Page last updated: 2024-10-21

normetanephrine and Bipolar Disorder

normetanephrine has been researched along with Bipolar Disorder in 28 studies

Normetanephrine: A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.

Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Research Excerpts

ExcerptRelevanceReference
"Recurrent fall/winter depressions that remit during spring and summer have been called Seasonal Affective Disorders (SAD) (Wehr and Rosenthal 1989)."1.28Changes in norepinephrine output following light therapy for fall/winter seasonal depression. ( Anderson, JL; Bloomingdale, KL; Mooney, JJ; Samson, JA; Schildkraut, JJ; Vasile, RG, 1992)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199026 (92.86)18.7374
1990's2 (7.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bunney, WE1
Davis, JM1
Weil-Malherbe, H1
Smith, ER1
Linnoila, M2
Karoum, F2
Potter, WZ2
Schatzberg, AF4
Orsulak, PJ4
Rosenbaum, AH1
Kruger, ER1
Schildkraut, JJ13
Cole, JO4
Grossman, F1
Gudeman, JE2
Rohde, WA2
LaBrie, RA2
Deleon-Jones, F1
Maas, JW5
Dekirmenjian, H4
Sanchez, J1
Anderson, JL1
Vasile, RG1
Mooney, JJ1
Bloomingdale, KL2
Samson, JA2
Secunda, SK1
Cross, CK1
Koslow, S1
Katz, MM1
Kocsis, JH1
Gerson, B1
Kizuka, PP1
Roy, A1
Pickar, D1
De Jong, J1
Rosenblatt, S3
Chanley, JD3
Leighton, WP3
Schanberg, SM1
Breese, GR1
Kopin, IJ1
Fawcett, JA2
Savage, C2
Messiha, FS2
Jones, FD1
Shopsin, B1
Wilk, S1
Gershon, S1
Davis, K1
Suhl, M1
Turek, I1
Hanlon, TE1
Greenspan, K2
Gordon, EK3
Levy, B1
Durell, J3
Draskoczy, PR1
Gershon, ES1
Reich, P1
Grab, EL1
Green, R1
Baer, L1
Aronoff, MS1
Fawcett, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cerebral Neuroinflammation During Major Depressive Episode: Multicentric Comparative Study.[NCT03314155]60 participants (Anticipated)Interventional2018-12-07Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for normetanephrine and Bipolar Disorder

ArticleYear
MHPG excretion by patients with affective disorders.
    International pharmacopsychiatry, 1974, Volume: 9, Issue:1

    Topics: Affective Symptoms; Bipolar Disorder; Brain; Catecholamines; Creatinine; Depression; Desipramine; De

1974

Trials

2 trials available for normetanephrine and Bipolar Disorder

ArticleYear
Catecholamine metabolism in affective disorders. II. Norepinephrine, normetanephrine, epinephrine, metanephrine, and VMA excretion in hypomanic patients.
    Archives of general psychiatry, 1969, Volume: 21, Issue:6

    Topics: Adult; Aged; Bipolar Disorder; Catecholamines; Clinical Trials as Topic; Epinephrine; Female; Humans

1969
Normetanephrine excretion and affective state in depressed patients treated with imipramine.
    The American journal of psychiatry, 1966, Volume: 123, Issue:6

    Topics: Affect; Bipolar Disorder; Clinical Trials as Topic; Depression; Female; Humans; Imipramine; Male; Mi

1966

Other Studies

25 other studies available for normetanephrine and Bipolar Disorder

ArticleYear
Biochemical changes in psychotic depression. High norepinephrine levels in psychotic vs neurotic depression.
    Archives of general psychiatry, 1967, Volume: 16, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adult; Anxiety; Bipolar Disorder; Catecholamines; Depression; Dopamine; E

1967
High positive correlation between urinary free tyramine excretion rate and "whole body" norepinephrine turnover in depressed patients.
    Biological psychiatry, 1982, Volume: 17, Issue:9

    Topics: Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged

1982
Catecholamine measures for diagnosis and treatment of patients with depressive disorders.
    The Journal of clinical psychiatry, 1980, Volume: 41, Issue:12 Pt 2

    Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Catecholamines; Depressive Disorder; Epinephrine

1980
Catecholamines in depression: a cumulative study of urinary norepinephrine and its major metabolites in unipolar and bipolar depressed patients versus healthy volunteers at the NIMH.
    Psychiatry research, 1999, Jul-30, Volume: 87, Issue:1

    Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder; Female; Humans; Longitudinal Stu

1999
Toward a biochemical classification of depressive disorders. I. Differences in urinary excretion of MHPG and other catecholamine metabolites in clinically defined subtypes of depressions.
    Archives of general psychiatry, 1978, Volume: 35, Issue:12

    Topics: Adult; Bipolar Disorder; Depression; Epinephrine; Female; Glycols; Humans; Male; Metanephrine; Metho

1978
Toward a biochemical classification of depressive disorders. II. Application of multivariate discriminant function analysis to data on urinary catecholamines and metabolites.
    Archives of general psychiatry, 1978, Volume: 35, Issue:12

    Topics: Adult; Bipolar Disorder; Depression; Epinephrine; Factor Analysis, Statistical; Female; Glycols; Hum

1978
Diagnostic subgroups of affective disorders and their urinary excretion of catecholamine metabolities.
    The American journal of psychiatry, 1975, Volume: 132, Issue:11

    Topics: Bipolar Disorder; Catecholamines; Depression; Female; Humans; Metanephrine; Methoxyhydroxyphenylglyc

1975
Changes in norepinephrine output following light therapy for fall/winter seasonal depression.
    Biological psychiatry, 1992, Oct-15, Volume: 32, Issue:8

    Topics: Adult; Arousal; Bipolar Disorder; Depressive Disorder; Female; Humans; Methoxyhydroxyphenylglycol; M

1992
Studies of amine metabolites in depressed patients. Relationship to suicidal behavior.
    Annals of the New York Academy of Sciences, 1986, Volume: 487

    Topics: Bipolar Disorder; Brain; Depressive Disorder; Epinephrine; Homovanillic Acid; Humans; Hydrocortisone

1986
Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders.
    Archives of general psychiatry, 1989, Volume: 46, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Algorithms; Bipolar Disorder; Depressive Disorder; Diagnosis,

1989
Suicidal behavior in depression: relationship to noradrenergic function.
    Biological psychiatry, 1989, Feb-01, Volume: 25, Issue:3

    Topics: Adult; Bipolar Disorder; Blood-Brain Barrier; Brain; Depressive Disorder; Female; Humans; Male; Meth

1989
Noradrenergic activity during the transition from depression to mania.
    Lancet (London, England), 1971, Mar-27, Volume: 1, Issue:7700

    Topics: Bipolar Disorder; Humans; Imipramine; Norepinephrine; Normetanephrine

1971
The investigation of adrenergic metabolism with 7H3-norepinephrine in psychiatric disorders. II. Temporal changes in the distribution of urinary tritiated metabolites in affective disorders.
    Journal of psychiatric research, 1969, Volume: 6, Issue:4

    Topics: Adjustment Disorders; Adult; Aged; Amines; Bipolar Disorder; Depression; Female; Humans; Injections,

1969
Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action.
    The American journal of psychiatry, 1967, Volume: 124, Issue:5

    Topics: Animals; Antidepressive Agents; Bipolar Disorder; Brain; Central Nervous System Stimulants; Chlorpro

1967
Biochemical criteria for classifying depressive disorders and predicting responses to pharmacotherapy: preliminary findings from studies of norepinephrine metabolism. Contributions to biochemistry.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1974, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Amphetamine; Anxiety; Bipolar Disorder; Brain; Depression; F

1974
Psychiatric and biochemical profiles of lithium therapy in mania. (Case report).
    Diseases of the nervous system, 1972, Volume: 33, Issue:6

    Topics: Adult; Bipolar Disorder; Dopamine; Female; Homovanillic Acid; Humans; Lithium; Norepinephrine; Norme

1972
Urinary catecholamine metabolites during behavioral changes in a patient with manic-depressive cycles.
    Science (New York, N.Y.), 1973, Jan-19, Volume: 179, Issue:4070

    Topics: Bipolar Disorder; Catecholamines; Catechols; Female; Glycols; Humans; Middle Aged; Normetanephrine;

1973
Cerebrospinal fluid MHPG. An assessment of norepinephrine metabolism in affective disorders.
    Archives of general psychiatry, 1973, Volume: 28, Issue:2

    Topics: Affective Symptoms; Bipolar Disorder; Brain; Chromatography; Depression; Diagnosis, Differential; Fe

1973
Dopamine-beta-hydroxylase: evidence for increased activity in sympathetic neurons during psychotic states.
    Science (New York, N.Y.), 1973, Nov-20, Volume: 182, Issue:4115

    Topics: Bipolar Disorder; Dopamine; Dopamine beta-Hydroxylase; Homovanillic Acid; Humans; Male; Methoxyhydro

1973
The effects of lithium on norepinephrine turnover and metabolism: basic and clinical studies.
    The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5

    Topics: Animals; Bipolar Disorder; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Humans; Imipram

1974
A psychopharmacological study of catecholamines in affective disorders.
    The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5

    Topics: Adult; Affective Symptoms; Bipolar Disorder; Catecholamines; Dopamine; Electroconvulsive Therapy; Fe

1974
Catecholamine metabolism in affective disorders. IV. Preliminary studies of norepinephrine metabolism in depressed patients treated with amitriptyline.
    Journal of psychiatric research, 1972, Volume: 9, Issue:3

    Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Catechols; Chromatography, Gas; Depression; Female; Gl

1972
Catecholamine metabolism in affective disorders. 3. MHPG and other catecholamine metabolites in patients treated with lithium carbonate.
    Journal of psychiatric research, 1970, Volume: 7, Issue:3

    Topics: Adrenal Medulla; Adult; Aged; Bipolar Disorder; Catecholamines; Catechols; Epinephrine; Female; Glyc

1970
Catecholamine metabolism, depression and stress.
    Nature, 1971, Apr-02, Volume: 230, Issue:5292

    Topics: Bipolar Disorder; Brain Chemistry; Catecholamines; Depression; Female; Glycols; Humans; Male; Middle

1971
The investigation of adrenergic metabolism with 7H3-norepinephrine in psychiatric disorders. I. Temporal changes in the distribution of urinary tritiated metabolites and the effects of drugs.
    Journal of psychiatric research, 1969, Volume: 6, Issue:4

    Topics: Amines; Bipolar Disorder; Chlorpromazine; Humans; Hydrogen-Ion Concentration; Injections, Intravenou

1969