norfluoxetine has been researched along with Sensitivity and Specificity in 22 studies
norfluoxetine: metabolite of fluoxetine; RN given refers to parent cpd without isomeric designation
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A selective, sensitive, simple, and rapid method for the simultaneous determination of fluoxetine (FL) and norfluoxetine (nor-FL) was developed and validated, and further applied to analyze plasma samples obtained from FL-treated patients with Parkinson disease (n = 18)." | 3.73 | Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study. ( Djordjevic, S; Kovacevic, I; Miljkovic, B; Pokrajac, M; Vuksanovic, J, 2005) |
| "A sensitive, robust gas chromatographic-mass spectrometric assay suitable for use in pharmacokinetic or bioequivalence studies is presented for the selective serotonin reuptake inhibitor, fluoxetine, and its major metabolite, norfluoxetine (N-desmethylfluoxetine)." | 1.30 | Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies. ( Addison, RS; Franklin, ME; Hooper, WD, 1998) |
| "Fluoxetine is an atypical antidepressant drug, which selectively inhibits the neuronal reuptake of serotonin, and is widely used in the treatment of depressive disorders." | 1.30 | Determination of fluoxetine and norfluoxetine in human plasma by high-pressure liquid chromatography with fluorescence detection. ( Bugamelli, F; Casamenti, G; Mandrioli, R; Raggi, MA; Volterra, V, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chow, TW | 1 |
| Szeitz, A | 1 |
| Rurak, DW | 1 |
| Riggs, KW | 1 |
| Li, Y | 1 |
| Emm, T | 1 |
| Yeleswaram, S | 1 |
| Oliveira, AF | 1 |
| de Figueiredo, EC | 1 |
| Dos Santos-Neto, AJ | 1 |
| Nielsen, MK | 1 |
| Johansen, SS | 1 |
| Houbart, V | 1 |
| Servais, AC | 1 |
| Charlier, TD | 1 |
| Pawluski, JL | 1 |
| Abts, F | 1 |
| Fillet, M | 1 |
| LLerena, A | 1 |
| Dorado, P | 1 |
| Berecz, R | 1 |
| González, A | 1 |
| Jesús Norberto, M | 1 |
| de la Rubia, A | 1 |
| Cáceres, M | 1 |
| Gatti, G | 1 |
| Bonomi, I | 1 |
| Marchiselli, R | 1 |
| Fattore, C | 1 |
| Spina, E | 1 |
| Scordo, G | 1 |
| Pacifici, R | 1 |
| Perucca, E | 1 |
| Guo, X | 1 |
| Fukushima, T | 1 |
| Li, F | 1 |
| Imai, K | 1 |
| Li, KM | 1 |
| Thompson, MR | 1 |
| McGregor, IS | 1 |
| Djordjevic, S | 1 |
| Kovacevic, I | 1 |
| Miljkovic, B | 1 |
| Vuksanovic, J | 1 |
| Pokrajac, M | 1 |
| Unceta, N | 1 |
| Barrondo, S | 1 |
| Ruiz de Azúa, I | 1 |
| Gómez-Caballero, A | 1 |
| Goicolea, MA | 1 |
| Sallés, J | 1 |
| Barrio, RJ | 1 |
| Nichols, JH | 1 |
| Charlson, JR | 1 |
| Lawson, GM | 1 |
| Eap, CB | 1 |
| Gaillard, N | 1 |
| Powell, K | 1 |
| Baumann, P | 1 |
| Ramaiya, A | 1 |
| March, C | 1 |
| Karnes, HT | 1 |
| Fontanille, P | 1 |
| Jourdil, N | 1 |
| Villier, C | 1 |
| Bessard, G | 1 |
| Holladay, JW | 1 |
| Dewey, MJ | 1 |
| Yoo, SD | 1 |
| Addison, RS | 1 |
| Franklin, ME | 1 |
| Hooper, WD | 1 |
| Raggi, MA | 2 |
| Mandrioli, R | 1 |
| Casamenti, G | 1 |
| Bugamelli, F | 1 |
| Volterra, V | 1 |
| Raap, DK | 1 |
| Garcia, F | 1 |
| Muma, NA | 1 |
| Wolf, WA | 1 |
| Battaglia, G | 1 |
| van de Kar, LD | 1 |
| Desiderio, C | 1 |
| Rudaz, S | 1 |
| Fanali, S | 1 |
| Sutherland, FC | 1 |
| Badenhorst, D | 1 |
| de Jager, AD | 1 |
| Scanes, T | 1 |
| Hundt, HK | 1 |
| Swart, KJ | 1 |
| Hundt, AF | 1 |
| Berzas Nevado, JJ | 1 |
| Contento Salcedo, AM | 1 |
| Villaseñor Llerena, MJ | 1 |
22 other studies available for norfluoxetine and Sensitivity and Specificity
| Article | Year |
|---|---|
A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS).
Topics: Animals; Chromatography, Liquid; Fluoxetine; Least-Squares Analysis; Reproducibility of Results; Sen | 2011 |
Simultaneous determination of fluoxetine and its major active metabolite norfluoxetine in human plasma by LC-MS/MS using supported liquid extraction.
Topics: Chromatography, Liquid; Drug Stability; Fluoxetine; Humans; Linear Models; Liquid-Liquid Extraction; | 2011 |
Analysis of fluoxetine and norfluoxetine in human plasma by liquid-phase microextraction and injection port derivatization GC-MS.
Topics: Drug Monitoring; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Linear Models; | 2013 |
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Analgesics; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chromatography, Hi | 2012 |
A validated microfluidics-based LC-chip-MS/MS method for the quantitation of fluoxetine and norfluoxetine in rat serum.
Topics: Animals; Chromatography, Liquid; Fluoxetine; Linear Models; Microfluidic Analytical Techniques; Mode | 2012 |
Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; | 2003 |
Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography.
Topics: Fluoxetine; Humans; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity | 2003 |
Determination of fluoxetine and norfluoxetine in rat plasma by HPLC with pre-column derivatization and fluorescence detection.
Topics: Animals; Chromatography, High Pressure Liquid; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Reprodu | 2003 |
Rapid quantitation of fluoxetine and norfluoxetine in serum by micro-disc solid-phase extraction with high-performance liquid chromatography-ultraviolet absorbance detection.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Reference Standards; Reproducibility of Re | 2004 |
Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study.
Topics: Adult; Aged; Chromatography, Liquid; Clinical Trials as Topic; Female; Fluoxetine; Humans; Male; Mas | 2005 |
Determination of fluoxetine, norfluoxetine and their enantiomers in rat plasma and brain samples by liquid chromatography with fluorescence detection.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fluoxetine; Rats; Reproducibility of Results; | 2007 |
Automated HPLC assay of fluoxetine and norfluoxetine in serum.
Topics: Autoanalysis; Chromatography, High Pressure Liquid; Fluoxetine; Humans; Quality Control; Sensitivity | 1994 |
Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry.
Topics: Fluoxetine; Fluvoxamine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; S | 1996 |
Single pump column switching technique employing a flow gradient and wavelength programmed fluorescence for simultaneous monitoring of serotonin, fluoxetine and norfluoxetine in rat brain microdialysate.
Topics: Animals; Calibration; Drug Monitoring; Fluoxetine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; | 1997 |
Direct analysis of fluoxetine and norfluoxetine in plasma by gas chromatography with nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Fluoxetine; Humans; Nitrogen; Phosphorus; Reproducibility of Results; Sensitivi | 1997 |
Quantification of fluoxetine and norfluoxetine serum levels by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Fluoxetine; Hydrogen-Ion Concentration; Kinet | 1997 |
Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies.
Topics: Adult; Antidepressive Agents, Second-Generation; Fluoxetine; Gas Chromatography-Mass Spectrometry; H | 1998 |
Determination of fluoxetine and norfluoxetine in human plasma by high-pressure liquid chromatography with fluorescence detection.
Topics: Calibration; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Fluoxetine; Hum | 1998 |
Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Brain; Drug Interactio | 1999 |
Enantiomeric separation of fluoxetine and norfluoxetine in plasma and serum samples with high detection sensitivity capillary electrophoresis.
Topics: Antidepressive Agents, Second-Generation; Electrophoresis, Capillary; Fluoxetine; Humans; Sensitivit | 1999 |
Sensitive liquid chromatographic-tandem mass spectrometric method for the determination of fluoxetine and its primary active metabolite norfluoxetine in human plasma.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Mass Spectrometry; Reproducibility of Resu | 2001 |
Micellar electrokinetic capillary chromatography for the determination of fluoxetine and its metabolite norfluoxetine in biological fluids.
Topics: Chromatography, Micellar Electrokinetic Capillary; Fluoxetine; Reproducibility of Results; Selective | 2002 |