normetanephrine has been researched along with Depressive Disorder in 28 studies
Normetanephrine: A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Desipramine treatment produced significant increases in urinary norepinephrine (NE) and normetanephrine (NMN) and plasma NE at Weeks 4 and 6, but not at Week 1." | 1.35 | Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3). ( Alpert, J; Hennen, J; Koutsos, M; McHale, N; Mooney, JJ; Pappalardo, K; Samson, JA; Schildkraut, JJ, 2008) |
| "Recurrent fall/winter depressions that remit during spring and summer have been called Seasonal Affective Disorders (SAD) (Wehr and Rosenthal 1989)." | 1.28 | Changes in norepinephrine output following light therapy for fall/winter seasonal depression. ( Anderson, JL; Bloomingdale, KL; Mooney, JJ; Samson, JA; Schildkraut, JJ; Vasile, RG, 1992) |
| "Treatment with lithium carbonate significantly reduced urinary norepinephrine, normetanephrine, 3-methoxy-4-hydroxyphenylglycol, and vanillylmandelic acid output as well as whole-body norepinephrine turnover." | 1.27 | Electroconvulsive treatment and lithium carbonate. Their effects on norepinephrine metabolism in patients with primary, major depressions. ( Karoum, F; Linnoila, M; Potter, WZ; Rosenthal, N, 1983) |
| "Thirteen patients with endogenous depression, compared to 25 normal controls, had a significantly greater ratio of the urinary excretion of norepinephrine plus its metabolite normetanephrine to either the sum of the two urinary norepinephrine metabolites 3-methoxy-4-hydroxyphenylglycol plus vanillylmandelic acid or to the sum of urinary norepinephrine and all of its metabolites." | 1.27 | Relative activity of metabolic pathways for norepinephrine in endogenous depression. ( Karoum, F; Linnoila, M; Pickar, D; Roy, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (71.43) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oei, TP | 1 |
| Dingle, GA | 1 |
| McCarthy, M | 1 |
| Schildkraut, JJ | 5 |
| Mooney, JJ | 3 |
| Samson, JA | 3 |
| Hennen, J | 1 |
| Pappalardo, K | 1 |
| McHale, N | 1 |
| Alpert, J | 1 |
| Koutsos, M | 1 |
| Linnoila, M | 13 |
| Karoum, F | 12 |
| Miller, T | 1 |
| Potter, WZ | 7 |
| Kelwala, S | 1 |
| Jones, D | 1 |
| Sitaram, N | 1 |
| Calil, HM | 1 |
| Kopin, IJ | 2 |
| Rosenthal, N | 1 |
| Schatzberg, AF | 2 |
| Orsulak, PJ | 2 |
| Rosenbaum, AH | 1 |
| Kruger, ER | 1 |
| Cole, JO | 2 |
| Grossman, F | 2 |
| Anderson, JL | 1 |
| Vasile, RG | 1 |
| Bloomingdale, KL | 2 |
| Manji, HK | 1 |
| Dawkins, K | 1 |
| Moleman, P | 1 |
| Tulen, JH | 1 |
| Blankestijn, PJ | 1 |
| Man in 't Veld, AJ | 1 |
| Boomsma, F | 1 |
| Santagostino, G | 1 |
| Preda, S | 1 |
| Cucchi, ML | 1 |
| Frattini, P | 1 |
| Secunda, SK | 1 |
| Cross, CK | 1 |
| Koslow, S | 1 |
| Katz, MM | 1 |
| Kocsis, JH | 1 |
| Maas, JW | 2 |
| Davis, JM | 1 |
| Koslow, SH | 1 |
| Gibbons, RD | 1 |
| Bowden, CL | 1 |
| Casper, R | 1 |
| Hanin, I | 1 |
| Javaid, JI | 1 |
| Chang, SS | 1 |
| Stokes, PE | 1 |
| Gerson, B | 1 |
| Kizuka, PP | 1 |
| Roy, A | 8 |
| Pickar, D | 8 |
| De Jong, J | 2 |
| Anokhina, ID | 1 |
| Bol'shakova, TD | 1 |
| Bremer, GP | 1 |
| Buniatian, AF | 1 |
| Ignatenko, LL | 1 |
| Guthrie, S | 1 |
| Chrousos, GP | 1 |
| Gold, PW | 1 |
| Douillet, P | 1 |
| Siever, LJ | 1 |
| Uhde, TW | 1 |
| Jimerson, DC | 1 |
| Lake, CR | 1 |
| Murphy, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Psychopharmacology of Biogenic Amines in Depression[NCT00320632] | Phase 4 | 43 participants | Interventional | 1990-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for normetanephrine and Depressive Disorder
| Article | Year |
|---|---|
Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients.
Topics: Antidepressive Agents; Brain; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; Mal | 1982 |
Urinary excretion of catecholamines and their metabolites in relation to circulating catecholamines. Six-hour infusion of epinephrine and norepinephrine in healthy volunteers.
Topics: Adult; Depressive Disorder; Double-Blind Method; Epinephrine; Humans; Infusions, Intravenous; Male; | 1992 |
26 other studies available for normetanephrine and Depressive Disorder
| Article | Year |
|---|---|
Urinary catecholamine levels and response to group cognitive behaviour therapy in depression.
Topics: Adult; Aged; Catecholamines; Cognitive Behavioral Therapy; Depressive Disorder; Epinephrine; Female; | 2010 |
Toward a rapidly acting antidepressant: the normetanephrine and extraneuronal monoamine transporter (uptake 2) hypothesis.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agent | 2004 |
Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3).
Topics: Adrenergic Uptake Inhibitors; Adult; Catecholamines; Depressive Disorder; Desipramine; Female; Human | 2008 |
Reliability of urinary monoamine and metabolite output measurements in depressed patients.
Topics: Depressive Disorder; Dopamine; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; | 1983 |
Monoamine metabolites as predictors of antidepressant response: a critique.
Topics: Antidepressive Agents; Brain; Depressive Disorder; Dopamine beta-Hydroxylase; Homovanillic Acid; Hum | 1983 |
Electroconvulsive treatment and lithium carbonate. Their effects on norepinephrine metabolism in patients with primary, major depressions.
Topics: Brompheniramine; Clorgyline; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Hu | 1983 |
High correlation of norepinephrine and its major metabolite excretion rates.
Topics: Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged | 1982 |
High positive correlation between urinary free tyramine excretion rate and "whole body" norepinephrine turnover in depressed patients.
Topics: Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged | 1982 |
Catecholamine measures for diagnosis and treatment of patients with depressive disorders.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Catecholamines; Depressive Disorder; Epinephrine | 1980 |
Catecholamines in depression: a cumulative study of urinary norepinephrine and its major metabolites in unipolar and bipolar depressed patients versus healthy volunteers at the NIMH.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder; Female; Humans; Longitudinal Stu | 1999 |
Changes in norepinephrine output following light therapy for fall/winter seasonal depression.
Topics: Adult; Arousal; Bipolar Disorder; Depressive Disorder; Female; Humans; Methoxyhydroxyphenylglycol; M | 1992 |
Combined measures of noradrenergic output and receptor responsivity in depression.
Topics: Animals; Clonidine; Depressive Disorder; Humans; Norepinephrine; Normetanephrine; Receptors, Adrener | 1992 |
Simultaneous measurement of total catecholamines and metanephrines in human urine by liquid chromatography with coulometric detection.
Topics: Catecholamines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Depressive Disor | 1991 |
Studies of amine metabolites in depressed patients. Relationship to suicidal behavior.
Topics: Bipolar Disorder; Brain; Depressive Disorder; Epinephrine; Homovanillic Acid; Humans; Hydrocortisone | 1986 |
Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls.
Topics: Biogenic Amines; Circadian Rhythm; Depressive Disorder; Epinephrine; Female; Homovanillic Acid; Huma | 1988 |
Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders.
Topics: Adolescent; Adult; Age Factors; Aged; Algorithms; Bipolar Disorder; Depressive Disorder; Diagnosis, | 1989 |
Suicidal behavior in depression: relationship to noradrenergic function.
Topics: Adult; Bipolar Disorder; Blood-Brain Barrier; Brain; Depressive Disorder; Female; Humans; Male; Meth | 1989 |
[Features of the functioning of the catecholamine and adrenocortical systems of patients with depression and different degrees of emotional tension].
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex; Catecholamines; Depressive Disorder; Dexamethasone; Dihyd | 1986 |
Thyrotropin releasing hormone test in unipolar depressed patients and controls: relationship to clinical and biologic variables.
Topics: Adult; Biogenic Amines; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; Mi | 1988 |
High intercorrelations among urinary outputs of norepinephrine and its major metabolites. A replication in depressed patients and controls.
Topics: Adult; Depressive Disorder; Female; Glycols; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; | 1988 |
Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Relationship to hypothalamic-pituitary-adrenal axis function in depression.
Topics: Adult; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal S | 1988 |
Cerebrospinal fluid corticotropin-releasing hormone in depression: relationship to noradrenergic function.
Topics: Adult; Corticotropin-Releasing Hormone; Depressive Disorder; Dexamethasone; Female; Humans; Male; Me | 1987 |
Relative activity of metabolic pathways for norepinephrine in endogenous depression.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nor | 1986 |
Urinary monoamines and monoamine metabolites in subtypes of unipolar depressive disorder and normal controls.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Catecholamines; Depressive Disorder; Dopamine; Female; | 1986 |
Indices of noradrenergic output in depression.
Topics: Adult; Blood Pressure; Depressive Disorder; Female; Heart Rate; Humans; Male; Metanephrine; Methoxyh | 1986 |
Urinary excretion of free tyramine and of norepinephrine and its metabolites in unipolar depressed patients.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nor | 1986 |