norquetiapine and Schizophrenia

norquetiapine has been researched along with Schizophrenia* in 2 studies

Trials

1 trial(s) available for norquetiapine and Schizophrenia

Article	Year
Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response. The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:8 Cumulative evidence indicates that neuropeptides play a role in the pathophysiology of schizophrenia. Early data showed increased neuropeptide Y (NPY) in cerebrospinal fluid (CSF) from schizophrenia patients and data from rodents show that antipsychotic drugs modulate NPY levels in and release from selected rat brain regions. In view of these findings we investigated whether the atypical antipsychotic quetiapine, originally used as an antipsychotic but subsequently shown to be efficient also in major depressive disorder and in both poles of bipolar disorder, would affect NPY-like immunoreactivity (-LI), and corticotropin-releasing hormone (CRH)-LI levels in CSF of schizophrenia patients. NPY-LI and CRH-LI in CSF were determined in 22 patients with schizophrenia. Lumbar puncture was performed at baseline and again after 4 wk of quetiapine treatment (600 mg/d). Patients were assessed with the Positive and Negative Syndrome Scale (PANSS) at baseline and at weekly intervals. Quetiapine treatment was associated with a significant increase in NPY-LI (p<0.001) and decrease in CRH-LI (p<0.01). Stepwise multiple regression analysis revealed that ΔNPY-LI and ΔCRH-LI levels predicted 63% (p<0.001) of the variability of the ΔPANSS total score, ΔNPY-LI 42% (p<0.05) of the ΔPANSS anxiety items (G2) and ΔCRH-LI 40% (p=0.05) of the ΔPANSS depression items (G6). These results suggest that while quetiapine's effects on monoamines are probably related to its antipsychotic properties, the modulation of NPY and CRH accounts for its antidepressant and anxiolytic effects and can be markers of response. Topics: Adolescent; Adult; Analysis of Variance; Antipsychotic Agents; Corticotropin-Releasing Hormone; Dibenzothiazepines; Electrocardiography; Electroencephalography; Female; Humans; Male; Middle Aged; Neuropeptide Y; Quetiapine Fumarate; Regression Analysis; ROC Curve; Schizophrenia; Tandem Mass Spectrometry; Treatment Outcome; Young Adult	2012

Article

Year

Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response.

The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:8

Cumulative evidence indicates that neuropeptides play a role in the pathophysiology of schizophrenia. Early data showed increased neuropeptide Y (NPY) in cerebrospinal fluid (CSF) from schizophrenia patients and data from rodents show that antipsychotic drugs modulate NPY levels in and release from selected rat brain regions. In view of these findings we investigated whether the atypical antipsychotic quetiapine, originally used as an antipsychotic but subsequently shown to be efficient also in major depressive disorder and in both poles of bipolar disorder, would affect NPY-like immunoreactivity (-LI), and corticotropin-releasing hormone (CRH)-LI levels in CSF of schizophrenia patients. NPY-LI and CRH-LI in CSF were determined in 22 patients with schizophrenia. Lumbar puncture was performed at baseline and again after 4 wk of quetiapine treatment (600 mg/d). Patients were assessed with the Positive and Negative Syndrome Scale (PANSS) at baseline and at weekly intervals. Quetiapine treatment was associated with a significant increase in NPY-LI (p<0.001) and decrease in CRH-LI (p<0.01). Stepwise multiple regression analysis revealed that ΔNPY-LI and ΔCRH-LI levels predicted 63% (p<0.001) of the variability of the ΔPANSS total score, ΔNPY-LI 42% (p<0.05) of the ΔPANSS anxiety items (G2) and ΔCRH-LI 40% (p=0.05) of the ΔPANSS depression items (G6). These results suggest that while quetiapine's effects on monoamines are probably related to its antipsychotic properties, the modulation of NPY and CRH accounts for its antidepressant and anxiolytic effects and can be markers of response.

Topics: Adolescent; Adult; Analysis of Variance; Antipsychotic Agents; Corticotropin-Releasing Hormone; Dibenzothiazepines; Electrocardiography; Electroencephalography; Female; Humans; Male; Middle Aged; Neuropeptide Y; Quetiapine Fumarate; Regression Analysis; ROC Curve; Schizophrenia; Tandem Mass Spectrometry; Treatment Outcome; Young Adult

2012

Other Studies

1 other study(ies) available for norquetiapine and Schizophrenia

Article	Year
Norquetiapine and depressive symptoms in initially antipsychotic-naive first-episode schizophrenia. Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:2 Topics: Adult; Antipsychotic Agents; Depression; Dibenzothiazepines; Female; Follow-Up Studies; Humans; Male; Psychiatric Status Rating Scales; Quetiapine Fumarate; Schizophrenia; Treatment Outcome; Young Adult	2013