antidepressi | 2003 |
Amitriptyline metabolism in elderly depressed patients and normal controls in relation to hypothalamic-pituitary-adrenal system function.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; | 1995 |
Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Diso | 1994 |
Using interpersonal psychotherapy (IPT) in a combined psychotherapy/medication research protocol with depressed elders. A descriptive report with case vignettes.
Topics: Aged; Aging; Antidepressive Agents, Tricyclic; Depression; Female; Geriatric Psychiatry; Humans; Mal | 1997 |
12 other studies available for nortriptyline and Aging
| Article | Year |
|---|---|
Seizure threshold in a large sample: implications for stimulus dosing strategies in bilateral electroconvulsive therapy: a report from CORE.
Topics: Aged; Aging; Antidepressive Agents, Tricyclic; Calibration; Depressive Disorder, Major; Dose-Respons | 2009 |
Plasma 10-hydroxynortriptyline in elderly depressed patients.
Topics: Adolescent; Adult; Aged; Aging; Creatinine; Depressive Disorder; Female; Humans; Male; Middle Aged; | 1984 |
Population pharmacokinetics of nortriptyline during monotherapy and during concomitant treatment with drugs that inhibit CYP2D6--an evaluation with the nonparametric maximum likelihood method.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Body Weight; Chromatography, High Press | 1994 |
Distribution of amitriptyline and nortriptyline in blood: role of alpha-1-glycoprotein.
Topics: Aging; Amitriptyline; Chromatography, High Pressure Liquid; Erythrocytes; Fetal Blood; Humans; Nortr | 1993 |
Plasma nortriptyline and cardiac responses in young and old rats.
Topics: Aging; Animals; Chromatography, Gas; Electrocardiography; Heart; Heart Rate; Kinetics; Myocardium; N | 1977 |
[Proceedings: Age and sex specificity of organ distribution and metabolism of chlorprothixene and nortriptyline in the rat (author's transl)].
Topics: Aging; Animals; Chlorprothixene; Female; Male; Nortriptyline; Rats; Sex Factors | 1976 |
Nortriptyline and weight change in depressed patients over 60.
Topics: Aged; Aging; Body Weight; Depressive Disorder; Humans; Nortriptyline; Psychiatric Status Rating Scal | 1992 |
Nortriptyline response in elderly depressed patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Depressive Disorder; Fe | 1992 |
Association between dosage and serum concentration of antidepressants.
Topics: Adult; Aged; Aging; Amitriptyline; Antidepressive Agents; Biotransformation; Chromatography, High Pr | 1990 |
Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression.
Topics: Adult; Aged; Aging; Amitriptyline; Body Weight; Depressive Disorder; Female; Humans; Middle Aged; Mo | 1990 |
Plasma 10-hydroxynortriptyline and renal function in elderly depressives.
Topics: Aged; Aged, 80 and over; Aging; Creatinine; Depressive Disorder; Humans; Kidney; Kidney Function Tes | 1987 |
Genetic control of nortriptyline kinetics in man: a study of relatives of propositi with high plasma concentrations.
Topics: Adolescent; Adult; Aged; Aging; Body Weight; Female; Genetics, Medical; Humans; Male; Middle Aged; N | 1971 |