norfluoxetine has been researched along with Pregnancy in 12 studies
norfluoxetine: metabolite of fluoxetine; RN given refers to parent cpd without isomeric designation
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this prospective clinical trial was to investigate the pharmacokinetics of fluoxetine and its active metabolite, norfluoxetine, during pregnancy, delivery, and lactation in mothers and their infants." | 9.10 | Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation. ( Ekblad, U; Heikkinen, T; Laine, K; Palo, P, 2003) |
| "Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery." | 7.73 | Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding. ( Fitzgerald, C; Grunau, RE; Kent, N; Kim, J; Misri, S; Oberlander, TF; Riggs, KW; Rurak, DW, 2006) |
| "To add to the limited data on the clinical pharmacology of antidepressants during pregnancy, we examined the dose-corrected chiral and racemic levels (level/dose) of fluoxetine (FLX) and norfluoxetine (NorFLX) during pregnancy and early postpartum." | 5.14 | Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing. ( Helsel, JC; Luther, JF; Perel, JM; Sit, D; Wisner, KL; Wisniewski, SR, 2010) |
| "Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery." | 3.73 | Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding. ( Fitzgerald, C; Grunau, RE; Kent, N; Kim, J; Misri, S; Oberlander, TF; Riggs, KW; Rurak, DW, 2006) |
| "Citalopram, fluoxetine and desmethylfluoxetine all cross the human placenta, and may, therefore, affect the perinatal outcome of infants exposed to these drugs during pregnancy." | 3.71 | Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta. ( Ekblad, U; Heikkine, T; Laine, K, 2002) |
| " The women were on stable daily doses of fluoxetine (10-60 mg/day) and all but two took the medication during the last trimester of pregnancy." | 3.71 | Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. ( Altshuler, LL; Fukuchi, A; Hendrick, V; Hostetter, A; Hwang, S; Leight, K; Mintz, J; Stowe, ZN; Suri, R, 2001) |
| " Accordingly, pharmacokinetic analysis of a series of fluoxetine and norfluoxetine administrations to pregnant baboons was performed." | 1.40 | Pharmacokinetics of fluoxetine in pregnant baboons (Papio spp.). ( Garland, M; Shoulson, RL; Stark, RL, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hudon Thibeault, AA | 2 |
| López de Los Santos, Y | 1 |
| Doucet, N | 1 |
| Sanderson, JT | 3 |
| Vaillancourt, C | 3 |
| Carvalho, DM | 1 |
| Lanchote, VL | 1 |
| Filgueira, GCO | 1 |
| Nardotto, GHB | 1 |
| Duarte, G | 1 |
| Cavalli, RC | 1 |
| Moisés, ECD | 1 |
| Clabault, H | 1 |
| Cohen, M | 1 |
| Shoulson, RL | 1 |
| Stark, RL | 1 |
| Garland, M | 1 |
| Laurent, L | 1 |
| Vo Duy, S | 1 |
| Sauvé, S | 1 |
| Caron, P | 1 |
| Guillemette, C | 1 |
| Sit, D | 1 |
| Perel, JM | 1 |
| Luther, JF | 1 |
| Wisniewski, SR | 1 |
| Helsel, JC | 1 |
| Wisner, KL | 1 |
| Heikkine, T | 1 |
| Ekblad, U | 2 |
| Laine, K | 2 |
| Heikkinen, T | 1 |
| Palo, P | 1 |
| Kim, J | 2 |
| Riggs, KW | 2 |
| Rurak, DW | 2 |
| Misri, S | 1 |
| Kent, N | 1 |
| Oberlander, TF | 1 |
| Grunau, RE | 1 |
| Fitzgerald, C | 1 |
| Hendrick, V | 1 |
| Stowe, ZN | 1 |
| Altshuler, LL | 1 |
| Mintz, J | 1 |
| Hwang, S | 1 |
| Hostetter, A | 1 |
| Suri, R | 1 |
| Leight, K | 1 |
| Fukuchi, A | 1 |
| Pohland, RC | 1 |
| Byrd, TK | 1 |
| Hamilton, M | 1 |
| Koons, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antidepressant Use During Pregnancy[NCT00279370] | 283 participants (Actual) | Observational | 1999-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for norfluoxetine and Pregnancy
| Article | Year |
|---|---|
Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Hum | 2010 |
Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation.
Topics: Adult; Child Development; Female; Fluoxetine; Humans; Infant, Newborn; Lactation; Male; Milk, Human; | 2003 |
10 other studies available for norfluoxetine and Pregnancy
| Article | Year |
|---|---|
Serotonin and serotonin reuptake inhibitors alter placental aromatase.
Topics: Aromatase; Cells, Cultured; Citalopram; Female; Fluoxetine; Humans; Molecular Docking Simulation; Pa | 2019 |
Pharmacokinetics and Transplacental Transfer of Fluoxetine Enantiomers and Their Metabolites in Pregnant Women.
Topics: Adult; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Humans; Pregnancy; Stereoisomerism; Young Adult | 2019 |
Effects of selective serotonin-reuptake inhibitors (SSRIs) in JEG-3 and HIPEC cell models of the extravillous trophoblast.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Cell Line; Cell Line, Tumor; Cell Movement; Ce | 2018 |
Pharmacokinetics of fluoxetine in pregnant baboons (Papio spp.).
Topics: Animals; Antidepressive Agents, Second-Generation; Female; Fetus; Fluoxetine; Humans; Papio; Pregnan | 2014 |
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit.
Topics: Aromatase; Cell Line, Tumor; Coculture Techniques; Estradiol; Estrogens; Female; Fluoxetine; Humans; | 2017 |
Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta.
Topics: Citalopram; Female; Fluoxetine; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Prospective St | 2002 |
Stereoselective pharmacokinetics of fluoxetine and norfluoxetine enantiomers in pregnant sheep.
Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Female; Fetus; Fluoxetine; Half-Life; In | 2004 |
Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding.
Topics: Adult; Aging; Antidepressive Agents, Second-Generation; Breast Feeding; Depressive Disorder, Major; | 2006 |
Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk.
Topics: Breast Feeding; Depression, Postpartum; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans | 2001 |
Placental transfer and fetal distribution of fluoxetine in the rat.
Topics: Animals; Autoradiography; Female; Fetus; Fluoxetine; Maternal-Fetal Exchange; Placenta; Pregnancy; R | 1989 |