Page last updated: 2024-09-03

norketamine and Depression

norketamine has been researched along with Depression in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (66.67)24.3611
2020's3 (33.33)2.80

Authors

AuthorsStudies
Hashimoto, K; Luo, A; Yang, C; Yang, J1
Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R1
Hashimoto, K1
Huang, C; Jiang, R; Liu, C; Wang, Y; Wu, Z; Xu, J; Yan, E; Yang, C; Yang, L; Zhou, L; Zhu, B1
Hashimoto, K; Shirayama, Y1
Chaki, S; Dong, C; Han, M; Hashimoto, K; Kobayashi, S; Ma, M; Manabe, T; Nakao, K; Nakazawa, K; Qu, Y; Ren, Q; Shirayama, Y; Toki, H; Yamaguchi, JI; Yang, C; Zhang, JC1
Hashimoto, K; Yang, C1
Liu, J; Osgood, SM; Shaffer, CL; Smith, DL; Trapa, PE1
Brutsche, N; Diazgranados, N; Franco-Chaves, J; Henter, ID; Ibrahim, L; Kronstein, P; Luckenbaugh, DA; Manji, HK; Moaddel, R; Wainer, I; Zarate, CA1

Reviews

2 review(s) available for norketamine and Depression

ArticleYear
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.
    Translational psychiatry, 2019, 11-07, Volume: 9, Issue:1

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Hippocampus; Humans; Ketamine; Prefrontal Cortex; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological

2019
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine.
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depression; Gastrointestinal Microbiome; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Spleen

2020

Trials

1 trial(s) available for norketamine and Depression

ArticleYear
Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Adolescent; Adult; Aged; Depression; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Riluzole; Time Factors; Young Adult

2012

Other Studies

6 other study(ies) available for norketamine and Depression

ArticleYear
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 191

    Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Female; Ketamine; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate

2020
Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 207

    Topics: Animals; Antidepressive Agents; Bacteria; Depression; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Ketamine; Lipopolysaccharides; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate

2021
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.
    The international journal of neuropsychopharmacology, 2018, 01-01, Volume: 21, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Helplessness, Learned; Ketamine; Male; Off-Label Use; Rats; Spermidine; Time Factors

2018
AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.
    Biological psychiatry, 2018, 10-15, Volume: 84, Issue:8

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Dendritic Spines; Depression; Hippocampus; Ketamine; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological

2018
Is (S)-norketamine an alternative antidepressant for esketamine?
    European archives of psychiatry and clinical neuroscience, 2019, Volume: 269, Issue:7

    Topics: Animals; Antidepressive Agents; Depression; Humans; Ketamine

2019
Enhancing ketamine translational pharmacology via receptor occupancy normalization.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ketamine; Macaca fascicularis; Male; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Species Specificity; Tritium

2014