norsecurinine and Leukemia-P388

norsecurinine has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for norsecurinine and Leukemia-P388

Article	Year
Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa. Organic letters, 2006, May-25, Volume: 8, Issue:11 [structure: see text] Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A (1) and B (2), as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses, and supported by their unique biosynthetic pathway as proposed. Both 1 and 2 were tested against two tumor cell lines, and alkaloid 1 showed weak activity against the P-388 cell line. Topics: Alkaloids; Animals; Azepines; Drug Screening Assays, Antitumor; Euphorbiaceae; Humans; Indolizines; Leukemia P388; Mice; Molecular Structure; Piperidines; Plant Roots; Plants, Medicinal	2006

Article

Year

Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa.

Organic letters, 2006, May-25, Volume: 8, Issue:11

[structure: see text] Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A (1) and B (2), as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses, and supported by their unique biosynthetic pathway as proposed. Both 1 and 2 were tested against two tumor cell lines, and alkaloid 1 showed weak activity against the P-388 cell line.

Topics: Alkaloids; Animals; Azepines; Drug Screening Assays, Antitumor; Euphorbiaceae; Humans; Indolizines; Leukemia P388; Mice; Molecular Structure; Piperidines; Plant Roots; Plants, Medicinal

2006